Ping Zhang, Peter Fleming, Christopher E Andoniou, Olivia G Waltner, Shruti S Bhise, Jose Paulo Martins, Benjamin A McEnroe, Valentina Voigt, Sheridan Daly, Rachel D Kuns, Adaeze P Ekwe, Andrea S Henden, Alda Saldan, Stuart Olver, Antiopi Varelias, Corey Smith, Christine R Schmidt, Kathleen S Ensbey, Samuel Rw Legg, Tomoko Sekiguchi, Simone A Minnie, Mark Gradwell, Irma Wagenaar, Andrew D Clouston, Motoko Koyama, Scott N Furlan, Glen A Kennedy, E Sally Ward, Mariapia A Degli-Esposti, Geoffrey R Hill, Siok-Keen Tey
Endothelial function and integrity are compromised after allogeneic bone marrow transplantation (BMT), but how this affects immune responses broadly remains unknown. Using a preclinical model of CMV reactivation after BMT, we found compromised antiviral humoral responses induced by IL-6 signaling. IL-6 signaling in T cells maintained Th1 cells, resulting in sustained IFN-γ secretion, which promoted endothelial cell (EC) injury, loss of the neonatal Fc receptor (FcRn) responsible for IgG recycling, and rapid IgG loss...
April 1, 2024: Journal of Clinical Investigation