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https://read.qxmd.com/read/30785926/towards-a-universal-concept-of-vulnerability-broadening-the-evidence-from-the-elderly-to-perinatal-health-using-a-delphi-approach
#1
Nynke de Groot, Gouke J Bonsel, Erwin Birnie, Nicole B Valentine
BACKGROUND: The concept 'vulnerability' is prevalent in the public domain, health care, social institutions and multidisciplinary research. Conceptual heterogeneity is present, hampering the creation of a common evidence-base of research achievements and successful policies. Recently an international expert group combined a specific literature review with a 2-stage Delphi procedure, arriving at a seemingly universal concept of vulnerability for the elderly with applications for research instruments...
2019: PloS One
https://read.qxmd.com/read/30785350/angiotensin-ii-and-salt-induced-decompensation-in-balb-cj-mice-is-aggravated-by-fluid-retention-related-to-low-oxidative-stress
#2
Sofia Jönsson, Mediha Becirovic-Agic, Henrik Isackson, Maria K Tveitarås, Trude Skogstrand, Fredrik Narfström, Tine Veronica Karlsen, Åsa Lidén, Sabine Leh, Madelene Ericsson, Stefan K Nilsson, Rolf K Reed, Michael Hultström
AIM: Balb/CJ mice are more sensitive to treatment with Angiotensin II (AngII) and high salt (Salt) diet compared to C57BL/6J. Together with higher mortality, they develop edema, signs of heart failure and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Balb/CJ after AngII+Salt treatment. METHODS: Male Balb/CJ and C57BL/6J mice were divided into five different treatment groups: Control, AngII, Salt, AngII+Salt, AngII+Salt+N-acetylcysteine...
February 20, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30785033/risk-reversibility-and-resilience-of-brain-circuitries-linked-to-opioid-dependence-a-diffusion-tensor-imaging-study-of-actively-opioid-using-subjects-and-three-comparison-groups
#3
Abhishek Ghosh, Debasish Basu, Niranjan Khandelwal, Chirag Kamal Ahuja, Subodh Bn, Devender Rana
BACKGROUND: Drug addiction is linked with micro-structural changes in the fronto-striatal white matter (WM) tracts. However, little is known regarding causality (risk factor for subsequent drug use vs. effect of chronic drug use) and reversibility of such changes. METHODS: In this study, 30-direction diffusion tensor imaging (DTI) was used to examine WM integrity of selected fronto-striatal circuitries: the orbito-frontal circuit (OFC), anterior cingulate (AC), inferior frontal circuit (IFC), and genu of corpus callosum (CC-G)...
February 13, 2019: Asian Journal of Psychiatry
https://read.qxmd.com/read/30784932/the-therapeutic-effects-of-nicotinamide-in-hepatocellular-carcinoma-through-blocking-igf-1-and-effecting-the-balance-between-nrf2-and-pkb
#4
Mohammed M H Al-Gayyar, Alaa Bagalagel, Ahmad O Noor, Diena M Almasri, Reem Diri
Insulin growth factor (IGF) family and their receptors play a great role in tumors' development. In addition, IGF-1 enhances cancer progression through regulating cell proliferation, angiogenesis, immune modulation and metastasis. Moreover, nicotinamide is association with protection against cancer. Therefore, we conducted this research to examine the therapeutic effects of nicotinamide against hepatocellular carcinoma (HCC) both in vivo and in vitro through affecting IGF-1 and the balance between PKB and Nrf2...
February 19, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30784789/effects-of-maternal-dietary-nitrate-supplementation-on-farrowing-and-placental-characteristics-level-of-asphyxiation-at-birth-and-piglet-vitality
#5
M van den Bosch, J Wijnen, I B van de Linde, A A M van Wesel, D Melchior, B Kemp, H van den Brand, C Clouard
We investigated whether maternal dietary nitrate supplementation, leading to nitric oxide (NO) formation, would affect duration of farrowing, levels of asphyxiation, vitality of piglets at birth and/or loss of potential viable piglets in the form of stillbirth and pre-weaning mortality. Data were collected from 190 crossbred (Yorkshire x Dutch Landrace) sows, which were allocated, balanced for parity, to six dietary nitrate levels (0, 0.03, 0.06, 0.09, 0.12 or 0.15% of nitrate). Sow received the lactational diet containing nitrate from approximately 7 days before farrowing until 5 days after farrowing...
February 12, 2019: Theriogenology
https://read.qxmd.com/read/30784067/intra-articular-mucilages-behavioural-and-histological-evaluations-for-a-new-model-of-articular-pain
#6
Laura Micheli, Carla Ghelardini, Elena Lucarini, Carmen Parisio, Elena Trallori, Lorenzo Cinci, Lorenzo Di Cesare Mannelli
OBJECTIVES: The creation of a new valid preclinical model of articular pain by the intra-articular (i.a.) injection of mucilages for the screening of new treatments against arthritis. METHODS: A single intra-articular injection (20 μl) of mucilages (from Althaea officinalis roots and Linum usitatissimun seeds) or vegetal components (Amorphophallus konjac gum powder and β-glucan, used as reference standard) were assessed in the rat. The pathology progression was monitored by behavioural measurements (paw pressure test, von Frey test, incapacitance test and beam balance test) and compared to that induced by the i...
February 19, 2019: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/30784055/postural-tremor-is-associated-with-gait-and-balance-impairments-in-community-dwelling-older-people
#7
Xitong Xu, Jie Chen, Meijie Chen, Zhuqin Gu, Shaozhen Ji, Shuying Liu, Piu Chan
OBJECTIVES: We sought to assess associations of postural tremor with gait and balance impairments among community-dwelling older people in both cross-sectional and longitudinal analyses. DESIGN: A prospective cohort study. SETTING: Communities in Beijing, China. PARTICIPANTS: This study included 7075 individuals aged 55 years or older. MEASUREMENTS: Postural tremor was assessed using a two-step method (tremor screening followed by a confirmation examination of positive cases) at baseline...
February 19, 2019: Journal of the American Geriatrics Society
https://read.qxmd.com/read/30783421/protective-effect-of-xin-ji-er-kang-on-cardiovascular-remodeling-in-high-salt-induced-hypertensive-mice
#8
Guangyao Huang, Pan Cheng, Ling Ding, Li Wang, Juan Hu, Yongxue Zhang, Guowei Cai, Meiling Chen, Aizong Shen, Shan Gao
The aim of the present study was to investigate the effects of Xin-Ji-Er-Kang (XJEK) on high salt-induced hypertensive mice. Mice with high-salt diet-induced hypertension were divided into four groups: Control (standard diet alone for 8 weeks), model (diet containing 8% NaCl for 8 weeks and intragastric administration of distilled water for the last 4 weeks), XJEK + high-salt-treated (diet containing 8% NaCl for 8 weeks and intragastric administration of XJEK for the last 4 weeks) and irbesartan + high-salt-treated (diet containing 8% NaCl for 8 weeks with intragastric administration of irbesartan for the last 4 weeks)...
March 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30783039/isoliquiritigenin-attenuates-neuroinflammation-in-traumatic-brain-injury-in-young-rats
#9
Jingjing Liu, Xin Xiong, Yutong Sui
OBJECTIVES: Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. This study aims to investigate the potential effects of isoliquiritigenin on neuroinflammation in a rat model of TBI. METHODS: The SH-SY5Y cells were subjected to cell injury induced by shear stress and the effect of isoliquiritigenin on cell apoptosis was measured...
February 15, 2019: Neuroimmunomodulation
https://read.qxmd.com/read/30782905/the-influence-of-perceived-medical-risks-and-psychosocial-concerns-on-photoprotection-behaviours-among-adults-with-xeroderma-pigmentosum-a-qualitative-interview-study-in-the-uk
#10
Myfanwy Morgan, Rebecca Anderson, Jessica Walburn, John Weinman, Robert Sarkany
BACKGROUND: A high level of photoprotection is required by people with xeroderma pigmentosum (XP), a rare skin disease, to reduce skin cancer and other risks. However poor photoprotection is thought to be widespread. PURPOSE: This study examines the influences on photoprotection behaviours in adults with XP. DESIGN: Inductive qualitative study with semistructured interviews. Analysis employed a framework approach. SETTING: National sample recruited through a specialist XP centre in London...
February 19, 2019: BMJ Open
https://read.qxmd.com/read/30782287/ameliorative-effect-of-probiotics-lactobacillus-paracaseii-and-protexin%C3%A2-and-prebiotics-propolis-and-bee-pollen-on-clindamycin-and-propionic-acid-induced-oxidative-stress-and-altered-gut-microbiota-in-a-rodent-model-of-autism
#11
Kawther Aabed, Ramesa Shafi Bhat, Nadine Moubayed, Manar Al-Mutiri, Majda Al-Marshoud, Alaa Al-Qahtani, Afaf Ansary
Colonization by toxin-producing bacteria in the gut plays a major role in bowel problems in autistic patients. Prebiotics can inhibit the growth of these pathogenic microbes by nourishing beneficial bacteria, while probiotics--live microorganisms--can balance the gut bacteria; thus, both together can maintain healthy bacteria in the gut. The present study was conducted to find the effect of probiotics and prebiotics in balancing the gut flora in a rodent model of autism linked with a clindamycin-induced altered gut...
January 31, 2019: Cellular and Molecular Biology
https://read.qxmd.com/read/30781945/flow-toolkit-for-measuring-gas-diffusivity-in-liquids
#12
Jisong Zhang, Andrew Teixeira, Haomiao Zhang, Klavs F Jensen
Precise knowledge of gas diffusivity in liquids is critical for describing complex multiphase reaction systems. Here we present a high-throughput flow concept to measure gas diffusivity in liquids. This strategy takes advantages of the tube-in-tube reactor design whereby semipermeable Teflon AF-2400 tubes facilitate fast mass transfer between gas and liquid without directly contacting the two fluids. Coupled pseudo-steady-state flux balances over the gas and liquid describe the gas dissolution rate and corresponding diffusivity with the aid of a single gas flow meter and a continuously ramped liquid flow rate...
February 20, 2019: Analytical Chemistry
https://read.qxmd.com/read/30781740/using-inertial-sensors-to-quantify-postural-sway-and-gait-performance-during-the-tandem-walking-test
#13
Kyoung Jae Kim, Yoav Gimmon, Jennifer Millar, Michael C Schubert
Vestibular dysfunction typically manifests as postural instability and gait irregularities, in part due to inaccuracies in processing spatial afference. In this study, we have instrumented the tandem walking test with multiple inertial sensors to easily and precisely investigate novel variables that can distinguish abnormal postural and gait control in patients with unilateral vestibular hypofunction. Ten healthy adults and five patients with unilateral vestibular hypofunction were assessed with the tandem walking test during eyes open and eyes closed conditions...
February 13, 2019: Sensors
https://read.qxmd.com/read/30781636/sub-lethal-doses-of-polybrominated-diphenyl-ethers-in-vitro-promote-oxidative-stress-and-modulate-molecular-markers-related-to-cell-cycle-antioxidant-balance-and-cellular-energy-management
#14
Simona Manuguerra, Cristóbal Espinosa Ruiz, Andrea Santulli, Concetta Maria Messina
In the present study, we evaluated the effects of different concentrations of the polybrominated diphenyl ethers (PBDEs) BDE-209, BDE-47 and BDE-99, on the vitality and oxidative stress of a HS-68 human cell culture exposed to the compounds for three days. The results showed that for this exposure time, only the highest concentrations produced a significant vitality reduction and oxidative stress induction ( p < 0.05), measured as reactive oxygen species (ROS). Subsequently, in order to verify the effects of sub-lethal doses, cells were exposed for a longer time and data collected, after 12 and 20 days, to study ROS production and some molecular markers related to cell cycle and stress (p53, pRB, PARP, c-Jun and c-Fos), antioxidant status and proliferation (ERK, c-Jun and c-Fos), energy balance (NRF2, AMPK, HIF)...
February 18, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30781568/enhanced-expression-of-qtl-qll9-dep1-facilitates-the-improvement-of-leaf-morphology-and-grain-yield-in-rice
#15
Xue Fu, Jing Xu, Mengyu Zhou, Minmin Chen, Lan Shen, Ting Li, Yuchen Zhu, Jiajia Wang, Jiang Hu, Li Zhu, Zhenyu Gao, Guojun Dong, Longbiao Guo, Deyong Ren, Guang Chen, Jianrong Lin, Qian Qian, Guangheng Zhang
In molecular breeding of super rice, it is essential to isolate the best quantitative trait loci (QTLs) and genes of leaf shape and explore yield potential using large germplasm collections and genetic populations. In this study, a recombinant inbred line (RIL) population was used, which was derived from a cross between the following parental lines: hybrid rice Chunyou84, that is, japonica maintainer line Chunjiang16B (CJ16); and indica restorer line Chunhui 84 (C84) with remarkable leaf morphological differences...
February 17, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30781343/trends-in-the-design-of-new-isobaric-labeling-reagents-for-quantitative-proteomics
#16
REVIEW
Remigiusz Bąchor, Mateusz Waliczek, Piotr Stefanowicz, Zbigniew Szewczuk
Modern mass spectrometry is one of the most frequently used methods of quantitative proteomics, enabling determination of the amount of peptides in a sample. Although mass spectrometry is not inherently a quantitative method due to differences in the ionization efficiency of various analytes, the application of isotope-coded labeling allows relative quantification of proteins and proteins. Over the past decade, a new method for derivatization of tryptic peptides using isobaric labels has been proposed. The labels consist of reporter and balanced groups...
February 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30780212/balance-in-signed-networks
#17
Alec Kirkley, George T Cantwell, M E J Newman
We consider signed networks in which connections or edges can be either positive (friendship, trust, alliance) or negative (dislike, distrust, conflict). Early literature in graph theory theorized that such networks should display "structural balance," meaning that certain configurations of positive and negative edges are favored and others are disfavored. Here we propose two measures of balance in signed networks based on the established notions of weak and strong balance, and we compare their performance on a range of tasks with each other and with previously proposed measures...
January 2019: Physical Review. E
https://read.qxmd.com/read/30779930/a-multidimensional-artefact-reduction-approach-to-increase-robustness-of-first-level-fmri-analyses-censoring-vs-interpolating
#18
Marko Wilke, Torsten Baldeweg
BACKGROUND: This manuscript describes a new, multidimensional and data-driven approach to identify outlying datapoints from a first-level fMRI dataset. NEW METHOD: Using three different indicators of data corruption (the fast variance component of DVARS [Δ%D-var], scan-to-scan total displacement [STS], and each scan's overall explained variance [R2 ]), it identifies outlying datapoints while being balanced using Akaike'c corrected criterion (AIC C ) to avoid overcorrection...
February 16, 2019: Journal of Neuroscience Methods
https://read.qxmd.com/read/30779605/effects-of-spinal-immobilization-and-spinal-motion-restriction-on-head-neck-kinematics-during-ambulance-transport
#19
Florent Thezard, Neil McDonald, Dean Kriellaars, Gordon Giesbrecht, Erin Weldon, Rob T Pryce
OBJECTIVE: To determine the influence of ambulance motion on head-neck (H-N) kinematics and to compare the effectiveness of two spinal precaution (SP) protocols: spinal immobilization (SI) and spinal motion reduction (SMR). METHODS: Eighteen healthy volunteers (7 females) underwent a series of standardized ambulance transport tasks, across various speeds, under the two SP protocols in a balanced order (n = 12 drivers, n = 7 ambulances). Inertial measurement units were placed on participants' heads and sternums, with another affixed to the stretcher mattress frame...
February 19, 2019: Prehospital Emergency Care
https://read.qxmd.com/read/30779467/short-sleep-and-low-milk-intake-are-associated-with-obesity-in-a-community-of-school-aged-children-from-argentina
#20
Alicia B Orden, Muriel S Lamarque, Débora Chan, Marcos A Mayer
OBJECTIVES: Understanding the factors related to obesity during childhood allows for improved preventive actions specifically adapted to particular communities. The purpose of this study was to identify individual and familiar factors related to obesity in children. METHODS: A cross-sectional study was conducted in an urban community in Argentina during the years 2015-2016. Weight and height were measured on a probabilistic sample of 1366 schoolchildren aged 6 to 12 years...
February 19, 2019: American Journal of Human Biology: the Official Journal of the Human Biology Council
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