keyword
https://read.qxmd.com/read/38215058/clinical-efficacy-of-blood-ultrafiltration-therapy-in-patients-with-acute-decompensated-chronic-heart-failure-running-title-blood-ultrafiltration-therapy-for-heart-failure
#21
JOURNAL ARTICLE
Yan-Wei He, Feng-Qin Wang, Fen-Fang Zhang, Huan-Zhen Chen
In this study, we investigated the clinical effects of blood ultrafiltration therapy in patients with acute decompensated chronic heart failure. We enrolled 78 patients with acute decompensated chronic heart failure who were admitted to a hospital from September 2017 to December 2021, and divided them into two groups based on the digital randomization method. The FQ-16 heart failure ultrafiltration dehydrating device blood ultrafiltration therapy was administered to the observation group (39 patients) for 8-16 hours, while the control group (39 patients) received the stepped drug therapy...
December 31, 2023: Physiological Research
https://read.qxmd.com/read/38211604/efficacy-and-safety-of-linaclotide-in-treating-functional-constipation-in-paediatric-patients-a-randomised-double-blind-placebo-controlled-multicentre-phase-3-trial
#22
RANDOMIZED CONTROLLED TRIAL
Carlo Di Lorenzo, Julie Khlevner, Gerardo Rodriguez-Araujo, Wangang Xie, Susanna Y Huh, Masakazu Ando, Jeffrey S Hyams, Samuel Nurko, Marc A Benninga, Michael Simon, Marcella E Hewson, Miguel Saps
BACKGROUND: Linaclotide, a guanylate cyclase C agonist, has been approved in the USA for the treatment of chronic idiopathic constipation and irritable bowel syndrome with predominant constipation in adults. We aimed to assess the efficacy and safety of linaclotide in paediatric patients aged 6-17 years with functional constipation. METHODS: This randomised, double-blind, placebo-controlled, multicentre, phase 3 study was done at 64 clinic or hospital sites in seven countries (USA, Canada, Israel, Italy, the Netherlands, Ukraine, and Estonia)...
March 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/38193986/chronic-intestinal-pseudo-obstruction-due-to-adult-onset-acquired-isolated-hypoganglionosis-with-muscular-atrophy-in-the-small-intestine-a-case-report-and-review-of-literature
#23
JOURNAL ARTICLE
Sayoko Tayama, Yoki Furuta, Miyuki Morito, Hideaki Naoe, Daiki Yoshii, Yasuyuki Uchida, Koichiro Yoshimaru, Yuji Miyamoto, Tomoaki Taguchi, Yasuhito Tanaka
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal disorder characterized by impaired propulsion of the digestive tract and associated with symptoms of intestinal obstruction, despite the absence of obstructive lesions. CIPO includes several diseases. However, definitive diagnosis of its etiology is difficult only with symptoms or imaging findings. CASE PRESENTATION: A 56-year-old man was referred to our hospital due to a 3-year history of continuous abdominal distention...
January 9, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38187602/mucus-polymer-concentration-and-in-vivo-adaptation-converge-to-define-the-antibiotic-response-of-pseudomonas-aeruginosa-during-chronic-lung-infection
#24
Matthew A Greenwald, Suzanne L Meinig, Lucas M Plott, Cristian Roca, Matthew G Higgs, Nicholas P Vitko, Matthew R Markovetz, Kaitlyn R Rouillard, Jerome Carpenter, Mehmet Kesimer, David B Hill, Jonathan C Schisler, Matthew C Wolfgang
UNLABELLED: The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes progressively more viscous with age and disease severity due to the concentration and overproduction of mucin and accumulation of host-derived extracellular DNA (eDNA). Respiratory mucus of MADs provides a niche for recurrent and persistent colonization by respiratory pathogens, including Pseudomonas aeruginosa , which is responsible for the majority of morbidity and mortality in MADs...
December 21, 2023: bioRxiv
https://read.qxmd.com/read/38150736/comparison-of-characteristics-of-children-with-severe-acute-and-chronic-malnutrition-hospitalized-with-diarrhea
#25
JOURNAL ARTICLE
Abu Sayem Mirza Md Hasibur Rahman, Md Ahshanul Haque, Fardaus Ara Begum, Md Farhad Kabir, Baharul Alam, Mohammod Jobayer Chisti, Tahmeed Ahmed, Sharika Nuzhat
Children with malnutrition present with aberrant laboratory parameters. This study aimed to identify high-risk diarrheal children with varied nutritional status. The data were obtained from the electronic database of Dhaka Hospital, International Centre for Diarrhoeal Disease Research, Bangladesh from 2019 to 2021. Among 1,068 children under 5 years of age with diarrhea, 177 (14%) had severe acute malnutrition (SAM; weight-for-length/height Z score < -3), 239 children (17%) had severe stunting (SS; length/height-for-age Z score < -3), and 652 did not have malnutrition (weight-for-length/height and weight-for-age and length/height-for-age Z score > -2)...
December 26, 2023: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38145990/roles-of-the-mechanosensitive-ion-channel-piezo1-in-the-renal-podocyte-injury-of-experimental-hypertensive-nephropathy
#26
JOURNAL ARTICLE
Satoyuki Ogino, Kei Yoshikawa, Takashi Nagase, Kaori Mikami, Miki Nagase
Glomerular podocyte injury plays an essential role in proteinuria pathogenesis, a hallmark of chronic kidney disease, including hypertensive nephropathy. Although podocytes are susceptible to mechanical stimuli, their mechanotransduction pathways remain elusive. Piezo proteins, including Piezo1 and 2, are mechanosensing ion channels that mediate various biological phenomena. Although renal Piezo2 expression and its alteration in rodent dehydration and hypertension models have been reported, the role of Piezo1 in hypertensive nephropathy and podocyte injury is unclear...
December 25, 2023: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38135857/mucus-transpiration-as-the-basis-for-chronic-cough-and-cough-hypersensitivity
#27
REVIEW
David A Edwards, Kian Fan Chung
Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which water appears to evaporate from laryngeal and tracheal mucus as from the surface of a leaf, as a potential cause of cough hypersensitivity. In this process, osmotic pressure differences form across mucus, pulling water toward the air, and preventing mucus dehydration. Recent research suggests that these osmotic differences grow on encounter with dry and dirty air, amplifying pressure on upper airway epithelia and initiating a cascade of biophysical events that potentially elevate levels of ATP, promote inflammation and acidity, threaten water condensation, and diminish mucus water permeability...
December 22, 2023: Lung
https://read.qxmd.com/read/38125533/predictors-of-hospital-mortality-and-multidrug-resistant-pathogens-in-hospitalized-pneumonia-patients-residing-in-the-community
#28
JOURNAL ARTICLE
Tomohiko Ukai, Takaya Maruyama, Shinichi Tomioka, Takumi Fukui, Shinya Matsuda, Kiyohide Fushimi, Hiroyasu Iso
BACKGROUND AND OBJECTIVE: The 2019 ATS/ADSA guidelines for adult community-acquired pneumonia (CAP) eliminated healthcare-associated pneumonia (HCAP) and considered it to be a form of CAP. This concept, however, was based on studies with relatively small sample sizes. METHODS: We investigated the risk factors of 30-day mortality, and methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa infections in patients with pneumonia coming from the community using the Diagnosis Procedure Combination database, a nationwide discharge database of acute care hospitals...
December 2023: Heliyon
https://read.qxmd.com/read/38103319/innovative-biochemisurgical-treatment-for-stabilisation-of-an-end-stage-chronic-wound-in-a-complex-vascular-compromized-patient
#29
A Algharib, L M C van Dortmont, M G R Hendrix, S Riedel, R Möller, G G Koning
INTRODUCTION: Treating advanced peripheral arterial occlusive disease (e.g. PAOD IV) poses a significant challenge, as conventional treatments quite often fall short at this stage. However, a range of interventions can be considered to postpone amputation. This study presents an example of advanced stage of Peripheral Artery Occlusive Disease (PAOD) stage IV, encompassing a history of a high thigh amputation on the left side, coupled with pronounced wound healing disorders. PRESENTATION OF CASE: Our patient, 55 years old, smoker and ASA Class III is in a left sided above-the knee-amputation situation...
December 13, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38077922/a-case-of-erythrodermic-psoriasis-successfully-treated-with-risankizumab
#30
Matteo Megna, Angelo Ruggiero, Antonia Salsano, Giuseppe Lauletta, Antonio Portarapillo, Ginevra Torta, Fabrizio Martora, Luca Potestio
Psoriasis is a chronic inflammatory cutaneous disease, affecting up to 3% of the worldwide population. Several clinical phenotypes can be distinguished. Among these, erythrodermic psoriasis (EP) is a rare and severe variant (less than 3% of cases), characterized by severe generalized erythema and scaling affecting at least 90% of the body surface area. EP is often a life-threatening condition, since several systemic symptoms (tachycardia, fever, fatigue, lymphadenopathy, dehydration, serum electrolyte disturbances) can be associated...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38051836/unique-usages-of-dehydrated-human-amnion-chorion-membrane-allografts-in-dermatology
#31
JOURNAL ARTICLE
Natalie Garcia, Victoria Jiminez, Lauren Graham, Conway Huang
Dehydrated human amnion chorion membrane (dHACM) allografts are synthetic skin substitutes derived from placental tissue. dHACM allografts are used for replacing lost or damaged dermal tissue, as they contain many of the components found within the extracellular matrix that are beneficial in wound healing. Common uses of dHACM allografts include the healing of diabetic and non-diabetic foot and leg ulcers, decubitus ulcers, and wounds following debridement. While these grafts have been proven to be beneficial in other disciplines of medicine, their potential for use in the field of dermatology is emerging...
December 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38021544/sacral-agenesis-late-presentation-and-the-psychological-impact-of-delayed-diagnosis
#32
Jyoti Bhutani, Vinayak Rengan, Vishnu Pansari, Deerush Kannan
Sacral agenesis (SA) is a rare condition characterized by the absence of one or more lower sacral vertebral bodies. In India, children with this condition often present late with symptoms primarily related to urinary and bowel dysfunction. Maternal diabetes is the only confirmed risk factor, significantly elevating the incidence rate. We discuss a case of a nine-year-old female who presented to the pediatric outpatient department (OPD) with chronic constipation and urinary retention, having experienced symptoms since infancy...
October 2023: Curēus
https://read.qxmd.com/read/38008355/dynamics-of-anti-toxoplasma-gondii-antibodies-and-seroconversion-during-pregnancy-and-lactation-in-naturally-infected-goats
#33
JOURNAL ARTICLE
K D Steffen, M L Gos, J M Unzaga, M C Venturini, R O Arias, G Moré
The objective of this work was to evaluate the dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation and relate it to hematological and dehydration parameters. Blood samples were obtained from 56 goats in the different physiological states (pregnancy, kidding and lactation) as in different years (2019, 2021 and 2022). A total of 266 serum samples were obtained and evaluated by indirect fluorescent antibody test (IFAT) to end titer...
November 24, 2023: Parasitology International
https://read.qxmd.com/read/37898916/the-prevalence-risk-factors-and-clinical-implications-of-dehydration-in-older-patients-a-cross-sectional-study
#34
JOURNAL ARTICLE
Kubra Atciyurt, Cihan Heybeli, Lee Smith, Nicola Veronese, Pinar Soysal
OBJECTIVES: Adequate hydration is essential for the maintenance of physiological functions. Older adults may not be able to maintain adequate hydration, which is often not recognized. Our aim was to investigate the prevalence, risk factors and clinical implications of dehydration in older adults. METHODS: This cross-sectional study included 964 older adults in one geriatric outpatient clinic in Turkey. Dehydration was defined as a calculated [1,86 × (Na+K)+1,15×glucose+urea +14] plasma osmolarity of ≥ 295 mOsm/L...
October 29, 2023: Acta Clinica Belgica
https://read.qxmd.com/read/37895029/vaping-induced-proteolysis-causes-airway-surface-dehydration
#35
JOURNAL ARTICLE
Arunava Ghosh, Raymond D Coakley, Neil E Alexis, Robert Tarran
Proteases such as neutrophil elastase cleave and activate the epithelial sodium channel (ENaC), causing airway dehydration. Our current study explores the impact of increased protease levels in vapers' airways on ENaC activity and airway dehydration. Human bronchial epithelial cultures (HBECs) were exposed to bronchoalveolar lavage fluid (BALF) from non-smokers, smokers and vapers. Airway surface liquid (ASL) height was measured by confocal microscopy as a marker of hydration. ENaC cleavage was measured by Western blotting...
October 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37893057/the-importance-of-optimal-hydration-in-patients-with-heart-failure-not-always-too-much-fluid
#36
REVIEW
Andrzej Wittczak, Maciej Ślot, Agata Bielecka-Dabrowa
Heart failure (HF) is a leading cause of morbidity and mortality and a major public health problem. Both overhydration and dehydration are non-physiological states of the body that can adversely affect human health. Congestion and residual congestion are common in patients hospitalized for HF and are associated with poor prognosis and high rates of rehospitalization. However, the clinical problem of dehydration is also prevalent in healthcare and community settings and is associated with increased morbidity and mortality...
September 30, 2023: Biomedicines
https://read.qxmd.com/read/37872220/chronic-dehydration-induces-injury-pathways-in-rats-but-does-not-mimic-histopathology-of-chronic-interstitial-nephritis-in-agricultural-communities
#37
JOURNAL ARTICLE
Gerd Schreurs, Stuart Maudsley, Cynthia Nast, Marleen Praet, Sylvina Da Silva Fernandes, Peter Boor, Patrick D'Haese, Marc E De Broe, Benjamin A Vervaet
CINAC-patients present renal proximal tubular cell lysosomal lesions which are also observed in patients experiencing calcineurin inhibitor (CNI) nephrotoxicity, suggesting that CINAC is a toxin-induced nephropathy. An alternative hypothesis advocates chronic dehydration as a major etiological factor for CINAC. Here, we evaluated histological and molecular changes in dehydrated versus toxin exposed rats. Wistar rats were divided in 3 groups. Group 1 (n = 6) had free access to drinking water (control group)...
October 23, 2023: Scientific Reports
https://read.qxmd.com/read/37857065/novel-phenolate-salts-of-bioactive-agents-cannabidiol-phenolate-salts
#38
JOURNAL ARTICLE
Pulikanti Guruprasad Reddy, Ayala Bar-Hai, Amnon Hoffman, Sir Marc Feldmann, Abraham J Domb
Bioactive phenolic compounds are commonly found in medications, with examples including apomorphine, estrone, thymol, estradiol, propofol, o-phenylphenol, l-Dopa, doxorubicin, tetrahydrocannabinol (THC), and cannabidiol (CBD). This study is the first to explore the creation and assessment of metal and ammonium phenolate salts using CBD as an example. CBD is used in medicine to treat anxiety, insomnia, chronic pain, and inflammation, but its bioavailability is limited due to poor water solubility. In this study exploit a synthetic route to convert CBD into anionic CBD-salts to enhance water solubility...
October 12, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/37842418/uncommon-presentation-of-cystic-fibrosis-a-case-report-and-literature-review
#39
Majed Abu Sirhan, Michael Kalinin, Lior Cohen, Evgenia Gurevich
Cystic fibrosis (CF) is a multiorgan disease, caused by autosomal recessive (AR) mutations in the cystic fibrosis transmembrane regulator (CFTR) acting primarily as a chloride channel. CF is most commonly diagnosed in Caucasian populations. Common clinical presentations in pediatric patients include chronic cough, respiratory tract infections such as pneumonia, digestive symptoms, and stunted growth, and malnutrition due to gastrointestinal malabsorption and pancreatic insufficiency. Excessive sweat sodium chloride losses due to dysfunctional sweat glands in CFTR result in volume contraction and secondary hyperaldosteronism leading to renal potassium losses and metabolic alkalosis...
September 2023: Curēus
https://read.qxmd.com/read/37841994/sodium-glucose-co-transporter-type-2-inhibitors-effect-on-quality-of-life-in-older-adult-population
#40
JOURNAL ARTICLE
Duygu Tutan, Ayşe Erdoğan Kaya, Mehmet Kayaalp
Introduction The global elderly population is expanding, with chronic conditions like diabetes diminishing their quality of life. Sodium-glucose co-transporter type 2 (SGLT-2) inhibitors hold promise in improving quality of life by addressing hypervolemia, obesity, and lipid irregularities. However, these drugs can lead to adverse effects, such as polyuria, dehydration, and weight loss, which may detrimentally impact older patients. We aimed to investigate the association between SGLT-2 inhibitors and quality of life in older adults with diabetes...
October 2023: Curēus
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