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Maryam Hussain, Germán Bonilla-Rosso, Cheong Kc Kwong Chung, Lukas Bäriswyl, Maria Pena Rodriguez, Brian S Kim, Philipp Engel, Mario Noti
BACKGROUND: Diet-induced obesity and food allergies rise in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested. OBJECTIVE: To test the role of high dietary fat intake, diet-induced obesity and associated changes in gut microbial community structure on food allergy pathogenesis. METHODS: Mice were fed a high fat diet (HFD) for 12 weeks prior to food allergen sensitization on an atopic dermatitis-like skin lesion followed by intra-gastric allergen challenge to induce experimental food allergy...
February 12, 2019: Journal of Allergy and Clinical Immunology
Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Jutta Renkonen, Pirkko Mattila, Teija Ojala, Sakari Joenvaara, Mika Mäkelä, Anna Pelkonen, Paula Kauppi, Tari Haahtela, Risto Renkonen, Sanna Toppila-Salmi
Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes.
February 12, 2019: Journal of Allergy and Clinical Immunology
M Giusti, M Gasser, P Valentini, L Pescollderungg, K Eisendle
Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy to protein mainly in cow milk (CM) that typically presents in early infancy. Projectile and repetitive vomiting are the main clinical symptoms after 1-4 hours of trigger food ingestion. Rapid recognition and installment of a specific diet are important to avoid serious complications in affected children (see figure 1).1 According to a multicenter Italian study2 atopy as co-morbidity is rarer than in other countries being 9% compared to a much higher frequency of 28% in Spain,3 57% in Australia4 and over 70% in the USA...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Daniel M Altmann
Neutrophils are appreciated to perform a wide range of pro- and anti-inflammatory effector functions in diverse settings. These go far beyond the response to acute infection, encompassing sterile injury, autoimmunity, allergy and tumours. There is growing appreciation of the nuances of their modes of action, especially elucidation of the nature and consequences of NETosis. New work suggests that it is time to give greater consideration to the anti-inflammatory role of neutrophils, such as in the control of cytokine release during sepsis...
March 2019: Immunology
Manon Ragonnet-Cronin, Yunyin W Hu, Sheldon R Morris, Zhijuan Sheng, Kathleen Poortinga, Joel O Wertheim
BACKGROUND: Transgender women are among the groups at highest risk for HIV infection, with a prevalence of 27·7% in the USA; and despite this known high risk, undiagnosed infection is common in this population. We set out to identify transgender women and their partners in a molecular transmission network to prioritise public health activities. METHODS: Since 2006, HIV protease and reverse transcriptase gene (pol) sequences from drug resistance testing have been reported to the Los Angeles County Department of Public Health and linked to demographic data, gender, and HIV transmission risk factor data for each case in the enhanced HIV/AIDS Reporting System...
February 11, 2019: Lancet HIV
Sara Barnes, Rhonda Stuart, Bernice Redley
BACKGROUND: Health service hand hygiene programs have seen widespread use of chlorhexidine solutions. Reports of both immediate and delayed hypersensitivity to chlorhexidine are increasing among health care workers. This study examined the prevalence of self-reported symptoms of sensitivity to chlorhexidine solutions among health care workers. METHODS: This study was a cross-sectional online anonymous survey of all workers at a single health service. RESULTS: Of the 1,050 completed responses, 76...
February 11, 2019: American Journal of Infection Control
Tesfaye Hambisa Mekonnen, Dawit Getachew Yenealem, Beyene Mindaye Tolosa
BACKGROUND: Occupational skin diseases are the second most common occupational diseases and are responsible for an estimated 25% of all lost work days. Occupational contact dermatitis (OCD) comprises 70-90% of all occupational skin diseases. In Ethiopia, information about the prevalence and factors which determine developments of contact dermatitis is not recognized. The objective of this study was to investigate prevalence and factors influencing the occurrences of occupational-related contact dermatitis among healthcare workers in Gondar town, Northwest Ethiopia...
February 14, 2019: Environmental Health and Preventive Medicine
Helen T Wang, Sara Anvari, Katherine Anagnostou
The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment...
February 5, 2019: Children
Amanda Agyemang, Scott Sicherer
Peanut allergy appears to have increased in prevalence, is often severe and is typically life-long. Therefore, reducing its incidence through a primary prevention strategy is a priority. Guidelines on peanut introduction have evolved with time and given evidence of peanut allergy risk reduction with early infant ingestion exposure, the current US advice promotes early introduction for infants, particularly targeting those at highest risk. Areas covered: This article describes the evolution of peanut introduction guidelines in infants in the US, as shaped by key research over the last 20-30 years and culminates in the landmark LEAP study It also compares and contrasts current iterations of peanut introduction guidelines in infants globally...
February 14, 2019: Expert Review of Clinical Immunology
(no author information available yet)
New England Journal of Medicine, Volume 380, Issue 7, Page 690-692, February 2019.
February 14, 2019: New England Journal of Medicine
Michael Seth Smith, Jairo Olivas, Kristy Smith
Manipulative therapies include osteopathic manipulative treatment and many other forms of manual therapies used to manage a variety of conditions in adults and children. Spinal manipulative therapy may provide short-term improvement in patients with acute or chronic low back pain, comparable with other standard treatments. When compared with oral analgesics, cervical manipulation and/or mobilization appears to provide better short-term pain relief and improved function in patients with neck pain. Manipulative therapies may be as effective as amitriptyline for treating migraine headaches and can reduce the frequency and intensity of pain...
February 15, 2019: American Family Physician
Camille Braun, Philippe Eigenmann
Food allergy reduces the quality of allergic children life because of a lethal risk. Current recommendations are favouring introduction of potentially allergenic foods according to usual, non-delayed, practices. In allergic children, intramuscular epinephrine is the key treatment of anaphylaxis. A self-injectable device must be prescribed in the presence of a severe reaction risk. Allergen avoidance is currently best to avoid an allergic reaction. Specific immunotherapy, essentially oral, is the only treatment for tolerance induction in allergic patients, and may be discussed to prevent severe reactions in the case of accidental ingestion...
February 13, 2019: Revue Médicale Suisse
Jart A F Oosterhaven, Julia Verbist, Marie-Louise A Schuttelaar
BACKGROUND AND OBJECTIVES: Studies of beekeepers have mostly focused on contact allergy to propolis. The overall prevalence of hand eczema (HE) in beekeepers has not been studied. Our objectives were to gain insight into the prevalence of HE in the Dutch beekeeper population; to define the impact of beekeeping activities on HE and vice versa; and to determine associated factors. PATIENTS AND METHODS: We used a cross-sectional online survey. Dutch beekeepers answered questions on beekeeping activities, the prevalence and characteristics of HE, including severity, and the impact of the disease on beekeeping...
February 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
I J Skypala, L Cecchi, M Shamji, E S Scala, S J Till
BACKGROUND: Although pollen-related food allergy occurs in all European populations, Lipid Transfer Protein (LTP) allergy is considered to manifests mainly in Mediterranean countries. We aimed to characterise adults presenting with LTP allergy in a Northern European country. METHOD: The clinical history and sensitisation patterns of subjects born and residing in the United Kingdom (UK), with a prior diagnosis of LTP allergy and sensitisation to the peach LTP allergen Pru p 3, were compared to UK subjects with pollen food syndrome (PFS)...
February 14, 2019: Allergy
Thimo Ruethers, Aya C Taki, Roni Nugraha, Trúc T Cao, Martina Koeberl, Sandip D Kamath, Nicholas A Williamson, Sean O'Callaghan, Shuai Nie, Sam S Mehr, Dianne E Campbell, Andreas L Lopata
BACKGROUND: Commercial allergen extracts for allergy skin prick testing (SPT) are widely used for diagnosing fish allergy. However, there is currently no regulatory requirement for standardisation of protein and allergen content, potentially impacting the diagnostic reliability of SPTs. We therefore sought to analyse commercial fish extracts for the presence and concentration of fish proteins and in vitro IgE reactivity using serum from fish-allergic patients. METHODS: Twenty-six commercial fish extracts from 5 different manufacturers were examined...
February 14, 2019: Allergy
Anna Brzęk, Andrzej Knapik, Jacek Sołtys, Weronika Gallert-Kopyto, Anna Famuła-Wąż, Ryszard Plinta
Asthma and body posture abnormalities in children and young people are major epidemiological problems worldwide. Asthma among children and adolescents, its relations with physical activity (PA) and PA relations with body posture were and are still being investigated.The aim of this study was to investigate how body posture is shaped in children diagnosed with asthma symptoms and whether body posture is associated with PA. The study involved 192 children. The main group consisted of 90 children diagnosed with asthma and allergies symptoms age 9 to 12 years old (x = 10...
February 2019: Medicine (Baltimore)
Radoslaw Jaworski, Andrzej Kansy, Katarzyna Dzierzanowska-Fangrat, Bohdan Maruszewski
BACKGROUND: Prophylactic antibiotic therapy is given routinely in the peri-operative period to prevent surgical site infection. However, in pediatric cardiac surgery, an optimal schedule has not been defined. Pediatric recommendations follow the guidelines for adults, which might be improper because of the inherent challenges in pediatric research and the heterogeneity of the population. Implementation of an effective prophylaxis protocol is needed for children undergoing cardiac surgery, especially in view of worldwide antibiotic overuse and the development of drug resistance...
February 14, 2019: Surgical Infections
Sophie-Caroline Campana, Thibault Canceill, Rémi Esclassan
SAPHO is an acronym for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis. The syndrome is difficult to diagnose because it may present many different manifestations in adults and children. Its origin is still unknown, although some infectious, genetic and immune hypotheses have been put forward. We report the case of a 49-year-old woman with SAPHO syndrome, who developed a serious cutaneous allergy following the insertion of a removable partial denture (RPD). The oral care and treatment of this patient are described...
February 14, 2019: Special Care in Dentistry
Igor Kaidashev, Halyna Morokhovets, Viktoriia Rodinkova, Jean Bousquet
BACKGROUND: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Ragweed pollen allergy was investigated due to its high allergenicity and wide expansion in Europe. OBJECTIVES: The study aimed to examine translations of "ragweed" and "hay fever" in native Cyrillic languages, especially in Ukrainian and Russian, and to compare the seasonality of queries in Ukraine with ragweed and mugwort pollen counts...
February 13, 2019: International Archives of Allergy and Immunology
Louise Heydenreich Jensen, Jeppe Madura Larsen, Charlotte Bernhard Madsen, Rune Rønhave Laursen, Lotte Neergaard Jacobsen, Katrine Lindholm Bøgh
BACKGROUND: Infant formulas (IFs) based on hydrolysed cow's milk proteins are central in the management of cow's milk allergy (CMA) in infants and small children. New IF compositions with improved prevention and treatment properties are needed, along with appropriate preclinical animal models, to evaluate these properties before introduction into humans. OBJECTIVES: We aimed to develop preclinical models for the assessment of the primary preventive and desensitising capacity of cow's milk IF in allergy-prone, high-IgE responder Brown Norway rats...
February 13, 2019: International Archives of Allergy and Immunology
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