Wei-Ting Chang, Po-Sen Huang, Li-Wei Su, Chia-Te Liao, Han Siong Toh, Yi-Chen Chen, Chung-Han Ho, Zhih-Cherng Chen, Po-Chao Hsu, Chon-Seng Hong
AIMS: Critical limb ischemia (CLI) is an emerging public health threat and lacks a reliable score for predicting the outcomes. The Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping (ABCD-GENE) risk score helps identify patients with coronary artery disease who have cytochrome P450 2C19 (CYP2C19) polymorphism-related drug resistance and are at risk for cardiovascular adverse events. However, its application to CLI remains unknown. In this study, we aim to validate a modified ACD-GENE-CLI score to improve the prediction of major adverse limb events (MALEs) in patients with CLI receiving clopidogrel...
December 12, 2023: Journal of Atherosclerosis and Thrombosis