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https://read.qxmd.com/read/30771137/impact-of-the-cyp2d6-phenotype-on-hyperprolactinemia-development-as-an-adverse-event-of-treatment-with-atypical-antipsychotic-agents-in-pediatric-patients
#1
Raluca Grădinaru, Nicoleta Andreescu, Laura Nussbaum, Liana Suciu, Maria Puiu
BACKGROUND: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers...
February 15, 2019: Irish Journal of Medical Science
https://read.qxmd.com/read/30770235/long-acting-injectable-antipsychotics-lais-for-maintenance-treatment-of-bipolar-and-schizoaffective-disorders-a-systematic-review
#2
REVIEW
Isabella Pacchiarotti, Jari Tiihonen, Georgios D Kotzalidis, Norma Verdolini, Andrea Murru, José Manuel Goikolea, Marc Valentí, Alberto Aedo, Eduard Vieta
Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression)...
February 12, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30768203/feasibility-and-early-outcomes-of-a-tailored-quitline-protocol-for-smokers-with-mental-health-conditions
#3
Kelly M Carpenter, Chelsea M Nash, Robert A Vargas-Belcher, Katrina A Vickerman, Vincent Haufle
INTRODUCTION: Adults with mental health conditions (MHCs) smoke at higher rates, are more nicotine dependent, and have more trouble quitting smoking than those without MHCs. About half of smokers who call state-funded quitlines report MHCs, and those with such conditions have cessation rates 8-10% lower than those without MHCs. This paper describes a clinical pilot of a tailored protocol for quitline callers with MHCs. METHODS: Callers to the Texas Tobacco Quit Line (TXQL) who self-reported MHCs were offered a tailored quitline program, offering up to 12 weeks of combination nicotine replacement (nicotine patch plus gum or lozenge) and seven counseling calls...
February 15, 2019: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://read.qxmd.com/read/30767656/antenatal-caregiving-representations-among-expectant-mothers-with-severe-mental-illness-a-cross-sectional-study
#4
Katrine Røhder, Maja Nyström-Hansen, Angus MacBeth, Kirstine Agnete Davidsen, Andrew Gumley, Jessica Brennan, Carol George, Susanne Harder
OBJECTIVE: The study explores predictors of antenatal caregiving representations among mothers with a history of severe mental illness (SMI). BACKGROUND: Attachment research has demonstrated that multifactorial assessment of antenatal caregiving representations predicts later maternal behaviour and child attachment. However, the field lacks research among clinical groups. Knowledge of factors influencing caregiving representations during pregnancy can contribute to our understanding of caregiving risk among SMI-mothers and inform intervention decisions...
February 15, 2019: Journal of Reproductive and Infant Psychology
https://read.qxmd.com/read/30764822/is-care-really-shared-a-systematic-review-of-collaborative-care-shared-care-interventions-for-adult-cancer-patients-with-depression
#5
Joanne Shaw, Suvena Sethi, Lisa Vaccaro, Lisa Beatty, Laura Kirsten, David Kissane, Brian Kelly, Geoff Mitchell, Kerry Sherman, Jane Turner
BACKGROUND: Collaborative care involves active engagement of primary care and hospital physicians in shared care of patients beyond usual discharge summaries. This enhances community-based care and reduces dependence on specialists and hospitals. The model, successfully implemented in chronic care management, may have utility for treatment of depression in cancer. The aim of this systematic review was to identify components, delivery and roles and responsibilities within collaborative interventions for depression in the context of cancer...
February 14, 2019: BMC Health Services Research
https://read.qxmd.com/read/30764678/agmatine-as-a-potential-therapeutic-intervention-in-bipolar-depression-the-preclinical-landscape
#6
Devon Watts, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Luiza Paul Géa, Taiane de Azevedo Cardoso, Flavio Kapczinski
Present antidepressant treatments are only helpful in a quarter of patients with bipolar depression, and new strategies are warranted. Increasing evidence suggests that accelerated polyamine metabolism is associated with the pathophysiology of depression. Polyamines regulate stress responses, inflammation, and neuronal signaling in the central and enteric nervous system. Agmatine is a promising target of altered polyamine metabolism considering its unique ability to regulate intracellular polyamine content and neuroprotective effects...
February 15, 2019: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/30761787/-first-experience-with-prostate-artery-embolization-for-benign-prostatic-hyperplasia
#7
M Yu Soluyanov, O A Shumkov, M A Smagin, V V Nimaev
This study aimed to evaluate the feasibility of the prostate artery embolization (PAE) in the management of patients with benign prostatic hyperplasia (BPH) in different age groups, depending on the severity of voiding dysfunction, findings of the prostate ultrasound, and the ASA surgical risk. MATERIALS AND METHODS: The study comprised 39 patients with grade II-III BPH. Patients were divided into three groups, depending on the prostate volume and the grade of anesthesia risk. Patients of the group 1 (n=12), group 2 (n=19), and group 3 (n=8) underwent a classical transvesical prostatic adenomectomy (TPA), bipolar transurethral resection (TUR) of the prostate, and PAE, respectively...
October 2018: Urologii︠a︡
https://read.qxmd.com/read/30761164/somatic-embryogenesis-in-selected-conifer-trees-pinus-nigra-arn-and-abies-hybrids
#8
REVIEW
Terézia Salaj, Katarína Klubicová, Radoslava Matusova, Ján Salaj
Somatic embryogenesis was achieved in the conifers Pinus nigra Arn. and in the hybrids Abies alba × A. cephalonica and Abies alba × A. numidica . For initiation of embryogenic tissue in P. nigra , immature zygotic embryos enclosed in megagametophytes were used. The initiated embryogenic cultures were maintained and proliferated on solid culture medium DCR supplemented with 9 μM 2,4-D and 2.2 μM BA. Microscopic investigations revealed the presence of bipolar early somatic embryos in proliferating tissue...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30760936/hormonal-imbalance-and-pituitary-adenoma-during-antipsychotic-treatment-in-an-adolescent-with-bipolar-affective-disorder
#9
Florina Rad, Alexandra Mariana Buica, Gianina Cristina Anghel, Mihaela Stancu, Iuliana Dobrescu
In this paper we present the case of a female teenager patient who was diagnosed with bipolar affective disorder and during psychotropic treatment with risperidone, the prolactin levels ranged between 55 ng/mL and 85 ng/mL at monthly repeated dosing. During this period, the patient presented somatic alterations in her state of health. The patient benefited from brain imaging, which revealed that in sella turcica is distinguished a well-defined and relatively homogeneous formation, measuring approximately 11/8 mm, suggestive of a pituitary adenoma...
January 2019: Rivista di Psichiatria
https://read.qxmd.com/read/30760516/mapping-of-modifiable-barriers-and-facilitators-of-medication-adherence-in-bipolar-disorder-to-the-theoretical-domains-framework-a-systematic-review-protocol
#10
Asta Ratna Prajapati, Alexandra Dima, Allan B Clark, Claire Gant, Chris Gibbons, Richard Gorrod, George Mosa, Sion Scott, Fujian Song, Bonnie Teague, Michael J Twigg, Jon Wilson, Debi Bhattacharya
INTRODUCTION: People with bipolar disorder require long-term treatment but it is estimated that 40% of these people do not adhere to prescribed medication regimens. Non-adherence increases the risk of relapse, hospitalisation and suicide. Some evidence syntheses report barriers to mental health treatment adherence but rarely delineate between modifiable and non-modifiable barriers. They also fail to distinguish between the patients' perspective and that of other stakeholders such as clinicians despite of their different understanding and priorities about adherence...
February 12, 2019: BMJ Open
https://read.qxmd.com/read/30758979/autologous-chondrocyte-implantation-for-bipolar-chondral-lesions-in-the-patellofemoral-compartment-clinical-outcomes-at-a-mean-9-years-follow-up
#11
Takahiro Ogura, Tim Bryant, Gergo Merkely, Tom Minas
BACKGROUND: Treating bipolar chondral lesions in the patellofemoral (PF) compartment is a challenging problem. There are few reports available on the treatment of bipolar chondral lesions in the PF compartment. PURPOSE: To evaluate the clinical outcomes and graft survivorship after autologous chondrocyte implantation (ACI) for the treatment of bipolar chondral lesions in the PF compartment. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The authors evaluated 58 patients who had ACI by a single surgeon for the treatment of symptomatic bipolar chondral lesions in the PF compartment between November 1995 and June 2014...
February 13, 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/30758698/addressing-mental-health-concerns-in-primary-care-practices-among-medical-residents-in-a-rural-setting
#12
Danielle L Terry, Christopher P Terry
Behavioral health issues like anxiety and depression negatively impact numerous aspects of primary care, including medical regimen adherence, communication, physical well-being, and engagement in beneficial health behaviors. This study aimed to examine internal and family medicine residents': (1) patterns of addressing mental health concerns (e.g., frequency of referral for psychotherapy and/or medication), (2) self-perceptions of competency in assessment and treatment of specific mental health disorders, and (3) frequency of utilization of efficacious therapeutic strategies during clinical encounters...
February 13, 2019: Journal of Clinical Psychology in Medical Settings
https://read.qxmd.com/read/30756134/targeting-the-immune-system-in-the-treatment-of-bipolar-disorder
#13
REVIEW
Joshua D Rosenblat
RATIONALE: Immune dysfunction has been strongly implicated in the pathophysiology of bipolar disorder (BD). As such, numerous clinical trials have investigated the effects of anti-inflammatory agents in the treatment of BD. OBJECTIVES: Review clinical studies evaluating the effects of anti-inflammatory agents in the treatment of BD during all illness phases (e.g., depression, mania, and euthymia). METHODS: Relevant databases were searched from inception to August 27, 2018 for clinical studies evaluating the effects of anti-inflammatory agents in BD...
February 13, 2019: Psychopharmacology
https://read.qxmd.com/read/30753085/cariprazine-for-the-treatment-of-bipolar-depression-a-review
#14
Renee-Marie Ragguett, Roger S McIntyre
Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is disproportionately mediated by depressive symptoms; economic costs of bipolar disorder are also disproportionately due to unremitting depressive symptoms. Relatively few treatment options have established unequivocal efficacy in the treatment of bipolar depression. Herein we review evidence regarding the efficacy of the D3 preferring D2 /D3 partial agonist cariprazine in the treatment of adults with bipolar depression...
February 12, 2019: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/30748126/concise-review-update-on-retinal-pigment-epithelium-transplantation-for-age-related-macular-degeneration
#15
REVIEW
Marco Zarbin, Ilene Sugino, Ellen Townes-Anderson
Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i.e., replace cells lost due to injury or disease for sight restoration as well as preservation). The first clinical trials of retinal pigment epithelium (RPE) transplantation for vision-threatening complications of age-related macular degeneration (AMD) have begun with some preliminary signs of success (e.g., improvement in vision in some patients, anatomic evidence of transplant-host integration with some evidence of host photoreceptor recovery, long-term survival of autologous induced pluripotent stem cell-derived RPE transplants without immune suppression) as well as limitations (e...
February 12, 2019: Stem Cells Translational Medicine
https://read.qxmd.com/read/30748087/successful-lithium-treatment-in-a-patient-on-hemodialysis
#16
Noel Engels, Adriaan M van Alphen, Tessa M Bosch, Rocco Hoekstra
In 2010 a 69-year old patient with bipolar I disorder, type 2 diabetes and hypertension was referred to the Nephrology outpatient clinic of the Maasstad Hospital for progressive kidney disease. Her creatinine was 205 μmol/L (estimated Glomerular Filtration Rate (eGFR) 22 mL/min/1.73m2 ). Her diabetes was well controlled at a HbA1c of 6.6% with repaglindine 4mg once daily (QD). This article is protected by copyright. All rights reserved.
February 12, 2019: Bipolar Disorders
https://read.qxmd.com/read/30747428/metabolomic-biomarkers-in-mental-disorders-bipolar-disorder-and-schizophrenia
#17
Melissa Quintero, Danijela Stanisic, Guilherme Cruz, João G M Pontes, Tássia Brena Barroso Carneiro Costa, Ljubica Tasic
Psychiatric disorders are some of the most impairing human diseases. Among them, bipolar disorder and schizophrenia are the most common. Both have complicated diagnostics due to their phenotypic, biological, and genetic heterogeneity, unknown etiology, and the underlying biological pathways, and molecular mechanisms are still not completely understood. Given the multifactorial complexity of these disorders, identification and implementation of metabolic biomarkers would assist in their early detection and diagnosis and facilitate disease monitoring and treatment responses...
2019: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30747422/interactome-studies-of-psychiatric-disorders
#18
Dong Ik Park, Christoph W Turck
High comorbidity and complexity have precluded reliable diagnostic assessment and treatment of psychiatric disorders. Impaired molecular interactions may be relevant for underlying mechanisms of psychiatric disorders but by and large remain unknown. With the help of a number of publicly available databases and various technological tools, recent research has filled the paucity of information by generating a novel dataset of psychiatric interactomes. Different technological platforms including yeast two-hybrid screen, co-immunoprecipitation-coupled with mass spectrometry-based proteomics, and transcriptomics have been widely used in combination with cellular and molecular techniques to interrogate the psychiatric interactome...
2019: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30745688/obsessive-compulsive-disorder-comorbid-with-schizophrenia-and-bipolar-disorder
#19
REVIEW
Lavanya P Sharma, Y C Janardhan Reddy
Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Symptoms (OCS) are known to be highly comorbid with bipolar disorder and schizophrenia. Comorbid OCD/OCS influences the course of schizophrenia and bipolar disorder. There is also some evidence to suggest that a diagnosis of OCD may be associated with elevated risk for later development of psychosis and bipolar disorder. Comorbid OCD/OCS is associated with a greater severity of schizophrenia phenotype and poorer prognosis. In addition, certain atypical antipsychotics, clozapine in particular are known to induce or worsen OCS in schizophrenia...
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745650/identification-of-factors-affecting-treatment-outcome-in-bipolar-disorder
#20
Lavanya Vedanarayanan, Ravindra Munoli, Girish Thunga, Sreedharan Nair, Pooja Poojari, Vijayanarayana Kunhikatta
Background and Aim: Treatment outcomes in bipolar disorder are highly variable, and several sociodemographic, clinical characteristics, and comorbidities play an important role. Early recognition of these factors will help the physicians to implement individualized treatment and a better clinical outcome. The present study was aimed at identifying the factors affecting treatment outcomes in bipolar disorder. Materials and Methods: All patients diagnosed with bipolar disorder as per diagnostic and statistical manual-IV criteria were included in the study...
January 2019: Indian Journal of Psychiatry
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