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Digestive Oncology

Qiang Sun, Haiyang Zhou, Zhiqian Hu
With the development of laparoscopic skills and instruments,totally laparoscopic gastrectomy for gastric cancer has become widely used in the clinic,mainly including totally laparoscopic proximal gastric reconstruction,distal gastrectomy for gastric cancer and total gastrectomy. Digestive tract reconstruction is the key procedure of totally laparoscopic gastrectomy for gastric cancer. Totally laparoscopic surgery has less trauma and better visualization than reconstruction in a small incision. At present,feasibility and safety of totally laparoscopic gastrectomy for gastric cancer have been preliminarily confirmed...
February 25, 2019: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Miodrag N Krstic, Dragana D Mijac, Dusan D Popovic, Aleksandra Pavlovic Markovic, Tomica Milosavljević
BACKGROUND: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide. SUMMARY: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at an early stage...
February 15, 2019: Digestive Diseases
Cesare Hassan, Piotr Tomasz Wysocki, Lorenzo Fuccio, Thomas Seufferlein, Mário Dinis-Ribeiro, Catarina Brandão, Jaroslaw Regula, Leonardo Frazzoni, Maria Pellise, Sergio Alfieri, Evelien Dekker, Rodrigo Jover, Gerardo Rosati, Carlo Senore, Cristiano Spada, Ian Gralnek, Jean-Marc Dumonceau, Jeanin E van Hooft, Eric van Cutsem, Thierry Ponchon
No abstract text is available yet for this article.
February 14, 2019: Endoscopy
Cesare Hassan, Piotr Tomasz Wysocki, Lorenzo Fuccio, Thomas Seufferlein, Mário Dinis-Ribeiro, Catarina Brandão, Jaroslaw Regula, Leonardo Frazzoni, Maria Pellise, Sergio Alfieri, Evelien Dekker, Rodrigo Jover, Gerardo Rosati, Carlo Senore, Cristiano Spada, Ian Gralnek, Jean-Marc Dumonceau, Jeanin E van Hooft, Eric van Cutsem, Thierry Ponchon
1:  We recommend post-surgery endoscopic surveillance for CRC patients after intent-to-cure surgery and appropriate oncological treatment for both local and distant disease.Strong recommendation, low quality evidence. 2:  We recommend a high quality perioperative colonoscopy before surgery for CRC or within 6 months following surgery.Strong recommendation, low quality evidence. 3:  We recommend performing surveillance colonoscopy 1 year after CRC surgery.Strong recommendation, moderate quality evidence. 4:  We do not recommend an intensive endoscopic surveillance strategy, e...
March 2019: Endoscopy
Qiyuan Shen, Changshun Yang, Jinsi Wang, Mengbo Lin, Shaoxin Cai, Weihua Li
OBJECTIVE: To explore the safety, feasibility and short-term efficacy of intracavitary uncut Roux-en-Y (URY) anastomosis in digestive tract reconstruction following laparoscopic total gastrectomy (LTG). METHODS: From November 2015 to January 2018, 67 gastric cancer patients underwent intracavitary URY following LTG to reconstruct the digestive tract at Oncological Surgery Department of Fujian Provincial Hospital. There were 41 males and 26 females with age of 50 to 81 (61...
January 25, 2019: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
A Lemoine, E Lambaudie, F Bonnet, E Leblanc, P Alfonsi
The following recommendations cover the perioperative management of ovarian, Fallopian tube and primary peritoneal cancers. Five questions related to pre-habilitation and enhanced recovery after surgery were evaluated. The conclusions and recommendations are based on an analysis of the level of evidence available in the literature. These recommendations are part of the overall recommendations for improving the management of ovarian, fallopian or primary peritoneal cancer, made with the support of INCa (Institut National du Cancer)...
January 24, 2019: Gynecologie, Obstetrique, Fertilite & Senologie
Emilien Bertin, Karen Benezery, Daniel Lam Cham Kee, Eric François, Ludovic Evesque, Mathieu Gautier, Jean-Pierre Gerard, Jean-Michel Hannoun-Levi, Alexander T Falk
Purpose: The aim of this study was to evaluate the efficacy and toxicity of high-dose-rate brachytherapy (HDR-BT) boost in anal squamous cell carcinoma (ASCC). Material and methods: This was a monocentric retrospective study involving patients treated by external irradiation (± chemotherapy), with HDR-BT boost, for a localized ASCC. Clinical evaluation was performed every six months. Oncological results were analyzed with: local relapse-free survival (LRFS), colostomy-free survival (CFS), metastatic-free survival (MFS), disease-free survival (DFS), and overall survival (OS)...
December 2018: Journal of Contemporary Brachytherapy
Shuze Zhang, Shanjun Tan, Yi Jiang, Qiulei Xi, Qingyang Meng, Qiulin Zhuang, Yusong Han, Xiangyu Sui, Guohao Wu
BACKGROUND & AIMS: Sarcopenia has been widely recognized as an important predictor of poor outcomes in patients with cancer after surgery, but the controversy remains, and its impact on surgical and oncologic outcomes in patients after abdominal surgery for digestive tract cancer is poorly described. The aim of this study was to evaluate the prognostic impact of sarcopenia on surgical and oncologic outcomes in patients after abdominal surgery for digestive tract cancer. METHODS: Six thousand four hundred and forty-seven consecutive patients who underwent abdominal surgery for digestive tract cancer in our institution were prospectively included...
December 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Beatriz Barbera-Carbonell, Pénélope St-Amour, Alice Vanoni, Nicolas Demartines, Daniel Clerc
Surgical management of oncologic situations in visceral surgery is increasing. Overall survival and related quality of life are improved, due to enhanced perioperative care, improvement in strategies like surgical technique and oncological therapy. Functional disorders, whether or not related to oncologic disease, are not to be forgotten. Often underestimated, and causing significant distress, they deserve our best care. In the present review, the recent progresses on three particular topics are summarized : sacral neuromodulation for fecal incontinence, low anterior resection syndrome and achalasia...
January 9, 2019: Revue Médicale Suisse
Rafael Medrano-Guzmán, Marisol Luna-Castillo, Waldo J Chable-Puc, Luis E García-Ríos, Domingo González-Rodríguez, Francisco I Nájera-Domínguez
Introduction: Pancreatic tumors and periampullary tumors have a similar clinical presentation; pancreatoduodenectomy represents the only possibility of cure or of increasing survival; with an average mortality of 5-10% and a morbidity of 20-40%. Objective: To determine the morbidity and mortality secondary to the pancreatoduodenectomy intervention in patients with pancreatic cancer or periampullary tumors in the Oncology Hospital of Centro Médico Nacional Siglo XXI (Mexico City) from 2008 to 2013...
2019: Cirugia y Cirujanos
Silviu Constantinoiu, Florin Achim, Adrian Constantin
Esophagectomy is standard indication for surgical treatment of resectable esophageal cancer, but it can also be performed for the management of benign conditions. Esophagectomy is followed by esophageal reconstruction using other parts of the digestive tract and is associated with increased postoperative morbidity and mortality. Gastric interposition with intrathoracic or cervical esophago- gastric anastomosis is currently the preferred technique for reconstruction after esophagectomy. The incidence of esophagectomy performed by the minimal invasive approach has increased in recent years due to the advanced technology of endoscopic surgery and image enhancement that provides a better estimate of anatomical plans, facilitates access to narrow spaces and more precise dissection with less tissue trauma...
November 2018: Chirurgia
Frederic Pamoukdjian, Thomas Aparicio, Florence Canoui-Poitrine, Boris Duchemann, Vincent Lévy, Philippe Wind, Nathalie Ganne, Georges Sebbane, Laurent Zelek, Elena Paillaud
BACKGROUND & AIMS: the obesity survival paradox is an emergent issue in oncology, but its existence remains unclear particularly in older cancer patients. We aimed to assess the obesity survival paradox in older cancer patients. METHODS: all consecutive cancer outpatients 65 years and older referred for geriatric assessment (GA) before a decision on cancer treatment between November 2013 and September 2016 were enrolled in the PF-EC cohort study. The main outcome was 6-month mortality...
December 13, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Solène Dermine, Maximilien Barret, Caroline Prieux, Sophie Ribière, Sarah Leblanc, Marion Dhooge, Catherine Brezault, Vered Abitbol, Benoit Terris, Frédéric Beuvon, Alexandre Rouquette, Bertrand Dousset, Sébastien Gaujoux, Philippe Soyer, Anthony Dohan, Jean-Emmanuel Bibault, Romain Coriat, Frédéric Prat, Stanislas Chaussade
Background  The recent development of endoscopic resection for superficial gastrointestinal cancers could justify the need for a dedicated oncological multidisciplinary meeting (MDM). The aim of our study was to evaluate the impact of the dedicated MDM on the management of superficial cancers of the digestive tract. Methods  A dedicated MDM was developed at our tertiary referral center. A retrospective review of the MDM conclusions for all patients referred from March 2015 to March 2017 was performed...
December 2018: Endoscopy International Open
Loig Vaugier, Clément Palpacuer, Emmanuel Rio, Aurore Goineau, David Pasquier, Xavier Buthaud, Guy De Laroche, Véronique Beckendorf, Paul Sargos, Gilles Créhange, Pascal Pommier, Geneviève Loos, Ali Hasbini, Igor Latorzeff, Marlon Silva, Fabrice Denis, Jean-Léon Lagrange, Loic Campion, Stéphane Supiot
PURPOSE: Limited pelvic nodal relapse of prostatic cancer is a paramount challenge for locoregional salvage treatments. Salvage whole pelvis radiotherapy as considered in the BLINDED trial, is an attractive option but with concerns about its toxicity. This article describes early toxicity with the technique. METHODS AND MATERIALS: BLINDED was a prospective multi-center phase II trial investigating high-dose salvage pelvic irradiation with an additional dose to the fluorocholine-based positron-emission-tomography (FCH-PET)-positive pelvic lymph nodes (PLN), combined with six-month androgen blockade...
December 14, 2018: International Journal of Radiation Oncology, Biology, Physics
Aziz Zaanan, Julien Taieb
The MSI phenotype in colon cancer is a good prognostic factor, with an impact probably more pronounced for stage II than stage III tumor. This survival advantage may be related to the tumor-infiltrating lymphocytes observed in MSI tumors, thus explaining the existence of a probably more effective anti-tumor immune response. In addition, the MSI status would also be a biomarker able to predict the lack of efficacy of adjuvant 5-fluorouracil (5FU) chemotherapy. In contrast, as observed in MSS colon cancer, the MSI tumors would have a survival benefit with the addition of oxaliplatin to adjuvant 5FU chemotherapy...
December 4, 2018: Bulletin du Cancer
Hanaa Amrani Hassani Joutei, Nabila Marchoudi, Wafaa Mahfoud, Ilham Sadaoui, Taoufiq Fechtali, Hakima Benomar
BACKGROUND AND STUDY AIMS: Targeted therapies have an increasing importance in digestive oncology. To our knowledge, we are the first to report the distribution of PI3KCA and BRAF mutations in Moroccan HER2 overexpressed patients, in order to introduce targeted therapy in the arsenal of therapeutic modalities for management in Morocco. PATIENTS AND METHODS: 98 gastric adenocarcinoma tissue samples were collected. Further histological and immunohistochemical examinations were carried out at the Laboratory of Anatomy Pathology in Pasteur Institute-Morocco, in order to select HER2 positive cases...
November 28, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Bojoura Schouten, Dominiek De Jonckheere, Marc Aerts, Jochen Decaestecker, Daan Walgraeve, Patrick Vankrunkelsven, Johan Hellings
PURPOSE: Systematic assessment of QOL and care needs was applied in two gastroenterology departments to support "Cancer Care for the Whole Patient." METHODS: Patients with digestive cancer were asked to complete the Cancer Rehabilitation Evaluation System-Short Form (CARES-SF) at the start of treatment and 3 months later. Both times CARES data were processed, and summary reports on the retained insights were sent to the reference nurse for use in further follow-up of the patient...
November 29, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
T Jínek, L Adamčík, R Vrba, M Duda, M Škrovina
INTRODUCTION: Gastric resections due to carcinoma belong to the most demanding procedures in visceral surgery. This is due to the requirements for the extent of resection and lymphadenectomy, coupled with the need for functional reconstruction of the digestive tract. The procedure is associated with 18-46% morbidity, which delays administration of adjuvant therapy and worsens oncological results. Identification of risk factors for potential complications may play an important role in the indication and perioperative care...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Evelyne Liuu, Nicolas Guyot, Simon Valero, Amelie Jamet, Houria El Ouazzani, Patrick Bouchaert, Jean-Marc Tourani, Virginie Migeot, Marc Paccalin
This study aimed to determine cancer prevalence occurring after the age of 75 in 45 French nursing homes (NH), as well as residents' characteristics and parameters associated with cancer-specific management. Descriptive retrospective study including 214 residents (mean age, 89.7 years) with cancer diagnosed after age 75. The studied parameters were sociodemographic, functional, nutritional and cognitive data; comorbidity assessment; date of tumoral diagnosis; cancer type; tumoral stage; treatment plan; multidisciplinary staff decision and oncologic follow-up...
October 29, 2018: European Journal of Cancer Care
Deepak B Vangala, Estelle Cauchin, Judith Balmaña, Lucian Wyrwicz, Eric van Cutsem, Ulrich Güller, Antoni Castells, Fatima Carneiro, Pascal Hammel, Michel Ducreux, Jean-Luc van Laethem, Tamara Matysiak-Budnik, Wolff Schmiegel
Patients with hereditary gastrointestinal (GI) cancers represent a substantial fraction of the overall affected population. Although awareness for hereditary GI cancer syndromes is on the rise, identification of patients and measures of surveillance are often unclear in everyday clinical routine. Therefore, the European Society of Digestive Oncology expert discussion 2018 at the World Congress on Gastrointestinal Cancer focussed on screening and surveillance of hereditary colorectal, gastric and pancreatic cancers...
October 17, 2018: European Journal of Cancer
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