keyword
https://read.qxmd.com/read/38534788/the-opposite-functions-of-cd30-ligand-isoforms
#1
JOURNAL ARTICLE
Ignat Printsev, Elyas Alalli, Janine Bilsborough
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell differentiation, cell death/survival, and cytokine production. The signaling pair has been implicated in hematopoietic malignancies and inflammatory disease, and a chemotherapy-CD30 antibody combination for the treatment of Hodgkin and other lymphomas has been developed...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533264/korean-red-ginseng-extract-prevents-bone-loss-in-an-oral-model-of-glucocorticoid-induced-osteoporosis-in-mice
#2
JOURNAL ARTICLE
Nicholas J Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R McCabe, Narayanan Parameswaran
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in a subcutaneous pellet model in mice, but its effect on gut microbiota and barrier function in this context is not known...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38531887/evaluation-of-immunomodulatory-potential-of-probiotic-conditioned-medium-on-murine-macrophages
#3
JOURNAL ARTICLE
Mohammad A A Al-Najjar, Shaymaa B Abdulrazzaq, Lujain F Alzaghari, Asma Ismail Mahmod, Amin Omar, Eliza Hasen, Tamara Athamneh, Wamidh H Talib, Dinesh Kumar Chellappan, Muna Barakat
Probiotics are a mixture of beneficial live bacteria and/or yeasts that naturally exist in our bodies. Recently, numerous studies have focused on the immunostimulatory effects of single-species or killed multi-species probiotic conditioned mediums on macrophages. This study investigates the immunostimulatory effect of commercially available active, multi-species probiotic conditioned medium (CM) on RAW264.7 murine macrophages. The probiotic CM was prepared by culturing the commercially available probiotic in a cell-culture medium overnight at 37 °C, followed by centrifugation and filter-sterilization to be tested on macrophages...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530131/precision-delivery-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-the-pancreas-via-intra-arterial-injection-prevents-the-onset-of-diabetes
#4
JOURNAL ARTICLE
Rosita Primavera, Shobha Regmi, Reza Yarani, Steven Levitte, Jing Wang, Abantika Ganguly, Shashank Chetty, Michele Guindani, Camillo Ricordi, Everett Meyer, Avnesh S Thakor
Mesenchymal stem cells (MSCs) are a promising therapy to potentially treat diabetes given their potent anti-inflammatory and immune-modulatory properties. While these regenerative cells have shown considerable promise in cell culture, their clinical translation has been challenging. In part, this can be attributed to these cells not reaching the pancreas to exert their regenerative effects following conventional intravenous (IV) injection, with the majority of cells being trapped in the lungs in the pulmonary first-pass effect...
March 26, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38529039/therapeutic-potential-to-target-sialylation-and-siglecs-in-neurodegenerative-and-psychiatric-diseases
#5
REVIEW
Jannis Wißfeld, Tawfik Abou Assale, German Cuevas-Rios, Huan Liao, Harald Neumann
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-like lectins (SIGLECs) expressed on microglia are key players in maintaining microglial homeostasis by recognizing intact sialylation. The finely balanced sialic acid-SIGLEC system ensures the prevention of excessive and detrimental immune responses in the CNS. However, loss of sialylation and SIGLEC receptor dysfunctions contribute to several chronic CNS diseases...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38526238/targeted-neuroinflammation-mitigation-using-inflammasome-inhibiting-nanoligomers-is-therapeutic-in-an-experimental-autoimmune-encephalomyelitis-mouse-model
#6
JOURNAL ARTICLE
Sadhana Sharma, Sydney Risen, Vincenzo S Gilberto, Sean Boland, Anushree Chatterjee, Julie A Moreno, Prashant Nagpal
Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal cord and brain and is characterized by severe neuroinflammation, demyelination, and subsequent neuronal damage, resulting in symptoms like loss of mobility. While untargeted and pan-immunosuppressive therapies have proven to be disease-modifying and manage (or prolong the time between) symptoms in many patients, a significant fraction are unable to achieve remission...
March 25, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38524134/autoimmune-and-neuropsychiatric-phenotypes-in-a-mecp2-transgenic-mouse-model-on-c57bl-6-background
#7
JOURNAL ARTICLE
Yaxi Li, Shu Zhang, Chenling Tang, Bowen Yang, Fatin Atrooz, Zhifeng Ren, Chandra Mohan, Samina Salim, Tianfu Wu
INTRODUCTION: Systemic Lupus Erythematosus (SLE) impacts the central nervous system (CNS), leading to severe neurological and psychiatric manifestations known as neuropsychiatric lupus (NPSLE). The complexity and heterogeneity of clinical presentations of NPSLE impede direct investigation of disease etiology in patients. The limitations of existing mouse models developed for NPSLE obstruct a comprehensive understanding of this disease. Hence, the identification of a robust mouse model of NPSLE is desirable...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38521213/inhibitors-of-bruton-s-tyrosine-kinase-as-emerging-therapeutic-strategy-in-autoimmune-diseases
#8
REVIEW
Mirre De Bondt, Janne Renders, Sofie Struyf, Niels Hellings
Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor signal transducer, initially identified as an essential signaling molecule for B cells, with genetic mutations resulting in a disorder characterized by disturbed B cell and antibody development. Subsequent research revealed the critical role of BTK in the functionality of monocytes, macrophages and neutrophils. Various immune cells, among which B cells and neutrophils, rely on BTK activity for diverse signaling pathways downstream of multiple receptors, which makes this kinase an ideal target to treat hematological malignancies and autoimmune diseases...
March 21, 2024: Autoimmunity Reviews
https://read.qxmd.com/read/38521112/identify-ctbp1-dt-as-an-immunological-biomarker-that-promotes-lipid-synthesis-and-apoptosis-resistance-in-kirc
#9
JOURNAL ARTICLE
Haolin Li, Mintian Fei, Yi Zhang, Qili Xu, Rui Feng, Jing Cao, Yan Qu, Haibing Xiao
Recently, mounting evidence has highlighted the essential function of the C-terminal binding protein-1 divergent transcript (CTBP1-DT) in malignancies. However, its role in kidney renal clear cell carcinoma (KIRC) remains largely unknown. Our study aimed to identify the potential function of CTBP1-DT in KIRC. RT-qPCR, Kaplan-Meier survival analysis, Cox regression analysis, and nomogram analysis were utilized to determine the expression and effects of CTBP1-DT on survival. The subcellular localization of CTBP1-DT was determined using RNA fluorescence in situ hybridization (FISH)...
March 21, 2024: Gene
https://read.qxmd.com/read/38520254/construction-of-an-oxidative-stress-associated-genes-signature-in-breast-cancer-by-machine-learning-algorithms
#10
JOURNAL ARTICLE
Daojun Hu, Bing Qin, Li Zhang, Hanli Bu
OBJECTIVE: To construct a prognostic model of a breast cancer-related oxidative stress-related gene (OSRG) signature using machine learning algorithms. METHODS: The OSRGs of breast cancer were constructed by least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis. The Cancer Genome Atlas (TCGA) was used to analyse the gene expression and prognostic value. The Human Protein Atlas was used to analyse the protein expression of hub genes...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38516355/case-report-profound-newborn-leukopenia-related-to-a-novel-rac2-variant
#11
Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J Kim-Chang, Paul L Martin, Amy P Stallings, John W Sleasman, Steven M Holland, Amy P Hsu, Thomas L Leto, Talal Mousallem
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and Escherichia coli bacteremia. He did not pass early confirmatory hearing screens. Initial blood counts and lymphocyte flow cytometry revealed profound neutropenia and lymphopenia with a T-/B-/NK- phenotype. Red blood cell adenosine deaminase 1 activity was within normal limits. A presumptive diagnosis of reticular dysgenesis was considered...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38515569/cytotoxic-response-of-tumor-infiltrating-lymphocytes-of-head-and-neck-cancer-slice-cultures-under-mitochondrial-dysfunction
#12
JOURNAL ARTICLE
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Roland Hartl, Matthias Santer, Daniel Dejaco, Teresa Bernadette Steinbichler, Julia Federspiel, Christof Seifarth, Marko Konschake, Susanne Sprung, Sieghart Sopper, Avneet Randhawa, Melissa Mayr, Benedikt Gabriel Hofauer, Herbert Riechelmann
BACKGROUND: Head and neck squamous cell carcinomas (HNSCC) are highly heterogeneous tumors. In the harsh tumor microenvironment (TME), metabolic reprogramming and mitochondrial dysfunction may lead to immunosuppressive phenotypes. Aerobic glycolysis is needed for the activation of cytotoxic T-cells and the absence of glucose may hamper the full effector functions of cytotoxic T-cells. To test the effect of mitochondrial dysfunction on cytotoxic T cell function, slice cultures (SC) of HNSCC cancer were cultivated under different metabolic conditions...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515237/nucleic-acid-based-vaccine-for-ovarian-cancer-cells-bench-to-bedside
#13
REVIEW
Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Ahmed Hjazi, Enwa Felix Oghenemaro, Irwanjot Kaur, Abhinav Kumar, Ahmed Muzahem Al-Ani, Enas R Alwaily, Ahmed Huseen Redhee, Yasser Fakri Mustafa
Ovarian cancer continues to be a difficult medical issue that affects millions of individuals worldwide. Important platforms for cancer immunotherapy include checkpoint inhibitors, chimeric antigen receptor T cells, bispecific antibodies, cancer vaccines, and other cell-based treatments. To avoid numerous infectious illnesses, conventional vaccinations based on synthetic peptides, recombinant subunit vaccines, and live attenuated and inactivated pathogens are frequently utilized. Vaccine manufacturing processes, however, are not entirely safe and carry a significant danger of contaminating living microorganisms...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38514993/zinc-doped-bioactive-glass-functionalized-polyetheretherketone-to-enhance-the-biological-response-in-bone-regeneration
#14
JOURNAL ARTICLE
Xiaoyu Zheng, Han Luo, Jingzhi Li, Zhenyu Yang, Xiaoquan Zhuan, Xiaoquan Li, Yuting Chen, Shicheng Huo, Xiaozhong Zhou
Polyether ether ketone (PEEK) is gaining recognition as a highly promising polymer for orthopedic implants, attributed to its exceptional biocompatibility, ease of processing, and radiation resistance. However, its long-term in vivo application faces challenges, primarily due to suboptimal osseointegration from postimplantation inflammation and immune reactions. Consequently, biofunctionalization of PEEK implant surfaces emerges as a strategic approach to enhance osseointegration and increase the overall success rates of these implants...
March 21, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38514720/the-immune-regulation-and-therapeutic-potential-of-the-smad-gene-family-in-breast-cancer
#15
JOURNAL ARTICLE
Zhuo Chen, Yu Wang, Xiaodi Lu, Hong Chen, Yiran Kong, Liwei Rong, Guonian Wang
Breast cancer is a serious threat to human health. The transforming growth factor-β signaling pathway is an important pathway involved in the occurrence and development of cancer. The SMAD family genes are responsible for the TGF-β signaling pathway. However, the mechanism by which genes of the SMAD family are involved in breast cancer is still unclear. Therefore, it is necessary to investigate the biological roles of the SMAD family genes in breast cancer. We downloaded the gene expression data, gene mutation data, and clinical pathological data of breast cancer patients from the UCSC Xena database...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514403/a-model-based-hierarchical-bayesian-approach-to-sholl-analysis
#16
JOURNAL ARTICLE
Erik VonKaenel, Alexis Feidler, Rebecca Lowery, Katherine Andersh, Tanzy Love, Ania Majewska, Matthew N McCall
MOTIVATION: Due to the link between microglial morphology and function, morphological changes in microglia are frequently used to identify pathological immune responses in the central nervous system. In the absence of pathology, microglia are responsible for maintaining homeostasis, and their morphology can be indicative of how the healthy brain behaves in the presence of external stimuli and genetic differences. Despite recent interest in high throughput methods for morphological analysis, Sholl analysis is still widely used for quantifying microglia morphology via imaging data...
March 21, 2024: Bioinformatics
https://read.qxmd.com/read/38513460/short-chain-fatty-acids-modulate-the-ipec-j2-cell-response-to-pathogenic-e-coli-lps-activated-pbmc
#17
JOURNAL ARTICLE
Melania Andrani, Luca Ferrari, Paolo Borghetti, Valeria Cavalli, Elena De Angelis, Francesca Ravanetti, Eleonora Dall'Olio, Paolo Martelli, Roberta Saleri
Intestinal disorders can affect pigs of any age, especially when animals are young and more susceptible to infections and environmental stressors. For instance, pathogenic E. coli can alter intestinal functions, thus leading to altered nutrient adsorption by interacting with local cells through lipopolysaccharide (LPS). Among several compounds studied to counteract the negative effects on the intestine, short-chain fatty acids (SCFA) were demonstrated to exert beneficial effects on gut epithelial cells and resident immune cells...
March 16, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38512448/current-approaches-in-glioblastoma-multiforme-immunotherapy
#18
REVIEW
Marjan Aghajani, Nazila Jalilzadeh, Ali Aghebati-Maleki, Amirhossein Yari, Peyman Tabnak, Amirhossein Mardi, Hossein Saeedi, Leili Aghebati-Maleki, Behzad Baradaran
Glioblastoma multiform (GBM) is the most prevalent CNS (central nervous system) tumor in adults, with an average survival length shorter than 2 years and rare metastasis to organs other than CNS. Despite extensive attempts at surgical resecting, the inherently permeable nature of this disease has rendered relapse nearly unavoidable. Thus, immunotherapy is a feasible alternative, as stimulated immune cells can enter into the remote and inaccessible tumor cells. Immunotherapy has revolutionized patient upshots in various malignancies and might introduce different effective ways for GBM patients...
March 21, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38511208/the-impact-of-ovarian-stimulation-on-the-human-endometrial-microenvironment
#19
JOURNAL ARTICLE
Anat Chemerinski, May Shen, Nuriban Valero-Pacheco, Qingshi Zhao, Trystn Murphy, Lea George, Alex Lemenze, Lauren Sherman, Debra Heller, Xiaowei Chen, Tracy Wu, Peter G McGovern, Sara S Morelli, Ripla Arora, Aimee M Beaulieu, Nataki C Douglas
STUDY QUESTION: How does ovarian stimulation (OS), which is used to mature multiple oocytes for ART procedures, impact the principal cellular compartments and transcriptome of the human endometrium in the periovulatory and mid-secretory phases? SUMMARY ANSWER: During the mid-secretory window of implantation, OS alters the abundance of endometrial immune cells, whereas during the periovulatory period, OS substantially changes the endometrial transcriptome and impacts both endometrial glandular and immune cells...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38510238/development-of-an-explainable-ai-system-using-routine-clinical-parameters-for-rapid-differentiation-of-inflammatory-conditions
#20
JOURNAL ARTICLE
Joerg Hoffmann, Anne Rheude, Andreas Neubauer, Cornelia Brendel, Michael C Thrun
INTRODUCTION: Inflammatory conditions in patients have various causes and require different treatments. Bacterial infections are treated with antibiotics, while these medications are ineffective against viral infections. Autoimmune diseases and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, require immunosuppressive therapies such as glucocorticoids, which may be contraindicated in other inflammatory states. In this study, we employ a combination of straightforward blood tests to devise an explainable artificial intelligence (XAI) for distinguishing between bacterial infections, viral infections, and autoimmune diseases/graft-versus-host disease...
2024: Frontiers in Immunology
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