keyword
https://read.qxmd.com/read/38534182/systematic-scoping-review-use-of-the-faecal-immunochemical-test-residual-buffer-to-enhance-colorectal-cancer-screening
#1
REVIEW
Timothy McAuliffe, Joseph C Anderson, Robin J Larson, Douglas J Robertson
BACKGROUND: The faecal immunochemical test (FIT) is an inexpensive and convenient modality to screen for colorectal cancer. However, its one-time sensitivity for detecting colorectal cancer and cancer precursors is limited. There is growing interest in using the non-haemoglobin contents of FIT residual buffer to enhance colonic neoplasia detection. AIM: To establish from the literature a framework to catalogue candidate biomarkers within FIT residual buffer for non-invasive colorectal cancer screening...
March 27, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38532587/-incidence-of-postoperative-complications-in-chinese-patients-with-gastric-or-colorectal-cancer-based-on-a-national-multicenter-prospective-cohort-study
#2
JOURNAL ARTICLE
S Q Zhang, Z Q Wu, B W Huo, H N Xu, K Zhao, C Q Jing, F L Liu, J Yu, Z R Li, J Zhang, L Zang, H K Hao, C H Zheng, Y Li, L Fan, H Huang, P Liang, B Wu, J M Zhu, Z J Niu, L H Zhu, W Song, J You, S Yan, Z Y Li
Objective: To investigate the incidence of postoperative complications in Chinese patients with gastric or colorectal cancer, and to evaluate the risk factors for postoperative complications. Methods: This was a national, multicenter, prospective, registry-based, cohort study of data obtained from the database of the Prevalence of Abdominal Complications After Gastro- enterological Surgery (PACAGE) study sponsored by the China Gastrointestinal Cancer Surgical Union. The PACAGE database prospectively collected general demographic characteristics, protocols for perioperative treatment, and variables associated with postoperative complications in patients treated for gastric or colorectal cancer in 20 medical centers from December 2018 to December 2020...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532583/-precision-nutritional-therapy-in-gastrointestinal-tumor
#3
JOURNAL ARTICLE
D Zhou, S J Wang, X Y Wang
Apart from individual genetic background, unhealthy lifestyle and diet, etc., nutrition also plays an important role in the occurrence and progression of gastrointestinal tumors. Although some patients with gastrointestinal tumors can be satisfied with the traditional nutritional support, it is apparently inadequate for the systemic management of all patients. Precision nutrition support, also known as personalized nutrition support, refers to safe and efficient individualized nutrition intervention based on the investigation of individual genetic background, life characteristics, metabolic indicators, intestinal microbial characteristics, and physiological status factors through big data analysis for the prevention and treatment of chronic diseases...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38531339/molecular-pathways-of-colorectal-cancer-development-mechanisms-of-action-and-evolution-of-main-systemic-therapy-compounds
#4
REVIEW
Chiara Pierantoni, Lorenzo Cosentino, Luigi Ricciardiello
Colorectal cancer is known as one of the "big killers" in oncology given its burden in terms on morbidity and mortality. Since the second half of the last century, similarly to what happened for other solid tumors, a large series of cytotoxic molecules have been developed and tested to treat this disease. Following new discoveries in terms of colorectal cancer pathogenesis and specific pathways involved such as angiogenesis, a new series of drugs have been developed: targeted therapies. In this review we will briefly describe colorectal cancer molecular biology and its main pathways in order to retrace the main stages of oncological treatment development for colorectal cancer from the first available treatments to novel approaches to the disease...
March 26, 2024: Digestive Diseases
https://read.qxmd.com/read/38528852/aberrant-glycosylation-in-pancreatic-ductal-adenocarcinoma-3d-organoids-is-mediated-by-kras-mutations
#5
JOURNAL ARTICLE
Hiromitsu Nakahashi, Tatsuya Oda, Osamu Shimomura, Yoshimasa Akashi, Kazuhiro Takahashi, Yoshihiro Miyazaki, Tomoaki Furuta, Yukihito Kuroda, Pakavarin Louphrasitthiphol, Bryan J Mathis, Hiroaki Tateno
Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC patients were digested and embedded into a 3D culture system...
2024: Journal of Oncology
https://read.qxmd.com/read/38514488/identification-roles-of-nfe2l3-in-digestive-system-cancers
#6
JOURNAL ARTICLE
Fan Li, Zhili Wen
BACKGROUND: Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to explore the clinical value and underlying mechanisms of NFE2L3 as a novel biomarker in DSC. METHODS: We utilized data from databases and clinical gastric cancer specimens to validate the aberrant expression level of NFE2L3 and further assessed the clinical value of NFE2L3...
March 22, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38511813/partial-distal-duodenectomy-in-patient-with-adenocarcinoma
#7
JOURNAL ARTICLE
Héctor Losada, Norberto Portillo, Andrés Troncoso, Renato Becker, Rocio Vera
BACKGROUND: Duodenal adenocarcinoma is a small percentage of gastrointestinal neoplasms, around 0.5%, and its treatment is based on resection of the tumor, classically by pancreaticoduodenectomy. In recent years, however, segmental resections of duodenal lesions, that do not involve the second portion or the periampullary region, have gained relevance with good surgical and oncological outcomes as well as the benefit of avoiding surgeries that can result in high morbidity and mortality...
2024: Brazilian Archives of Digestive Surgery: ABCD
https://read.qxmd.com/read/38507039/how-to-incorporate-chronic-health-conditions-in-oncologic-decision-making-and-care-for-older-patients-with-cancer-a-survey-among-healthcare-professionals
#8
JOURNAL ARTICLE
P A L Nelleke Seghers, Siri Rostoft, Shane O'Hanlon, Anita O'Donovan, Karlijn Schulkes, Isacco Montroni, Johanneke E A Portielje, Hans Wildiers, Pierre Soubeyran, Marije E Hamaker
PURPOSE: A substantial proportion of patients with cancer are older and experience multimorbidity. As the population is ageing, the management of older patients with multimorbidity including cancer will represent a significant challenge to current clinical practice. METHODS: This study aimed to (1) identify which chronic health conditions may cause change in oncologic decision-making and care in older patients and (2) provide guidance on how to incorporate these in decision-making and care provision of older patients with cancer...
March 20, 2024: European Geriatric Medicine
https://read.qxmd.com/read/38505912/a-systems-biology-approach-unveils-a-critical-role-of-dpp4-in-upper-gastrointestinal-cancer-patient-outcomes
#9
JOURNAL ARTICLE
Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan
Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive...
2024: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/38496762/intestinal-organoid-modeling-bridging-the-gap-from-experimental-model-to-clinical-translation
#10
REVIEW
Taotao Liu, Xiaoqi Li, Hao Li, Jingjing Qin, Hui Xu, Jun Wen, Yaqin He, Cao Zhang
The 3D culture of intestinal organoids entails embedding isolated intestinal crypts and bone marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process leads to the formation of hollow microspheres with structures resembling intestinal epithelial cells, which are referred to as intestinal organoids. These structures encompass various functional epithelial cell types found in the small intestine and closely mimic the organizational patterns of the small intestine, earning them the name "mini-intestines"...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38488909/global-analysis-of-t-cell-groups-reveals-immunological-features-and-common-antigen-targets-of-digestive-tract-tumors
#11
JOURNAL ARTICLE
Xiaoxue Li, Yuchao Zhang, Shiwei Guo, Zhenchuan Wu, Hailong Wang, Yi Huang, Yue Wang, Mengni Qiu, Jingyu Lang, Yichuan Xiao, Yufei Zhu, Gang Jin, Landian Hu, Xiangyin Kong
BACKGROUND: T cells are key players in the tumor immune microenvironment (TIME), as they can recognize and eliminate cancer cells that express neoantigens derived from somatic mutations. However, the diversity and specificity of T-cell receptors (TCRs) that recognize neoantigens are largely unknown, due to the high variability of TCR sequences among individuals. METHODS: To address this challenge, we applied GLIPH2, a novel algorithm that groups TCRs based on their predicted antigen specificity and HLA restriction, to cluster the TCR repertoire of 1,702 patients with digestive tract cancer...
March 15, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38488023/biological-functions-of-circrna-in-regulating-the-hallmarks-of-gastrointestinal-cancer-review
#12
JOURNAL ARTICLE
Mengjun Qiu, Youxiang Chen, Chunyan Zeng
Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells in 1979, but it was not characterized in detail until 2012, when high‑throughput sequencing technology was more advanced and available. Consequently, the mechanism of circRNA formation and its biological function have been progressively elucidated by researchers. circRNA is abundant in eukaryotic cells and exhibits a certain degree of organization, timing and disease‑specificity. Additionally, it is poorly degradable, meeting the characteristics of an ideal clinical biomarker...
May 2024: International Journal of Oncology
https://read.qxmd.com/read/38485867/nationwide-audit-of-postoperative-mortality-and-complications-after-digestive-cancer-surgery-will-new-legal-thresholds-be-sufficient
#13
JOURNAL ARTICLE
Jérémie Thereaux, Bogdan Badic, Basile Fuchs, Anais Caillard, Margaux Geier, Karin Lacut, Francis Couturaud, Jean-Philippe Metges
BACKGROUND: French policymakers recently chose to regulate high-risk digestive cancer surgery (DCS). A minimum of five cases per year should be performed for each of the following types of curative cancer surgery: esophagus/esogastric junction (ECS), stomach (GCS), liver (LCS, metastasis included), pancreas (PCS), and rectum (RCS). This study aimed to evaluate the hypothetical beneficial effects of the new legal minimal volume thresholds on the rates of 90-day postoperative mortality (90POM) for each high-risk DCS...
March 14, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38485558/enterocolitis-and-other-immunotherapy-and-targeted-therapy-related-gastrointestinal-manifestations-a-review-for-gastroenterologist
#14
REVIEW
O Gómez Escudero
New oncologic treatments, particularly immunotherapy (IT), have revolutionized the treatment of advanced-stage malignant tumors. Immune checkpoint inhibitors are the main form of IT and act by increasing T cell activity and the organism's immune response against neoplastic cells. Targeted therapy is another form of IT that acts by inhibiting oncogenes or inflammation signaling and tumor angiogenesis pathways. However, these mechanisms of tumor destruction can interfere with the host's immune self-tolerance or with the mechanisms of epithelial tissue repair and predispose to immune system-mediated adverse events that can affect multiple organs, including the digestive tract...
March 13, 2024: Revista de Gastroenterología de México
https://read.qxmd.com/read/38484002/impact-of-covid-19-related-experiences-on-health-related-quality-of-life-in-cancer-survivors-in-the-united-states
#15
JOURNAL ARTICLE
Amy K Otto, Sarah Prinsloo, Akina Natori, Richard W Wagner, Telma I Gomez, Jewel M Ochoa, Shelley S Tworoger, Cornelia M Ulrich, Sairah Ahmed, Jennifer L McQuade, Anita R Peoples, Michael H Antoni, Julienne E Bower, Lorenzo Cohen, Frank J Penedo
OBJECTIVE: Little evidence exists on the impact of the COVID-19 pandemic on cancer survivors, limiting recommendations to improve health-related quality of life (HRQoL) in this population. We describe survivors' pandemic experiences and examine associations between COVID-19-related exposures, psychosocial experiences, and HRQoL. METHODS: Between May 2020-April 2021, survivors completed cross-sectional questionnaires capturing COVID-19-related exposures (e.g., exposure to virus, job loss); psychosocial experiences (i...
2024: PloS One
https://read.qxmd.com/read/38482240/the-efficacy-associated-biomarkers-for-immune-checkpoint-inhibitors-in-gastrointestinal-cancer-a-literature-review
#16
REVIEW
Peixi Zhao, Rui Jin, Bin Zhao, Le Han, Wenjuan Chen, Nina Hao, Yi Cui, Ankit Madan, Joy Awosika, Shane Lloyd, Yili Zhang
BACKGROUND AND OBJECTIVE: Immune checkpoint inhibitors (ICIs) have been widely applied and studied in the treatment of gastrointestinal (GI) cancers, and have achieved good results. However, in clinical practice, it has been observed that only some patients respond well to ICIs, and some patients may experience various degrees of adverse reactions during the treatment. Timely evaluation of the potential therapeutic effects and adverse reactions of ICIs for patients has important clinical significance...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38482225/bmp6-inhibits-gastric-cancer-growth-and-predicts-good-prognosis
#17
JOURNAL ARTICLE
Chao Song, Mengmeng Liu, Ganggang Wang, Zijin Xu, Siyang Han, Maozhen Peng, Liang Liu, Wenquan Wang, Yaolin Xu, Qianzhi Ni, Junyi He
BACKGROUND: Gastric cancer (GC) is a common tumors in the digestive tract, and effective treatment methods are still lacking. Bone morphogenetic protein 6 (BMP6) is closely related to the occurrence and development of various tumors, but its relevance to GC is still unclear. The aim of the study was to explore the relationship between BMP6 and the occurrence and development of GC. METHODS: In this study, we investigated the relationship between BMP6 and the prognosis of GC patients using bioinformatics technology and clinical tissue samples...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38477384/measurement-practices-of-alanine-aminotransferase-in-children-temporal-changes-and-etiology-for-increased-values
#18
JOURNAL ARTICLE
Linnea Aitokari, Pauliina Hiltunen, Heini Huhtala, Kalle Kurppa, Laura Kivelä
Data on alanine aminotransferase (ALT) measurement practices and diagnoses associated with increased values are limited. We evaluated these issues by collecting ALT measurements from 1- to 16-year-old patients investigated in 1992-2018 in a tertiary center. Diagnoses were gathered in 2008-2018. Altogether 145,092 measurements from 28,118 children were taken 42% undergoing repeated testing. Testing increased from 21/1000 to 81/1000 children and the prevalence of elevated values fluctuated between 18% and 26%...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38474880/a-narrative-review-comparing-nutritional-screening-tools-in-outpatient-management-of-cancer-patients
#19
REVIEW
Delia Gil-Andrés, Luis Cabañas-Alite
Malnutrition during cancer has a negative impact on prognosis and quality of life. Therefore, it is important to identify those patients at higher nutritional risk to prevent its development. There are nutritional screening tools, such as MUST and NRS-2002, that focus on the patient on admission to hospital. However, most patients will develop malnutrition in the outpatient or ambulatory setting. This study aims to determine which nutritional screening tool is most effective in assessing nutritional risk in the outpatient oncology patient, highlighting the parameters analysed by these tools...
March 6, 2024: Nutrients
https://read.qxmd.com/read/38472961/updates-in-diagnosis-and-endoscopic-management-of-cholangiocarcinoma
#20
REVIEW
Roxana-Luiza Caragut, Madalina Ilie, Teodor Cabel, Deniz Günșahin, Afrodita Panaitescu, Christopher Pavel, Oana Mihaela Plotogea, Ecaterina Mihaela Rînja, Gabriel Constantinescu, Vasile Sandru
Cholangiocarcinoma (CCA) is an adenocarcinoma originating from the epithelial cells of the bile ducts/hepatocytes or peribiliary glands. There are three types of cholangiocarcinoma: intrahepatic, perihilar and distal. CCA represents approximately 3% of the gastrointestinal malignancies. The incidence of CCA is higher in regions of the Eastern world compared to the Western countries. There are multiple risk factors associated with cholangiocarcinoma such as liver fluke, primary sclerosing cholangitis, chronic hepatitis B, liver cirrhosis and non-alcoholic fatty liver disease...
February 24, 2024: Diagnostics
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