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Maria Vogel, Anett Georgi, Frank-Dieter Kopinke, Katrin Mackenzie
Nanoscale zero-valent iron (nZVI) is a powerful reductant for many water pollutants. The lifetime of nZVI in aqueous environments is one of its limitations. Sulfidation of the nZVI surface by reduced sulfur species is known to significantly modify the particle properties. In the present study we examined various post-synthesis sulfidation methods applied on Carbo-Iron, a composite material where iron nanostructures are embedded in colloidal activated carbon (AC) particles. In such cases, where ZVI is surrounded by carbon, sulfidation largely inhibits the anaerobic corrosion of ZVI in water whereas its dechlorination activity was slightly increased...
February 10, 2019: Science of the Total Environment
Palloma Mendes Conceição, Alison Felipe Alencar Chaves, Marina Valente Navarro, Daniele Gonçalves Castilho, Juliana Cristina P Calado, Ana Elisa Coronel Janu Haniu, Patricia Xander, Wagner L Batista
Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that cause paracoccidioidomycosis (PCM), the major systemic mycosis in Latin America. The capacity to evade the innate immune response of the host is due to P. brasiliensis ability to respond and to survive the nitrosative stress caused by phagocytic cells. However, the regulation of signal transduction pathways associated to nitrosative stress response are poorly understood. Ras GTPase play an important role in the various cellular events in many fungi...
February 14, 2019: Nitric Oxide: Biology and Chemistry
Joana Rita Carvalho, Carlos Freitas, Paula Moura Santos, Mariana Machado, Cilénia Baldaia, Ana Valente, Luís Carrilho-Ribeiro, Rui Tato Marinho
No abstract text is available yet for this article.
February 13, 2019: Gastroenterología y Hepatología
Eutilério F C Chaúque, J Catherine Ngila, Sekhar C Ray, Lwazi Ndlwana
Bimetallic nanoparticles are effective for the removal of organic pollutants from environmental water samples through catalytic degradation reactions. Hence, this work reports on the preparation of Fe/Ag bimetallic nanoparticles immobilized on electrospun polyacrylonitrile nanofibers (PAN NFs) pre-functionalized with EDTA and ethylenediamine (EDA) chelating agents. Characterization techniques included attenuated total reflectance coupled to Fourier transform infrared spectrometer (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA)...
February 13, 2019: Journal of Environmental Management
Utsav Dalal, Sivamohan N Reddy
This research work aims to develop a biomaterial entrapped with iron nanoparticles by green synthesis method in which biomass act as both reducing and capping agent. Iron nanoparticles embedded in Citrus limetta peels were characterised using ICP-MS for determination of metal loading, XRD, XPS for crystallinity and oxidation states, TEM followed by FESEM-EDS for particle size and morphology. Sizes of nanoparticles were found to be in the range of 4-70 nm. Batch experiments were conducted to study the effect of different parameters such as contact time, amount of biomaterial and volume of chromium(VI) solution for 2500 mg L-1 of Cr(VI)...
February 15, 2019: Environmental Science and Pollution Research International
Jinjian Fu, Ling Li, Zhuoxin Liang, Shaolin Xu, Nan Lin, Peixu Qin, Xiaohua Ye, Eric McGrath
BACKGROUND: The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptococcus pneumoniae (S.pneumoniae) recovered from Chinese children. METHODS: A retrospective study was conducted to enrol patients younger than 18 years diagnosed as AOM. Middle ear fluid specimens were collected then cultured for bacterial pathogens...
February 15, 2019: BMC Infectious Diseases
Andrew D Wiese, Xiang Huang, Chang Yu, Edward F Mitchel, Moe H Kyaw, Marie R Griffin, Carlos G Grijalva
INTRODUCTION: The impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on the occurrence of first and subsequent otitis media (OM) episodes in early childhood is unclear. We compared the risk of OM episodes among children age <2 years before and after PCV13 introduction accounting for the dependence between OM episodes. METHODS: We identified consecutive annual (July-June) cohorts of Tennessee Medicaid-enrolled children (2006-2014) from birth through age two years...
February 16, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Bruno F O Nascimento, Nelson A M Pereira, Artur J M Valente, Teresa M V D Pinho E Melo, Marta Pineiro
Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents whose full potential can be achieved using nanocarriers. This review provides an overview on nanotheranostic agents based on polymeric micelles and porphyrins developed so far.
February 15, 2019: Pharmaceutics
M Aguilar, L Ali Cavasonza, G Ambrosi, L Arruda, N Attig, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, V Bindi, W de Boer, K Bollweg, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, Y H Chang, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, V Choutko, C H Chung, C Clark, G Coignet, C Consolandi, A Contin, C Corti, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, T H Hsieh, H Huang, Z C Huang, M Incagli, Yi Jia, H Jinchi, K Kanishev, B Khiali, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, J Q Li, Q Li, T X Li, Z H Li, C Light, C H Lin, T Lippert, F Z Liu, Hu Liu, Z Liu, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, Xi Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, D C Mo, M Molero, P Mott, L Mussolin, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, M Paniccia, A Pashnin, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, V Plyaskin, M Pohl, V Poireau, A Popkow, L Quadrani, X M Qi, X Qin, Z Y Qu, P G Rancoita, D Rapin, A Reina Conde, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, C Solano, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, J W Song, Z T Sun, M Tacconi, X W Tang, Z C Tang, J Tian, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, J Vizán, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, J Wei, Z L Weng, H Wu, R Q Xiong, W Xu, Q Yan, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J H Zhang, Z Zhang, F Zhao, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
Precision measurements of cosmic ray positrons are presented up to 1 TeV based on 1.9 million positrons collected by the Alpha Magnetic Spectrometer on the International Space Station. The positron flux exhibits complex energy dependence. Its distinctive properties are (a) a significant excess starting from 25.2±1.8  GeV compared to the lower-energy, power-law trend, (b) a sharp dropoff above 284_{-64}^{+91}  GeV, (c) in the entire energy range the positron flux is well described by the sum of a term associated with the positrons produced in the collision of cosmic rays, which dominates at low energies, and a new source term of positrons, which dominates at high energies, and (d) a finite energy cutoff of the source term of E_{s}=810_{-180}^{+310}  GeV is established with a significance of more than 4σ...
February 1, 2019: Physical Review Letters
Elisabetta Mattioli, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H De Vos, Cristina Capanni, Giovanna Lattanzi
We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response. We further showed that lamin A/C-HDAC2 interaction is altered in Hutchinson-Gilford Progeria syndrome and other progeroid laminopathies. Here, we show that both inhibitors of lamin A maturation and small molecules inhibiting HDAC activity affect lamin A/C interaction with HDAC2. While statins, which inhibit prelamin A processing, reduce protein interaction, HDAC inhibitors strengthen protein binding...
2019: Frontiers in Cell and Developmental Biology
A L Dorigan de Matos Furlanetto, Caroline Valente, G R Martinez, M E Merlin Rocha, J B B Maurer, S M S C Cadena
Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered those studies by exposing these cells to cold stress (4 ± 1 °C for either 24 or 48 h) and evaluating parameters associated with oxidative stress and alterations in the cellular and mitochondrial responses...
February 14, 2019: Free Radical Research
Lin Xu, Yongheng Huang
Batch test was conducted to investigate Se(IV) removal kinetics and mechanism by zero valent iron (ZVI) in presence of Fe(II) under anaerobic condition. Dissolved Fe(II) activated and enhanced Se(IV) reduction by ZVI, which also determined the removal efficiency, reduction rate, final corrosion products and their structures. Se(IV) was completely removed at initial Fe(II)/Se(IV) ≥ 1.0, and the specific rate constant significantly increased from 0.6 to 3.44 L h-1  m-2 with the augment of ratio from 1...
February 4, 2019: Science of the Total Environment
Rui M B Maciel, Cleber P Camacho, Ligia Vm Assumpcao, Natassia Elena Bufalo, André L Carvalho, Gisah A de Carvalho, Luciana A Castroneves, Francisco M de Castro, Lucieli Ceolin, Janete Maria Cerutti, Rossana Corbo, Tânia M B L Ferraz, Carla Vaz Ferreira, M Inez C França, Henrique C R Galvão, Fausto Germano-Neto, Hans Graf, Alexander A L Jorge, Ilda S Kunii, Márcio W Lauria, Vera L G Leal, Susan C Lindsey, Delmar Muniz Lourenco-Jr, Lea Maria Zanini Maciel, Patrícia K R Magalhães, João R M Martins, M Cecilia Martins-Costa, Glaucia M F S Mazeto, Anelise Impellizzeri, Célia Regina Nogueira, Edenir I Palmero, Cencita Cordeiro Pessoa, Bibiana Prada, Debora R Siqueira, M Sharmila A Sousa, Rodrigo Toledo, Flávia O F Valente, F Vaisman, Laura Sterian Ward, Shana S Weber, Rita V Weiss, Ji H Yang, Magnus Regio Dias Da Silva, Ana O Hoff, Sergio Pa Toledo, Ana Luiza Maia
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries...
February 1, 2019: Endocrine Connections
Peter Valent, Wolfgang Kern, Gregor Hoermann, Jelena D Milosevic Feenstra, Karl Sotlar, Michael Pfeilstöcker, Ulrich Germing, Wolfgang R Sperr, Andreas Reiter, Dominik Wolf, Michel Arock, Torsten Haferlach, Hans-Peter Horny
The development of leukemia is a step-wise process that is associated with molecular diversification and clonal selection of neoplastic stem cells. Depending on the number and combinations of lesions, one or more sub-clones expand/s after a variable latency period. Initial stages may develop early in life or later in adulthood and include premalignant (indolent) stages and the malignant phase, defined by an acute leukemia. We recently proposed a cancer model in which the earliest somatic lesions are often age-related early mutations detectable in apparently healthy individuals and where additional oncogenic mutations will lead to the development of an overt neoplasm that is usually a preleukemic condition such as a myelodysplastic syndrome...
February 12, 2019: International Journal of Molecular Sciences
José Augusto Sedrez-Porto, Eliseu Aldrighi Münchow, Lisia Lorea Valente, Maximiliano Sergio Cenci, Tatiana Pereira-Cenci
The aim of this study was to investigate the mechanical performance and the fracture behavior of endocrown restorations prepared using distinct restorative materials. A total of 42 sound molars with similar crown size and shape were cut at 2 mm above the cementoenamel junction and endodontically treated. They were categorized according to the restorative material used to fabricate endocrown restorations (n=7), namely, conventional composite (Filtek™ Z350 XT), bulk fill composite (Filtek™ Bulk Fill), conventional composite modeled using resin adhesives (SBMP: Scotchbond™ Multipurpose Adhesive; or SBU: Scotchbond™ Universal Adhesive), and IPS e...
February 11, 2019: Brazilian Oral Research
Mohammad Javad Amiri, Maryam Khozaei, Antonio Gil
The Thomas equation is a popular model that has been widely used to predict breakthrough curves (BTCs) when describing the dynamic adsorption of different pollutants in a fixed-bed column system. However, BTCs commonly exhibit unsymmetrical patterns that cannot be predicted using empirical equations such as the Thomas model. Fortunately, adaptive neural-based fuzzy inference systems (ANFISs) can be used to model complex patterns found in adsorption processes in a fixed-bed column system. Consequently, a new hybrid model merging Thomas and an ANFIS was introduced to estimate the performance of BTCs, which were obtained for Cd(II) ion adsorption on ostrich bone ash-supported nanoscale zero-valent iron (nZVI)...
February 2019: Journal of Water and Health
Yanyan Gong, Yao Huang, Mengxia Wang, Fangfei Liu, Tong Zhang
Mercury contamination in soil and water has become a major concern to environmental quality and human health. Among the existing remediation technologies for mercury pollution control, sorption via iron-based materials has received wide attention as they are environmental friendly and economic, and their reactivity is high and controllable through modulating the morphology and surface properties of particulate materials. This paper aimed to provide a comprehensive overview on environmental application of a variety of iron-based sorbents, namely, zero valent iron, iron oxides, and iron sulfides, for mercury remediation...
February 12, 2019: Bulletin of Environmental Contamination and Toxicology
Michael Valente, Helen M Dewey, Philip M Choi
This retrospective study assessed the pattern of telemetry usage and rates of atrial fibrillation (AF) detection in the 6 months pre- and post-implementation of stroke unit monitored telemetry; 122/154 (79%) of patients had telemetry prior to implementation of stroke unit based telemetry and 164/194 (85%) in the 5 months post (P = 0.31). The use of stroke unit based telemetry was associated with a small increase of telemetry usage and significant increase in telemetry hours per patient. AF detection was similar during the two study periods...
February 2019: Internal Medicine Journal
Paula K Braverman
Human papillomavirus (HPV), the most common sexually transmitted viral infection worldwide, is the causative agent for cervical cancer and attributed to anogenital cancers as well as oropharyngeal cancer. Three effective, safe, prophylactic HPV vaccines have been licensed, and studies have demonstrated decreases in HPV prevalence and HPV-related disease endpoints without evidence of waning protection to date. In the United States, only the 9-valent vaccine, which covers 90% of the cancers attributed to HPV in US registries, is available...
February 1, 2019: Pediatric Annals
Cosimo Prestigio, Daniele Ferrante, Pierluigi Valente, Silvia Casagrande, Ennio Albanesi, Yuchio Yanagawa, Fabio Benfenati, Pietro Baldelli
Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity of GABAergic interneurons. Thus, the definition of reliable criteria able to guarantee an unequivocal identification of excitatory and inhibitory cultured hippocampal neurons is an unmet need. To reach this goal, we compared the electrophysiological properties and the localization and size of the axon initial segment (AIS) of cultured hippocampal neurons, taking advantage from GAD67-GFP knock-in mice, which expressing green fluorescent protein (GFP) in gamma-aminobutyric acid (GABA)-containing cells, allowed to unambiguously determine the precise nature of the neuron under study...
February 12, 2019: Molecular Neurobiology
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