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Transcranial alternating current

Kate E Hoy, Susan McQueen, David Elliot, Sally Herring, Jerome J Maller, Paul B Fitzgerald
Depression following a Traumatic Brain Injury (TBI) is common and difficult to treat using standard approaches. The current study investigated, for the first time, Transcranial Magnetic Stimulation for the treatment of post TBI depression. We specifically assessed the safety, tolerability and efficacy of TMS in this patient population. We also explored cognitive outcomes. 21 patients with a current episode of major depression subsequent to a TBI participated in a randomized double blind placebo controlled trial of rTMS...
February 2, 2019: Journal of Neurotrauma
Thanuja Dharmadasa, José M Matamala, James Howells, Neil G Simon, Steve Vucic, Matthew C Kiernan
PURPOSE: Clinical application of transcranial magnetic stimulation (TMS) has rapidly increased but the majority of studies have targeted upper limb muscles, with few exploring the lower-limb. Differences of coil choice have added to methodological difficulties of lower-limb studies and have challenged consistent interpretation of these parameters. The aims of this study were to determine the optimal coil choice for assessing lower-limb cortical excitability and assess laterality of normal cortical function...
January 30, 2019: Neuroscience Letters
Monika Bender, Vincenzo Romei, Paul Sauseng
Recent research suggests alteration of visual working memory capacity by modulation of parietal theta frequency via transcranial alternating current stimulation (tACS). However, it remains to be clarified whether this effect is partly driven by co-stimulation of prefrontal cortex and subcortical structures. It was hypothesized that focal tACS over the parietal lobe without additional prefrontal or subcortical stimulation should lead to similar effects as reported in the literature. Healthy, young participants were tested on a visual working memory paradigm while receiving either focal parietal tACS at 4 Hz, at 7 Hz or sham stimulation...
January 29, 2019: Brain Topography
Joan M Stilling, Oury Monchi, Farnaz Amoozegar, Chantel T Debert
BACKGROUND: Headache is among the most prevalent causes of disability worldwide. Non-pharmacologic interventions, including neuromodulation therapies, have been proposed in patients who are treatment resistant or intolerant to medications. OBJECTIVE: To perform a systematic review on the use of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for the treatment of specific headache disorders (ie, migraine, tension, cluster, posttraumatic)...
January 23, 2019: Headache
Boateng Asamoah, Ahmad Khatoun, Myles Mc Laughlin
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that the current reaching the cortex may not be strong enough to entrain neural activity. Here, we propose a new hypothesis to reconcile these opposing results: tACS effects are caused by transcutaneous stimulation of peripheral nerves in the skin and not transcranial stimulation of cortical neurons...
January 17, 2019: Nature Communications
Siddharth Kohli, Alexander J Casson
Transcranial electrical stimulation is a widely used non-invasive brain stimulation approach. To date, EEG has been used to evaluate the effect of transcranial Direct Current Stimulation (tDCS) and transcranial Alternating Current Stimulation (tACS), but most studies have been limited to exploring changes in EEG before and after stimulation due to the presence of stimulation artifacts in the EEG data. This paper presents two different algorithms for removing the gross tACS artifact from simultaneous EEG recordings...
January 7, 2019: Sensors
Monica B Berntsen, Nicholas R Cooper, Gethin Hughes, Vincenzo Romei
Cortical activity in frontal, parietal, and motor regions during sequence observation correlates with performance on sequence reproduction. Increased cortical activity observed during observation has therefore been suggested to represent increased learning. Causal relationships have been demonstrated between M1 and motor sequence reproduction and between parietal cortex and bimanual learning. However, similar effects have not been reported for frontal regions despite a number of reports implicating its involvement in encoding of motor sequences...
December 19, 2018: Behavioural Brain Research
Francis O'Neill, Paul Sacco, Eleanor Bowden, Rebecca Asher, Girvan Burnside, Trevor Cox, Turo Nurmikko
Background: Successful response to repetitive transcranial magnetic stimulation (rTMS) of the motor cortex requires continued maintenance treatments. Transcranial Direct Current Stimulation (tDCS) may provide a more convenient alternative. Methods: This pilot study aimed to examine the feasibility of a randomized, double-blind, double-crossover pilot study for patients to self-administer tDCS motor cortex stimulation for 20 minutes/day over five consecutive days...
2018: Journal of Pain Research
Caroline Di Bernardi Luft, Ioanna Zioga, Nicholas M Thompson, Michael J Banissy, Joydeep Bhattacharya
Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way for accessing more remote ideas. In the first experiment, participants completed the compound remote associate task (RAT) in three separate sessions: during right temporal alpha (10 Hz) transcranial alternating current brain stimulation (tACS), left temporal alpha tACS, and sham tACS...
December 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
Aaron P Jones, Jaehoon Choe, Natalie B Bryant, Charles S H Robinson, Nicholas A Ketz, Steven W Skorheim, Angela Combs, Melanie L Lamphere, Bradley Robert, Hope A Gill, Melissa D Heinrich, Michael D Howard, Vincent P Clark, Praveen K Pilly
Sleep is critically important to consolidate information learned throughout the day. Slow-wave sleep (SWS) serves to consolidate declarative memories, a process previously modulated with open-loop non-invasive electrical stimulation, though not always effectively. These failures to replicate could be explained by the fact that stimulation has only been performed in open-loop, as opposed to closed-loop where phase and frequency of the endogenous slow-wave oscillations (SWOs) are matched for optimal timing. The current study investigated the effects of closed-loop transcranial Alternating Current Stimulation (tACS) targeting SWOs during sleep on memory consolidation...
2018: Frontiers in Neuroscience
Matt Craddock, Ekaterini Klepousniotou, Wael El-Deredy, Ellen Poliakoff, Donna Lloyd
Ongoing, pre-stimulus oscillatory activity in the 8-13 Hz alpha range has been shown to correlate with both true and false reports of peri-threshold somatosensory stimuli. However, to directly test the role of such oscillatory activity in behaviour, it is necessary to manipulate it. Transcranial alternating current stimulation (tACS) offers a method of directly manipulating oscillatory brain activity using a sinusoidal current passed to the scalp. We tested whether alpha tACS would change somatosensory sensitivity or response bias in a signal detection task in order to test whether alpha oscillations have a causal role in behaviour...
December 5, 2018: International Journal of Psychophysiology
Véronique Desbeaumes Jodoin, Jean-Philippe Miron, Paul Lespérance
OBJECTIVE: Major depressive disorder (MDD) is a prevalent condition in older adults. Although antidepressant drugs are commonly prescribed, efficacy is variable, and older patients are more prone to side effects. Repetitive transcranial magnetic stimulation (rTMS) is an alternative therapy used increasingly in the treatment of MDD. Even though recent studies have shown efficacy of rTMS in elderly depressed patients, the safety and efficacy of accelerated rTMS has not been studied in this population...
November 2, 2018: American Journal of Geriatric Psychiatry
Alessia Gallucci, Pedro H Lucena, Géraldine Martens, Aurore Thibaut, Felipe Fregni
Opioid misuse leading to dependence is a major health issue. Recent studies explored valid alternatives to treat pain in postsurgical settings. This systematic review aims to discuss the role of transcranial direct current stimulation (tDCS) in preventing and treating postoperative pain and opioid dependence. PubMed and Embase databases were screened, considering studies testing tDCS effects on pain and opioid consumption in surgical settings and opioid addiction. Eight studies met our inclusion criteria...
December 5, 2018: Pain Management
Danielle D Sliva, Christopher J Black, Paul Bowary, Uday Agrawal, Juan F Santoyo, Noah S Philip, Benjamin D Greenberg, Christopher I Moore, Stephanie R Jones
The (8-12 Hz) neocortical alpha rhythm is associated with shifts in attention across sensory systems, and is thought to represent a sensory gating mechanism for the inhibitory control of cortical processing. The present preliminary study sought to explore whether alpha frequency transcranial alternating current stimulation (tACS) could modulate endogenous alpha power in the somatosensory system, and whether the hypothesized modulation would causally impact perception of tactile stimuli at perceptual threshold...
2018: Frontiers in Psychology
Anli Liu, Mihály Vöröslakos, Greg Kronberg, Simon Henin, Matthew R Krause, Yu Huang, Alexander Opitz, Ashesh Mehta, Christopher C Pack, Bart Krekelberg, Antal Berényi, Lucas C Parra, Lucia Melloni, Orrin Devinsky, György Buzsáki
Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals...
November 30, 2018: Nature Communications
Charles S H Robinson, Natalie B Bryant, Joshua W Maxwell, Aaron P Jones, Bradley Robert, Melanie Lamphere, Angela Combs, Hussein M Al Azzawi, Benjamin C Gibson, Joseph L Sanguinetti, Nicholas A Ketz, Praveen K Pilly, Vincent P Clark
BACKGROUND: Poor sleep quality is a common complaint, affecting over one third of people in the United States. While sleep quality is thought to be related to slow-wave sleep (SWS), there has been little investigation to address whether modulating slow-wave oscillations (SWOs) that characterize SWS could impact sleep quality. Here we examined whether closed-loop transcranial alternating current stimulation (CL-tACS) applied during sleep impacts sleep quality and efficiency. METHODS: CL-tACS was used in 21 participants delivered at the same frequency and in phase with endogenous SWOs during sleep...
November 22, 2018: Brain Sciences
Ignacio Jáuregui-Lobera, José V Martínez-Quiñones
Neuromodulation can affect the functioning of the central nervous system (CNS), and emotional/eating behavior is an exciting facet of that functioning. Therefore, it would be possible to offer an alternative (or complement) treatment to psychotropic medications and different psychological and nutritional approaches to both eating disorders (EDs) and obesity. Although there are a number of publications in these areas, a systematic review has not been conducted to date. Abstracts, letters, conference reports, dissertations, and reviews were excluded...
2018: Neuropsychiatric Disease and Treatment
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized by chronic inflammation, demyelination, synaptopathy and neurodegeneration. Patients may exhibit sensory, motor, cognitive, emotional and behavioral symptoms throughout their disease process. Nowadays, the challenge is to find optimal treatment for MS symptoms, especially that available pharmacological interventions are faced by modest therapeutic outcomes and numerous side effects. Thus, finding alternative strategies might be of help in this context...
December 2018: Neurodegenerative Disease Management
Suellen Marinho Andrade, Eliane Araújo de Oliveira, Nelson Torro Alves, Ana Cristina Gomes Dos Santos, Camila Teresa Ponce Leon de Mendonça, Danielle Dorand Amorim Sampaio, Edyllaine Elidy Querino Cavalcante da Silva, Égina Karoline Gonçalves da Fonsêca, Evelyn Thais de Almeida Rodrigues, Gabriela Nayara Siqueira de Lima, Jamerson Carvalho, Jessyca Alves Silvestre da Silva, Manuella Toledo, Marine Raquel Diniz da Rosa, Marcia Queiroz de Carvalho Gomes, Melquisedek Monteiro de Oliveira, Moema Teixeira Maia Lemos, Nágylla Gomes Lima, Penha Inácio, Petra Maria da Cruz Ribeiro E Rodrigues, Rayssa Gabriela Dantas Ferreira, Renata Cavalcante, Renata Emanuela Lyra de Brito Aranha, Regina Neves, Rodrigo Marmo da Costa E Souza, Thainá Magalhães Portugal, Wanessa Kallyne Nascimento Martins, Vivian Pontes, Thiago Monteiro de Paiva Fernandes, Israel Contador, Bernardino Fernández-Calvo
Despite advances in the treatment of Alzheimer's disease (AD), there is currently no prospect of a cure, and evidence shows that multifactorial interventions can benefit patients. A promising therapeutic alternative is the use of transcranial direct current stimulation (tDCS) simultaneously with cognitive intervention. The combination of these non-pharmacological techniques is apparently a safe and accessible approach. This study protocol aims to compare the efficacy of tDCS and cognitive intervention in a double-blind, randomized and factorial clinical trial...
2018: Frontiers in Aging Neuroscience
Shota Miyaguchi, Naofumi Otsuru, Sho Kojima, Hirotake Yokota, Kei Saito, Yasuto Inukai, Hideaki Onishi
Transcranial alternating current stimulation (tACS) modulates neural connectivity in the cortical area under the electrodes. Although gamma tACS over the M1 and the cerebellar hemisphere has been shown to improve motor performance, the details of this effect remain unclear. This study aimed to clarify whether the effect of gamma tACS over the M1 and the cerebellar hemisphere is a phase-specific. We applied tACS at 70 Hz over the left M1 and the right cerebellar hemisphere to 20 healthy adults while they performed a visuomotor control task using their right index finger for 30 s...
November 13, 2018: Neuroscience Letters
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