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https://read.qxmd.com/read/30762613/number-of-ecg-replicates-influences-the-estimated-qt-prolonging-effect-of-a-drug
#1
H E C van der Wall, P Gal, M J B Kemme, G J P van Westen, J Burggraaf
INTRODUCTION: The present analysis addressed the effect of the number of ECG replicates extracted from a continuous ECG on estimated QT interval prolongation for different QT correction formulas. METHODS: For one hundred healthy volunteers, who received a compound prolonging the QT interval, 18 ECG replicates within a 3 minute window were extracted from 12-lead Holter ECGs. Ten QT correction formulas were deployed and the QTc interval was controlled for baseline and placebo and averaged per dose level...
February 6, 2019: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/30756396/pulmonary-vein-anatomy-addressed-by-computed-tomography-and-relation-to-success-of-second-generation-cyroballoon-ablation-in-paroxysmal-atrial-fibrillation
#2
Bart A Mulder, Meelad I H Al-Jazairi, Bauke K O Arends, Niels Bax, Leonard A Dijkshoorn, Uzaifa Sheikh, Eng Shiong Tan, Ans C P Wiesfeld, Robert G Tieleman, Rozemarijn Vliegenthart, Michiel Rienstra, Isabelle C van Gelder, Yuri Blaauw
BACKGROUND: Cryoballoon isolation is considered a safe and effective treatment for atrial fibrillation (AF). However, recurrence of AF after first cryoballoon ablation occurs in ~30% of patients. Pre-procedurally identifying patients at risk of AF recurrence could be beneficial. HYPOTHESIS: Our aim was to determine how pulmonary vein (PV) anatomy influences the recurrence of AF using the second-generation cryoballoon in patients with paroxysmal AF. METHODS: We included 88 consecutive patients with paroxysmal AF undergoing PVI procedure with a second-generation 28-mm cryoballoon...
February 13, 2019: Clinical Cardiology
https://read.qxmd.com/read/30753398/from-patient-specific-induced-pluripotent-stem-cells-to-clinical-translation-in-long-qt-syndrome-type-2
#3
Peter J Schwartz, Massimiliano Gnecchi, Federica Dagradi, Silvia Castelletti, Gianfranco Parati, Carla Spazzolini, Luca Sala, Lia Crotti
Aims: Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor + Ivacaftor (LUM + IVA) could shorten the QTc in the same two patients. Methods and results: After hospital admission and 1 day of baseline recordings, half dose LUM + IVA was administered on Day 1, followed by full dose (LUM 800 mg + IVA 500 mg) for 7 days...
February 6, 2019: European Heart Journal
https://read.qxmd.com/read/30741360/a-randomized-trial-evaluating-the-accuracy-of-af-detection-by-four-external-ambulatory-ecg-monitors-compared-to-permanent-pacemaker-af-detection
#4
Will Eysenck, Nick Freemantle, Neil Sulke
PURPOSE: Several external cardiac monitors (ECMs) have recently been developed. These have never been compared to 'gold standard' monitoring with concurrently implanted DDDRP pacemakers. The accuracy of AF detection of Zio XT Monitor (ZM), NUUBO Vest (NV) and Carnation Ambulatory Monitor (CAM) compared with Novacor 'R' Test 4 (RT) in patients (pts) with DDDRP PPM advanced Holters as the comparator, was evaluated. METHODS: Twenty-one pts. with AF and a DDDRP PPM, each acting as their own control subject, wore every ECM for 2 weeks in randomized order...
February 11, 2019: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/30736718/the-belgian-experience-with-concomitant-surgical-ablation-of-atrial-fibrillation-a-multi-centre-prospective-registry
#5
Lucas Van Hoof, Kristof De Brabandere, Steffen Fieuws, Bernard Stockman, Herbert Gutermann, Filip Rega
BACKGROUND: The Belgian 'National Institute for Health and Disability Insurance (RIZIV-INAMI)' requested prospective collection of data on all ablations in Belgium to determine the outcomes of surgical ablation of atrial fibrillation (AF) during concomitant cardiac surgery. METHODS: 890 patients undergoing concomitant ablation for AF between 2011 and 2016 were prospectively followed. Freedom from AF with and without anti-arrhythmic drugs was calculated for 817 patients with follow-up beyond the 3-month blanking period and for 574 patients with sufficient rhythm-related follow-up consisting of at least one Holter registration or a skipped Holter due to AF being evident on ECG...
February 8, 2019: Acta Cardiologica
https://read.qxmd.com/read/30723724/heart-rate-and-heart-rate-variability-of-rhesus-macaques-macaca-mulatta-affected-by-left-ventricular-hypertrophy
#6
Yu Ueda, Taylor L Slabaugh, Ashley L Walker, Eric S Ontiveros, Paul-Michael Sosa, Rachel Reader, Jeffrey A Roberts, Joshua A Stern
Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk of sudden cardiac death due to HCM has been reported to be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities of arrhythmias as well as heart rate variability (HRV) as an assessment of autonomic balance. Sudden cardiac death in association with naturally-occurring left ventricular hypertrophy (LVH) has been reported in a colony of rhesus macaques and is under investigation as a potential non-human primate model of human HCM...
2019: Frontiers in Veterinary Science
https://read.qxmd.com/read/30720638/qt-prolongation-and-variability-new-ecg-signs-of-atrial-potentials-dispersion-before-atrial-fibrillation-onset
#7
Massimo Magnano, Cristina Gallo, Pier Paolo Bocchino, Marco Briguglio, Anna Rivetti, Fiorenzo Gaita, Matteo Anselmino
AIMS: QT interval may be considered an indirect marker of atrial repolarization. Aim of our study was to verify if QT interval variations precede the onset of atrial fibrillation (AF). METHODS: We analyzed 21 AF onsets recorded at 24-h Holter ECG. Triggering supraventricular extrabeats (TSVEB) were identified and matched to nontriggering supraventricular extrabeats (NTSVEB) with the same prematurity index. QT and QTc intervals and their variability (max-min QT interval) were measured in the 10 beats preceding TSVEB and NTSVEB...
January 31, 2019: Journal of Cardiovascular Medicine
https://read.qxmd.com/read/30703839/-progress-in-systemic-sclerosis-early-targeted-and-intensive-therapy-is-the-key-to-success
#8
Gabriela Riemekasten
This literature review summarizes the main findings in systemic sclerosis (SSc) made in the last few years. Accordingly, the disease pathogenesis is mainly driven by the adaptive immune system, which is proven by the effects of autologous stem cell transplantation. Particularly, autoantibodies can activate both adaptive as well as innate immune cells as identified for the anti-angiotensin receptor antibodies. In addition, major achievements come from the early recognition of organ complications, which mainly appear in the first years upon Raynaud`s phenomenon...
February 2019: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/30701827/diagnostic-utility-of-long-term-remote-ecg-monitoring-in-compare-with-24-hour-holter-monitoring-in-patients-with-atrial-fibrillation-after-catheter-radiofrequency-ablation-in-the-early-postoperative-period
#9
G V Ryabykina, Z O Shokhzodaeva, O V Sapelnikov, M I Makeev, E Sh Kozhemyakina, E V Shchedrina, V E Volkov, R S Akchurin
AIM: To evaluate the diagnostic utility of long-term remote monitoring of ECG compared with 24 hour Holter monitoring for the detection of cardiac arrhythmias and conduction disturbance in patients with atrial fibrillation (AF) after catheter radiofrequency ablation (RFA; isolation) of the pulmonary veins. MATERIALS AND METHODS: The study included 62 patients aged 58.5±11.1 years, with paroxysmal or persistent AF, after catheter RFA (pulmonary veins isolation)...
December 30, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30689112/myocardial-infarction-with-non-obstructive-coronary-arteries-a-focus-on-vasospastic-angina
#10
REVIEW
M A Beijk, W V Vlastra, R Delewi, T P van de Hoef, S M Boekholdt, K D Sjauw, J J Piek
Vasospastic angina (VSA) is considered a broad diagnostic category including documented spontaneous episodes of angina pectoris produced by coronary epicardial vasospasm as well as those induced during provocative coronary vasospasm testing and coronary microvascular dysfunction due to microvascular spasm. The hallmark feature of VSA is rest angina, which promptly responds to short-acting nitrates; however, VSA can present with a great variety of symptoms, ranging from stable angina to acute coronary syndrome and even ventricular arrhythmia...
January 28, 2019: Netherlands Heart Journal
https://read.qxmd.com/read/30680493/validation-of-wearable-textile-electrodes-for-ecg-monitoring
#11
Yayoi Tetsuou Tsukada, Miwa Tokita, Hiroshige Murata, Yasuhiro Hirasawa, Kenji Yodogawa, Yu-Ki Iwasaki, Kuniya Asai, Wataru Shimizu, Nahoko Kasai, Hiroshi Nakashima, Shingo Tsukada
A highly conductive textile was woven from nano-fibers coated with the PEDOT-PSS polymer. The aim of this study was to assess the usefulness of textile electrodes for ECG recording as a smart garment. Electrode textile pads and lead wires were sewn to the lining of sportswear and their tolerability to repeated washings were tested up to 150 times. The electrical conductivity of the textile electrode remained functional for up to 50 machine washes. To assess the level of motion artifacts or noise during the daily monitoring of ECG, a single lead ECG with conventional or textile electrodes was recorded during supine rest, seated rest, upright trunk rotation (i...
January 24, 2019: Heart and Vessels
https://read.qxmd.com/read/30672637/coincidence-of-andersen-tawil-syndrome-and-marfan-syndrome-a-case-report
#12
Michalina Krych, Joanna Ponińska, Zofia T Bilińska, Rafał Płoski, Elżbieta K Biernacka
We report on a 44-year-old woman with coincidence of two genetic disorders: Andersen-Tawil syndrome and Marfan syndrome. In both, life-threatening arrhythmias could occur. A 44-year-old woman presented acute ascending aortic dissection with aortic arch involvement and chronic thoracic descending and abdominal aortic dissection. Clinical and genetic examination confirmed Marfan syndrome (MFS) diagnosis. Due to repolarization disorder in ECG and premature ventricular contractions in Holter ECG, the sequencing data were analyzed again and mutation in KCNJ2 gene was identified...
January 23, 2019: Annals of Noninvasive Electrocardiology
https://read.qxmd.com/read/30669678/a-novel-wearable-device-for-continuous-ambulatory-ecg-recording-proof-of-concept-and-assessment-of-signal-quality
#13
Christian Steinberg, François Philippon, Marina Sanchez, Pascal Fortier-Poisson, Gilles O'Hara, Franck Molin, Jean-François Sarrazin, Isabelle Nault, Louis Blier, Karine Roy, Benoit Plourde, Jean Champagne
Diagnosis of arrhythmic disorders is challenging because of their short-lasting, intermittent character. Conventional technologies of noninvasive ambulatory rhythm monitoring are limited by modest sensitivity. We present a novel form of wearable electrocardiogram (ECG) sensors providing an alternative tool for long-term rhythm monitoring with the potential of increased sensitivity to detect intermittent or subclinical arrhythmia. The objective was to assess the signal quality and R-R coverage of a wearable ECG sensor system compared to a standard 3-lead Holter...
January 21, 2019: Biosensors
https://read.qxmd.com/read/30641305/validation-of-a-novel-single-lead-ambulatory-ecg-monitor-cardiostat%C3%A2-compared-to-a-standard-ecg-holter-monitoring
#14
Isabelle Nault, Philippe André, Benoit Plourde, François Leclerc, Jean-François Sarrazin, François Philippon, Gilles O'Hara, Franck Molin, Christian Steinberg, Karine Roy, Louis Blier, Jean Champagne
BACKGROUND: Cardiostat™ is a single lead ambulatory ECG monitor. Recording is made through 2 electrodes positioned in a lead 1-like configuration. We first validated its accuracy for atrial fibrillation detection compared to a 12-lead ECG. In the second phase of the study, arrhythmia detection accuracy was compared between Cardiostat™ ambulatory ECG and a standard 24 h Holter ECG monitoring. METHOD/RESULTS: Phase one of the study included patients undergoing cardioversion for atrial fibrillation (AF) or atrial flutter...
December 19, 2018: Journal of Electrocardiology
https://read.qxmd.com/read/30622395/evaluation-of-heart-rate-variability-in-drug-free-panic-disorder-patients
#15
Gözde Şirin Durdu, Meral Kayikcioğlu, Şebnem Pirildar, Timur Köse
Introduction: It is well-known that autonomic function is impaired in panic disorder (PD). Heart rate variability (HRV) is a reliable and noninvasive method to evaluate autonomic functions. The aim of this study is to evaluate 24-hour heart rate variability (HRV) parameters in drug-free panic disorder patients. These results are compared with those obtained from healthy controls. Methods: Thirty-two (mean age 33.12±11.94 years, 20 female, 12 male) drug-free patients for at least 2 weeks, (for fluoksetin 3 weeks) diagnosed with panic disorder (PD) on the basis of DSM-IV criteria were included in the study...
December 2018: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/30617993/very-low-frequency-heart-rate-variability-predicts-the-development-of-post-stroke-infections
#16
Dirk Brämer, Albrecht Günther, Sven Rupprecht, Samuel Nowack, Josephine Adam, Fenja Meyer, Matthias Schwab, Ralf Surber, Otto W Witte, Heike Hoyer, Dirk Hoyer
Stroke-induced immunodepression is a major risk factor for severe infectious complications in the immediate post-stroke period. We investigated the predictive value of heart rate variability (HRV) to identify patients at risk of post-stroke infection, systemic inflammatory response syndrome, or severe sepsis during the post-acute interval from days 3 to 5 after stroke onset. A prospective, observational monocentric cohort study was conducted in a university hospital stroke unit of patients with ischemic infarction in the territory of the middle cerebral artery without an ongoing infection at admission...
January 7, 2019: Translational Stroke Research
https://read.qxmd.com/read/30616021/impact-of-diurnal-variations-in-the-qrs-complex-and-t-waves-on-the-eligibility-of-subcutaneous-implantable-cardioverter-defibrillators
#17
Naoyuki Miwa, Yasutoshi Nagata, Tetsuo Yamaguchi, Masashi Nagase, Takeshi Sasaki, Toshihiro Nozato, Takashi Ashikaga, Masahiko Goya, Kenzo Hirao
BACKGROUND: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are an established therapy for preventing sudden cardiac death. However, a considerable number of patients still undergo inappropriate shocks even after conventional pre-implantation ECG screening. OBJECTIVE: This study aimed to elucidate the additional impact of diurnal variations in the QRS complex and T-waves of 24-h Holter monitoring on the S-ICD eligibility. METHODS: Patients with transvenous ICDs who did not need pacing were selected for the study...
January 4, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30616004/serial-follow-up-of-two-surgical-strategies-for-the-repair-of-tetralogy-of-fallot
#18
Bartholomew V Simon, Subhashini Subramanian, Michael F Swartz, Hongyue Wang, Nader Atallah-Yunes, George M Alfieris
OBJECTIVE: Adverse events following tetralogy of Fallot repair include arrhythmia, reoperation and death. While limiting the right ventriculotomy mitigates these events over the short- and intermediate-term, the impact over the long-term is unknown. METHODS: Children requiring tetralogy of Fallot repair were divided into two groups: extended right ventriculotomy vs limited right ventriculotomy with transatrial ventricular septal defect closure. Follow-up office ECGs and Holter monitoring, exercise stress tests, and echocardiograms were obtained in the first, second, and third postoperative decades...
January 4, 2019: Seminars in Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30591749/prevalence-of-early-repolarization-pattern-and-its-association-with-sudden-cardiac-death-and-arrhythmia-over-one-year-follow-up-in-an-egyptian-cohort
#19
Ahmed Tageldien Abdellah, Mohamed El Wazir, Hanan Kamal, Hesham Hegazy
Background and objectives: Early repolarization pattern (ERP) is not uncommon electrocardiography (ECG) finding and could be associated with arrhythmia and sudden cardiac death (SCD). We aimed to prospectively determine the prevalence of ERP and its association with arrhythmia and SCD during one-year follow-up in an outpatient Egyptian cohort. Methods: Clinical assessment and ECG were performed to 1850 consecutive individuals presented at the outpatient clinic of Suez Canal University Hospital (SCUH)...
December 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://read.qxmd.com/read/30575190/ambient-fine-particulate-matter-pm2-5-exposure-is-associated-with-idiopathic-ventricular-premature-complexes-burden-a-cohort-study-with-consecutive-holter-recordings
#20
Tsung-Ying Tsai, Li-Wei Lo, Shin-Huei Liu, Wen-Han Cheng, Yu-Hui Chou, Wei-Lun Lin, Yamada Shinya, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, Jo-Nan Liao, Tze-Fan Chao, Ta-Chuan Tuan, Shih-Ann Chen
BACKGROUND: Epidemiological evidence has shown an association between ambient fine particulate matter (PM2.5) exposure and cardiovascular mortality. Increased ventricular premature complex (VPC) burden can cause left ventricular dilatation and dysfunction. We aimed to investigate the relationship between acute PM2.5 exposure and VPC burden in patients without structural heart disease. METHODS: We reviewed 26,820 patients who underwent 24-h Holter electrocardiogram (ECG) recordings between Jan 1, 2013 to Dec 1, 2016...
December 21, 2018: Journal of Cardiovascular Electrophysiology
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