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"Maternal sepsis" OR "neonatal sepsis"

Niccolò Parri, Giulia Trippella, Catiuscia Lisi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Neonatal sepsis represents a major cause of morbidity and mortality in neonates. No diagnostic test has been demonstrated to be sufficiently accurate to confirm or exclude neonatal sepsis. This study aimed to evaluate the diagnostic accuracy of presepsin (P-SEP) for neonatal sepsis. Areas covered: A systematic review of literature was performed on Medline and EMBASE. A meta-analysis was performed to calculate pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic of P-SEP for neonatal sepsis...
February 18, 2019: Expert Review of Anti-infective Therapy
Antonio Segado-Arenas, Lidia Atienza-Cuevas, José Roman Broullón-Molanes, Moisés Rodríguez-González, Simón Pedro Lubián-López
Listeriosis is a sporadic infectious disease, which affects high-risk populations, such as the elderly, pregnant women, newborns, and immunocompromised patients. During pregnancy, listeriosis usually presents like a mild non-specific infection, but it may be responsible for fetal loss, preterm labor, early onset neonatal sepsis, and neonatal death. We report the case of a late stillbirth secondary to maternal chorioamnionitis. Listeria monocytogenes was isolated from the amniotic fluid and the fetal pleural fluid...
October 2018: Autopsy & Case Reports
Supram Hosuru Subramanya, Rajesh Amberpet, Dinesh Chaudhary, Niranjan Nayak, Shashiraja Padukone, Indira Bairy, Shishir Gokhale
Background: Vancomycin-resistant enterococcal infections in the neonatal ICU are growing global problems. We report a case of neonatal septicemia by multidrug-resistant vancomycin-resistant Enterococcus faecium (VRE), the source of infection being the mother's gut. Case presentation: A newborn male child admitted to the neonatal intensive care unit (NICU) was diagnosed to have mild meconium aspiration syndrome, early onset neonatal septicemia, and bacteremia by multidrug and vancomycin-resistant Enterococcus faecium ...
2019: Antimicrobial Resistance and Infection Control
Asmaa A El-Madbouly, Asmaa A El Sehemawy, Noha A Eldesoky, Heba Mohammed Abd Elgalil, Amal M Ahmed
Background: Neonatal sepsis (NS) is an important cause of morbidity and mortality among newborns. Its diagnosis depends mainly on blood culture that takes at least 48 hours to give results. Therefore, searching for biomarkers for early diagnosis is of value. We aimed to assess presepsin, soluble triggering receptor expressed on myeloid cells (sTREM-1), and neutrophil CD64 (nCD64) as early diagnostic biomarkers in NS, and to compare them individually and in combination. Methods: This hospital-based case-control study has been conducted on 60 full-term neonates recruited from the neonatal intensive care unit, Al-Zahraa Hospital, Al-Azhar University, Cairo, Egypt...
2019: Infection and Drug Resistance
Istemi Han Celik, Ilter Arifoglu, Zehra Arslan, Gonul Aksu, Ahmet Yagmur Bas, Nihal Demirel
BACKGROUND: The complete blood cell count (CBC) and peripheral blood smear were the most commonly ordered tests for the diagnosis of neonatal sepsis. Delta neutrophil index (DNI) shows leucocyte differentiation and calculated while CBC is performed. AIMS: We aimed to evaluate the value of DNI in neonatal sepsis. STUDY DESIGN: DNI was measured with Siemens Advia 2120 and 2120i devices. DNI was calculated as (neutrophil and eosinophil count in myeloperoxidase channel)-(polymorphonuclear leucocyte count in nuclear lobularity channel)...
February 13, 2019: Early Human Development
Mehmet Mutlu, Yakup Aslan, Filiz Aktürk Acar, Şebnem Kader, G Ülçin Bayramoğlu, Gurdal Yılmaz
OBJECTIVE: Neonatal sepsis , especially nosocomial sepsis (NS) is one of the main causes of mortality and morbidity  in neonates. Our aim was to investigate microorganisms responsible of NS and antimicrobial susceptibility patterns and to compare them in the different period. METHODS: Blood culture registers from the Microbiology Laboratory were reviewed for the study population. The neonates with proven NS were enrolled in the study. Microorganisms responsible for NS and antimicrobial susceptibility patterns were recorded Results: The incidence of gram-positive, gram-negative and fungal microorganisms were 61...
February 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
S N Nabi, A K Basak, M Kamruzzaman, A F Pervez, M Musharraf, N Sultana, A M Moniruzzaman, B K Majumder, M A Mostakim
Neonatal sepsis is one of the major health problems throughout the world and major cause of morbidity and mortality in developing countries. Positive blood culture considers the gold standard for confirmation of neonatal sepsis, but it does not provide rapid diagnosis. So this study was designed to find out the performance of haematological parameters in early diagnosis of neonatal sepsis. The objective of the study was to evaluate the performance of haematological parameters individually and in combination in early diagnosis of neonatal sepsis...
January 2019: Mymensingh Medical Journal: MMJ
Nobuhiro Asai, Yusuke Koizumi, Atsuko Yamada, Daisuke Sakanashi, Hiroki Watanabe, Hideo Kato, Arufumi Shiota, Mao Hagihara, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo
BACKGROUND: Pantoea is a Gram-negative, non-encapsulated, non-spore-forming, ubiquitous straight rod which can be isolated from geographical and ecological sources such as plant surfaces, buckwheat seeds, human feces, and the environment. The genus Pantoea is a rare pathogen in a clinical setting, and is divided into 20 different species such as Pantoea agglomerans, Pantoea ananatis, Pantoea deleyi, Pantoea dispersa, Pantoea septica, Pantoea stewartii or Pantoea rwandensis. Pantoea dispersa has been reported to cause other infections, including respiratory infections, neonatal sepsis, and bloodstream infections...
February 13, 2019: Journal of Medical Case Reports
Pedro Jesús Saturno-Hernández, Ofelia Poblano-Verástegui, Sergio Flores-Hernández, Daniel Ángel-García, Gabriel Jaime O Shea-Cuevas, Víctor Manuel Villagrán-Muñoz, María Elizabeth Halley-Castillo, Verónica Delgado-Sánchez
OBJECTIVE: Develop and pilot indicators of quality of care to neonates with relevant conditions in Mexico (prematurity, neonatal sepsis, perinatal asphyxia, and intrauterine hypoxia). MATERIALS AND METHODS: Own indicators were built based on key recommendations of national clinical practice guidelines and indicators found in international repositories. With previous search, selection and prioritization, the indicators were piloted within two hospitals. The feasibility of measuring, (kappa index) reliability and usefulness was analyzed to detect quality problems...
2019: Salud Pública de México
Byron Brook, Nelly Amenyogbe, Rym Ben-Othman, Bing Cai, Danny Harbeson, Freddy Francis, Aaron C Liu, Natallia Varankovich, James Wynn, Tobias R Kollmann
Neonatal sepsis remains a global burden. A preclinical model to screen effective prophylactic or therapeutic interventions is needed. Neonatal mouse polymicrobial sepsis can be induced by injecting cecal slurry intraperitoneally into day of life 7 mice and monitoring them for the following week. Presented here are the detailed steps necessary for the implementation of this neonatal sepsis model. This includes making a homogeneous cecal slurry stock, diluting it to a weight- and litter-adjusted dose, an outline of the monitoring schedule, and a definition of observed health categories used to define humane endpoints...
January 27, 2019: Journal of Visualized Experiments: JoVE
Bo Sun, Lian-Fang Liang, Jie Li, Dan Yang, Xiao-Bing Zhao, Ke-Gang Zhang
We aimed to systematically assess the overall value of interleukin 6 (IL-6) in diagnosing neonates with sepsis. A systematic literature search was conducted using the following electronic databases: PubMed, Embase, and Cochrane, to identify eligible studies through the index words updated till November 2018. Cross-sectional studies, as well as prospective cohort studies, were included in the above-mentioned group of eligible studies. We also searched the literature sources that had a link to the present study, which were further assessed by heterogeneity through the use of a proper-effects model to calculate pooled weighted specificity, sensitivity, and diagnostic odds ratio (DOR)...
February 7, 2019: International Wound Journal
Kim Prince, Fierdoz Omar, Yaseen Joolay
Background: Biomarkers assist in diagnosing neonatal sepsis but often provide results 6 to 48 h later. Bedside C-reactive protein (CRP) test may help to expedite clinical management. We assessed the performance of point of care test (POCT) CRP against routine laboratory analysis and determined the time difference in obtaining results. Methods: A prospective observational study was conducted over 4 months. Neonates clinically indicated, had CRP simultaneously tested using the POCT and laboratory assays...
January 31, 2019: Journal of Tropical Pediatrics
Ingrid Anne Mandy Schierz, Giuseppa Pinello, Ettore Piro, Mario Giuffrè, Giovanni Corsello
OBJECTIVE:  Methemoglobinemia (MetHb) is a rare congenital or acquired cause of infantile cyanosis. We examined the role of MetHb in a neonatal intensive care unit (NICU). STUDY DESIGN:  A retrospective observational study was conducted reviewing blood gas analyses of hospitalized newborns over a 2-year period. MetHb-positive patients (MetHb >1.8%) were matched with a control group for gestational age, weight, disease, and illness severity at admission. Maternal, neonatal, clinical, and laboratory parameters were collected and analyzed in both groups...
February 1, 2019: American Journal of Perinatology
Peter Adatara, Agani Afaya, Solomon Mohammed Salia, Richard Adongo Afaya, Kennedy Diema Konlan, Eric Agyabeng-Fandoh, Ethel Agbinku, Esther Aku Ayandayo, Irene Gifty Boahene
Worldwide, neonatal sepsis accounts for an estimated 26% of under-five deaths, with sub-Saharan Africa having the highest mortality rates. Though worldwide neonatal deaths have decreased by over 3.6 million per year since 2000, neonatal sepsis remains a notable hindrance to the progress in the decline of cause-specific mortality rates especially in sub-Saharan Africa. This study aimed at examining the risk factors of neonatal sepsis at the Trauma and Specialist Hospital, Winneba. The study was an unmatched case control retrospective study...
2019: TheScientificWorldJournal
Naomi-Liza Denning, Weng-Lang Yang, Laura Hansen, Jose Prince, Ping Wang
INTRODUCTION: Neonatal sepsis remains a leading cause of infant mortality. Cold-inducible RNA binding protein (CIRP) is an inflammatory mediator that induces TNF-α production in macrophages. C23 is a CIRP-derived peptide that blocks CIRP from binding its receptor. We therefore hypothesized that treatment with C23 reduces systemic inflammation and protects the lungs in neonatal sepsis. METHODS: Sepsis was induced in C56BL/6 mouse pups (5-7 days) by intraperitoneal injection of adult cecal slurry (0...
January 4, 2019: Journal of Pediatric Surgery
Maja Zakošek Pipan, Tanja Švara, Irena Zdovc, Bojan Papić, Jana Avberšek, Darja Kušar, Janko Mrkun
BACKGROUND: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. This bacterium was previously isolated from the canine milk and, although, its transmission from the dam's milk to the newborn puppies causing a neonatal sepsis was suggested, this hypothesis has not been confirmed...
January 28, 2019: BMC Veterinary Research
Lauren A Plante, Luis D Pacheco, Judette M Louis
Maternal sepsis is a significant cause of maternal morbidity and mortality and is a preventable cause of maternal death. The purpose of this guideline is to summarize what is known about sepsis and to provide guidance for the management of sepsis in pregnancy and the postpartum period. The following are SMFM recommendations: (1) we recommend that sepsis and septic shock be considered medical emergencies and that treatment and resuscitation begin immediately (GRADE 1B); (2) we recommend that providers consider the diagnosis of sepsis in pregnant patients with otherwise unexplained end organ damage in the presence of an infectious process, regardless of the presence of fever (GRADE 1B); (3) we recommend that empiric broad-spectrum antibiotics be administered as soon as possible, ideally within 1 hour, in any pregnant woman in whom sepsis is suspected (GRADE 1B); (4) we recommend obtaining cultures (blood, urine, respiratory, and others as indicated) and serum lactate levels in pregnant or postpartum women in whom sepsis is suspected or identified...
January 23, 2019: American Journal of Obstetrics and Gynecology
Jiaosheng Zhang, Laura Folgori, Yingfen Hsia, Mike Sharland, Yonghong Yang
BACKGROUND: Antimicrobial resistance (AMR) is a major health threat in China. Very limited information is available on AMR rates in Chinese neonates, with data often published in local languages. METHODS: We undertook a systematic review and the aims were to (i) review the AMR rates for bloodstream isolates from Chinese neonates and (ii) estimate the likely efficacy of first-line treatments for neonatal sepsis on selected pathogens. Medline, Embase, and the Chinese language only CNKI databases were systematically searched for papers published in 2000-2016 combining terms for "China" AND 'Neonates' AND 'Antimicrobial resistance' AND 'Blood Culture'...
January 10, 2019: Pediatric Infectious Disease Journal
Suman Chaurasia, Sindhu Sivanandan, Ramesh Agarwal, Sally Ellis, Mike Sharland, M Jeeva Sankar
No abstract text is available yet for this article.
January 22, 2019: BMJ: British Medical Journal
Ge Zheng, Wenna Xiang, Minli Pan, Yihua Huang, Zhishu Li
BACKGROUND: Many studies have investigated the role of microRNA-25 (miR-25) in the initiation and progression of sepsis in newborns. In this study, we aim to explore how rs41274221 polymorphism in miR-25 compromises the interaction between miR-25 and CD69, so as to understand the mechanisms involved in the control of sepsis in newborns. METHODS: Computational analysis, luciferase assay, real-time polymerase chain reaction (PCR), and western blot analysis were performed in this study...
January 21, 2019: Journal of Cellular Physiology
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