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https://read.qxmd.com/read/30894830/enriched-environments-as-a-potential-treatment-for-developmental-disorders-a-critical-assessment
#1
REVIEW
Natalie J Ball, Eduardo Mercado, Itzel Orduña
The beneficial effects of enriched environments have been established through a long history of research. Enrichment of the living conditions of captive animals in the form of larger cages, sensory stimulating objects, and opportunities for social interaction and physical exercise, has been shown to reduce emotional reactivity, ameliorate abnormal behaviors, and enhance cognitive functioning. Recently, environmental enrichment research has been extended to humans, in part due to growing interest in its potential therapeutic benefits for children with neurodevelopmental disorders (NDDs)...
2019: Frontiers in Psychology
https://read.qxmd.com/read/30893144/cancer-cachexia-a-clinical-challenge
#2
Josep M Argilés, Sílvia Busquets, Francisco Javier López-Soriano
PURPOSE OF REVIEW: The aim of this article is to review the metabolic background of the cachectic syndrome and to analyze the recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. RECENT FINDINGS: The main changes associated with the development of this multiorganic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. Among the most promising approaches for the treatment of cachexia include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and antimyostatin peptides...
March 18, 2019: Current Opinion in Oncology
https://read.qxmd.com/read/30892694/exercise-and-cardiovascular-progenitor-cells
#3
Rian Q Landers-Ramos, Ryan M Sapp, Daniel D Shill, James M Hagberg, Steven J Prior
Autologous stem/progenitor cell-based methods to restore blood flow and function to ischemic tissues are clinically appealing for the substantial proportion of the population with cardiovascular diseases. Early preclinical and case studies established the therapeutic potential of autologous cell therapies for neovascularization in ischemic tissues. However, trials over the past ∼15 years reveal the benefits of such therapies to be much smaller than originally estimated and a definitive clinical benefit is yet to be established...
March 14, 2019: Comprehensive Physiology
https://read.qxmd.com/read/30890937/trimetazidine-attenuates-exhaustive-exercise-induced-myocardial-injury-in-rats-via-regulation-of-the-nrf2-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Hongming Zhang, Moyan Liu, Yuyan Zhang, Xiaoyan Li
Exhausted exercise has been reported to cause the damage of myocardial structure and function in terms of cardiomyocyte apoptosis, oxidative stress, and energy metabolism disturbance. Trimetazidine (TMZ), as an anti-ischemic agent, has been approved to be effective in promoting myocardial energy metabolism, anti-inflammatory, and anti-oxidation. However, few studies examined the effects of TMZ on myocardial injury induced by exhausted exercise. To investigate whether TMZ could ameliorate the exhaustive exercise-induced myocardial injury and explore the underlying mechanisms, here the rat model of exhaustive exercise was induced by prolonged swimming exercise and TMZ was administrated to rats before exhaustive exercise...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30890834/salat-muslim-prayer-as-a-therapeutic-exercise
#5
Muhammad Osama, Reem Javed Malik
'Salat' is a Muslim prayer mandatory for all Muslims five times a day. It is comparable to performing a mildintensity exercise, because most of the joints and musclesundergo exercise during different positions and movements adopted in Salat. Though Salat is practised by all Muslims, evidence is very limited regarding the biomechanics and therapeutic effects of Salat as an exercise. However, literature shows activation of biceps brachii, triceps brachii, pectoralis major, scapular musculature, rectus femoris, biceps femoris, tibialis anterior and gastrocnemius during different postures of Salat...
March 2019: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/30890122/-exercise-during-hemodialysis-and-health-promoting-behaviors-a-clinical-trial
#6
Alireza Dashtidehkordi, Nahid Shahgholian, Fatemeh Attari
BACKGROUND: Health promoting behaviors are among the determinants of health. Hemodialysis causes significant changes in the lives of patients and affects their health promoting behaviors. Accordingly, this study aimed at investigating the effect of exercise during hemodialysis on health promotion behaviors in patients undergoing hemodialysis. METHODS: This study was a two-stage (before and after) clinical trial. The sample of the study consisted of 60 hemodialysis patients in two hospitals in Isfahan who were selected randomly and divided into two groups of control and intervention using random allocation method...
March 19, 2019: BMC Nephrology
https://read.qxmd.com/read/30888307/content-reporting-in-post-stroke-therapeutic-circuit-class-exercise-programs-in-randomized-control-trials
#7
Daniel McEwen, Jennifer O'Neil, Marcel Miron-Celis, Lucie Brosseau
BACKGROUND: Therapeutic exercise in the form of group circuit-class training can improve mobility and gait while being cost-effective among patients who survived a stroke. Accurate clinical replication of interventions, especially when they are effective, is needed to advance research and treatment. However, replication is difficult when reporting is not detailed. OBJECTIVE: The objective of this study was to assess the quality of reporting of interventions within the selected studies using three different scales and to assess the criterion validity between the scales...
March 19, 2019: Topics in Stroke Rehabilitation
https://read.qxmd.com/read/30886231/dnajb3-attenuates-metabolic-stress-and-promotes-glucose-uptake-by-eliciting-glut4-translocation
#8
Abdelilah Arredouani, Abdoulaye Diane, Namat Khattab, Ilham Bensmail, Imad Aoude, Mohamed Chikri, Ramzi Mohammad, Abdul Badi Abou-Samra, Mohammed Dehbi
Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. We recently showed that DNAJB3 co-chaperone is downregulated in obese and diabetic patients and that physical exercise restores its normal expression with a significant improvement of the clinical outcomes. In 3T3-L1 adipocytes, DNAJB3 has a role in improving the sensitivity to insulin and glucose uptake. In co-immunoprecipitation assays, DNAJB3 interacts with both JNK1 and IKKβ kinases. However, the functional impact of such interaction on their activities has not been investigated...
March 18, 2019: Scientific Reports
https://read.qxmd.com/read/30878496/robotic-assisted-shoulder-rehabilitation-therapy-effectively-improved-post-stroke-hemiplegic-shoulder-pain-a-randomized-controlled-trial
#9
Min-Su Kim, Sung Hoon Kim, Se-Eung Noh, Heui Je Bang, Kyoung-Moo Lee
OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of a newly developed shoulder robot on post-stroke hemiplegic shoulder pain DESIGN: Prospective, single-blind randomized controlled trial. SETTING: Inpatient department of a tertiary university hospital. PARTICIPANTS: Hemiplegic shoulder pain patients (n=38) were consecutively recruited and randomly assigned to an intervention or control group. INTERVENTIONS: A newly developed robot was designed to perform joint mobilization and stretching exercises with patients lying in the supine position...
March 13, 2019: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/30876438/upper-limb-strength-training-in-subacute-stroke-patients-study-protocol-of-a-randomised-controlled-trial
#10
Susan Högg, Manfred Holzgraefe, Insa Wingendorf, Jan Mehrholz, Christoph Herrmann, Mark Obermann
BACKGROUND: Stroke patients are often affected by arm paresis, have functional impairments and receive help from professional or informal caregivers. Progressive resistance training is a common intervention for functional impairments after paresis. Randomised controlled trials (RCT) showed benefits for functional recovery after resistance training. However, there is a lack of evidence for strength training in subacute stroke patients. The aim of this study is to investigate safety and effectiveness of arm strength training in subacute stroke patients...
March 15, 2019: Trials
https://read.qxmd.com/read/30875990/targeting-white-adipose-tissue-with-exercise-or-bariatric-surgery-as-therapeutic-strategies-in-obesity
#11
REVIEW
Flávia Giolo De Carvalho, Lauren M Sparks
Adipose tissue is critical to whole-body energy metabolism and has become recognized as a bona fide endocrine organ rather than an inert lipid reservoir. As such, adipose tissue is dynamic in its ability to secrete cytokines, free fatty acids, lipokines, hormones and other factors in response to changes in environmental stimuli such as feeding, fasting and exercise. While excess adipose tissue, as in the case of obesity, is associated with metabolic complications, mass itself is not the only culprit in obesity-driven metabolic abnormalities, highlighting the importance of healthy and metabolically adaptable adipose tissue...
March 15, 2019: Biology
https://read.qxmd.com/read/30874927/effectiveness-of-therapeutic-inflatable-ball-self-exercises-for-improving-shoulder-function-and-quality-of-life-in-breast-cancer-survivors-after-sentinel-lymph-node-dissection
#12
REVIEW
Minseock Kim, Minyoung Lee, Minhee Kim, Sejun Oh, SeungPil Jung, Bumchul Yoon
BACKGROUND: The survival rate of breast cancer survivors (BCSs) is > 90%. Particular issues are upper arm dysfunction caused by surgery and treatments. Physical activity has been recommended to improve shoulder function and quality of life (QoL) in BCSs. However, rehabilitation programs tend not to be continuous. PURPOSE: To explore the effectiveness of therapeutic inflatable ball self-exercise for improving shoulder function and QoL in breast cancer survivors (BCSs) following breast cancer surgery...
March 12, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30873714/the-experience-of-mindful-yoga-for-older-adults-with-depression
#13
Ka Chun Lee, Wai Kit Tang, Daniel Bressington
INTRODUCTION: Mindful yoga combines yoga techniques with the mindfulness-based stress reduction approach. Previous studies on mindful yoga have reported improvements in depression for working-age adults, but no studies have been conducted with older people. AIMS: To explore the experiences of older adults with depression participating in a mindful yoga group to establish if the approach has potential as a future intervention for this client group. METHOD: This study adopted a qualitative descriptive method and used inductive content analysis...
March 15, 2019: Journal of Psychiatric and Mental Health Nursing
https://read.qxmd.com/read/30870417/molecular-and-antigenic-characterization-of-trypanosoma-cruzi-tolt-proteins
#14
Maite Lobo, Virginia Balouz, Luciano Melli, Giannina Carlevaro, María E Cortina, María de Los Milagros Cámara, Gaspar E Cánepa, Santiago J Carmona, Jaime Altcheh, Oscar Campetella, Andrés E Ciocchini, Fernán Agüero, Juan Mucci, Carlos A Buscaglia
BACKGROUND: TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors. Preliminary biochemical studies indicated that TolT resolved in SDS-PAGE as ~3-5 different bands with sizes between 34 and 45 kDa, and that this heterogeneity could be ascribed to differences in polypeptide glycosylation. However, the recurrent identification of TolT-deduced peptides, and variations thereof, in trypomastigote proteomic surveys suggested an intrinsic TolT complexity, and prompted us to undertake a thorough reassessment of this antigen...
March 14, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30867601/amp-activated-protein-kinase-the-current-landscape-for-drug-development
#15
REVIEW
Gregory R Steinberg, David Carling
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into its structure, regulation and physiological roles have been revealed. While exercise, caloric restriction, metformin and many natural products increase AMPK activity and exert a multitude of health benefits, developing direct activators of AMPK to elicit beneficial effects has been challenging. However, in recent years, direct AMPK activators have been identified and tested in preclinical models, and a small number have entered clinical trials...
March 13, 2019: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/30867130/exercise-reveals-proline-dehydrogenase-as-a-potential-target-in-heart-failure
#16
REVIEW
Jose B N Moreira, Martin Wohlwend, Simone Fenk, Ingrid Åmellem, Arnar Flatberg, Jasenka Kraljevic, Jasna Marinovic, Marko Ljubkovic, Geir Bjørkøy, Ulrik Wisløff
The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these mechanisms will identify novel therapeutic targets. In search of these mechanisms we took advantage of unbiased RNA-sequencing (RNA-seq) technology to discover cardiac gene targets whose expression is disrupted in heart failure (HF) and rescued by exercise in a rat model...
March 10, 2019: Progress in Cardiovascular Diseases
https://read.qxmd.com/read/30866613/multifidus-muscles-lipid-content-is-associated-with-intervertebral-disc-degeneration-a-quantitative-magnetic-resonance-imaging-study
#17
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Mitsunori Yoshimoto, Toshihiko Yamashita
Study Design: Cross-sectional study. Purpose: To determine the association between fatty degeneration of the multifidus muscle (Mm) and intervertebral disc degeneration (IVDD) using quantitative magnetic resonance imaging (MRI). Overview of Literature: Few studies have reported on quantitative MRI analysis of the relation between the Mm and IVDD. Methods: The subjects with chronic low back pain comprised 45 patients (19 males, 26 females; mean age, 63...
March 15, 2019: Asian Spine Journal
https://read.qxmd.com/read/30865387/enantioselective-disposition-of-r-r-formoterol-s-s-formoterol-and-their-respective-glucuronides-in-urine-following-single-inhaled-dosing-and-application-to-doping-control
#18
Glenn A Jacobson, Morten Hostrup, Christian K Narkowicz, David S Nichols, E Haydn Walters
Formoterol is a long-acting beta2-adrenoceptor agonist (LABA) used for treatment of asthma and exercise-induced bronchoconstriction. Formoterol is usually administered as a racemic (rac-) mixture of (R,R)- and (S,S)-enantiomers. While formoterol is restricted by the World Anti-Doping Agency (WADA), inhalation of formoterol is permitted to a predetermined dose (54 μg/24 hours) and a urine threshold of 40 ng/mL. However, chiral switch enantiopure (R,R)-formoterol is available, effectively doubling the therapeutic advantage for the same threshold...
March 13, 2019: Drug Testing and Analysis
https://read.qxmd.com/read/30864854/effects-of-green-and-ripe-coffee-in-the-metabolic-profile-and-muscle-enzymes-in-animals-practicing-physical-exercise
#19
Henrique Bosso, Giovanna Emanuella Piffer Soares Arantes, Sandra Maria Barbalho, Élen Landgraf Guiguer, Maricelma da Silva Soares de Souza, Patrícia Cincotto Dos Santos Bueno, Agnaldo Bruno Chies, Priscilla Bianca de Oliveira, Claudemir Gregório Mendes, Adriano Cressoni Araújo
Many studies have shown that plants can be therapeutic alternatives in the prevention or treatment of various diseases. Among these, green coffee may present different pharmacological effects related to the regulation of glycemia and lipid metabolism and is related to the prevention of cardiovascular diseases. The objective of our study was to evaluate the effects of using green and ripe coffee on the metabolic profile and muscular enzymes after the practice of physical exercises in Wistar rats. We included six groups: G1 (control group), G2 (group submitted to swimming), G3 (group that consumed green coffee), G4 (group that consumed green coffee and was submitted to swimming), G5 (group that consumed ripe coffee), and G6 (group that consumed ripe coffee and was submitted to swimming)...
March 13, 2019: Journal of Medicinal Food
https://read.qxmd.com/read/30860878/exercise-training-promotes-a-gdf15-associated-reduction-in-fat-mass-in-older-adults-with-obesity
#20
Hui Zhang, Ciaran E Fealy, John P Kirwan
Obesity is a major risk factor for metabolic disease. Growth differentiation factor 15 (GDF15) has shown promise as a weight loss agent for obesity in animal studies. In healthy lean humans, fasting plasma GDF15 increases after acute exercise. However, the role of GDF15 in human obesity, and the response of plasma GDF15 to exercise training in obese patients is unknown. Here, twenty-four sedentary, obese volunteers (age: 65 ± 1 yr; BMI: 35.3 ± 0.9 kg/m2 ) participated in a supervised 12-wk aerobic exercise intervention: 1hr/day, 5 days/wk at ~85% HRmax with controlled isocaloric diet...
March 12, 2019: American Journal of Physiology. Endocrinology and Metabolism
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