Jae Sung Lim, Eun Jae Jeon, Hye Sun Go, Hyung-Jin Kim, Kye Young Kim, Thi Quynh Trang Nguyen, Da Young Lee, Kyu Suk Kim, Federico Pietrocola, Seol Hee Hong, Shee Eun Lee, Kyoung-Shim Kim, Tae-Shin Park, Dong-Hee Choi, Yu-Jin Jeong, Jong-Hwan Park, Hyeon Sik Kim, Jung-Joon Min, Yong Sook Kim, Joon Tae Park, Jae-Ho Cho, Gil-Woo Lee, Ji Hyeon Lee, Hyon E Choy, Sang Chul Park, Chul-Ho Lee, Joon Haeng Rhee, Manuel Serrano, Kyung A Cho
Addressing age-related immunological defects through therapeutic interventions is essential for healthy aging, as the immune system plays a crucial role in controlling infections, malignancies, and in supporting tissue homeostasis and repair. In our study, we show that stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes. This enhancement in healthspan is evidenced by diminished hair loss and ocular lens opacity, increased bone mineral density, improved stem cell activity, delayed thymic involution, heightened cognitive capacity, and the prevention of pulmonary lung fibrosis...
January 2, 2024: Nature Communications