Homam Moussa Pacha, Tanveer Mir, Yasser Al-Khadra, Yasar Sattar, Waqas Ullah, Nathan Zaher, Bachar Ahmad, Abdul-Rahman M Suleiman, Fahed Darmoch, Mohamad Soud, Haroon Faraz, Zaher Hakim, M Chadi Alraies
OBJECTIVES: To study the risk factors associated with 30-readmission postperipheral vascular intervention (PVI) in peripheral artery disease (PAD). BACKGROUND: There has been a paucity of data regarding the trend and predictors of PVI readmission. METHODS: We performed an observational cohort study of patients admitted with peripheral vascular disease for PVI using the NRD for the years 2010-2014. PVI was defined as angioplasty, atherectomy, and/or stenting of lower limb vessels...
April 16, 2021: Catheterization and Cardiovascular Interventions
Pedro Pujante Alarcón, Edelmiro Luis Menéndez Torre, Paula Morales Sánchez, Raúl Rodríguez Escobedo, Santiago Conde Barreiro, Gemma Rojo Martínez, Elías Delgado Alvarez
INTRODUCTION AND OBJECTIVES: Atherosclerotic cardiovascular disease and heart failure are the leading cause of morbidity and mortality in patients with diabetes. The objective of this work is to know the prevalence of atherosclerotic cardiovascular diseases and heart failure in people diagnosed with diabetes in Spain during 2017 and compare them with those not diagnosed with diabetes according to age and sex. METHODS: Data for diagnoses of diabetes mellitus (DM), acute myocardial infarction (AMI), stroke, peripheral artery disease (PAD) or heart failure (HF) for 2017 were obtained from the National Health System's Primary Care Clinical Database (BDCAP)...
March 30, 2021: Medicina Clínica
Changhwan Kim, Yong Sook Yang, Gi Wook Ryu, Mona Choi
AIMS: Peripheral arterial disease (PAD) is associated with morbidity and mortality, comprising a significant percentage of amputations. As it affects the quality of life of patients with PAD, it is an important health issue. Therefore, the risk factors affecting the outcomes of limb salvage after revascularization should be well investigated. The aim of this review is to summarize risk factors of amputation-free survival (AFS) after interventions targeting patients with PAD to develop evidence-based intervention for improving patient outcomes...
March 31, 2021: European Journal of Cardiovascular Nursing
Nawaf J Shatnawi, Nabil A Al-Zoubi, Hassan M Hawamdeh, Yousef S Khader, Mowafeq Heis, Mamoon Al Omari, Bassem Bataineh
Aims: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the time of PAD diagnosis. Patients and methods: A retrospective study was conducted at King Abdullah University Hospital during the period August 2011 to December 2015. Consecutive patients with type 2 diabetes presented with symptomatic PAD confirmed by computed tomography-angiography (CTA) were included in this study...
2021: Therapeutic Advances in Endocrinology and Metabolism
Ebaa Al-Ozairi, Mahir K Jallo, Khadija Hafidh, Dalal M Alhajeri, Tarek Ashour, Eissa F N Mahmoud, Zeyad Abd ElAal, Maysoon Loulou
INTRODUCTION: Understanding comorbid conditions with type 2 diabetes mellitus (T2DM) is critical for clinical decision-making regarding the choice of pharmacotherapy. This study aimed at describing the prevalence and co-prevalence of comorbidities, including chronic kidney disease (CKD) and cardiovascular disease (CVD) (coronary artery disease (CAD), cerebrovascular disease, peripheral arterial disease (PAD) and congestive heart failure (CHF)) among patients with T2DM. METHODS: A cross-sectional multi-center observational study on 300 patients with T2DM...
March 10, 2021: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
E Hope Weissler, J Antonio Gutierrez, Manesh R Patel, Rajesh V Swaminathan
PURPOSE OF REVIEW: Certain comorbidities and lesion characteristics are associated with increased risk for procedural complications, limb events, and cardiovascular events following peripheral vascular intervention (PVI) in patients with peripheral arterial disease (PAD). The purpose of this review is to provide an overview of high-risk modifiable and unmodifiable patient characteristics and its relative impact on clinical outcomes such as amputation risk and mortality. Furthermore, general approaches to potentially mitigating these risks through pre-intervention planning and use of modern devices and techniques are discussed...
March 5, 2021: Current Cardiology Reports
Christian Labenz, Karel Kostev, Saleh A Alqahtani, Peter R Galle, Jörn M Schattenberg
OBJECTIVE: Type 2 Diabetes (T2D) is a major risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD). The published prevelance in epidemiological studies in this high risk population exceeds 70%. The aim of this analysis was to investigate the impact of NAFLD on T2D patients in Germany. METHODS: Using the Disease Analyzer Database (IQVIA), T2D patients with NAFLD diagnosed in Germany were matched to a cohort without NAFLD controlling for age, sex, physician, index year and metabolic comorbidities and assessed for their risk of developing myocardial infarction, stroke, peripheral arterial disease (PAD) or chronic kidney disease, as well as the type of T2D treatment on NAFLD...
February 18, 2021: Experimental and Clinical Endocrinology & Diabetes
Waqas Ullah, Salman Zahid, Nishant Thalambedu, Maria Khan, H Todd Massey, Donald Haas, Vakhtang Tchantchaleishvili, Eduardo Rame
BACKGROUND: Left ventricular assist device (LVAD) candidacy screening includes evaluation for peripheral arterial disease (PVD). However, given current evidence, the impact of PAD on post-LVAD complications remains unknown. METHODS: The National Inpatient Sample (NIS) database (2002-2017) was utilized to identify all LVAD cases. The in-hospital safety endpoints included major cardiovascular adverse events and its components. A propensity-matched analysis was used to obtain adjusted odds ratios (aOR)...
February 9, 2021: Artificial Organs
Andrew W Gardner, Polly S Montgomery, Ming Wang, Biyi Shen
OBJECTIVES: To determine (a) whether patients with peripheral artery disease (PAD) who walked at least 7,000 and 10,000 steps/day had better ambulatory function and health-related quality of life (HRQoL) than patients who walked less than 7,000 steps/day, and (b) whether differences in ambulatory function and HRQoL in patients grouped according to these daily step count criteria persisted after adjusting for covariates. METHODS: Two hundred forty-eight patients were assessed on their daily ambulatory activity for one week with a step activity monitor, and were grouped according to daily step count targets...
November 27, 2020: Journal of Vascular Surgery
Martina Gurgitano, Giulia Signorelli, Giovanni Maria Rodà, Alessandro Liguori, Marco Pandolfi, Giuseppe Granata, Antonio Arrichiello, Anna Maria Ierardi, Aldo Paolucci, Gianpaolo Carrafiello
Diabetes mellitus (DM) is one of the most common metabolic diseases worldwide; its global burden has increased rapidly over the past decade, enough to be considered a public health emergency in many countries. Diabetic foot disease and, particularly diabetic foot ulceration, is the major complication of DM: through a skin damage of the foot, with a loss of epithelial tissue, it can deepen to muscles and bones and lead to the amputation of the lower limbs. Peripheral arterial disease (PAD) in patients with diabetes, manifests like a diffuse macroangiopathic multi-segmental involvement of the lower limb vessels, also connected to a damage of collateral circulation; it may also display characteristic microaneurysms and tortuosity in distal arteries...
September 23, 2020: Acta Bio-medica: Atenei Parmensis
Cindy H Nguyen, Scott G Thomas, Susan Marzolini
PURPOSE: Cardiac rehabilitation (CR) yields improvements in cardiorespiratory fitness (peak oxygen uptake [VO2peak]). Predictors of change in VO2peak have been reported among patients with coronary artery disease (CAD) but have not been compared with peripheral artery disease (PAD). This study determined predictors of improved VO2peak among patients with PAD, CAD, and concomitant PAD and CAD (PAD/CAD) following a 6-mo home-based outpatient CR program (1supervised and 4 home weekly sessions)...
November 11, 2020: Journal of Cardiopulmonary Rehabilitation and Prevention
Andrew W Gardner, Polly S Montgomery, Ming Wang, Biyi Shen, Ana I Casanegra, Federico Silva-Palacios, Shangming Zhang, William A Pomilla, Omar L Esponda, Marcos Kuroki
PURPOSE: We compared the prevalence of participants with and without symptomatic peripheral artery disease (PAD) who met the goals of attaining >7000 and 10 000 steps/d, and we determined whether PAD status was significantly associated with meeting the daily step count goals before and after adjusting for demographic variables, comorbid conditions, and cardiovascular risk factors. METHODS: Participants with PAD (n = 396) and without PAD (n = 396) were assessed on their walking for 7 consecutive days with a step activity monitor...
November 11, 2020: Journal of Cardiopulmonary Rehabilitation and Prevention
Krishna K Patel, Hani Alturkmani, Kensey Gosch, Carlos Mena-Hurtado, Mehdi H Shishehbor, Poghni A Peri-Okonny, Mark A Creager, John A Spertus, Kim G Smolderen
Background Patients with peripheral artery disease (PAD) and coexisting diabetes mellitus (DM) have greater PAD progression and adverse limb events. Our aim was to study whether PAD-specific health status differs by DM. Methods and Results The PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) trial is a 16-center international registry that includes patients with recent exacerbations or new-onset symptomatic PAD presenting to specialty clinics...
November 6, 2020: Journal of the American Heart Association
Tanner I Kim, Anand Brahmandam, Timur P Sarac, Kristine C Orion
The development of highly active antiretroviral therapy (HAART) has significantly improved the life expectancy of patients with human immunodeficiency virus (HIV), but has led to the rise of chronic conditions including peripheral artery disease (PAD). However, trends and outcomes among patients with HIV undergoing lower extremity revascularization are poorly characterized. The aim of this study was to investigate the trends and perioperative outcomes of lower extremity revascularization among patients with HIV and PAD in a national database...
October 6, 2020: Vascular Medicine
Simin Hua, Carmen R Isasi, Jorge R Kizer, Kunihiro Matsushita, Matthew A Allison, Wassim Tarraf, Qibin Qi, Sonia G Ponce, Martha Daviglus, Robert C Kaplan
Background Underuse of cardiovascular medications for secondary prevention among individuals with peripheral artery disease (PAD) has been reported. Little is known about PAD treatment status in the Hispanic/Latino population in the United States, who may have limited access to health care and who have worse clinical outcomes than non-Hispanic individuals. Methods and Results We studied the use of cardiovascular therapies in 1244 Hispanic/Latino individuals recruited from 4 sites in the United States, including 826 individuals who reported diagnosis of PAD by physician and 418 individuals with coronary artery disease alone, in the Hispanic Community Health Study/Study of Latinos...
August 5, 2020: Journal of the American Heart Association
Tuany Eichwald, Sebastien Talbot
The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common neurodegenerative diseases, as well as chronic pain. Adipocytes are a major neuroendocrine organ that continually, and systemically, releases pro-inflammatory factors. While the exact mechanisms driving obesity-induced pain remain poorly defined, nociceptor hypersensitivity may result from the systemic state of inflammation characteristic of obesity as well as weight surplus-induced mechanical stress...
2020: Frontiers in Human Neuroscience
Mary O Whipple, Erica N Schorr, Kristine M C Talley, Julian Wolfson, Ruth Lindquist, Ulf G Bronas, Diane Treat-Jacobson
BACKGROUND: Although supervised exercise therapy (SET) is effective in improving walking distance among adults with symptomatic peripheral artery disease (PAD), some research suggests that individuals with comorbid PAD and type 2 diabetes mellitus (T2DM) may experience a blunted response to SET. It is unknown whether free-living sedentary time changes during SET, and if increases in sedentary time could, in part, explain poor response to SET. OBJECTIVES: The purposes of this pilot study were to: 1) determine if older adults with PAD (with and without T2DM) engaging in SET change their sedentary behavior; and 2) examine the relationship between changes in sedentary behavior and SET outcomes...
April 9, 2020: Annals of Vascular Surgery
Sikandar Z Khan, Monica S O'Brien-Irr, Mariel Rivero, Raphael Blochle, Gregory S Cherr, Maciej L Dryjski, Hasan H Dosluoglu, James Lukan, Vincent L Rowe, Linda M Harris
OBJECTIVE: Angiotensin Converting Enzyme inhibitors & Angiotensin Receptor Blockers (ACE/ARB) reduce the risk of cardiovascular events in patients with peripheral arterial disease (PAD). However, their effect on limb-specific outcomes is unclear. The objective of this study was to assess the effect of ACE/ARB on limb salvage and survival in patients undergoing peripheral vascular interventions (PVI) for chronic limb threatening ischemia (CLTI). METHODS: Vascular Quality Initiative (VQI) registry was used to identify patients undergoing PVI for CLTI between April 1, 2010 - June 1, 2017...
April 7, 2020: Journal of Vascular Surgery
Amol Gupta, Akinsansoye K Dosekun, Vinod Kumar
Patients with peripheral arterial disease (PAD) and critical limb ischemia are at risk for limb amputation and require urgent management to restore blood flow. Patients with PAD often have several comorbidities, including chronic kidney disease, diabetes mellitus, and hypertension. Diagnostic and interventional angiography using iodinated contrast agents provides excellent image resolution but can be associated with contrast-induced nephropathy (CIN). The use of carbon dioxide (CO2 ) as a contrast agent reduces the volume of iodine contrast required for angiography and reduces the incidence of CIN...
February 26, 2020: World Journal of Cardiology
Rachael O Forsythe, Jan Apelqvist, Edward J Boyko, Robert Fitridge, Joon Pio Hong, Konstantinos Katsanos, Joseph L Mills, Sigrid Nikol, Jim Reekers, Maarit Venermo, R Eugene Zierler, Nicolaas C Schaper, Robert J Hinchliffe
Clinical outcomes of patients with diabetes, foot ulceration, and peripheral artery disease (PAD) are difficult to predict. The prediction of important clinical outcomes, such as wound healing and major amputation, would be a valuable tool to help guide management and target interventions for limb salvage. Despite the existence of a number of classification tools, no consensus exists as to the most useful bedside tests with which to predict outcome. We here present an updated systematic review from the International Working Group of the Diabetic Foot, comprising 15 studies published between 1980 and 2018 describing almost 6800 patients with diabetes and foot ulceration...
March 2020: Diabetes/metabolism Research and Reviews
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