Jonathan P Sturgeon, Joice Tome, Cherlynn Dumbura, Florence D Majo, Deophine Ngosa, Kuda Mutasa, Kanekwa Zyambo, Ellen Besa, Kanta Chandwe, Chanda Kapoma, Benjamin Mwapenya, Kusum J Nathoo, Claire D Bourke, Robert Ntozini, Bernard Chasekwa, Melanie Smuk, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Paul Kelly, Andrew J Prendergast
Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge mortality, especially in children with comorbidities such as HIV; however, the underlying pathogenesis of complicated SAM is poorly understood. Targeted multiplex biomarker analysis in children hospitalized with SAM ( n = 264) was conducted on plasma samples, and inflammatory markers were assessed on stool samples taken at recruitment, discharge, and 12 to 24 and 48 weeks after discharge from three hospitals in Zimbabwe and Zambia...
February 28, 2024: Science Translational Medicine