keyword
https://read.qxmd.com/read/38127284/acetylation-of-foxo1-activates-bim-expression-involved-in-cvb3-induced-cardiomyocyte-apoptosis
#1
JOURNAL ARTICLE
Yanan Hu, Lu Yi, Yeyi Yang, Zhixiang Wu, Min Kong, Zhijuan Kang, Zuocheng Yang
Viral myocarditis (VMC) is the major reason for sudden cardiac death among both children and young adults. Of these, coxsackievirus B3 (CVB3) is the most common causative agent of myocarditis. Recently, the role of signaling pathways in the pathogenesis of VMC has been evaluated in several studies, which has provided a new perspective on identifying potential therapeutic targets for this hitherto incurable disease. In the present study, in vivo and in vitro experiments showed that CVB3 infection leads to increased Bim expression and triggers apoptosis...
December 21, 2023: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/36999403/tropisetron-restores-normal-expression-of-bad-sirt1-sirt3-and-sirt7-in-the-rat-pressure-overload-induced-cardiac-hypertrophy-model
#2
JOURNAL ARTICLE
Alireza Karimollah, Anahid Hemmatpur, Fatemeh Safari, Mahsa Fakhrgholami, Tina Travat
Tropisetron exerts a protective effect against cardiac complications, particularly cardiac hypertrophy. Oxidative stress and apoptosis are the main contributors to the pathogenesis of cardiac hypertrophy. Sirtuins, a family of histone deacetylases, are connected to cellular oxidative stress signaling and antioxidant defense. Sirtuins are also linked to apoptosis which is an important mechanism in the progression of cardiac hypertrophy to heart failure. Literature also suggests that tropisetron impedes apoptosis, partly mediated through an antioxidant mechanism...
March 31, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/36322712/polysulfide-protects-against-diabetic-cardiomyopathy-through-sulfhydration-of-ppar%C3%AE-and-sirt-3
#3
JOURNAL ARTICLE
Siping Xiong, Haijian Sun, Xu Cao, Zhi-Yuan Wu, Mengyuan Zhu, Lei Cao, Xiaowei Nie, Jinsong Bian
AIMS: Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and heart failure. However, the effective therapy for DCM is still lacking. Polysulfide contains chains of sulfur atoms, and accumulative evidences have shown that it actively participates in mammalian physiology or pathophysiology. Nevertheless, the potential effects and mechanisms of polysulfide in DCM need further investigation. In the present study, Na2S4, a polysulfide donor, was employed to investigate the therapeutic effects of polysulfide in DCM...
November 2, 2022: Antioxidants & Redox Signaling
https://read.qxmd.com/read/35921947/doxorubicin-induced-cardio-toxicity-through-sirtuins-mediated-mitochondrial-disruption
#4
REVIEW
Nisar Ahmad, Arfan Ullah, Peng Chu, Wenzhang Tian, Zeyao Tang, Zhaolin Sun
The chemotherapeutic drug Doxorubicin is the most commonly prescribed in the world. However, its clinical wide application is limited due to harmful side effects like cardiotoxicity. The cardiotoxic mechanism of DOX is not fully clear, however, it is considered as a potential etiological factor to the generation of ROS and Iron complexes, impairment, Ca2 ⁺homeostasis, mitochondrial dysfunction, and cell membrane damage. Moreover, it is generally believed that mitochondrial dysfunction plays a central role in the cardiotoxic effect of DOX...
July 31, 2022: Chemico-biological Interactions
https://read.qxmd.com/read/35656292/potential-role-of-lisinopril-in-reducing-atherosclerotic-risk-evidence-of-an-antioxidant-effect-in-human-cardiomyocytes-cell-line
#5
JOURNAL ARTICLE
Lucia Scisciola, Rosaria Anna Fontanella, Surina, Giovanna Garofalo, Maria Rosaria Rizzo, Giuseppe Paolisso, Michelangela Barbieri
The cellular mechanisms involved in myocardial ischemia/reperfusion injury (I/R) pathogenesis are complex but attributable to reactive oxygen species (ROS) production. ROS produced by coronary endothelial cells, blood cells (e.g., leukocytes and platelets), and cardiac myocytes have the potential to damage vascular cells directly and cardiac myocytes, initiating mechanisms that induce apoptosis, inflammation, necrosis, and fibrosis of myocardial cells. In addition to reducing blood pressure, lisinopril, a new non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor, increases the antioxidant defense in animals and humans...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35080993/effects-of-chronic-intermittent-hypoxia-on-left-cardiac-function-in-young-and-aged-mice
#6
JOURNAL ARTICLE
Qin Wei, Xuan Xu, Long Chen, Tao Wang, Liang Xie, Fu-Chao Yu, Si-Fan Song, Zhi-Qiang Sheng, Jia-Yi Tong
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease that is characterized by chronic intermittent hypoxia (CIH), and its impact is related to age. This study aims to assess the age-related impact of CIH on cardiac function and to further explore the mechanism. After 8 wk of severe CIH exposure, the hearts of young mice showed slight physiological hypertrophy, decreased diastolic function, and collagen I accumulation but no obvious change in contractile function. However, the contractile function of the hearts of aged mice was severely decreased...
March 1, 2022: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/34630972/autophagy-stimulation-delayed-biological-aging-and-decreased-cardiac-differentiation-in-rabbit-mesenchymal-stem-cells
#7
JOURNAL ARTICLE
Mehdi Hassanpour, Omid Cheraghi, Reza Rahbarghazi, Mohammad Nouri
Introduction: Cardiovascular disease (CVD) is a type of disease that affects the function of cardiac-vascular tissues. This study aimed to consider the possible effects of autophagy, as an intrinsic catabolic pathway of cells, on the differentiation and aging process of mesenchymal stem cells (MSCs). Methods: In this study, bone marrow-derived MSCs were obtained from rabbit bone marrow aspirates. The stemness feature was confirmed by using flow cytometry analysis Cells at passage three were treated with 50 μM Metformin and 15μM hydroxychloroquine (HCQ) for 72 hours...
2021: Journal of Cardiovascular and Thoracic Research
https://read.qxmd.com/read/34405591/muscle-specific-sirtuin-3-overexpression-does-not-attenuate-the-pathological-effects-of-high-fat-high-sucrose-feeding-but-does-enhance-cardiac-serca2a-activity
#8
JOURNAL ARTICLE
Christopher J Oldfield, Teri L Moffatt, Kimberley A O'Hara, Bo Xiang, Vernon W Dolinsky, Todd A Duhamel
Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+ ) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca2+ in cardiomyocytes. SERCA2a is altered by diet and acetylation, independently; however, it is unknown if diet alters cardiac SERCA2a acetylation. Sirtuin (SIRT) 3 is an enzyme that might preserve health under conditions of macronutrient excess by modulating metabolism via regulating deacetylation of target proteins. Our objectives were to determine if muscle-specific SIRT3 overexpression attenuates the pathological effects of high fat-high sucrose (HFHS) feeding and if HFHS feeding alters cardiac SERCA2a acetylation...
August 2021: Physiological Reports
https://read.qxmd.com/read/33155221/using-ultrasound-three-dimensional-speckle-tracking-technology-to-explore-the-role-of-sirt1-in-ventricular-remodeling-after-myocardial-infarction
#9
JOURNAL ARTICLE
Y Wang, H-F Hu, H-L Liu, H Li, C Feng, J-J Deng, L Li, D-D Zhou
OBJECTIVE: To investigate the role of SIRT1 in ventricular remodeling after myocardial infarction using ultrasound three-dimensional speckle tracking (3D-STI). PATIENTS AND METHODS: Fifty-eight patients with acute myocardial infarction diagnosed in the Second Affiliated Hospital of Qiqihar Medical College from June 2015 to July 2017 were enrolled in the study. They were divided into ventricular remodeling group and ventricular non-remodeling group. Fifty-eight healthy people underwent physical examination were controls...
October 2020: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/33073318/dpp-4-inhibitor-induces-fgf21-expression-via-sirtuin-1-signaling-and-improves-myocardial-energy-metabolism
#10
JOURNAL ARTICLE
Nozomi Furukawa, Norimichi Koitabashi, Hiroki Matsui, Hiroaki Sunaga, Yogi Umbarawan, Mas Rizky A A Syamsunarno, Aiko Yamaguchi, Masaru Obokata, Hirofumi Hanaoka, Tomoyuki Yokoyama, Masahiko Kurabayashi
Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac performance under pressure overload. Mice were treated with either vehicle or vilda, followed by transverse aortic constriction (TAC). After 3 weeks of TAC, cardiac hypertrophy and impairment of systolic function were attenuated in vilda-treated mice. Pressure-volume analysis showed that vilda treatment significantly improved left-ventricular contractile efficiency in TAC heart...
January 2021: Heart and Vessels
https://read.qxmd.com/read/32986958/circadian-mutant-mice-with-obesity-and-metabolic-syndrome-are-resilient-to-cardiovascular-disease
#11
JOURNAL ARTICLE
Cristine J Reitz, Faisal J Alibhai, Bruna Gazzi de Lima-Seolin, Ashley Nemec-Bakk, Neelam Khaper, Tami A Martino
Obesity and metabolic syndrome commonly underlie cardiovascular disease. ClockΔ19/Δ19 mice fed a normal diet develop obesity and metabolic syndrome; however, it is not known whether they develop or are resilient to cardiovascular disease. We found that ClockΔ19/Δ19 mice do not develop cardiac dysfunction, despite their underlying conditions. Moreover, in contrast to wild-type controls fed a high-fat diet (HFD), ClockΔ19/Δ19 HFD mice still do not develop cardiovascular disease. Indeed, ClockΔ19/Δ19 HFD mice have preserved heart weight despite their obesity, no cardiomyocyte hypertrophy, and preserved heart structure and function, even after 24 wk of a HFD...
November 1, 2020: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/32105749/glycyrrhiza-glabra-licorice-root-extract-attenuates-doxorubicin-induced-cardiotoxicity-via-alleviating-oxidative-stress-and-stabilising-the-cardiac-health-in-h9c2-cardiomyocytes
#12
JOURNAL ARTICLE
Shishir Upadhyay, Anil K Mantha, Monisha Dhiman
ETHNOPHARMACOLOGICAL RELEVANCE: Doxorubicin (DOX) is an effective anti-neoplastic drug, however; it has downside effects on cardiac health and other vital organs. The herbal remedies used in day to day life may have a beneficial effect without disturbing the health of the vital organs. Glycyrrhiza glabra L. is a ligneous perennial shrub belonging to Leguminosae/Fabaceae/Papilionaceae family growing in Mediterranean region and Asia and widespread in Turkey, Italy, Spain, Russia, Syria, Iran, China, India and Israel...
February 24, 2020: Journal of Ethnopharmacology
https://read.qxmd.com/read/31636805/stimulation-of-na-k-atpase-with-an-antibody-against-its-4-th-extracellular-region-attenuates-angiotensin-ii-induced-h9c2-cardiomyocyte-hypertrophy-via-an-ampk-sirt3-ppar-%C3%AE-signaling-pathway
#13
JOURNAL ARTICLE
Siping Xiong, Hai-Jian Sun, Lei Cao, Mengyuan Zhu, Tengteng Liu, Zhiyuan Wu, Jin-Song Bian
Activation of the renin-angiotensin system (RAS) contributes to the pathogenesis of cardiovascular diseases. Sodium potassium ATPase (NKA) expression and activity are often regulated by angiotensin II (Ang II). This study is aimed at investigating whether DR-Ab, an antibody against 4th extracellular region of NKA, can protect Ang II-induced cardiomyocyte hypertrophy. Our results showed that Ang II treatment significantly reduced NKA activity and membrane expression. Pretreatment with DR-Ab preserved cell size in Ang II-induced cardiomyopathy by stabilizing the plasma membrane expression of NKA and restoring its activity...
2019: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/31046448/resveratrol-attenuates-cardiomyocyte-apoptosis-in-rats-induced-by-coronary-microembolization-through-sirt1-mediated-deacetylation-of-p53
#14
JOURNAL ARTICLE
Qing Mao, Xiulin Liang, Yufu Wu, Yongxiang Lu
OBJECTIVE: Coronary microembolization (CME)-induced cardiomyocyte apoptosis is the primary factor in causing cardiac dysfunction. Resveratrol (RES) is known to play a protective role in a variety of cardiovascular diseases, yet it is not known whether RES has a protective role in CME. Therefore, the effect of RES on cardiomyocyte apoptosis and cardiac function damage which are induced by CME in rats was investigated in this study. METHODS: Fifty Sprague-Dawley rats were separated into 5 groups randomly (10 rats were included in each): sham group, CME group, RES+CME group, RES+CME+Sirtuin-1 (SIRT-1) inhibitor EX527 (RES+CME+EX) group, and CME+EX group...
May 2, 2019: Journal of Cardiovascular Pharmacology and Therapeutics
https://read.qxmd.com/read/29849892/short-duration-swimming-exercise-after-myocardial-infarction-attenuates-cardiac-dysfunction-and-regulates-mitochondrial-quality-control-in-aged-mice
#15
JOURNAL ARTICLE
Dajun Zhao, Yang Sun, Yanzhen Tan, Zhengbin Zhang, Zuoxu Hou, Chao Gao, Pan Feng, Xing Zhang, Wei Yi, Feng Gao
Background: Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear. Methods and Results: 18-Month-old mice after stable MI were randomly submitted to different durations of exercise, including 15 and 60 min swimming training (ST) once per day, five times a week for 8 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/29532856/sirt3-deficiency-exacerbates-p53-parkin%C3%A2-mediated-mitophagy-inhibition-and-promotes-mitochondrial-dysfunction-implication-for-aged-hearts
#16
JOURNAL ARTICLE
Yan Li, Ying Ma, Liqiang Song, Lu Yu, Le Zhang, Yingmei Zhang, Yuan Xing, Yue Yin, Heng Ma
Mitochondrial dynamics have critical roles in aging, and their impairment represents a prominent risk factor for myocardial dysfunction. Mitochondrial deacetylase sirtuin (SIRT)3 contributes greatly to the prevention of redox stress and cell aging. The present study explored the role of SIRT3 on myocardium aging. Western blot analysis demonstrated that SIRT3 expression levels were significantly lower in the myocardia of aged mice compared with young mice. Immunoprecipitation and western blot assays indicated that the activity of mitochondrial manganese superoxide dismutase (MnSOD) and peroxisome proliferator‑activated receptor γ coactivator (PGC)‑1α was reduced in the aged heart...
June 2018: International Journal of Molecular Medicine
https://read.qxmd.com/read/28503736/hydrogen-sulfide-pretreatment-improves-mitochondrial-function-in-myocardial-hypertrophy-via-a-sirt3-dependent-manner
#17
JOURNAL ARTICLE
Guoliang Meng, Jieqiong Liu, Shangmin Liu, Qiuyi Song, Lulu Liu, Liping Xie, Yi Han, Yong Ji
BACKGROUND AND PURPOSE: Hydrogen sulfide (H2 S) is a gaseous signal molecule with antioxidative properties. Sirtuin 3 (SIRT3) is closely associated with mitochondrial function and oxidative stress. The study was to investigate whether and how H2 S improved myocardial hypertrophy via a SIRT3-dependent manner. EXPERIMENTAL APPROACH: Neonatal rat cardiomyocytes were pretreated with NaHS (50 μM) for 4 h followed by angiotensin II (Ang II, 100 nM) for 24 h. SIRT3 was silenced with siRNA technology...
April 2018: British Journal of Pharmacology
https://read.qxmd.com/read/27634872/mitochondrial-aldehyde-dehydrogenase-obliterates-insulin-resistance-induced-cardiac-dysfunction-through-deacetylation-of-pgc-1%C3%AE
#18
JOURNAL ARTICLE
Nan Hu, Jun Ren, Yingmei Zhang
Insulin resistance contributes to the high prevalence of type 2 diabetes mellitus, leading to cardiac anomalies. Emerging evidence depicts a pivotal role for mitochondrial injury in oxidative metabolism and insulin resistance. Mitochondrial aldehyde dehydrogenase (ALDH2) is one of metabolic enzymes detoxifying aldehydes although its role in insulin resistance remains elusive. This study was designed to evaluate the impact of ALDH2 overexpression on insulin resistance-induced myocardial damage and mechanisms involved with a focus on autophagy...
November 22, 2016: Oncotarget
https://read.qxmd.com/read/26053177/resveratrol-upregulates-cardiac-sdf-1-in-mice-with-acute-myocardial-infarction-through-the-deacetylation-of-cardiac-p53
#19
JOURNAL ARTICLE
Wang Hong, Shimosawa Tatsuo, Wang Shou-Dong, Zhang Qian, Hou Jian-Feng, Wang Jue, Jin Chen, Qian Hai-Yan, Yang Yue-Jin
AIMS: We previously demonstrated that resveratrol (RSV) administration causes cardiac stromal cell-derived factor (SDF)-1 upregulation and can enhance the mobilization of stem cells in mice with acute myocardial infarction (AMI). However, the upstream signal transduction involved in SDF-1 regulation in the setting of AMI and RSV administration remains unclear. Because RSV is a sirtuin 1 (SIRT1) activator and SIRT proteins act as deacetylases, we investigated the role of SIRT1 in SDF-1 upregulation and its subsequent effects...
2015: PloS One
https://read.qxmd.com/read/25975092/high-dose-of-epigallocatechin-3-gallate-inhibits-proliferation-and-induces-apoptosis-of-h9c2-cardiomyocytes-through-down-regulation-of-sirt1
#20
JOURNAL ARTICLE
Yi Cai, Li Zhao, Yuan Qin, Yanhuan He
BACKGROUND: Previous studies have suggested that high doses of (-)-epigallocatechin-3-gallate (EGCG) can induce toxicity in the liver, kidneys, and intestine. However, there have been no reports of myocardiotoxicity following treatment with EGCG. In this study, we investiged the proliferation and apoptosis of H9C2 cardiomyocytes treated with high dose of EGCG. METHODS: Cell proliferation was measured by CCK8 assay, cell apoptosis rate was evaluated by TUNEL assay, and the expression alterations of Sirtuin 1 (SIRT1) protein was detected by Western blotting...
January 2015: Die Pharmazie
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