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Laboratory elderly

Christian Nitsche, Andreas A Kammerlander, Klaus Knechtelsdorfer, Jakob A Kraiger, Georg Goliasch, Carolina Dona, Laurin Schachner, Begüm Öztürk, Christina Binder, Franz Duca, Stefan Aschauer, Daniel Zimpfer, Diana Bonderman, Christian Hengstenberg, Julia Mascherbauer
OBJECTIVES: The aim of the present long-term study was to assess the incidence and mode of valve hemodynamic deterioration (VHD) of bioprosthetic aortic valves, as well as associated factors. BACKGROUND: Modern definitions of bioprosthetic valve deterioration recommend the use of echocardiography for the assessment of transprosthetic gradients and valvular regurgitation. METHODS: A total of 466 consecutive patients (mean age 73.5 ± 7.5 years, 56...
March 13, 2019: JACC. Cardiovascular Imaging
Ali M Omari, Leen S Omari, Hazar H Dagash, Waleed M Sweileh, Nehal Natour, Sa'ed H Zyoud
BACKGROUND: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Therefore this study aimed to assess the nutritional status among HDP and to establish the factors associated with MN in these patients...
March 15, 2019: BMC Nephrology
L C García Gómez, L Castilla Guerra, M Gandullo Moro, R Cano Alba, M Paniagua García, M Á Colmenero Camacho
BACKGROUND: Diagnosing pulmonary embolisms can be challenging, given that its presentation shares clinical manifestations with other conditions. For patients 80 years of age or older, the healthcare challenge increases due to associated comorbidity when compared with younger patients (<80 years). OBJECTIVE: The aim of our study was to report the incidence of pulmonary embolism in elderly patients in our setting and identify differences in the clinical manifestations, comorbidity and laboratory parameters between these 2 groups of patients...
March 11, 2019: Revista Clínica Española
Minmin Chen, Yanhua Zhang, Yanping Du, Wei Hong, Wenjing Tang, Huilin Li, Songbai Zheng, Qun Cheng
In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications. INTRODUCTION: We attempted to explore the epidemiology and clinical characteristics of hip fracture in the elderly. METHODS: One thousand five hundred thirty-nine patients aged over 65 years were included in the retrospective study. From the medical records, information was gathered about pre-fracture conditions, as well as fracture type, surgical details, laboratory indicators, postoperative complications, length of stay, outcomes, and costs of hospitalization...
March 12, 2019: Archives of Osteoporosis
FelipeM de Santana, DiogoS Domiciano, MichelA Gonçalves, LuanaG Machado, CamilleP Figueiredo, JaquelineB Lopes, ValériaF Caparbo, LilliamTakayama Biologist, PauloR Menezes, RosaMR Pereira
Body composition changes resulting from ageing may impact older adults survival. However, its influence on mortality risk is uncertain. Currently, the best method for body composition analysis in clinical practice is dual energy X-ray absorptiometry (DXA). Nonetheless, the few studies on body composition by DXA and mortality risk in elderlies have some limitations. We investigated the association between body composition by DXA and mortality in a cohort of elderly subjects. Eight hundred and thirty nine (839) community-dwelling subjects (516 women, 323 men), ≥65 years, were assessed by questionnaire on clinical data, laboratory exams and body composition by DXA at baseline...
March 13, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Hugo R Ramos, Luis E López, Walter Quiroga Castro, César Mj Serra
Cardiac troponins are pivotal in the evaluation of patients who suffer from acute chest pain, and the introduction of the High-Sensitivity Cardiac Troponins (hs-cTn) has shown that there are differences between male and female patients. Recent recommendations from experts point out that an appropriate evaluation must take into account the patients' sex, but there is no clear evidence of the implementation of this recommendation in the clinical practice, and the matter has sparked controversy. If the same cut-off value is used for both sexes, myocardial infarction in men might be overdiagnosed, especially in the elderly, who have relatively higher values, and might be underdiagnosed in most women...
March 6, 2019: Hellenic Journal of Cardiology: HJC
Ying-Min Lin, Min Wang, Nuan-Xin Sun, Yan-Yan Liu, Teng-Fei Yin, Chen Chen
BACKGROUND: Malnutrition is very common in elderly patients admitted to the hospital. The aim of our study is to assess the nutritional status of elderly patients and the use of nutritional support in a tertiary care hospital in China and to analyze the impacts of nutritional status and nutritional support on clinical outcomes. METHODS: Statistical analysis was performed on a sample of 745 elderly patients in the geriatric medicine department of Qilu Hospital of Shandong University from March 2012 to March 2015...
2019: PloS One
Maria E Santolaya, Luis Thompson, Dona Benadof, Cecilia Tapia, Paulette Legarraga, Claudia Cortés, Marcela Rabello, Romina Valenzuela, Pamela Rojas, Ricardo Rabagliati
BACKGROUND: Active surveillance is necessary for improving the management and outcome of patients with candidemia. The aim of this study was to describe epidemiologic and clinical features of candidemia in children and adults in tertiary level hospitals in Chile. METHODS: We conducted a prospective, multicenter, laboratory-based survey study of candidemia in 26 tertiary care hospitals in Chile, from January 2013 to October 2017. RESULTS: A total of 780 episodes of candidemia were included, with a median incidence of 0...
2019: PloS One
Fernando Saldias Peñafiel, Javiera Gassmann Poniachik, Alejandro Canelo López, Orlando Díaz Patiño
BACKGROUND: Molecular biological techniques allow the identification of more pathogens associated with community-acquired pneumonia (CAP). AIM: To compare clinical and laboratory parameters of patients with CAP caused by different groups of pathogens. MATERIAL AND METHODS: In a prospective study, immunocompetent adult patients hospitalized with CAP were tested for the presence of a broad range of possible respiratory pathogens using bacterial cultures, polymerase chain reaction, urinary antigen testing and serology...
December 2018: Revista Médica de Chile
Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila
In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains unknown because, unlike humans, common laboratory animals lack neuromelanin. Synthesis of peripheral melanins is mediated by tyrosinase, an enzyme also present at low levels in the brain. Here we report that overexpression of human tyrosinase in rat substantia nigra results in age-dependent production of human-like neuromelanin within nigral dopaminergic neurons, up to levels reached in elderly humans...
March 7, 2019: Nature Communications
Jia Zhang, Zhaoqing Du, Jianbin Bi, Zheng Wu, Yi Lv, Xufeng Zhang, Rongqian Wu
BACKGROUND: Pyogenic liver abscess (PLA) in the elderly is insufficiently elucidated. A few studies attempted to investigate the role of age in PLA have yielded controversial results. The purpose of this study was to explore the possible differences in the comorbidity, microbiological characteristics and clinical course between elderly and young PLA patients. METHODS: The clinical data of 332 adult PLA patients who received treatment at our hospital from January 2010 to December 2016 were collected...
March 7, 2019: BMC Infectious Diseases
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
INTRODUCTION: Gabapentin (GBP) is an analog of γ-aminobutyric acid and was originally designed as an anticonvulsant. Because its mechanism of action is unclear, assumed to have no abuse potential, and apparent lack of toxicity, GBP is used widely off-label to treat an array of disorders, including essential tremor. CASE REPORT: We present a case of an elderly woman diagnosed with essential tremor, in which GBP was initiated. In the following day, she complained of urinary incontinence with the absence of dysuria and urgency...
March 4, 2019: Clinical Neuropharmacology
Salvatore Saporito, Matthew A D Brodie, Kim Delbaere, Jildou Hoogland, Harmke Nijboer, Sietse Menno Rispens, Gabriele Spina, Martin Stevens, Janneke Annegarn
Mobility impairment is common in older adults and influences negatively the quality of life. Mobility may changes rapidly following hospital discharge. The Timed Up and Go test (TUG) is often used to assess functional mobility; however, because TUG may require supervision from a trained clinician, assessments may be infrequent. &#13; Objective. In this paper, we aim at providing a method to evaluate TUG remotely from activities in free-living, enabling continuous remote mobility monitoring without expert supervision...
March 6, 2019: Physiological Measurement
Nathan J Jacobson, Robert E Van Demark, Bradley Reeves
Osteomyelitis pubis is a rare orthopedic infection, accounting for less than 1-2 percent of all hematogenous osteomyelitis. Osteomyelitis pubis generally affects children, elderly patients who have undergone genitourinary procedures, and parenteral drug users. Interestingly, cases of acute osteomyelitis pubis have also been documented in previously young, healthy athletes. The diagnosis is often difficult to differentiate from osteitis pubis, which is a self-limiting, painful inflammatory condition affecting the symphysis pubis...
December 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
M Falcone, G Tiseo, F Dentali, E Foglia, M Campanini, F Menichetti, A Mazzone
OBJECTIVES: To describe clinical features and outcome of patients with bloodstream infections (BSIs) due to Enterococcus spp and identify predictive factors of mortality. METHODS: This analysis is part of a prospective multicenter observational study of consecutive hospitalized patients with BSIs. The study was conducted from March 2012 to December 2012 in 31 Internal Medicine wards (IMWs) in Italy (SNOOPII study). Patients with BSI due to Enterococcus spp were selected from the whole cohort...
February 27, 2019: Journal of Global Antimicrobial Resistance
Camilla J Williams, Brendon J Gurd, Jacob T Bonafiglia, Sarah Voisin, Zhixiu Li, Nicholas Harvey, Ilaria Croci, Jenna L Taylor, Trishan Gajanand, Joyce S Ramos, Robert G Fassett, Jonathan P Little, Monique E Francois, Christopher M Hearon, Satyam Sarma, Sylvan L J E Janssen, Emeline M Van Craenenbroeck, Paul Beckers, Véronique A Cornelissen, Nele Pattyn, Erin J Howden, Shelley E Keating, Anja Bye, Dorthe Stensvold, Ulrik Wisloff, Ioannis Papadimitriou, Xu Yan, David J Bishop, Nir Eynon, Jeff S Coombes
There is heterogeneity in the observed O2peak response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare O2peak trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volumes were classified by the duration of total interval time. High-volume High Intensity Interval Training (HIIT) included studies that had participants complete more than 15 min of high intensity efforts per session...
2019: Frontiers in Physiology
Rok Civljak, Tatjana Tot, Ann R Falsey, Eva Huljev, Jasmina Vranes, Suncanica Ljubin-Sternak
AIM: To investigate the viral aetiology of acute respiratory infection (ARI) in hospitalized adults and elderly patients in Croatia, compare the prevalence of detected viruses, and to determine clinical characteristics and seasonal occurrence of investigated infections. METHODS: From January 2016 to June 2018, a total of 182 adult patients presented with symptoms of ARI and admitted to the hospital were tested for 15 respiratory viruses by multiplex RT-PCR. Clinical data were collected by retrospective analysis of the patient's chart...
February 22, 2019: Journal of Medical Virology
Hiroyuki Suzuki, Yusuke Kawamura, Keiichi Kinowaki, Norio Akuta, Kayoko Kasuya, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Hiromitsu Kumada
Adult-onset type II citrullinemia (CTLN2) is a urea cycle disease characterized by neurological and psychiatric abnormalities associated with hyperammonemia. One of the pathological features of CTLN2 is the presence of hepatocyte steatosis. The condition progresses in almost all CTLN2 patients to nonalcoholic fatty liver disease (NAFLD). We herein report a 74-year-old woman who developed CTLN2 without hepatocyte steatosis. The diagnosis was based on clinical and laboratory findings and confirmed by two liver biopsies conducted within 7 years, as well as by a DNA analysis, which demonstrated mutations in the SLC25A13 gene...
February 25, 2019: Internal Medicine
Bopeththe Vidanelage Kameera Madhusanka Bopeththa, S M M Niyaz, Chathuranga Medagedara
BACKGROUND: Hyponatremia is defined as a serum sodium level of less than 135 mEq/L in a patient. Although hyponatremia is not an uncommon laboratory finding, especially in the elderly, hunting for the etiology is a challenging issue for any clinician. The three first-line investigations that are required for further analysis are urine osmolality, serum osmolality, and urinary sodium levels in addition to clinical assessment of volume status. CASE PRESENTATION: A 69-year-old previously well Sinhalese man presented with lethargy, loss of appetite, vomiting, and altered behavior of 1 week's duration...
February 23, 2019: Journal of Medical Case Reports
M Skála, V Liška, V Třeška
INTRODUCTION: Diverticula of the small bowel are quite rare findings, frequently confirme only by necropsy. The authors describe the signs and symptoms resulting from complications of small bowel diverticula as well as the diagnostic options and treatment modalities. The paper also presents the results of treatment in the Department of Surgery at University Hospital in Pilsen. METHOD: Our retrospective study involved 6 patients who were operated on due to complications of small bowel mesenteric diverticulum at the Department of Surgery at University Hospital in Pilsen between 1 January 2006 and 1 January 2016...
2019: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
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