Benjamin T Kopp, Sydney E Ross, Dinesh Bojja, Lokesh Guglani, Joshua D Chandler, Rabindra Tirouvanziam, Misty Thompson, James E Slaven, James F Chmiel, Christopher Siracusa, Don B Sanders
BACKGROUND: Detecting airway inflammation non-invasively in infants with cystic fibrosis (CF) is difficult. We hypothesized that markers of inflammation in CF [IL-1β, IL-6, IL-8, IL-10, IL-17A, neutrophil elastase (NE) and tumor necrosis factor (TNF-α)] could be measured in infants with CF from nasal fluid and would be elevated during viral infections or clinician-defined pulmonary exacerbations (PEx). METHODS: We collected nasal fluid, nasal swabs, and hair samples from 34 infants with CF during monthly clinic visits, sick visits, and hospitalizations...
November 15, 2023: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society