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JOURNAL ARTICLE
Alexander Kurz, Dieter Krahl, Heinz Kutzner, Raymond Barnhill, Antonio Perasole, Maria Teresa Fernandez Figueras, Gerardo Ferrara, Stephan A Braun, Hans Starz, Mar Llamas-Velasco, Jochen Sven Utikal, Stefan Fröhling, Christof von Kalle, Jakob Nikolas Kather, Lucas Schneider, Titus J Brinker
BACKGROUND: Historically, cancer diagnoses have been made by pathologists using two-dimensional histological slides. However, with the advent of digital pathology and artificial intelligence, slides are being digitised, providing new opportunities to integrate their information. Since nature is 3-dimensional (3D), it seems intuitive to digitally reassemble the 3D structure for diagnosis. OBJECTIVE: To develop the first human-3D-melanoma-histology-model with full data and code availability...
August 18, 2023: European Journal of Cancer
#2
JOURNAL ARTICLE
Isabel Kolm, Anastasia M Konstantinova, Heinz Kutzner, Andre Barghorn, Tomas Vanecek, Joanna Mangana, Dmitry V Kazakov
Cuticular poroma is a rare variant of poroma composed of exclusively or predominantly cuticular cells, namely of large cells with ample eosinophilic cytoplasm. We report 7 cases of this rare tumor identified among 426 neoplasms diagnosed as poroma or porocarcinoma. The patients were 4 males and 3 females, ranging in age from 18 to 88 years. All presented with a solitary asymptomatic nodule. The location included knee (2 cases), shoulder, thigh, shin, lower arm, and neck (each 1). All lesions were surgically removed...
June 15, 2023: American Journal of Dermatopathology
#3
JOURNAL ARTICLE
Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner, Doris Helbig
Metabolic reprogramming mediated by hypoxia-inducible factors play a crucial role in many human cancers. HIF-1α is activated under hypoxic conditions and is considered a key regulator of oxygen homoeostasis during tumor proliferation under hypoxia. Aim of this research was to analyze the immunohistochemical expression of HIF-1α, VEGF-A, Glut-1, MCT4, and CAIX in atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). 21 paraffin-embedded AFX and 22 PDS were analysed by immunohistochemistry, namely HIF-1α, VEGF-A (referred to as VEGF throughout the manuscript), Glut-1, MCT4, and CAIX...
July 2022: Acta Dermatovenerologica Croatica: ADC
#4
JOURNAL ARTICLE
Klaus J Busam, Meagan J Judge, Christopher K Bichakjian, Daniel Coit, Heinz Kutzner, Luis Requena, Richard A Scolyer, Catherine M Stefanato, Benjamin A Wood, Noreen M Walsh
Accurate and complete pathology reports are critical for the optimal management of cancer patients. Protocols for the pathologic reporting of Merkel cell carcinoma (MCC) have been developed independently by the Royal College of Pathologists (UK) and the College of American Pathologists. In this study, data elements for pathologic reporting of MCC were analyzed by an international panel of pathologists and clinicians with the aim of developing a common, internationally agreed upon dataset useful for clinical practice...
November 1, 2022: American Journal of Surgical Pathology
#5
Sofia Antunes-Duarte, Ana Marcos-Pinto, Lars E French, Heinz Kutzner, Luís Soares-de-Almeida
No abstract text is available yet for this article.
August 2022: JAAD Case Reports
#6
JOURNAL ARTICLE
Gioia Pedroni, Alessia Paganelli, Sara Bassoli, Heinz Kutzner, Anna Maria Cesinaro, Cristina Magnoni
No abstract text is available yet for this article.
June 16, 2022: Dermatology Reports
#7
JOURNAL ARTICLE
Anne Zaremba, Philipp Jansen, Rajmohan Murali, Anand Mayakonda, Anna Riedel, Manuel Philip, Christian Rose, Jörg Schaller, Hansgeorg Müller, Heinz Kutzner, Inga Möller, Nadine Stadtler, Julia Kretz, Antje Sucker, Agnes Bankfalvi, Elisabeth Livingstone, Lisa Zimmer, Susanne Horn, Annette Paschen, Christoph Plass, Dirk Schadendorf, Eva Hadaschik, Pavlo Lutsik, Klaus Griewank
Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases a definitive diagnostic assessment remains challenging and additional diagnostic biomarkers would be advantageous. We analyzed melanomas, nevi, Spitz nevi and atypical spitzoid tumors using parallel sequencing (exons of 611 genes and 507 gene translocation analysis) and methylation arrays (850k Illumina EPIC)...
June 23, 2022: International Journal of Cancer. Journal International du Cancer
#8
JOURNAL ARTICLE
Catarina Correia, Sonia Fernandes, Paulo Filipe, Heinz Kutzner, Luis Soares-de-Almeida-
Chondrosarcoma is the second-most common primary malignant bone tumor but chondrosarcoma of small bones of the hand is extremely rare, representing less than 2% of all cases, with exceedingly rare skin metastases. Cutaneous metastases of chondrosarcoma represent less than 3% of all cutaneous metastases. According to PubMed, there are only four previous case reports of cutaneous metastases originating from chondrosarcoma of small bones of the hand. We present an additional case of cutaneous metastases of phalangeal chondrosarcoma with a unique immunophenotype...
March 15, 2022: Dermatology Online Journal
#9
REVIEW
Katja Hauser, Alexander Kurz, Sarah Haggenmüller, Roman C Maron, Christof von Kalle, Jochen S Utikal, Friedegund Meier, Sarah Hobelsberger, Frank F Gellrich, Mildred Sergon, Axel Hauschild, Lars E French, Lucie Heinzerling, Justin G Schlager, Kamran Ghoreschi, Max Schlaak, Franz J Hilke, Gabriela Poch, Heinz Kutzner, Carola Berking, Markus V Heppt, Michael Erdmann, Sebastian Haferkamp, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Jakob N Kather, Stefan Fröhling, Daniel B Lipka, Achim Hekler, Eva Krieghoff-Henning, Titus J Brinker
BACKGROUND: Due to their ability to solve complex problems, deep neural networks (DNNs) are becoming increasingly popular in medical applications. However, decision-making by such algorithms is essentially a black-box process that renders it difficult for physicians to judge whether the decisions are reliable. The use of explainable artificial intelligence (XAI) is often suggested as a solution to this problem. We investigate how XAI is used for skin cancer detection: how is it used during the development of new DNNs? What kinds of visualisations are commonly used? Are there systematic evaluations of XAI with dermatologists or dermatopathologists? METHODS: Google Scholar, PubMed, IEEE Explore, Science Direct and Scopus were searched for peer-reviewed studies published between January 2017 and October 2021 applying XAI to dermatological images: the search terms histopathological image, whole-slide image, clinical image, dermoscopic image, skin, dermatology, explainable, interpretable and XAI were used in various combinations...
May 2022: European Journal of Cancer
#10
JOURNAL ARTICLE
Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner
Metabolic reprogramming mediated by hypoxia-inducible factors and its downstream targets plays a crucial role in many human malignancies. Excessive proliferation of tumor cells under hypoxic conditions leads to metabolic reprogramming and altered gene expression enabling tumors to adapt to their hypoxic environment. Here we analyzed the metabolic signatures of primary cutaneous melanomas with positive and negative sentinel node status in order to evaluate potential differences in their metabolic signature...
January 7, 2022: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
#11
JOURNAL ARTICLE
Sarah Haggenmüller, Roman C Maron, Achim Hekler, Jochen S Utikal, Catarina Barata, Raymond L Barnhill, Helmut Beltraminelli, Carola Berking, Brigid Betz-Stablein, Andreas Blum, Stephan A Braun, Richard Carr, Marc Combalia, Maria-Teresa Fernandez-Figueras, Gerardo Ferrara, Sylvie Fraitag, Lars E French, Frank F Gellrich, Kamran Ghoreschi, Matthias Goebeler, Pascale Guitera, Holger A Haenssle, Sebastian Haferkamp, Lucie Heinzerling, Markus V Heppt, Franz J Hilke, Sarah Hobelsberger, Dieter Krahl, Heinz Kutzner, Aimilios Lallas, Konstantinos Liopyris, Mar Llamas-Velasco, Josep Malvehy, Friedegund Meier, Cornelia S L Müller, Alexander A Navarini, Cristián Navarrete-Dechent, Antonio Perasole, Gabriela Poch, Sebastian Podlipnik, Luis Requena, Veronica M Rotemberg, Andrea Saggini, Omar P Sangueza, Carlos Santonja, Dirk Schadendorf, Bastian Schilling, Max Schlaak, Justin G Schlager, Mildred Sergon, Wiebke Sondermann, H Peter Soyer, Hans Starz, Wilhelm Stolz, Esmeralda Vale, Wolfgang Weyers, Alexander Zink, Eva Krieghoff-Henning, Jakob N Kather, Christof von Kalle, Daniel B Lipka, Stefan Fröhling, Axel Hauschild, Harald Kittler, Titus J Brinker
BACKGROUND: Multiple studies have compared the performance of artificial intelligence (AI)-based models for automated skin cancer classification to human experts, thus setting the cornerstone for a successful translation of AI-based tools into clinicopathological practice. OBJECTIVE: The objective of the study was to systematically analyse the current state of research on reader studies involving melanoma and to assess their potential clinical relevance by evaluating three main aspects: test set characteristics (holdout/out-of-distribution data set, composition), test setting (experimental/clinical, inclusion of metadata) and representativeness of participating clinicians...
October 2021: European Journal of Cancer
#12
LETTER
Rita Bouceiro-Mendes, Pedro M Garrido, Maria Mendonça-Sanches, Heinz Kutzner, Luís Soares-de-Almeida
No abstract text is available yet for this article.
October 1, 2021: American Journal of Dermatopathology
#13
JOURNAL ARTICLE
Titus J Brinker, Lennard Kiehl, Max Schmitt, Tanja B Jutzi, Eva I Krieghoff-Henning, Dieter Krahl, Heinz Kutzner, Patrick Gholam, Sebastian Haferkamp, Joachim Klode, Dirk Schadendorf, Achim Hekler, Stefan Fröhling, Jakob N Kather, Sarah Haggenmüller, Christof von Kalle, Markus Heppt, Franz Hilke, Kamran Ghoreschi, Markus Tiemann, Ulrike Wehkamp, Axel Hauschild, Michael Weichenthal, Jochen S Utikal
AIM: Sentinel lymph node status is a central prognostic factor for melanomas. However, the surgical excision involves some risks for affected patients. In this study, we therefore aimed to develop a digital biomarker that can predict lymph node metastasis non-invasively from digitised H&E slides of primary melanoma tumours. METHODS: A total of 415 H&E slides from primary melanoma tumours with known sentinel node (SN) status from three German university hospitals and one private pathological practice were digitised (150 SN positive/265 SN negative)...
September 2021: European Journal of Cancer
#14
REVIEW
Julia Höhn, Achim Hekler, Eva Krieghoff-Henning, Jakob Nikolas Kather, Jochen Sven Utikal, Friedegund Meier, Frank Friedrich Gellrich, Axel Hauschild, Lars French, Justin Gabriel Schlager, Kamran Ghoreschi, Tabea Wilhelm, Heinz Kutzner, Markus Heppt, Sebastian Haferkamp, Wiebke Sondermann, Dirk Schadendorf, Bastian Schilling, Roman C Maron, Max Schmitt, Tanja Jutzi, Stefan Fröhling, Daniel B Lipka, Titus Josef Brinker
BACKGROUND: Recent years have been witnessing a substantial improvement in the accuracy of skin cancer classification using convolutional neural networks (CNNs). CNNs perform on par with or better than dermatologists with respect to the classification tasks of single images. However, in clinical practice, dermatologists also use other patient data beyond the visual aspects present in a digitized image, further increasing their diagnostic accuracy. Several pilot studies have recently investigated the effects of integrating different subtypes of patient data into CNN-based skin cancer classifiers...
July 2, 2021: Journal of Medical Internet Research
#15
JOURNAL ARTICLE
Alistair Robson, Werner Kempf, Isabel Kolm, Heinz Kutzner, Zena Willsmore, Mufaddal Moonim
Primary extramedullary plasmacytoma is rare monoclonal proliferation of plasma cells, which arise in various nonosseous anatomic locations without detectable underlying systemic disease. Historically, cutaneous infiltrates rich in mature neoplastic plasma cells have fallen into one of the following categories, plasmacytoma, lymphoplasmacytic lymphoma, and marginal zone lymphoma, which included immunocytoma. Since 2005, each of these was subsumed under the marginal zone lymphoma umbrella, largely on the basis of acknowledged diagnostic difficulties in some of these cases...
December 1, 2021: American Journal of Dermatopathology
#16
JOURNAL ARTICLE
Miriam Groß, Carsten Speckmann, Annette May, Tania Gajardo-Carrasco, Katharina Wustrau, Sarah Lena Maier, Marcus Panning, Daniela Huzly, Abbas Agaimy, Yenan T Bryceson, Sharon Choo, C W Chow, Gregor Dückers, Anders Fasth, Sylvie Fraitag, Katja Gräwe, Sabine Haxelmans, Dirk Holzinger, Ole Hudowenz, Judith Hübschen, Claudia Khurana, Korbinian Kienle, Roman Klifa, Klaus Korn, Heinz Kutzner, Tim Lämmermann, Svea Ledig, Dan Lipsker, Marie Meeths, Nora Naumann-Bartsch, Jelena Rascon, Anne Schänzer, Maximilian Seidl, Bianca Tesi, Christelle Vauloup-Fellous, Beate Vollmer-Kary, Klaus Warnatz, Claudia Wehr, Bénédicte Neven, Pablo Vargas, Fernando E Sepulveda, Kai Lehmberg, Annette Schmitt-Gräff, Stephan Ehl
BACKGROUND: Rubella virus-induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. OBJECTIVE: To understand the defective effector mechanism allowing rubella vaccine virus persistence in granulomas. METHODS: Starting from an index case with Griscelli syndrome type 2 and rubella skin granulomas, we combined an international survey with a literature search to identify patients with cytotoxicity defects and granuloma...
May 22, 2021: Journal of Allergy and Clinical Immunology
#17
Tatjana D Wahjudi, Heinz Kutzner, Matthias Bleeke, Peter H Hoeger
We report the case of a 4-year-old boy, post-human stem cell transplantation for severe combined immunodeficiency (SCID) due to adenosine deaminase deficiency (ADA), who developed multiple dermatofibrosarcoma protuberans (DFSP). We hypothesize a role for chimerism leading to accumulation of toxic metabolites which can cause DNA strand breaks and inhibit lymphocyte activation. Patients with ADA-SCID should remain under lifelong dermatologic surveillance as DFSP lesions can be quite inconspicuous.
July 2021: Pediatric Dermatology
#18
MULTICENTER STUDY
Julia Höhn, Eva Krieghoff-Henning, Tanja B Jutzi, Christof von Kalle, Jochen S Utikal, Friedegund Meier, Frank F Gellrich, Sarah Hobelsberger, Axel Hauschild, Justin G Schlager, Lars French, Lucie Heinzerling, Max Schlaak, Kamran Ghoreschi, Franz J Hilke, Gabriela Poch, Heinz Kutzner, Markus V Heppt, Sebastian Haferkamp, Wiebke Sondermann, Dirk Schadendorf, Bastian Schilling, Matthias Goebeler, Achim Hekler, Stefan Fröhling, Daniel B Lipka, Jakob N Kather, Dieter Krahl, Gerardo Ferrara, Sarah Haggenmüller, Titus J Brinker
BACKGROUND: Clinicians and pathologists traditionally use patient data in addition to clinical examination to support their diagnoses. OBJECTIVES: We investigated whether a combination of histologic whole slides image (WSI) analysis based on convolutional neural networks (CNNs) and commonly available patient data (age, sex and anatomical site of the lesion) in a binary melanoma/nevus classification task could increase the performance compared with CNNs alone. METHODS: We used 431 WSIs from two different laboratories and analysed the performance of classifiers that used the image or patient data individually or three common fusion techniques...
May 2021: European Journal of Cancer
#19
JOURNAL ARTICLE
María-Teresa Muñoz-Jiménez, Leyla Blanco, Yolanda Ruano, Rosario Carrillo, Ángel Santos-Briz, Erika Riveiro-Falkenbach, Luis Requena, Heinz Kutzner, María Concepción Garrido, José-Luis Rodríguez-Peralto
TERT promoter (TERTp) mutations widely occur in multiple human neoplasms, and they have been related to different clinicopathological features. To date, this mutation has not been identified in sebaceous tumors. Here, we analyzed TERTp mutations in 91 sebaceous neoplasms (17 adenomas, 45 sebaceomas, and 29 carcinomas). We detected mutations in 26.7% (8 of 29) of sebaceous carcinomas by pyrosequencing and Sanger sequencing. No mutation was detected in adenomas or sebaceomas. The difference was significant between sebaceoma and carcinoma...
September 2021: Virchows Archiv: An International Journal of Pathology
#20
LETTER
Titus J Brinker, Max Schmitt, Eva I Krieghoff-Henning, Raymond Barnhill, Helmut Beltraminelli, Stephan A Braun, Richard Carr, Maria-Teresa Fernandez-Figueras, Gerardo Ferrara, Sylvie Fraitag, Raffaele Gianotti, Mar Llamas-Velasco, Cornelia S L Müller, Antonio Perasole, Luis Requena, Omar P Sangueza, Carlos Santonja, Hans Starz, Esmeralda Vale, Wolfgang Weyers, Achim Hekler, Jakob N Kather, Stefan Fröhling, Dieter Krahl, Tim Holland-Letz, Jochen S Utikal, Andrea Saggini, Heinz Kutzner
No abstract text is available yet for this article.
March 2022: Journal of the American Academy of Dermatology
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