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Brush Cytology, Biliary Biopsy

Masako Akatsuka, Takayoshi Nakajima, Shinichi Ikuta, Tsukasa Aihara, Kurando Kusunoki, Yu Kitamura, Noriko Ichise, Ikumi Hamano, Ryo Okamoto, Yoshihiko Nakamoto, Fumihiko Kimura, Hidenori Yanagi, Ayako Kakuno, Naoki Yamanaka
A 74-year-old man was admitted to a local hospital with liver dysfunction. Imaging modalities revealed bile duct stenosis at the bifurcation of the anterior and posterior trunk. Exfoliative cytology of the bile and brushing cytology of the bile duct both revealed Class Ⅴ, and biopsy from the stenotic bile duct showed well differentiated adenocarcinoma. We diagnosed the patient with hilar cholangiocarcinoma and performed extended right bisectionectomy and biliary reconstruction after percuta- neous transhepatic right portal vein embolization(PTPE)...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Bita Geramizadeh, Maryam Moughali, Atefeh Shahim-Aein, Soghra Memari, Ziba Ghetmiri, Alireza Taghavi, Kamran Bagheri Lankarani
Aim: In this study we tried to find out the accuracy of biliary tract brushing cytology in our center as the largest referral center in the south of Iran. Background: Common bile duct brushing cytology has been introduced as the method of choice for the diagnosis of pancreaticobiliary malignancies. However, there have been controversial reports about the sensitivity, specificity and overall accuracy of this method in the English literature. Methods: During the study period (2012-2016) there has been 166 cases of common bile duct brushing cytology taken during endoscopic retrograde cholangiopancreatography (ERCP)...
2018: Gastroenterology and Hepatology From Bed to Bench
Ying-Chun Ren, Chun-Lan Huang, Su-Min Chen, Qiu-Yan Zhao, Xin-Jian Wan, Bai-Wen Li
BACKGROUND:  Tissue sampling for biliary stricture is important for differential diagnosis and further treatment. The aim of this study was to assess a novel dilation catheter-guided mini-forceps biopsy (DCMB) method in the diagnosis of malignant biliary strictures. METHODS:  42 patients with malignant biliary stricture who underwent both brush cytology and DCMB during endoscopic retrograde cholangiopancreatography between October 2014 and November 2015 were retrospectively included...
August 2018: Endoscopy
Diogo Turiani Hourneaux Moura, Eduardo Guidamarães Hourneaux de Moura, Sergio Eiji Matuguma, Marcos Eduardo Dos Santos, Eduardo Turiani Hourneaux Moura, Felipe Iankelevich Baracat, Everson LA Artifon, Spencer Cheng, Wanderley Marque Bernardo, Danielle Chacon, Ryan Tanigawa, José Jukemura
Background and study aims:  Biliary strictures are frequently a challenging clinical scenario and the anatomopathological diagnosis is essential in the therapeutic management, whether for curative or palliative purposes. The acquisition of specimens is necessary since many benign diseases mimic biliopancreatic neoplasms. Endscopic retrograde cholangiopancreatography (ERCP) is the traditionally used method despite the low sensitivity of biliary brush cytology and forceps biopsy. On the other hand, several studies reported good accuracy rates using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)...
June 2018: Endoscopy International Open
Akihisa Kato, Itaru Naitoh, Hiroyuki Kato, Kazuki Hayashi, Katsuyuki Miyabe, Michihiro Yoshida, Yasuki Hori, Makoto Natsume, Naruomi Jinno, Takeshi Yanagita, Shuji Takiguchi, Satoru Takahashi, Takashi Joh
Endoscopic transpapillary brush cytology and forceps biopsy during endoscopic retrograde cholangiopancreatology are generally used to obtain pathological evidence of biliary strictures. Recently, the new endoscopic scraper Trefle® has been reported and demonstrated high cancer detectability in malignant biliary strictures. This device is used to scrape the stricture over the guidewire, and, in the original method, the tissue and/or cell samples obtained are subjected to histological and/or cytological analysis separately...
March 15, 2018: World Journal of Gastrointestinal Oncology
Christian Brooks, Valerie Gausman, Chanthel Kokoy-Mondragon, Khushboo Munot, Sunil P Amin, Amit Desai, Claudine Kipp, John Poneros, Amrita Sethi, Frank G Gress, Michel Kahaleh, Vundavalli V Murty, Reem Sharaiha, Tamas A Gonda
BACKGROUND AND AIMS: Our goal was to compare the diagnostic accuracy of FISH in the detection of malignancy compared with other standard diagnostic modalities, including brush cytology and biopsy specimens over a 10-year period of prospective data collection. METHODS: We conducted a review of all consecutive biliary strictures evaluated between 2006 and 2016. Patients with a final pathologic diagnosis or conclusive follow-up were included. We evaluated the performance of FISH polysomy (CEP 3, 7, and 17) and 9p21 deletion as well as cholangioscopic biopsy (CBx) and EUS-FNA...
March 2018: Digestive Diseases and Sciences
Hiroki Tanaka, Shimpei Matsusaki, Youichirou Baba, Yoshiaki Isono, Tomohiro Sase, Hiroshi Okano, Tomonori Saito, Katsumi Mukai, Tetsuya Murata, Hiroki Taoka
BACKGROUND/AIMS: It is sometimes difficult to distinguish between malignant and benign biliary strictures using imaging studies alone, and pathological diagnosis is necessary. The aim of this study was to determine the usefulness of endoscopic transpapillary tissue sampling and factors predictive of diagnostic accuracy. METHODS: From April 2008 to December 2014, 136 patients underwent endoscopic transpapillary tissue sampling for malignant biliary strictures. The cytological and histological findings were reported as negative, suspicious, or positive...
March 2018: Clinical Endoscopy
Johannes Boos, Raphael J Yoo, Jennifer Steinkeler, Gamze Ayata, Muneeb Ahmed, Ammar Sarwar, Jeffrey Weinstein, Salomao Faintuch, Olga R Brook
OBJECTIVES: To evaluate percutaneous brush cytology, forceps biopsy and a tandem procedure consisting of both, in the diagnosis of malignant biliary obstruction. METHODS: A retrospective review of consecutive patients who underwent biliary brush cytology and/or forceps biopsy between 01/2010 and 09/2014 was performed. The cytology and pathology results were compared to the composite outcome (including radiological, pathological and clinical data). Cost for tandem procedure compared to brush cytology and forceps biopsy alone was calculated...
February 2018: European Radiology
Hiromichi Araki, Shuya Shimizu, Katsumi Hayashi, Tomonori Yamada, Atsunori Kusakabe, Hiroshi Kanie, Yusuke Mizuno, Issei Kojima, Akitoshi Saitou, Kazuhiro Nagao, Yuka Suzuki, Tadashi Toyohara, Takanori Suzuki, Erika Uchida, Konomu Uno, Takahiro Nakazawa
We report a case of a 70-year-old man with acute acalculous cholecystitis caused by Giardia lamblia. Contrast-enhanced computed tomography (CT) showed distention of the gallbladder due to a pericholecystic abscess without gallstones. Magnetic resonance cholangiopancreatography and drip infusion cholecystocholangiography-CT demonstrated a stricture of the hilar bile duct and cystic duct obstruction. We conducted transpapillary bile duct brush cytology and a biopsy of the hilar bile duct stricture; numerous active trophozoites of Giardia lamblia were observed without malignant findings...
2017: Internal Medicine
Andrés Figueroa Marrero, Carlos M Chavarría-Herbozo, Carlos de la Serna Higuera, Manuel Pérez-Miranda
Bile duct brush cytology, intraductal biopsy and EUS-FNA are all used to characterize biliary strictures, with suboptimal sensitivity. Surgical resection without confirmed malignancy is undesirable. Cholangioscopy with targeted biopsies appears to increase the diagnostic yield in indeterminate biliary strictures, but it is still considered optional.
March 2017: Revista Española de Enfermedades Digestivas
Diogo Turiani Hourneaux De Moura, Eduardo Guimarães Hourneaux De Moura, Wanderlei Marques Bernardo, Eduardo Turiani Hourneaux De Moura, Felipe I Baraca, André Kondo, Sérgio Eijii Matuguma, Everson Luis Almeida Artifon
Background and Aims: There are no systematic reviews comparing the use of endoscopic retrograde cholangiopancreatography (ERCP)-based brush cytology and forceps biopsy and endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for the diagnosis of malignant biliary stricture; so in this revision, we will compare ERCP against EUS-FNA for tissue diagnosis of malignant biliary stricture. Design: A systematic review was conducted of comparative studies (prospective or retrospective) analyzing EUS and ERCP for tissue diagnosis of malignant biliary stricture...
January 2018: Endoscopic Ultrasound
L Zender, N P Malek
Cholangiocellular carcinoma (CCA) is the second most frequent primary liver carcinoma and is an aggressive tumor, which is mostly diagnosed in advanced stages. The overall survival is poor. Histpathological analysis of tumor biopsies or cytological analysis of biliary brushings can be used to confirm the diagnosis. A differentiation is made between distal, perihilar and intrahepatic CCA. The anatomical position determines the diagnostic and therapeutic strategy. Before diagnostic or therapeutic measures are undertaken it is essential to resolve biliary obstruction via endoscopic stenting or percutaneous biliary drainage...
December 2016: Der Internist
B Njei, T R McCarty, S Varadarajulu, U Navaneethan
BACKGROUND: The accuracy of current endoscopic modalities for diagnosing cholangiocarcinoma in primary sclerosing cholangitis (PSC) is suboptimal. AIM: To evaluate the comparative effectiveness of endoscopic retrograde cholangiopancreatography (ERCP)-based modalities, independently or in combination, for the diagnosis of cholangiocarcinoma in patients with PSC-induced biliary strictures. METHODS: Searches of PubMed, EMBASE, Web of Science and the Cochrane Library databases were performed through December 2015...
December 2016: Alimentary Pharmacology & Therapeutics
Basile Njei, Thomas R McCarty, Shyam Varadarajulu, Udayakumar Navaneethan
BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is a leading cause of morbidity and mortality in patients with primary sclerosing cholangitis (PSC). Although several ERCP-based diagnostic modalities are available for diagnosing CCA, it is unclear whether one modality is more cost-effective than the others. The primary aim of this study was to compare the cost-effectiveness of ERCP-based techniques for diagnosing CCA in patients with PSC-induced biliary strictures. METHODS: We performed a cost utility analysis to assess the net monetary benefit for accurately diagnosing CCA using 5 different diagnostic strategies: (1) ERCP with bile duct brushing for cytology, (2) ERCP with brushings for cytology and fluorescence in situ hybridization (FISH)-trisomy, (3) ERCP with brushings for cytology and FISH-polysomy, (4) ERCP with intraductal biopsy sampling, and (5) single-operator cholangioscopy (SOC) with targeted biopsy sampling...
April 2017: Gastrointestinal Endoscopy
Hiep Nguyen Canh, Kenichi Harada
Biliary epithelial cells preferentially respond to various insults under chronic pathological conditions leading to reactively atypical changes, hyperplasia, or the development of biliary neoplasms (such as biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and cholangiocarcinoma). Moreover, benign biliary strictures can be caused by a variety of disorders (such as IgG4-related sclerosing cholangitis, eosinophilic cholangitis, and follicular cholangitis) and often mimic malignancies, despite their benign nature...
December 2016: Medical Molecular Morphology
Juliana F Yang, Reem Z Sharaiha, Gloria Francis, Kunal Karia, C A Kistler, Sobia N Laique, Raza Hasan, Monica Gaidhane, Amy Tyberg, Michel Kahaleh, Thomas E Kowalski, David E Loren, Ali Siddiqui
BACKGROUND: The aim of this study was to assess the operating characteristics of using the confocal endomicroscopy miniprobe (pCLE) compared to cholangioscopic targeted biopsies for the detection of malignancy in biliary tract strictures. METHODS: We conducted a retrospective analysis of data of patients who underwent evaluation of indeterminate biliary strictures after inconclusive brush cytology. Only those patients with a final pathologic diagnosis or a conclusive >12 months follow-up were included...
September 2016: Minerva Gastroenterologica e Dietologica
Shafqat Mehmood, Asif Loya, Muhammed Aasim Yusuf
PURPOSE: To evaluate the diagnostic yield of biliary brush cytology and the factors affecting positive results in patients with biliary strictures. PATIENTS AND METHODS: The medical records of all patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with biliary brush cytology at our institution from November 2004 to December 2013 were reviewed in this retrospective study. The yield of positive brush cytology and the factors affecting positive yield, such as stricture location, age, gender and preprocedure CA 19...
2016: Acta Cytologica
Shyam Varadarajulu, Ji Young Bang, Muhammad K Hasan, Udayakumar Navaneethan, Robert Hawes, Shantel Hebert-Magee
BACKGROUND AND AIMS: Tissue diagnosis, regardless of technique or endoscope used, can be challenging in patients with indeterminate biliary strictures (IDBSs). This exploratory study evaluated the utility and role of rapid onsite evaluation of touch imprint cytology (ROSE-TIC) when single-operator cholangioscopy (SOC)-guided biopsies of IDBSs are performed. METHODS: Patients with IDBSs were evaluated by intraprocedural ROSE-TIC during SOC-guided biopsy procedures...
October 2016: Gastrointestinal Endoscopy
Itaru Naitoh, Takahiro Nakazawa, Akihisa Kato, Kazuki Hayashi, Katsuyuki Miyabe, Shuya Shimizu, Hiromu Kondo, Yuji Nishi, Michihiro Yoshida, Shuichiro Umemura, Yasuki Hori, Toshiya Kuno, Satoru Takahashi, Hirotaka Ohara, Takashi Joh
OBJECTIVE: The diagnostic yields of endoscopic transpapillary brush cytology and forceps biopsies for malignant biliary strictures (MBS) remain unclear and predictive factors for diagnosis have not been established. We aimed to clarify the diagnostic yields of both methods and the predictive factors METHODS: We reviewed 241 patients with biliary strictures who underwent transpapillary brush cytology (n = 202) or forceps biopsy (n= 208) between 2004 and 2014 at a single academic center...
January 2016: Journal of Digestive Diseases
Michèle Fior-Gozlan, Diane Giovannini, Maud Rabeyrin, Anne Mc Leer-Florin, Marie-Hélène Laverrière, Philippe Bichard
BACKGROUND: The cytologic diagnosis obtained by brushing or biopsy in malignant biliary strictures is considered to be highly specific but poorly sensitive. The diagnostic association of biliary brushing and bile exfoliate cytology has been suggested but is rarely performed in clinical practice. The objective of this study was to assess the diagnostic performance of bile aspiration associated with biliary brushing during therapeutic endoscopic retrograde cholangiopancreatography (ERCP)...
May 2016: Cancer Cytopathology
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