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Cristian Del Bo', Mirko Marino, Daniela Martini, Massimiliano Tucci, Salvatore Ciappellano, Patrizia Riso, Marisa Porrini
The Mediterranean diet (MD) is characterized by high consumption of fruits, vegetables, cereals, potatoes, poultry, beans, nuts, lean fish, dairy products, small quantities of red meat, moderate alcohol consumption, and olive oil. Most of these foods are rich sources of bioactive compounds which may play a role in the protection of oxidative stress including DNA damage. The present review provides a summary of the evidence deriving from human intervention studies aimed at evaluating the impact of Mediterranean diet on markers of DNA damage, DNA repair, and telomere length...
February 13, 2019: Nutrients
Katarzyna Śliżewska, Bożena Cukrowska, Stefania Smulikowska, Joanna Cielecka-Kuszyk
The aim of the study was to investigate the toxic effects of aflatoxin B₁ (AFB₁) and efficacy of a probiotic preparation containing L. reuteri , L. plantarum , L. pentosus , L. rhamnosus and L. paracasei and Saccharomyces cerevisiae yeasts to ameliorate their effects in broiler chickens. A total of 168 one-day-old female Ross 308 broilers were randomly allocated to six groups. Three wheat and soybean meal-based diets were prepared: Control diet and diets contaminated with 1 or 5 mg/kg AFB₁ supplied in moldy wheat...
February 13, 2019: Toxins
Elisa Anleu, Marcela Reyes, Marcela Araya B, Marcela Flores, Ricardo Uauy, María Luisa Garmendia
OBJECTIVE: Evaluate if an intervention based on nutritional counseling decreases total sugars and energy consumption in overweight and obese pregnant women, compared to their previous consumption and compared to women who only received routine counseling. METHODS: Randomized study of two groups: dietary counseling (Intervention Group: IG) and routine counseling (Control Group: CG). The intervention consisted of three educational sessions focused on decreasing intake of foods that most contribute to sugars consumption...
February 13, 2019: Nutrients
Rachelle Annechino, Tamar M J Antin
Research suggests that many people in the US are misinformed about the relative harms of various tobacco and nicotine products. Concerns about public misinformation have often been framed as relevant only to the degree that public health institutions agree to prioritize conventional approaches to tobacco harm reduction. We argue that while the information priorities of public health professionals are important, ethical and credible information sharing also requires consideration of broader issues related to public trust...
February 13, 2019: International Journal of Environmental Research and Public Health
Lewis McDonald, Fredrik P Glasser, Mohammed S Imbabi
The production of Portland cement accounts for approximately 7% of global anthropogenic CO₂ emissions. Carbon CAPture and CONversion (CAPCON) technology under development by the authors allows for new methods to be developed to offset these emissions. Carbon-negative Precipitated Calcium Carbonate (PCC), produced from CO₂ emissions, can be used as a means of offsetting the carbon footprint of cement production while potentially providing benefits to cement hydration, workability, durability and strength...
February 13, 2019: Materials
Zhuo Chen, Dan Zhang, Jia-Jia Guo, Wei Tao, Rui-Xue Gong, Ling Yao, Xing-Long Zhang, Wei-Guo Cao
Hawk tea is a rich and edible resource, traditionally used as a beverage in South China. This drink has many pharmacologic effects, such as acting as an antioxidant and reducing blood sugar and lipids. The objective of this work was to explore the active compound contents, bioactivities and their monthly changes, and optimize the harvest time. In the present study, Hawk tea from each month in 2017 was collected and extracted with 70% ( v/v ) ethanol. The contents of the total flavonoids and total phenols were determined using the colorimetric method...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yumin Zhao, Weifeng Gui, Yishu Zhang, Gang Mo, Dayu Li, Shigui Chong
BACKGROUND: Heavy ion radiation has more advantages than traditional radiation therapy in the treatment of cancer, mainly because of its superior biological effects. However, there is currently no reliable evidence that heavy ion radiation can induce cell death in hydatid cysts at the cellular and molecular level. In addition, we believe heavy ion therapy could be a potential alternative approach for the treatment of hydatid cysts. METHODOLOGY/PRINCIPAL FINDING: The hydatid cysts and protoscolices were obtained from an experimentally infected KunMing mice...
February 18, 2019: Diseases (Basel)
Beata Hornik, Jan Duława, Czesław Marcisz, Wojciech Korchut, Jacek Durmała
Muscle activity during a hemodialysis procedure improves its efficacy. We have formulated a hypothesis that vibrations generated by a specially-designed dialysis chair can, the same as physical exercise, affect the filtering of various fluids between fluid spaces during the hemodialysis procedure. This prospective and interventional study included 21 dialyzed patients. During a single dialysis session, each patient used a prototype device with the working name "vibrating chair". The chair's drive used a low-power cage induction motor, which, along with the worm gear motor, was a part of the low-frequency (3...
February 18, 2019: International Journal of Environmental Research and Public Health
Ji Hye Han, Yong Sun Lee, Jun Hyung Im, Young Wan Ham, Hee Pom Lee, Sang Bae Han, Jin Tae Hong
Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidative stress and memory loss in lipopolysaccharide (LPS) administered mice model. Additionally, we investigated the anti-oxidant activity and the anti-neuroinflammatory response of AXT in LPS-treated BV-2 microglial cells...
February 18, 2019: Marine Drugs
Pattarapon Khemrattrakool, Jintana Yanola, Nongkran Lumjuan, Pradya Somboon
Many insect vector species of medical and veterinary importance are found abundantly in areas where animals are held. In these areas, they often rest for a period of time on objects around the animals both before and after blood feeding. However, the use of neurotoxic insecticides for vector control is not advised for use in such shelters as these chemicals can pose hazards to animals. The present study evaluated the efficacy of pyriproxyfen (PPF), an insect growth regulator, applied to polypropylene sheets and resting boxes on the reproductivity of mosquitoes found in animal shelters in Chiang Mai, Thailand...
February 18, 2019: Insects
Simona Manuguerra, Cristóbal Espinosa Ruiz, Andrea Santulli, Concetta Maria Messina
In the present study, we evaluated the effects of different concentrations of the polybrominated diphenyl ethers (PBDEs) BDE-209, BDE-47 and BDE-99, on the vitality and oxidative stress of a HS-68 human cell culture exposed to the compounds for three days. The results showed that for this exposure time, only the highest concentrations produced a significant vitality reduction and oxidative stress induction ( p < 0.05), measured as reactive oxygen species (ROS). Subsequently, in order to verify the effects of sub-lethal doses, cells were exposed for a longer time and data collected, after 12 and 20 days, to study ROS production and some molecular markers related to cell cycle and stress (p53, pRB, PARP, c-Jun and c-Fos), antioxidant status and proliferation (ERK, c-Jun and c-Fos), energy balance (NRF2, AMPK, HIF)...
February 18, 2019: International Journal of Environmental Research and Public Health
Xin Zhao, Minshu Du, Feng Liu
As the sole metal that could reduce CO₂ to substantial amounts of hydrocarbons, Cu plays an important role in electrochemical CO₂ reduction, despite its low energy efficiency. Surface morphology modification is an effective method to improve its reaction activity and selectivity. Different from the pretreated modification method, in which the catalysts self-reconstruction process was ignored, we present operando synthesis by simultaneous electro-dissolution and electro-redeposition of copper during the CO₂ electroreduction process...
February 17, 2019: Materials
Rosario Ferrer-Cascales, Natalia Albaladejo-Blázquez, Miriam Sánchez-SanSegundo, Irene Portilla-Tamarit, Oriol Lordan, Nicolás Ruiz-Robledillo
The increase in the prevalence of bullying and cyberbullying in recent years worldwide is undeniable. Although several intervention programs oriented towards the reduction of bullying and cyberbullying have been developed and implemented, significant disparities have been found regarding their efficacy. In most of the cases, the lack of the implementation of interventions involving all of the school community could be on the basis of this limited efficacy. The present study aimed to evaluate the effectiveness of the TEI Program, an intervention based on peer tutoring, in the reduction of bullying and cyberbullying, and in the improvement of school climate...
February 16, 2019: International Journal of Environmental Research and Public Health
Muhammad Jamshed Khan, Kamyar Shameli, Awis Qurni Sazili, Jinap Selamat, Suriya Kumari
Green synthesis of silver nanoparticles is desirable practice. It is not only the required technique for industrial and biomedical purposes but also a promising research area. The aim of this study was to synthesize green curcumin silver nanoparticles (C-Ag NPs). The synthesis of C-Ag NPs was achieved by reduction of the silver nitrate (AgNO₃) in an alkaline medium. The characterizations of the prepared samples were conducted by ultraviolet visible (UV-vis) spectroscopy, powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED) and zeta potential (ZP) analyses...
February 16, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
James Logue, Walter Vargas Licona, Timothy K Cooper, Becky Reeder, Russel Byrum, Jing Qin, Nicole Deiuliis Murphy, Yu Cong, Amanda Bonilla, Jennifer Sword, Wade Weaver, Gregory Kocher, Gene G Olinger, Peter B Jahrling, Lisa E Hensley, Richard S Bennett
Following the largest Ebola virus disease outbreak from 2013 to 2016, viral RNA has been detected in survivors from semen and breast milk long after disease recovery. However, as there have been few cases of sexual transmission, it is unclear whether every RNA positive fluid sample contains infectious virus. Virus isolation, typically using cell culture or animal models, can serve as a tool to determine the infectivity of patient samples. However, the sensitivity of these methods has not been assessed for the Ebola virus isolate, Makona...
February 16, 2019: Viruses
Hailong Lu, Lili Zhang, Jinxia Ma, Nur Alam, Xiaofan Zhou, Yonghao Ni
Metal⁻organic framework (MOF)-based derivatives are attracting increased interest in various research fields. In this study, nano-cellulose MOF-derived carbon-doped CuO/Fe₃O₄ nanocomposites were successfully synthesized via direct calcination of magnetic Cu-BTC MOF (HKUST-1)/Fe₃O₄/cellulose microfibril (CMF) composites in air. The morphology, structure, and porous properties of carbon-doped CuO/Fe₃O₄ nanocomposites were characterized using SEM, TEM, powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), and vibrating sample magnetometry (VSM)...
February 16, 2019: Nanomaterials
Hyun-Jong Jang, Ji-Eun Kim, Kyoung Hoon Jeong, Sung Chul Lim, Seong Yun Kim, Kyung-Ok Cho
Hericium erinaceus (HE), a culinary-medicinal mushroom, has shown therapeutic potential in many brain diseases. However, the role of HE in status epilepticus (SE)-mediated neuronal death and its underlying mechanisms remain unclear. We investigated the neuroprotective effects of HE using a pilocarpine-induced SE model. Male C57BL/6 mice received crude extracts of HE (60 mg/kg, 120 mg/kg, or 300 mg/kg, p.o.) for 21 d from 14 d before SE to 6 d after SE. At 7 d after SE, cresyl violet and immunohistochemistry of neuronal nuclei revealed improved hippocampal neuronal survival in animals treated with 60 mg/kg and 120 mg/kg of HE, whereas those treated with 300 mg/kg of HE showed similar neuronal death to that of vehicle-treated controls...
February 16, 2019: International Journal of Molecular Sciences
Rafal Kaminski, Marta Maksymowicz-Wleklik, Krzysztof Kulinski, Katarzyna Kozar-Kaminska, Agnieszka Dabrowska-Thing, Stanislaw Pomianowski
Meniscal tears are the most common orthopaedic injuries, with chronic lesions comprising up to 56% of cases. In these situations, no benefit with surgical treatment is observed. Thus, the purpose of this study was to investigate the effectiveness and safety of percutaneous intrameniscal platelet rich plasma (PRP) application to complement repair of a chronic meniscal lesion. This single centre, prospective, randomized, double-blind, placebo-controlled study included 72 patients. All subjects underwent meniscal trephination with or without concomitant PRP injection...
February 16, 2019: International Journal of Molecular Sciences
Mindaugas Stankunas, Snieguole Kaseliene, Akvile Girciene, Agis Tsouros, Mark Avery
BACKGROUND AND OBJECTIVES: In 2014⁻2017, the Lithuanian University of Health Sciences and partners implemented the project, 'Development of the Model for the Strengthening of the Capacities to Identify and Reduce Health Inequalities', which was financed by The Norwegian Financial Mechanism 2009⁻2014 Public Health Initiatives Program. One of objectives of this project was to increase the awareness about public health and related specialist knowledge and skills in the field of health inequalities...
February 15, 2019: Medicina
Waleed M Ismael, Mingsheng Gao, Asma A Al-Shargabi, Ammar Zahary
Due to the ever-increasing number and diversity of data sources, and the continuous flow of data that are inevitably redundant and unused to the cloud, the Internet of Things (IoT) brings several problems including network bandwidth, the consumption of network energy, cloud storage, especially for paid volume, and I/O throughput as well as handling huge amount of stored data in the cloud. These call for data pre-processing at the network edge before data transmission over the network takes place. Data reduction is a method for mitigating such problems...
February 15, 2019: Sensors
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