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Jingying Wang, Songshan Li, Zhijia Li, Junpeng Li, Xiaoming Peng, Shujiao Li, Lifen Jiang, Hui Liu, Kang Zeng
5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection...
February 6, 2019: Photodiagnosis and Photodynamic Therapy
Natalia A Taborda, Luis A Correa, Manuel Geronimo Feria, María T Rugeles
BACKGROUND: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immune responses that correlate with viral control; however, the histopathological characterization of GALT in those patients is still missing. In this study, we evaluated pathological alterations in GALT, trying to associate them with clinical parameters of HIV infected patients with or without evidence of viral control...
January 29, 2019: Current HIV Research
Lixue Zhang, Xiufang Li, Xinqiao Liu, Ying Gao, Qingning Tang
BACKGROUND: Condyloma acuminatum(CA)is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO2 laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is an effective therapy which targets on HPV infected sites. Some studies demonstrate that when combined with use of CO2 lasers, photodynamic therapy can become more effective. METHODS: We attempted to clinically cure a series of CA grown on cervix, urethra, urinary meatus, vulva, crissum and anal canal with treatment of topical CO2 laser combined photodynamic therapy and report herein 6 cases...
January 28, 2019: Photodiagnosis and Photodynamic Therapy
Eduardo Lazcano-Ponce, Staci L Sudenga, B Nelson Torres, Mark Stoler, Leith León-Maldonado, Betania Allen-Leigh, Héctor Posso, Manuel Quiterio, María Del Pilar Hernández-Nevarez, Jorge Salmerón, Anna R Giuliano
OBJECTIVE: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs. MATERIALS AND METHODS: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types...
November 2018: Salud Pública de México
Sasha J Betz
Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Mechanisms of infection, epidemiology, clinical presentations, histologic features, and differential diagnoses of the HPV-related oral pathologies are discussed...
January 29, 2019: Head and Neck Pathology
Langanani Mbodi, Trudy Smith, Reubina Wadee
In this case study, we have presented a rare case of concomitant human papillomavirus condylomata lesions of both breast nipples and giant vulval warts in an HIV-positive woman on antiretroviral therapy. The woman underwent successful surgical excision and reconstruction for both breast nipple condylomata and vulval warts. Histology of the excised breast nipple and vulval tissue confirmed low-risk human papillomavirus infection. Concomitant vulval and bilateral breast nipple condylomata pose a management dilemma...
2019: SAGE Open Medical Case Reports
Yi Zhan, Rong Xiao, Zhiwei Zhang
Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases.
December 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Meriem El Bessi, Wejih Dougaz, Meriem Jones, Hichem Jerraya, Chadli Dziri
No abstract text is available yet for this article.
January 6, 2019: Journal of Gastrointestinal Cancer
Hu Shaoshan, Yang Yun, Jiang Bingbing, Su Dongqiang, Zhang Likun, Huang Zheng, Zhang Feng
BACKGROUND: Human papilloma virus (HPV) infection and condyloma acuminatum (CA) in the genital area are often existence in extensive and multi-point fashion. Laser ablation combined with topical photodynamic therapy (PDT) is a feasible approach for genital CA but its effectiveness and limitation need to be evaluated. METHODS: This single-arm prospective study consisted of 100 newly diagnosed CA cases of both sexes. All patients underwent laser ablation and three times of aminolaevulinic acid-based photodynamic therapy (ALA-PDT)...
December 20, 2018: Photodiagnosis and Photodynamic Therapy
Maria O Zayko, Rowena E Velilla, M Salah Shurbaji
BACKGROUND A condyloma acuminatum is a sexually transmitted, human papillomavirus (HPV) associated, neoplasm. In men, it is predominantly found on external genitalia and rarely progresses more proximally than the distal penile urethra. Condyloma acuminata of the prostatic urethra are rare and are usually seen as an extension of, or in association with external lesions. Therefore, it is not typically considered in the differential diagnosis of isolated papillary lesions limited to the prostatic urethra. CASE REPORT A 62-year-old male with rheumatoid arthritis treated with abatacept presented to urology due to a history of intermittent bladder self-catheterization for urinary obstruction...
December 22, 2018: American Journal of Case Reports
O O Orenuga, Oluwo A, R T Oluwakuyide, A B Olawuyi
Squamous papillomas are common lesions of the oral mucosa. They are benign proliferating lesions often painless, slow growing and with a cauliflower appearance. However, its clinical appearance which sometimes mimics exophytic carcinoma, verrucous carcinoma or condyloma acuminatum raises concern when it occurs in the oral cavity. Squamous papilloma occurs predominantly in 30- to 50-year old's. However, they may be seen in children <10 years and accounted for 8% of all oral tumors in children. There is no sex predilection...
December 2018: Nigerian Journal of Clinical Practice
Lai San Wong, Yi-Chien Yang
No abstract text is available yet for this article.
November 2018: Indian Journal of Dermatology
Daniel Grace, Mark Gaspar, Rachelle Paquette, Ron Rosenes, Ann N Burchell, Troy Grennan, Irving E Salit
The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Gay, bisexual, and other men who have sex with men (GBM) living with HIV are disproportionately impacted by HPV-associated anal cancer, with rates about 100-fold that of the general population. Fortunately, HPV vaccination has proven efficacy in preventing both anogenital warts (condyloma) in males and anal pre-cancers (anal intraepithelial neoplasia; AIN) in GBM up to the age of 26. We conducted in-depth, semi-structured interviews with 25 HIV-positive gay men in Toronto to gain an understanding of their knowledge and experiences related to HPV and the HPV vaccine...
2018: PloS One
Halle E Foss, Jacqueline J Blank, Sarah J Lundeen, Carrie Y Peterson, Kirk A Ludwig, Timothy J Ridolfi
BACKGROUND: Human papillomavirus is a common sexually transmitted infection that may affect the oropharynx, genitalia, or anus. Some strains of this virus may cause bulky growths around the anus known as giant anal condylomas. These can become large, disfiguring, and may cause bleeding, as well as difficulty with defecation and hygiene. Surgical management is usually necessary for large condylomas, whereas office-based procedures are common for smaller lesions. It is unclear why some develop large anal margin tumors, whereas others develop limited disease...
December 2018: Journal of Surgical Research
Jiajia Xie, Chunping Ao, Junpeng Li, Lifen Jiang, Hui Liu, Kang Zeng
Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4h treatment of 5-aminolevulinic acid (ALA), patients received photodynamic therapy (PDT). Each patient received HPV test before every PDT cycle...
November 14, 2018: Journal of Dermatological Treatment
Stephen K Tyring, Theodore Rosen, Brian Berman, Nathan Stasko, Todd Durham, Tomoko Maeda-Chubachi
BACKGROUND: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Genital warts (condyloma acuminata) are primarily caused by human papillomavirus (HPV) types 6 and 11. Available treatments have low tolerability and efficacy rates and are inconvenient for the patient. Genital warts can recur if HPV is incompletely eradicated during treatment...
October 1, 2018: Journal of Drugs in Dermatology: JDD
Tina Hsu, Zachary P Nahmias, Ilana S Rosman, David Sheinbein
No abstract text is available yet for this article.
October 2018: JAAD Case Reports
Matthew Hum, Eunice Chow, Nan Schuurmans, Marlene Dytoc
Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. The patient, a 66-year-old female, was referred to Dermatology for large protruding verrucous plaques that covered the entire surface of her external vulva, perineum and perianal area. These lesions developed after being treated for genital warts with cantharidin...
2018: SAGE Open Medical Case Reports
Xianmin Meng, Yongguo Li, Hong Luan, Xiuyan Shi
Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups...
November 2018: Experimental and Therapeutic Medicine
Morena Burati, Marco Chiarelli, Sabina Terragni, Fulvio Tagliabue, Lorenzo Ripamonti, Matteo Maternini, Angelo Guttadauro
Giant condyloma acuminatum (GCA) is a rare cauliflower-like lesion, also known as Buschke-L ewenstein tumor (BLT). Although characterized by benign histological features, the local behavior of GCA is extremely aggressive, showing progressive infiltration of the surrounding structures leading to tissue destruction by compression. As the correlation between HPV and GCA development grew stronger, the majority of the Authors came to the conclusion that HPV can not only cause CA but, associated with particular risk factors, it can lead to much more serious conditions such as BLT...
2018: Annali Italiani di Chirurgia
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