keyword
https://read.qxmd.com/read/38536561/exploring-the-causal-relationship-between-takayasu-arteritis-and-inflammatory-bowel-disease-using-mendelian-randomization
#1
JOURNAL ARTICLE
Xiaoli Pang, Huizhong Yang, Chi Wang, Suyan Tian
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have reported many cases of IBD-TA coexistence. Additionally, the incidence of IBD in patients with TA is estimated to be significantly higher than the incidence in the general population. Therefore, the two diseases are anticipated to be linked. Mendelian randomization (MR) analysis assesses whether an exposure might causally affect an outcome by using genetic variants inherited randomly at conception, thereby reducing the impact of confounding and reverse causality...
March 27, 2024: Immunologic Research
https://read.qxmd.com/read/38536552/il-6-enhances-the-activation-of-pi3k-akt-mtor-gsk-3%C3%AE-by-upregulating-grpr-in-hippocampal-neurons-of-autistic-mice
#2
JOURNAL ARTICLE
Heli Li, Xinyuan Wang, Cong Hu, Jinru Cui, Hao Li, Xiaoping Luo, Yan Hao
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in the inflamed brain of ASD. Multiple studies highlight the role of GRPR in regulating ASD like abnormal behavior and enhancing the PI3K signaling. However, the molecular mechanism by which GRPR regulates PI3K signaling in neurons of individuals with ASD is still unclear. In this study, we utilized a maternal immune activation model to investigate the effects of GRPR on PI3K signaling in the inflamed brain of ASD mice...
March 27, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38536531/minimally-invasive-approaches-to-diagnose-and-monitor-eosinophilic-gi-diseases
#3
REVIEW
Ellie J M Furuta, Glenn T Furuta, Robin Shandas
PURPOSE OF REVIEW: This review seeks to understand novel avenues for eosinophilic GI disease management. Biomarkers offer a unique and non-invasive approach to tracking EoE disease progression. While no biomarkers have definitively met the diagnostic criteria for eosinophilic GI diseases, some biomarkers have been shown to be associated with disease activity. Here, we examine the potential of recently studied biomarkers. RECENT FINDINGS: Current research shows advancements in blood, luminal fluid, and breath testing...
March 27, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38536099/correction-selective-inhibition-of-the-interaction-between-sars-cov-2-spike-s1-and-ace2-by-spidar-peptide-induces-anti-inflammatory-therapeutic-responses
#4
Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan
Paidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38536025/correction-dx5-cd49b-positive-t-cells-are-not-synonymous-with-cd1d-dependent-nkt-cells
#5
Daniel G Pellicci, Kirsten J L Hammond, Jonathan Coquet, Konstantinos Kyparissoudis, Andrew G Brooks, Katherine Kedzierska, Rachael Keating, Stephen Turner, Stuart Berzins, Mark J Smyth, Dale I Godfrey
Pellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs)...
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38534679/the-application-of-knowledge-based-clinical-decision-support-systems-to-detect-antibiotic-allergy
#6
JOURNAL ARTICLE
Nayoung Han, Ock Hee Oh, John Oh, Yoomi Kim, Younghee Lee, Won Chul Cha, Yun Mi Yu
Prevention of drug allergies is important for patient safety. The objective of this study was to evaluate the outcomes of antibiotic allergy-checking clinical decision support system (CDSS), K-CDSTM . A retrospective chart review study was performed in 29 hospitals and antibiotic allergy alerts data were collected from May to August 2022. A total of 15,535 allergy alert cases from 1586 patients were reviewed. The most frequently prescribed antibiotics were cephalosporins (48.5%), and there were more alerts of potential cross-reactivity between beta-lactam antibiotics than between antibiotics with the same ingredients or of the same class...
March 7, 2024: Antibiotics
https://read.qxmd.com/read/38534135/chronic-rhinosinusitis-with-nasal-polyposis-and-biological-agents-the-aria-italy-survey
#7
JOURNAL ARTICLE
C Lombardi, G Passalacqua, F Menzella, R F Mauritz Canevari, G Danesi, A M Pusateri, M Carone, C Vancheri, F Di Marco, C Micheletto, G Manzotti, M Di Gioacchino, M B Bilò, M Gelardi, G Senna, G W Canonica
Background. Chronic rhinosinusitis (CRS) is an inflammatory disease that affects the nasal mucosa and the paranasal sinuses. CRS can be associated by nasal polyposis (CRSwNP phenotype) in up to 30% of patients and it is frequently associated with bronchial asthma. CRSwNP shows predominantly an underlying activation of type 2 inflammatory pathways with the involvement of eosinophils, IgE, interleukin (IL)-4, IL-5 and IL-13. Biological drugs that target these inflammatory cytokines are currently a therapeutic option recognized by guidelines for the treatment of uncontrolled form of the disease...
March 27, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38534034/management-of-interdental-papillary-defects-using-subperiosteal-hyaluronic-acid-injection-overlay-technique-a-prospective-longitudinal-clinical-study
#8
JOURNAL ARTICLE
Wiam Hamadeh, Rola Alhabashneh, Reem Abdelhafez, Yousef Khader
OBJECTIVE: Currently, there is no established treatment protocol to treat interdental papillary loss. This research aimed to evaluate the outcomes of interdental papillary reconstruction using minimally invasive surgery, with injectable hyaluronic acid gel. METHOD AND MATERIALS: Seventeen patients were included, each with five sites of class 1 papillary recession (40 sites in the maxilla and 45 sites in the mandible). Subperiosteal tunneling was performed through a horizontal incision made apical to the base of the papilla without penetrating it...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38534020/environmental-exposures-drive-the-development-of-allergic-diseases
#9
EDITORIAL
Luo Zhang, Cezmi A Akdis
No abstract text is available yet for this article.
March 27, 2024: Allergy
https://read.qxmd.com/read/38533720/tumor-associated-macrophages-as-key-contributors-and-targets-in-current-and-future-therapies-for-melanoma
#10
REVIEW
Shabana Habib, Gabriel Osborn, Zena Willsmore, Min Waye Chew, Sophie Jakubow, Amanda Fitzpatrick, Yin Wu, Khushboo Sinha, Hawys Lloyd-Hughes, Jenny L C Geh, Alastair D MacKenzie-Ross, Sean Whittaker, Victoria Sanz-Moreno, Katie E Lacy, Sophia N Karagiannis, Rebecca Adams
INTRODUCTION: Despite the success of immunotherapies for melanoma in recent years, there remains a significant proportion of patients who do not yet derive benefit from available treatments. Immunotherapies currently licensed for clinical use target the adaptive immune system, focussing on Tcell interactions and functions. However, the most prevalent immune cells within the tumor microenvironment (TME) of melanoma are macrophages, a diverse immune cell subset displaying high plasticity, to which no current therapies are yet directly targeted...
March 27, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38533367/co-occurrence-of-otitis-media-with-effusion-and-another-environment-dependent-disease-selected-allergic-conditions
#11
JOURNAL ARTICLE
Oksana Wojas, Edyta Krzych-Fałta, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Bolesław Samoliński, Piotr Samel-Kowalik
INTRODUCTION: Otitis media eith effusion (OME) is an inflammatory condition of the middle ear that involves accumulation of sterile fluid or effusion in the tympanic cavity with the tympanic membrane intact. The pathophysiology of OME is undoubtedly multifactorial. AIM: To assess the co-occurrence of OME, allergic rhinitis, and asthma. MATERIAL AND METHODS: The study involved a group of 18,617 subjects aged 6-7 years, 13-14 years, or 20-44 years...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533354/history-of-pollutant-adjuvants-in-respiratory-allergy
#12
REVIEW
Dennis Shusterman
Combined exposures to allergens and air pollutants emerged as a topic of concern in scientific circles by the 1980's, when it became clear that parallel increases in respiratory allergies and traffic-related air pollution had been occurring during the 20th century. Although historically there has been a tendency to treat exposure-related symptoms as either allergic or toxicologic in nature, cross-interactions have since been established between the two modalities. For example, exposure to selected air pollutants in concert with a given allergen can increase the likelihood that an individual will become sensitized to that allergen, strongly suggesting that the pollutant acted as an adjuvant ...
2024: Front Allergy
https://read.qxmd.com/read/38532599/high-sensitivity-of-host-helios-neuropilin-1-treg-to-pretransplant-conditioning-hampers-development-of-ox40-bright-integrin-%C3%AE-7-regulatory-cells-in-acute-gastrointestinal-gvhd
#13
JOURNAL ARTICLE
Nikolett Lupsa, Barbara Érsek, Csenge Böröczky, Dávid Kis, Eszter Szarka, Katalin Lumniczky, Géza Sáfrány, Zoltán S Zádori, Árpád Szöőr, Edit I Buzás, Zoltán Pós
This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin-1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI-aGvHD). Host CD4+ /CD25hi /Foxp3+ Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA-4, CD39, OX40, integrin-β7, LAG3, TGFβ/LAP, granzyme-A, -B, and interleukin-10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none...
March 26, 2024: European Journal of Immunology
https://read.qxmd.com/read/38532556/mast-cell-activation-identified-through-urine-mediators
#14
JOURNAL ARTICLE
Matthew P Giannetti, Grace Godwin, Julia Middlesworth, Andrew Espeland, Jennifer Nicoloro-SantaBarbara, Mariana Castells
No abstract text is available yet for this article.
March 26, 2024: Allergy
https://read.qxmd.com/read/38532489/real-world-association-between-systemic-corticosteroid-exposure-and-complications-in-us-patients-with-severe-asthma
#15
JOURNAL ARTICLE
Thomas B Casale, Thomas Corbridge, Guillaume Germain, François Laliberté, Sean D MacKnight, Julien Boudreau, Mei S Duh, Arijita Deb
BACKGROUND: Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. OBJECTIVE: Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma. METHODS: This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID: 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts: SCS use and non/burst-SCS use...
March 26, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38532203/topical-application-of-ozonated-sunflower-oil-accelerates-the-healing-of-lesions-of-cutaneous-leishmaniasis-in-mice-under-meglumine-antimoniate-treatment
#16
JOURNAL ARTICLE
Ana Paula Pivotto, Lucas Bonatto de Souza Lima, Alexandra Michelon, Camilla Zottesso Pellon Ferreira, Rinaldo Ferreira Gandra, Thaís Soprani Ayala, Rafael Andrade Menolli
Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an option to enhance the standard treatment due to the wound-healing activity reported in the literature. In this study, we evaluated the efficiency of ozonated sunflower oil as an adjuvant in treating cutaneous lesions caused by Leishmania amazonensis. BALB/c mice were infected with L. amazonensis, and after the lesions appeared, they were treated in four different schedules using the drug treatment with meglumine antimoniate (Glucantime®), with or without ozonated oil...
March 27, 2024: Medical Microbiology and Immunology
https://read.qxmd.com/read/38532057/mechanisms-of-medicinal-pharmaceutical-and-immunomodulatory-action-of-probiotics-bacteria-and-their-secondary-metabolites-against-disease-management-an-overview
#17
REVIEW
Sundas Nasreen, Shaukat Ali, Saiqa Andleeb, Muhammad Summer, Tauqeer Hussain, Kaleem Imdad, Chaman Ara, Hafiz Muhammad Tahir
Probiotics or bacteriotherapy is today's hot issue for public entities (Food and Agriculture Organization, and World Health Organization) as well as health and food industries since Metchnikoff and his colleagues hypothesized the correlation between probiotic consumption and human's health. They contribute to the newest and highly efficient arena of promising biotherapeutics. These are usually attractive in biomedical applications such as gut-related diseases like irritable bowel disease, diarrhea, gastrointestinal disorders, fungal infections, various allergies, parasitic and bacterial infections, viral diseases, and intestinal inflammation, and are also worth immunomodulation...
March 27, 2024: Folia Microbiologica
https://read.qxmd.com/read/38531697/modified-screening-and-management-strategies-for-chronic-rhinosinusitis-in-hematologic-patients-receiving-hematopoietic-stem-cell-transplantation
#18
JOURNAL ARTICLE
Yen-Hui Lee, Chih-Feng Lin, Te-Huei Yeh, Huai-Hsuan Huang, Yi-Tsen Lin
OBJECTIVES: Given the lack of consensus on the screening and treatment for chronic rhinosinusitis (CRS) in the patients undergoing hematopoietic stem cell transplantation (HSCT), we reviewed the risk factors for CRS to improve the efficiency of sinonasal screening and analyzed the effect of treating CRS in search of guidance for modifying current management strategies for rhinosinusitis in HSCT patients. METHODS: We conducted a nested case-control study in a retrospective cohort of hematologic patients receiving HSCT from April 2011 to April 2021 and collected data on demographics, smoking/atopic status, hematological diseases, and features of rhinosinusitis for analysis...
March 25, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38531299/recent-advance-in-sesame-allergens-influence-of-food-processing-and-their-detection-methods
#19
REVIEW
Jianhua Zeng, Feifei Ma, Ligong Zhai, Chuanlai Du, Jinlong Zhao, Zhenxing Li, Jin Wang
Sesame (Sesamum indicum L.) is a valuable oilseed crop with numerous nutritional benefits containing a diverse range of bioactive compounds. However, sesame is also considered an allergenic food that triggers various mild to severe adverse reactions (e.g., anaphylaxis). Strict dietary avoidance of sesame components is the best option to protect the sensitized consumers. Sesame or sesame-derived foods are always consumed after certain food processing operations, which would cause a considerable impact on the structure of sesame proteins, changing their sensitization capacity and detectability...
March 21, 2024: Food Chemistry
https://read.qxmd.com/read/38531202/dehydrozaluzanin-c-derivative-protects-septic-mice-by-alleviating-over-activated-inflammatory-response-and-promoting-the-phagocytosis-of-macrophages
#20
JOURNAL ARTICLE
Ying-Xiang Zou, Tian-Nan Xiang, Li-Rong Xu, Huan Zhang, Yu-He Ma, Lu Zhang, Chun-Xian Zhou, Xiao Wu, Qi-Lin Huang, Biao Lei, Jing-Wen Mu, Xiang-Yang Qin, Xin Jiang, Yue-Juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments...
March 25, 2024: International Immunopharmacology
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