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Colistin resistant klebsiella

Sergio García-Fernández, María García-Castillo, German Bou, Jorge Calvo, Emilia Cercenado, Mercedes Delgado, Cristina Pitart, Xavier Mulet, Nuria Tormo, Diego López Mendoza, Jazmín Díaz-Regañón, Rafael Cantón
Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multi-drug resistant (MDR) bacteria. Consequently, new antimicrobials and combinations are needed. We evaluated the activity of ceftolozane-tazobactam against Enterobacterales (n=400) and Pseudomonas aeruginosa (n=80) isolates collected from patients in Spanish intensive care units (ICUs) with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Overall susceptibility of ceftolozane-tazobactam in P...
February 12, 2019: International Journal of Antimicrobial Agents
Fatma Eser, Gül Ruhsar Yılmaz, Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Ziya Cibali Açıkgöz, Mehmet Akın Taşyaran
Background/aim: This study aimed to evaluate the risk factors of patients colonized with carbapenem-resistant Enterobacteriaceae (CRE). Materials and methods: The study was conducted between January 2010 and March 2016. The colonized group consisted of patients who had a CRE strain in their rectal swab cultures, whereas patients with negative rectal surveillance cultures for CRE who were concurrently hospitalized in the same units with the colonized group patients were included in the control group...
February 11, 2019: Turkish Journal of Medical Sciences
Yi-Tsung Lin, Chin-Fang Su, Chien Chuang, Jung-Chung Lin, Po-Liang Lu, Ching-Tai Huang, Jann-Tay Wang, Yin-Ching Chuang, L Kristopher Siu, Chang-Phone Fung
Background: In a multicenter study from Taiwan, we aimed to investigate the outcome of patients who received different antimicrobial therapy in carbapenem-resistant Enterobacteriaceae bloodstream infections and proposed a new definition for tigecycline use. Methods: Patients from 16 hospitals in Taiwan who received appropriate therapy for bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae and Escherichia coli were enrolled in the study between January 2012 and June 2015...
February 2019: Open Forum Infectious Diseases
Dee Shortridge, Leonard R Duncan, Michael A Pfaller, Robert K Flamm
Ceftolozane-tazobactam (C-T) is a combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. C-T was approved by the US Food and Drug Administration in 2014 and by the European Medicine Agency in 2015 for use in adults to treat complicated urinary tract infections, acute pyelonephritis, and complicated intra-abdominal infections with metronidazole. Studies for paediatric indications are planned. The Programme to Assess Ceftolozane-tazobactam Susceptibility monitors C-T resistance to Gram-negative (GN) isolates worldwide...
February 1, 2019: International Journal of Antimicrobial Agents
Ahmed El-Nawawy, Magdy A-F Ramadan, Manal A-M Antonios, Shams A-F Arafa, Eman Hamza
PURPOSE: Therapy of severe pneumonia is very challenging in view of the current widespread bacterial resistance to many antibiotics especially extended spectrum ß-lactams, carbapenems, and anti-pseudomonal drugs. The current study aimed at assessing antimicrobial sensitivity pattern and optimization of the antibiotic stewardship program applied in a university affiliated pediatric intensive care unit (PICU). SUBJECTS AND METHODS: This prospective cohort study included all patients aged 1 month to 12 years, admitted to the PICU with severe pneumonia episodes indicated for mechanical ventilation, and were followed up and investigated...
January 30, 2019: Journal of Global Antimicrobial Resistance
Giustino Parruti, Antonella Frattari, Ennio Polilli, Vincenzo Savini, Antonina Sciacca, Augusta Consorte, Donatella Concetta Cibelli, Adriana Agostinone, Francesco Di Masi, Alessandro Pieri, Pierluigi Cacciatore, Giancarlo Di Iorio, Paolo Fazii, Tullio Spina
BACKGROUND: Infections caused by multidrug-resistant Enterobacteriaceae are hard to treat and life-threatening due to reduced therapeutic options. Systemic infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae strains have increased in many European regions, becoming frequent in many clinical settings, and are associated with high mortality. The co-formulation of ceftazidime, a third-generation cephalosporin, with avibactam, a new suicide inhibitor beta-lactamase inhibitor able to block most Klebsiella pneumoniae carbapenemases, has been recently licensed, with promising results in patients with limited or absent therapeutic options...
January 22, 2019: Journal of Medical Case Reports
Devrim Dundar, Zehra Duymaz, Serpil Genc, Doganhan Kadir Er, Arzu İrvem, Neslisah Kandemir
The aim of the study is to determine in-vitro effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin against carbapenem-resistant Enterobacteriaceae (CRE) isolates. A total of 25 CRE isolates were included to the study. The minimum inhibition concentrations of imipenem, colistin-sulphate and tigecycline were determined with broth dilution method. Synergistic effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin were investigated by microdilution checkerboard technique...
October 2018: Journal of Chemotherapy
Huoxiang Zhou, Wei Guo, Jiangfeng Zhang, Yi Li, Pengyuan Zheng, Hongmei Zhang
OBJECTIVES: Klebsiella pneumoniae colonized in human gastrointestinal tract is a significant risk factor for extra-intestinal infections in severely ill patients. Recent reports indicated the high rate of K. pneumoniae infections results from patients'own gut microbiota. Here we report the draft genome sequence of a multi-drug resistant (MDR) K.pneumoniae strain SM32 (ST1916) harbouring the blaAIM-1 gene isolated from a chronic diarrhoea patient in China. METHODS: The whole genomic DNA was sequenced using Illumina MiSeq platform...
January 15, 2019: Journal of Global Antimicrobial Resistance
Griselda Berberian, Martín Brizuela, María T Rosanova, Mónica Travaglianti, Alejandra Mastroiani, Vanesa Reijtman, Graciela Fiorili, Dora Santa Cruz, Graciela Castro
INTRODUCTION: Multidrug resistant Gramnegative (MDRGN) infections are an increasing problem in neonatal intensive care units. The objective of this study was to establish the epidemiological, clinical, microbiological, and evolutionary characteristics of carbapenem-resistant MDRGN infections and the risk factors for them at the Division of Neonatology of a tertiary care hospital. POPULATION AND METHOD: A retrospective cohort study was done in this Division in patients with a documented MDRGN infection between 4/24/2013 and 4/29/2015...
February 1, 2019: Archivos Argentinos de Pediatría
Anastasia Geladari, Maria Simitsopoulou, Charalampos Antachopoulos, Emmanuel Roilides
Carbapenem-resistant Klebsiella pneumoniae (CR- Kp ) can cause biofilm-related bloodstream infections associated with significant morbidity and mortality worldwide. We investigated the bactericidal activities of colistin (CST), rifampicin (RIF), meropenem (MEM), gentamicin (GEN) and tigecycline (TGC) alone and that of CST in combination with RIF, MEM, GEN or TGC against CR- Kp mature biofilms. Twenty CR- Kp blood isolates were derived from equal number of bloodstream infections in adult patients. Biofilm formation was assessed by staining with 0...
January 14, 2019: Antimicrobial Agents and Chemotherapy
Wejdene Mansour, Raoudha Grami, Nadia Jaidane, Aziza Messaoudi, Karama Charfi, Lotfi Ben Romdhane, Anis Bel Haj Khalifa, Mohamed Khedher, Noureddine Boujaafar, Olfa Bouallègue, Hedi Mammeri
OBJECTIVES: The whole-genome sequence (WGS) of Klebsiella pneumoniae KP3771 isolate was characterized. This strain was recovered from the urine sample of an 80-year-old man hospitalized in an intensive care unit of the University Hospital Tahar Sfar in Tunisia. MATERIALS AND METHODS: WGS using a MiSeq platform was used. The assembled genome was subjected to several software analyses. RESULTS: K. pneumoniae KP3771 was resistant to all antibiotics but colistin and tigecycline...
January 7, 2019: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Bulent Durdu, Meliha Meric Koc, Ismail N Hakyemez, Yasemin Akkoyunlu, Hayrettin Daskaya, Bilge Sumbul Gultepe, Turan Aslan
BACKGROUND We investigated the factors affecting antibiotic resistance in the intensive care unit (ICU)-related hospital-acquired infections caused by Klebsiella pneumoniae (KP-HAI) and the effects of antibiotics used for high-level antibiotic resistance on patient survival. MATERIAL AND METHODS This retrospective study was performed at the adult ICU of Bezmialem Vakif University Hospital. Patients who were followed up between 01 January 2012 and 31 May 2017 were evaluated. Each KP strain was categorized according to resistance patterns and analyzed...
January 7, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Golnaz Mobasseri, Cindy Shuan JuTeh, Peck Toung Ooi, Kwai Lin Thong
OBJECTIVE: Colistin is the last line therapy for infections caused by multidrug resistant Gram negative bacteria. The objective of the study was to determine the phenotypic and genotypic characteristics of colistin-resistant K. pneumoniae isolated from swine samples in Malaysia. METHODS: A total of 46 swine K. pneumoniae strains isolated from 2013 to 2015 in Malaysia were analyzed for the production of ESBLs and carbapenemase. The resistance traits and the genetic diversity of these strains were characterized by PCR, conjugation, plasmid analysis and pulsed field gel electrophoresis...
January 3, 2019: Journal of Global Antimicrobial Resistance
Hajnalka Tóth, Adina Fésus, Orsolya Kungler-Gorácz, Bence Balázs, László Majoros, Krisztina Szarka, Gábor Kardos
Background: Increasing antibiotic resistance may reciprocally affect consumption and lead to using broader-spectrum alternatives; a vicious cycle that may gradually limit therapeutic options. The study aims at demonstrating the abovementioned vicious cycle in Gram-negative bacteria and at showing the utility of vector autoregressive (VAR) models for analysis of time-series in explanatory and dependent roles simultaneously. Methods: Monthly drug consumption data in defined daily doses per 100 bed-days and incidence densities of Gram-negative bacteria (Escherichia coli, Klebsiella spp...
December 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Piotr Świątek, Małgorzata Strzelecka
BACKGROUND: Infections caused by multidrug-resistant (MDR) strains, i.e., strains resistant to at least 1 antibiotic of the 3 groups of antibacterial agents, are among the most difficult to treat. New compounds with an antimicrobial action are being sought in order to avoid the complete resistance of bacteria to drugs and the spread of MDR strains. OBJECTIVES: The aim of the research was to determine the antimicrobial activity of the new isothiazolopyridine derivatives...
December 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Huichuan Zhang, Dongdong Zhao, Jingjing Quan, Xiaoting Hua, Yunsong Yu
OBJECTIVES: The mcr-1 gene is the first reported plasmid-mediated colistin resistance gene. It has caused world-wide concern about the colistin resistance in Gram-negative bacteria. The aim of this research was to study the impact of mcr-1 on the selection of high-level colistin resistance (HLCR) mutations in Escherichia coli and Klebsiella pneumoniae. METHODS: We detected the HLCR mutation rates of Enterobacteriaceae strains (K. pneumoniae XH209, KP10 and E. coli Q3, ATCC 25922) and their transformants harbouring the mcr-1 gene...
December 14, 2018: Clinical Microbiology and Infection
Silva Tafaj, Floriana Gona, Perlat Kapisyzi, Alma Cani, Alban Hatibi, Silvia Bino, Albana Fico, Andi Koraqi, Gentian Kasmi, Daniela Cirillo
OBJECTIVES: Carbapenemases represent a public health threat as they can spread through horizontal gene transfer and cause outbreaks. NDM-1 is a metallo-ß-lactamase that has spread rapidly in the last decade causing worldwide alarm. We aimed to describe the first isolate of NDM-1 producing and XDR Klebsiella pneumoniae in Albania, its clinical context and genetic characterization. METHODS: Strain was isolated from both oral and rectal ICU admission screening swabs of a 70 years old male patient with no history of international travel in the previous six months...
December 14, 2018: Journal of Global Antimicrobial Resistance
Shio-Shin Jean, Nan-Yao Lee, Hung-Jen Tang, Min-Chi Lu, Wen-Chien Ko, Po-Ren Hsueh
Carbapenem-resistant Enterobacteriaceae (CRE), a major resistance concern emerging during the last decade because of significantly compromising the efficacy of carbapenem agents, has currently become an important focus of infection control. Many investigations have shown a high association of CRE infections with high case-fatality rates. In Taiwan, a few surveys observed that a significant proportion (29-47%) of the CR- Klebsiella pneumoniae isolates harbored a plasmidic allele encoding K. pneumoniae carbapenemases (KPC, especially KPC-2)...
2018: Frontiers in Microbiology
Gonzalo De Sanctis, Augusto Ferraris, Laura Ducatenzeiler, José Benso, Lucas Fernández-Otero, Federico Angriman
BACKGROUND: The emergence of colistin resistant carbapenemase-producing Klebsiella represents a therapeutic challenge and a worldwide problem. AIM: To estimate the in-hospital mortality and identify the associated risk factors among patients with colistin-resistant carbapenemase-producing Klebsiella pneumoniae (KPC) that present with a clinical infection. METHODS: We carried a retrospective cohort study, including adult patients infected with colistin-resistant KPC hospitalized at a tertiary teaching hospital in Buenos Aires, Argentina during the year 2016...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Zhongqiang Yan, Yu Zhou, Mingmei Du, Yanling Bai, Bowei Liu, Meiliang Gong, Hongbin Song, Yigang Tong, Yunxi Liu
BACKGROUND: Following the alarming outbreak of carbapenem-resistant Klebsiella pneumonia (CRKP) in five intensive care units (ICUs) of a tertiary care hospital in China, a prospective investigation of CRKP colonized/infected patients was conducted. AIM: To describe the diffusion and transmission of CRKP among epidemiologically linked ICU patients, staff and environment. METHODS: Enhanced CRKP infected/colonized case monitoring was performed by the real-time nosocomial infection surveillance system (RT-NISS)...
December 6, 2018: Journal of Hospital Infection
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