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Surgical histopathology

Marios K Georgakis, Georgios Tsivgoulis, Apostolos Pourtsidis, Eleni Th Petridou
BACKGROUND: Gliomatosis cerebri is a rare but fatal widespread infiltrating central nervous system tumor. We aimed to describe diagnostic and prognostic features of gliomatosis cerebri among children and adolescents. METHODS: We conducted a systematic literature review for published case reports and case series on patients with histologically confirmed gliomatosis cerebri and extracted data on an individual patient level for those aged 0-18 years. Multivariable Cox proportional hazard models were fit for overall survival...
March 19, 2019: Journal of Child Neurology
Sarah Alessi, Paola Pricolo, Paul Summers, Marco Femia, Elena Tagliabue, Giuseppe Renne, Roberto Bianchi, Gennaro Musi, Ottavio De Cobelli, Barbara Alicja Jereczek-Fossa, Massimo Bellomi, Giuseppe Petralia
OBJECTIVES: To evaluate whether low PI-RADS v2 assessment categories are effective at excluding extraprostatic extension (EPE) of prostate cancer (≥pT3a PCa). METHODS: The local institutional ethics committee approved this retrospective analysis of 301 consecutive PCa patients. Patients were classified as low- or intermediate/high-risk based on clinical parameters and underwent pre-surgical multiparametric magnetic resonance imaging. A PI-RADS v2 assessment category and ESUR EPE score were assigned for each lesion by two readers working in consensus...
March 18, 2019: European Radiology
Esther Kho, Lisanne L de Boer, Koen Van de Vijver, Frederieke van Duijnhoven, Marie-Jeanne T F D Vrancken Peeters, Henricus J C M Sterenborg, Theo J Ruers
PURPOSE: Complete tumor removal during cancer surgery remains challenging due to the lack of accurate techniques for intraoperative margin assessment. This study evaluates the use of hyperspectral imaging for margin assessment by reporting its use in fresh human breast specimens. EXPERIMENTAL DESIGN: Hyperspectral data was first acquired on tissue slices from 18 patients, after gross sectioning of the resected breast specimen. This dataset, which contained over 22...
March 18, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Michael D White, Nitin Agarwal, Daniel A Tonetti
INTRODUCTION: Solitary brain tumors can propose a diagnostic dilemma due to the difficulty of differentiating between primary brain tumor and metastatic disease. Similar radiologic appearance on routine magnetic resonance imaging (MRI) necessitates the need for additional noninvasive testing. The aim of this study is to determine the clinical utility of preoperative whole-body screen with computed tomography (CT) scanning in order to detect metastatic disease in patients with solitary brain tumors...
March 15, 2019: World Neurosurgery
X Cheng, Y Shu, B Chen
INTRODUCTION: Immunoglobulin G4-related sclerosing disease (IgG4-RSD) is a chronic fibro-inflammatory disease involving systemic multi-organ lesions, such as the salivary and lacrimal glands, lymph nodes and pancreas. The diagnosis of this disease is reliant upon clinical manifestations, laboratory tests, histopathologic results and radiological data. Some studies have found that IgG4-RSD has otological manifestations, whereas there were few studies introducing the diagnosis, therapy and long-term follow-up results of solely otological IgG4-RSD...
March 15, 2019: European Annals of Otorhinolaryngology, Head and Neck Diseases
Paweł Sadłecki, Marek Grabiec, Dariusz Grzanka, Jakub Jóźwicki, Paulina Antosik, Małgorzata Walentowicz-Sadłecka
Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). Recent studies demonstrated that epithelial-mesenchymal transition (EMT) is crucial for the progression of EOCs. EMT plays a key role in cancer invasion, metastasis formation and chemotherapy resistance. An array of novel EMT transcription factors from the zinc finger protein family have been described recently, among them zinc finger protein 143 (ZNF143) and zinc finger protein 281 (ZNF281). The study included tissue specimens from 42 patients...
March 18, 2019: Journal of Ovarian Research
Michael C Topf, Quang H Pham, Jill N D'Souza, Mark Chaskes, Madalina Tuluc, David M Cognetti, Adam J Luginbuhl
BACKGROUND: Melanotic schwannoma is a rare tumor with indeterminate biologic behavior and varying treatment recommendations. METHODS: We report 2 cases of pigmented melanotic schwannoma of the head and neck and perform literature review. The pathologic and immunohistochemical characteristics of melanotic schwannoma are reviewed. RESULTS: Two cases of melanotic schwannoma are presented. Both cases underwent surgical resection with one patient receiving adjuvant radiation therapy...
February 2019: Ear, Nose, & Throat Journal
Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J Nowakowski, Piotr Dzięgiel, Mariusz Krzysztof Majewski, Marcin Jozwik, Marta Majewska
Anti-Müllerian hormone (AMH) is a commonly known factor secreted by Sertoli cells, responsible for regression of the Müllerian ducts in male fetuses. AMH has also other functions in humans. In vivo and in vitro studies have shown that AMH inhibits cell cycle and induces apoptosis in cancers with AMH receptors. The aim of the study was to assess whether the tissue of pre-cancerous states of endometrium (PCS) and various histopathologic types of endometrial cancer (EC) exhibit the presence of AMH. We aimed to investigate whether the potential presence of the protein concerns menopausal women or those regularly menstruating, and whether is related to cancers with a good or a bad prognosis, as well as what other factors may influence AMH expression...
March 15, 2019: International Journal of Molecular Sciences
Regi Kurien, Vedantam Rupa, Meera Thomas
PURPOSE: Phosphaturic mesenchymal tumour (PMT) of the paranasal sinuses is a rare tumour that is associated with oncogenous osteomalacia causing predominant musculoskeletal symptoms. We present a series of eight patients diagnosed to have PMT of the paranasal sinuses with varied presentation and highlight the appropriate evaluation required to arrive at the diagnosis. METHODS: Retrospective review of eight patients diagnosed to have PMT-causing tumour-induced osteomalacia with follow-up data...
March 16, 2019: European Archives of Oto-rhino-laryngology
Jinson Paul, Kripa Elizabeth Cherian, Nitin Kapoor, Thomas Vizhalil Paul
Oncogenic osteomalacia is a potentially curable condition caused by phosphaturic mesenchymal tumours. We present the case of 54-year-old woman who presented with bony pains and muscle weakness, and was erroneously treated with bisphosphonates elsewhere on the basis of Dual Energy X-ray Absorptiometry (bone density) scan that showed 'severe osteoporosis'. Further evaluation revealed the presence of hypophosphatemia, with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid avid lesion involving left mandible on PET scan...
March 16, 2019: BMJ Case Reports
Ida Pesonen, Cristian Ortiz, Giovanni Ferrara
A 39 years old African man presented with fatigue, loss of weight and night sweats; radiology showed a possible usual interstitial pneumonia pattern. The patient missed follow-up visits, and presented again after 3 years with productive cough and general illness. Pulmonary function tests showed a decline of FVC compared to a previous investigation. The CT scans showed progression of the interstitial lung disease, and a multidisciplinary conference recommended to proceed with a surgical lung biopsy. Histopathology showed an atypical pattern, with bronchiolar metaplasia...
March 14, 2019: Medicina
Chetna Tailor, W Spencer Ashby, Donald R Gorassini, Stephen P Lownie, Kimberley Walsh, David Pelz, Robert R Hammond
OBJECTIVEEndovascular approaches have evolved from a technique practiced at very few centers to a widely available option in the management of arteriovenous malformations (AVMs) of the central nervous system. Embolization can be employed as definitive therapy or as an adjunct to surgical excision. A wide variety of embolic agents have been successfully developed and used in the clinical setting. In addition to facilitating vascular occlusion, embolic agents induce a number of reactive and destructive changes in vessel walls and the surrounding tissue...
March 15, 2019: Journal of Neurosurgery
Deborah R Smith, Yandong Bian, Cheng-Chia Wu, Anurag Saraf, Cheng-Hung Tai, Tavish Nanda, Andrew Yaeh, Matthew E Lapa, Jacquelyn I S Andrews, Simon K Cheng, Guy M McKhann, Michael B Sisti, Jeffrey N Bruce, Tony J C Wang
PURPOSE: Non-small cell lung cancer (NSCLC) brain metastases are associated with substantial morbidity and mortality. During recent years, accompanying dramatic improvements in systemic disease control, NSCLC brain metastases have emerged as an increasingly relevant clinical problem. However, optimal surveillance practices remain poorly defined. This purpose of this study was to further characterize the natural history, clinical course and risk factors associated with earlier development of subsequent NSCLC brain metastases to better inform clinical practice and help guide survivorship care...
March 14, 2019: Journal of Neuro-oncology
Lingling Zhao, Shaoguang Feng, Peng Wu, Xin-He Lai, Chengjie Lv, Guorong Chen
BACKGROUND: Intussusception secondary to pathologic lead points (PLPs) is a potential surgical emergency and almost all cases need surgery. The aim of this study was to evaluate the clinical manifestations, physical examinations and surgical outcomes of secondary intussusception (SI) caused by PLPs, as well as to improve the diagnosis and treatment of PLPs in children and infants. MATERIALS AND METHODS: We retrospectively reviewed the records of 83 children and infants who were diagnosed with intussusception secondary to PLPs in our institution...
March 14, 2019: Pediatric Surgery International
Jens Heichel, Udo Siebolts, Claudia Wickenhauser, Arne Viestenz
BACKGROUND: A pyogenic granuloma is a frequent palpebral pseudotumor. Showing a typical clinical picture after an inflammation (hordeolum, chalazion) it can be easily diagnosed and sometimes a histopathological analysis is thought to be unnecessary. METHODS: A case report of a patient suffering from a palpebral metastasis of a clear cell renal cell carcinoma (cRCC) as an atypical differential diagnosis of an inflammatory pseudotumor of the eyelid is presented...
March 14, 2019: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Karam Asmaro, Mohamed Abouelleil, Sameah Haider, Hesham Mostafa Zakaria, Ciprian Gradinaru, Abir Mukherjee, Ian Lee
BACKGROUND: Intraspinal dermoid tumors are usually rare benign growths that occur as a result of defects during neural tube formation. They make up less than 1% of tumors in the spine and are associated with spinal dysraphisms or sinus tracts. Although rare, malignant transformation into squamous cell carcinoma has been previously reported. Malignant transformation into adenocarcinoma, however, represents a novel phenotypic differentiation pattern that is hitherto undescribed. CASE DESCRIPTION: A 45 year-old woman presented with acute symptoms of cauda equina syndrome...
March 11, 2019: World Neurosurgery
Chang Ding, Wei Chen, Fujun Liu, Moli Xiong, Jing Chen
BACKGROUND: Ollier disease (OD) is a rare, nonhereditary bone disease that is characterized by the presence of multiple enchondromatosis (3 or more) with a typical asymmetrical distribution and mainly confined to the appendicular skeleton. Ollier disease's most serious complication is the transformation of an enchondroma into chondrosarcoma. The most common sites for chondrosarcoma are in the pelvic and shoulder bones, the superior metaphyseal and diaphyseal regions of the extremities...
March 11, 2019: World Neurosurgery
Alexandra Maby, Benoit Guay, François Thuot
BACKGROUND: Infantile myofibromatosis is the most common benign fibrous tumor in infants. Three different types have been reported in the literature. The most commonly affected areas are the head, the neck and the trunk. Our patient showed a very high level of mandibular destruction resistant to all mandibular sparing treatment strategies requiring segmental mandibulectomy and complex reconstruction. CASE PRESENTATION: We describe a rare case of multicentric infantile myofibromatosis with mandibular bone destruction...
March 14, 2019: Journal of Otolaryngology—Head & Neck Surgery
Isidro Mateo, Lic Vet, Rocio Paniagua, Grado Vet, Ana Cloquell, Lic Vet, Fernando Vazquez, Lic Vet
Although intervertebral disc extrusions are extremely frequent in dogs, those affecting the cranial thoracic spine in large-breed dogs have not been reported. In this case report, the clinical, radiological, surgical, and histopathological findings in two German shepherd dogs with T3-T4 disc extrusions are reported. Clinical and imaging findings (acute onset and radiological evidence of lateralized disc material dispersed beyond the margins of the intervertebral disc space) allowed proper diagnosis of disc extrusion...
March 14, 2019: Journal of the American Animal Hospital Association
Laura M Fernandez, Albert Parlade, Elliot Wasser, Giovanna Dasilva, Rafael U de Azevedo, Cinthia Ortega, Rodrigo O Perez, Angelita Habr-Gama, Mariana Berho, Steven D Wexner
BACKGROUND: The observation of inferior oncologic outcomes after surgery for proximal colon cancers has led to the investigation of alternative treatment strategies, including surgical procedures and neoadjuvant systemic chemotherapy in selective patients. OBJECTIVE: The purpose of this study was to determine the accuracy of CT staging in proximal colon cancer in detecting unfavorable pathologic features that may aid in the selection of ideal candidates with unfavorable pathologic features for alternative treatment strategies, including extended lymph node dissection and/or neoadjuvant chemotherapy...
March 8, 2019: Diseases of the Colon and Rectum
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