Shubham Jain, Ravi Thanage, Falguni Panchal, Pravin M Rathi, Renuka Munshi, Suhas S Udgirkar, Qais Q Contractor, Sanjay J Chandnani, Nair P Sujit, Partha Debnath, Anupam Singh
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) has multifactorial origin. Genetic and environmental factors lead to the biology of this complex disorder. In this study, we screened parents of cases with NAFLD and compared them with parents of cases without NAFLD to see its familial aggregation and the role of patatin-like phospholipase domain containing 3 (PNPLA3). METHOD: It was a cross-sectional study. Parents of probands with NAFLD and without NAFLD were screened with abdominal sonography, anthropometry, blood tests, transient elastography, and PNPLA3 polymorphism...
July 2021: Journal of Clinical and Experimental Hepatology