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Hongliang Zhang, Xiaojie Wei, Shunyu Lu, Xing Lin, Jianchun Huang, Lixiu Chen, Xiang Huang, Luhui Jiang, Yuchun Li, Luhui Qin, Jinbin Wei, Renbin Huang
BACKGROUND: Hyperglycemia stimulated epithelial-mesenchymal transition (EMT) plays a critical role in initiating and progressing renal fibrosis in diabetic kidney disease (DKD). It is crucial to explore novel renal protective drugs for the treatment of DKD. OBJECTIVE: The present study is to confirm our hypothesis and to accumulate the information for the application of DMDD (2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione) as a novel therapeutic agent to potentially inhibit renal fibrogenesis and EMT in the DKD...
March 13, 2019: Biomedicine & Pharmacotherapy
Wanzheng Wang, Litao Wu, Xiaojuan Du, Fujun Zhang, Sayyed Hanif Ullah, Ting Lei, Dongming Li, Xiaofei Yan
Long-time consumption of high-fat food is a direct cause of cardiovascular diseases, and high-fat-related inflammation plays an important role in it. Toll-like receptors (TLRs), especially TLR2 and TLR4, play important roles in high-fat-related inflammation. However, the impact of TLR2 on high-fat-associated cardiovascular complications is still unknown. In this study, we try to investigate the relationship between TLR2 and high-fat-related cardiac injury. SD rats were allocated to either a control group which were fed with normal diet or a high-fat group which were fed with high-fat diet for 5 months...
March 16, 2019: Acta Biochimica et Biophysica Sinica
Ryan D Roberts
Bone biologists have long understood how estrogen drives osteoclasts to make new bone. While evidence hinted that a loss of estrogen signals might also play a role in bone-forming cancers like osteosarcoma, this idea has remained untested. Lillo Osuna and colleagues present data demonstrating widespread epigenetic silencing of estrogen receptor in human osteosarcomas. Exposure to demethylating agents caused reexpression of estrogen receptor, which promoted therapeutic differentiation of these tumors. See related article by Lillo Osuna et al...
March 15, 2019: Cancer Research
Gaurav Sablok, Ali Amiryousefi, Xiaolan He, Jaakko Hyvönen, Péter Poczai
We report the first plastome sequence of giant ragweed ( Ambrosia trifida ); with this new genome information, we assessed the phylogeny of Asteraceae and the transcriptional profiling against glyphosate resistance in giant ragweed. Assembly and genic features show a normal angiosperm quadripartite plastome structure with no signatures of deviation in gene directionality. Comparative analysis revealed large inversions across the plastome of giant ragweed and the previously sequenced members of the plant family...
2019: Frontiers in Plant Science
Robert O Deaner, Vittorio Addona, Brian Hanley
Much research has explored the physiological, energetic, environmental, and psychological factors that influence pacing in endurance events. Although this research has generally neglected the role of psychological variation across individuals, recent studies have hinted at its importance. Here we conducted an online survey of over 1,300 marathon runners, testing whether any of five psychological constructs - competitiveness, goal achievement, risk taking in pace (RTP), domain-specific risk taking, and willingness to suffer in the marathon - predicted slowing in runners' most recent marathons...
2019: Frontiers in Psychology
Antía Brañas, Guillermo Lahera, María Luisa Barrigón, Manuel Canal-Rivero, Miguel Ruiz-Veguilla
INTRODUCTION: Childhood trauma has been reported as a risk factor for psychosis. Different types of traumatic experiences in childhood could lead to different clinical manifestations in psychotic disorders. MATERIAL AND METHODS: We studied differences in social cognition (emotion recognition and theory of mind) and clinical symptoms in a sample of 62 patients with psychosis (less than 5 years of illness) and childhood trauma, analysing performance by trauma type...
March 11, 2019: Revista de Psiquiatrí́a y Salud Mental
Jan-David Freund, Anja Linberg, Sabine Weinert
Interaction quality and child temperament predict early and later child development. Research hints at transactional interrelations of both aspects but lacks adequate data to examine this assumption. Maternal psychosocial resources are suspected moderators in this context but rarely taken into account. Drawing on data of the German National Educational Panel Study we conducted a cross-lagged panel analysis on the longitudinal interplay of maternal interaction quality and children's negative affectivity at 6-8, 16-18, and 25-27 months and compared mothers with and without accumulated strains...
March 11, 2019: Infant Behavior & Development
Sriram Boothalingam, David W Purcell, Chris Allan, Prudence Allen, Ewan Macpherson
OBJECTIVES: We sought to investigate whether children referred to our audiology clinic with a complaint of listening difficulty, that is, suspected of auditory processing disorder (APD), have difficulties localizing sounds in noise and whether they have reduced benefit from spatial release from masking. DESIGN: Forty-seven typically hearing children in the age range of 7 to 17 years took part in the study. Twenty-one typically developing (TD) children served as controls, and the other 26 children, referred to our audiology clinic with listening problems, were the study group: suspected APD (sAPD)...
March 7, 2019: Ear and Hearing
L Chen, J Jia, Y Zang, J Li, B Wan
Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully elucidated. In present study, RT-qPCR assay was performed to detect the expression of miR-101 and enhancer of zeste homolog 2 (EZH2) mRNA. Western blot assay was conducted to determine protein expression of LC3-Ⅰ, LC3-Ⅱ, p62 and EZH2...
March 7, 2019: Neoplasma
Vincent Esposito, Laurenz Rettig, Elisabeth M Bothschafter, Yunpei Deng, Christian Dornes, Lucas Huber, Tim Huber, Gerhard Ingold, Yuichi Inubushi, Tetsuo Katayama, Tomoya Kawaguchi, Henrik Lemke, Kanade Ogawa, Shigeki Owada, Milan Radovic, Mahesh Ramakrishnan, Zoran Ristic, Valerio Scagnoli, Yoshikazu Tanaka, Tadashi Togashi, Kensuke Tono, Ivan Usov, Yoav W Windsor, Makina Yabashi, Steven L Johnson, Paul Beaud, Urs Staub
Material properties can be controlled via strain, pressure, chemical composition, or dimensionality. Nickelates are particularly susceptible due to their strong variations of the electronic and magnetic properties on such external stimuli. Here, we analyze the photoinduced dynamics in a single crystalline NdNiO3 film upon excitation across the electronic gap. Using time-resolved reflectivity and resonant x-ray diffraction, we show that the pump pulse induces an insulator-to-metal transition, accompanied by the melting of the charge order...
November 2018: Structural Dynamics (Melville, N.Y.)
Andreas Zanzoni, Lionel Spinelli, Diogo M Ribeiro, Gian Gaetano Tartaglia, Christine Brun
The coordination of the synthesis of functionally-related proteins can be achieved at the post-transcriptional level by the action of common regulatory molecules, such as RNA-binding proteins (RBPs). Despite advances in the genome-wide identification of RBPs and their binding transcripts, the protein-RNA interaction space is still largely unexplored, thus hindering a broader understanding of the extent of the post-transcriptional regulation of related coding RNAs. Here, we propose a computational approach that combines protein-mRNA interaction networks and statistical analyses to provide an inferred regulatory landscape for more than 800 human RBPs and identify the cellular processes that can be regulated at the post-transcriptional level...
March 13, 2019: Scientific Reports
Edisa Rehic, Dana Hoenig, Bianca E Kamba, Anna Goehring, Eckhard Hofmann, Raphael Gasper, Anja Matena, Peter Bayer
Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 ( Tb Par42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. Tb Par42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl- cis/trans -isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of Tb Par42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein...
March 7, 2019: Biomolecules
Jayangika N Dahanayake, Elaheh Shahryari, Kirsten M Roberts, Micah E Heikes, Chandana Kasireddy, Katie Mitchell-Koch
The solvation layer surrounding a protein is clearly an intrinsic part of protein structure-dynamics-function, and our understanding of how hydration dynamics influence protein function is emerging. We have recently reported simulations indicating a correlation between regional hydration dynamics and the structure of the solvation layer around different regions of the enzyme Candida antarctica lipase B, wherein the radial distribution function (RDF) was used to calculate pairwise entropy, providing a link between dynamics (diffusion) and thermodynamics (excess entropy) known as Rosenfeld scaling...
March 13, 2019: Journal of Chemical Information and Modeling
Sabyasachi Pradhan, Inderjeet Kalia, Sourav Singha Roy, Om P Singh, Tridibes Adak, Agam P Singh, Suman K Dhar
Proliferative cell nuclear antigen (PCNA) is the processivity factor for various DNA polymerases and it functions in response to DNA damage in eukaryotic system. Plasmodium falciparum contains two PCNAs, while PCNA1 has been attributed to DNA replication, the role of PCNA2 has been assigned to DNA damage response in erythrocytic developmental stages. Although a recent transposon mediated knockout strategy qualified pcna2 as a nonessential gene in Plasmodium berghei, a conventional homologous recombination-based knockout strategy has not been employed for this gene yet...
March 13, 2019: IUBMB Life
Marialuisa Donati
Our traditional Western worldview is often unconsciously based on a polarized, dichotomous perspective. However, many of Jung's ideas hint at a deep interrelation between opposites, such as inside and outside, which are, as the principle of synchronicity shows, rooted in a conceptualization of psyche and matter conceived as intertwined. Another pair of philosophical concepts, traditionally considered as opposites, needs further investigation: that between imagination and reality. If we are lucky in our daily practice as analysts, we can use imagination as a powerful tool to help people discover themselves as individuals and to get in deeper, more lively and responsible touch with reality...
April 2019: Journal of Analytical Psychology
Ann-Kathrin Grefe, Björn Kuttich, Lukas Stühn, Robert Stark, Bernd Stühn
Nanoporous ion track-etched polycarbonate is ideally suited for the study of confined polymers via small angle X-ray scattering (SAXS) due to the strictly parallel orientation of the pores as well as their uncorrelated lateral distribution. Nanopores with radii ranging from 17 to 213 nm are prepared and coated with SiO2 via atomic layer deposition in order to obtain a well-defined and homogeneous surface. A low molecular weight polyethylene glycol (PEG) homopolymer with a semicrystalline lamellar bulk structure is introduced into the nanopores via melt infiltration...
March 12, 2019: Soft Matter
Phillip Staibano, Daniel Lelli, Darren Tse
BACKGROUND: Vertigo remains a diagnostic challenge for primary care, emergency, and specialist physicians. Multidisciplinary clinics are increasingly being employed to diagnose and manage patients with dizziness. We describe, for the first time in Canada, the clinical characteristics of patients presenting with chronic and acute dizziness to both a multidisciplinary chronic dizziness clinic (MDC) and a rapid access dizziness (RAD) clinic at The Ottawa Hospital (TOH). METHODS: We performed a retrospective review of all patients presenting to the MDC and RAD clinics at TOH from July 2015 to August 2017...
March 11, 2019: Journal of Otolaryngology—Head & Neck Surgery
Giulia Torriani, Jennifer Mayor, Gert Zimmer, Stefan Kunz, Sylvia Rothenberger, Olivier Engler
Hantaviruses are emerging rodent-borne negative-strand RNA viruses associated with severe human diseases. Zoonotic transmission occurs via aerosols of contaminated rodent excreta and cells of the human respiratory epithelium represent likely early targets. Here we investigated cellular factors involved in entry of the pathogenic Old and New World hantaviruses Hantaan virus (HTNV) and Andes virus (ANDV) into human respiratory epithelial cells. Screening of a kinase inhibitor library using a biocontained recombinant vesicular stomatitis virus pseudotype platform revealed differential requirement for host kinases for HTNV and ANDV entry and provided first hints for an involvement of macropinocytosis...
February 21, 2019: Virology
Joana Carlevaro-Fita, Rory Johnson
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary determinant of their molecular functions. LncRNAs are often thought of as chromatin-restricted regulators of gene transcription and chromatin structure. However, a rich population of cytoplasmic lncRNAs has come to light, with diverse roles including translational regulation, signaling, and respiration. RNA maps of increasing resolution and scope are revealing a subcellular world of highly specific localization patterns and hint at sequence-based address codes specifying lncRNA fates...
March 7, 2019: Molecular Cell
Hongmei Shen, Jie Xu, Yueyan Wang
Informed by the Situational Theory of Problem Solving (STOPS), this study used data from the Health Information National Trends Survey, a large and representative national sample, to examine predictors of information seeking and information accessing of health information, including cancer-related information. We found that the independent variables in STOPS-problem recognition, involvement recognition, and referent criterion- well predicted people's information seeking of cancer-related information and accessing of health information on line...
March 8, 2019: Journal of Health Communication
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