keyword
https://read.qxmd.com/read/38535880/operational-differences-between-product-development-partnership-pharmaceutical-industry-and-investigator-initiated-clinical-trials
#21
JOURNAL ARTICLE
Eric I Nebie, Peter van Eeuwijk, Hélène N Sawadogo, Elisabeth Reus, Jürg Utzinger, Christian Burri
Medicine development is a lengthy endeavour. Increasing regulatory stringency and trial complexity might lead to reduced efficiency, dwindled output, and elevated costs. However, alternative models are possible. We compared the operational differences between pharmaceutical industry sponsored trials, product development partnership trials, and investigator-initiated trials to identify key drivers of inefficiency in clinical research. We conducted an exploratory mixed-methods study with stakeholders, including clinical trial sponsors, contract research organisations, and investigators...
February 29, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535877/integrated-strategies-for-aedes-aegypti-control-applied-to-individual-houses-an-approach-to-mitigate-vectorial-arbovirus-transmission
#22
JOURNAL ARTICLE
Danielle Cristina Tenório Varjal de Melo, Eloína Maria de Mendonça Santos, Morgana Nascimento Xavier, Josimara do Nascimento, Victor Araújo Barbosa, André Luiz de Sá Oliveira, Marcos Vinícius Meiado, Maria Alice Varjal de Melo-Santos, Marcelo Henrique Santos Paiva, Gabriel da Luz Wallau, Cláudia Maria Fontes de Oliveira
Aedes aegypti and Culex quinquefasciatus mosquitoes are vectors of different arboviruses that cause a large burden of disease in humans worldwide. A key step towards reducing the impact of arboviruses on humans can be achieved through integrated mosquito surveillance and control approaches. We carried out an integrated approach of mosquito surveillance and control actions to reduce populations of these insects along with a viral surveillance in a neighborhood of Recife (Northeastern Brazil) with high mosquito densities and arbovirus transmission...
February 24, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535819/botulinum-toxin-for-pain-relief-in-cancer-patients-a-systematic-review-of-randomized-controlled-trials
#23
REVIEW
Lorenzo Lippi, Alessandro de Sire, Alessio Turco, Martina Ferrillo, Serdar Kesikburun, Alessio Baricich, Stefano Carda, Marco Invernizzi
Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers)...
March 15, 2024: Toxins
https://read.qxmd.com/read/38535759/angioid-streaks-remain-a-challenge-in-diagnosis-management-and-treatment
#24
REVIEW
Georgios Tsokolas, Charalambos Tossounis, Straton Tyradellis, Lorenzo Motta, Georgios D Panos, Theo Empeslidis
Aim : Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch's membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods : A literature search was performed using "PubMed", "Web of Science", "Scopus", "ScienceDirect", "Google Scholar", "medRxiv", and "bioRxiv...
March 5, 2024: Vision
https://read.qxmd.com/read/38535736/weekly-programming-of-hamstring-related-training-contents-in-european-professional-soccer
#25
JOURNAL ARTICLE
Pedro Gómez-Piqueras, Antonio Martínez-Serrano, Tomás T Freitas, Antonio Gómez Díaz, Irineu Loturco, Enric Giménez, Joao Brito, David García-López, Hernan Giuria, Paulino Granero-Gil, Shaun Huygaerts, Francesc Cos, Julio Calleja-González, Emmanuel Vallance, Eduardo Sáez de Villarreal, Pedro E Alcaraz
Hamstring injuries in soccer continue to be a challenge for professionals who work with soccer players daily. Although its origin is multifactorial, the proper management of neuromuscular fatigue during the training microcycle is a very important factor to consider. There are no clear guidelines regarding the weekly distribution of certain exercises that demand the hamstrings. The main objective of this study was to describe the usual training practices of professional European soccer teams. An international observational survey design was applied to some of the strength and conditioning coaches of professional soccer teams...
March 5, 2024: Sports
https://read.qxmd.com/read/38535716/interprofessional-paediatric-high-fidelity-simulation-training-a-mixed-methods-study-of-experiences-and-readiness-among-nursing-and-medical-students
#26
JOURNAL ARTICLE
Helmut Beichler, Simone Grandy, Silke Neumaier, Anneliese Lilgenau, Hannah Schwarz, Michael Wagner
BACKGROUND: Training in communication skills between nursing and medical students during interprofessional paediatric emergency simulation training represents a significant aspect of safe patient care. Evidence highlights that poor communication in paediatric emergency scenarios jeopardises patient safety. Through realistic simulations, students practice the communication strategies of crisis resource management (CRM), such as "closed-loop communication", "speaking up", and "team time-out"...
March 7, 2024: Nursing Reports
https://read.qxmd.com/read/38535715/the-rising-challenge-of-poor-health-literacy-of-patients-with-systemic-sclerosis-preliminary-data-identify-important-unmet-needs-in-an-italian-cohort
#27
JOURNAL ARTICLE
Khadija El Aoufy, Maria Ramona Melis, Paolo Iovino, Stefano Bambi, Chiara Lorini, Guglielmo Bonaccorsi, Ilaria Galetti, Carla Garbagnati, Paola Canziani, Silvia Tonolo, Marco Mitola, Serena Guiducci, Daniel E Furst, Marco Matucci-Cerinic, Laura Rasero, Silvia Bellando-Randone
RATIONALE AND AIM: Health literacy (HL) is pivotal for the successful self-management of chronic diseases. Little HL information is currently available in SSc patients; therefore, the present study aims at evaluating the HL levels in an Italian cohort of SSc patients. METHODS: SSc patients were enrolled with the support of Italian patient associations, from September 2022 to March 2023. Health literacy characteristics were derived from the Health Literacy Scale European Questionnaire-16 (HLS-EU-Q16), consisting of 16 items designed on a four-point Likert scale ranging from "very difficult" to "very easy", and three HL levels were identified: inadequate HL (0-8 score); problematic HL (9-12 score); and sufficient HL (13-16 score)...
March 5, 2024: Nursing Reports
https://read.qxmd.com/read/38535552/human-papillomavirus-hpv-infection-and-risk-behavior-in-vaccinated-and-non-vaccinated-paraguayan-young-women
#28
JOURNAL ARTICLE
María Liz Bobadilla, Verónica Villagra, Héctor Castro, Marta von Horoch, Soraya Araya, Gerardo Deluca, Vanessa Salete de Paula
Cervical cancer is a global health concern and ranks fourth among the most prevalent cancers in women worldwide. Human papillomavirus (HPV) infection is a known precursor of cervical cancer and preventive measures include prophylactic vaccines. This study focused on sexually active Paraguayan women aged 18-25 years, exploring the intersection of HPV vaccination and sexual behavior. Among 254 participants, 40.9% received the Gardasil-4 vaccine, with no significant differences in sexual behavior between the vaccinated and unvaccinated sexually active groups...
February 27, 2024: Pathogens
https://read.qxmd.com/read/38535546/diagnosis-and-management-of-infections-in-patients-with-mendelian-susceptibility-to-mycobacterial-disease
#29
REVIEW
Aparna Dalvi, Umair Ahmed Bargir, Gita Natraj, Ira Shah, Manisha Madkaikar
The diagnosis and treatment of patients with mendelian susceptibility to mycobacterial disease (MSMD) pose consistent challenges due to the diverse infection spectrum observed in this population. Common clinical manifestations include Bacillus Calmette-Guérin vaccine (BCG) complications in countries where routine BCG vaccination is practiced, while in non-BCG-vaccinating countries, Non-Tuberculous Mycobacteria (NTM) is prevalent. In tuberculosis-endemic regions, Mycobacterium tuberculosis (MTB) has a high prevalence, along with other intracellular organisms...
February 25, 2024: Pathogens
https://read.qxmd.com/read/38535516/two-versus-three-infusion-regimens-of-n-acetylcysteine-for-acetaminophen-overdose
#30
JOURNAL ARTICLE
Shadi Tamur, Bader Alyahya, Faisal Alsani, Ammar Abdulraheem Bahauddin, Maryam Aljaid, Sultan Al-Malki, Ahmad Alzahrani, Abdullah Khayat, Anwar Shams, Dominic S Chalut
BACKGROUND: Acetaminophen overdose is a common clinical condition, often leading to liver toxicity. Current treatments involve the three-infusion N-Acetylcysteine (NAC) regimen (FDA-labeled), which may be complex, time-consuming, and need to be changed. An alternative uses two infusions instead, which offers possible advantages regarding simplicity and administration errors. This study sought to compare the respective efficacies and safety outcomes when treating acute acetaminophen overdose among children and adolescents...
March 20, 2024: Pediatric Reports
https://read.qxmd.com/read/38535464/algae-based-supplements-claiming-weight-loss-properties-authenticity-control-and-scientific-based-evidence-on-their-effectiveness
#31
JOURNAL ARTICLE
Fátima Fernandes, Raquel Martins, Mariana Barbosa, Patrícia Valentão
The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L...
March 5, 2024: Marine Drugs
https://read.qxmd.com/read/38535429/translation-adaptation-and-validation-of-the-greek-version-of-the-kerlan-jobe-orthopaedic-clinic-shoulder-and-elbow-score-in-greek-overhead-athletes
#32
JOURNAL ARTICLE
Eleftherios Paraskevopoulos, Anna Christakou, Stefanos Karanasios, Amalia Panagiota Louka, George M Pamboris, Maria Papandreou
Athletes engaging in overhead activities often face injury risks, emphasising the need for reliable assessment tools. This study focused on the translation and psychometric evaluation of the Kerlan-Jobe Orthopaedic Clinic (KJOC) Shoulder and Elbow Score into Greek (Gr-KJOC) for assessing upper limb function in Greek-speaking overhead athletes. The Gr-KJOC underwent meticulous translation and adaptation processes, ensuring linguistic equivalence and cultural relevance. A sample of 60 athletes participated in the psychometric evaluation, including assessments of internal consistency, test-retest reliability, construct validity, and structural validity...
March 12, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535417/multimodal-rehabilitation-management-of-a-misunderstood-parsonage-turner-syndrome-a-case-report-during-the-covid-19-pandemic
#33
Fabio Santacaterina, Marco Bravi, Mirella Maselli, Federica Bressi, Silvia Sterzi, Sandra Miccinilli
During the second wave of the COVID-19 pandemic, a young adult presented symptoms that were reported at first evaluation to be a frozen shoulder (adhesive capsulitis). The patient's history, clinical manifestations related to the onset of pain, unilateral weakness, and physical examination led to a physiotherapy referral. Subsequent instrumental investigations showed an idiopathic brachial neuritis known as Parsonage-Turner Syndrome (PTS). Contrary to recent descriptions in the literature, the patient did not experience PTS either after COVID-19 vaccination or after COVID-19 virus infection...
February 23, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535399/monitoring-the-season-prevalence-relationship-of-vairimorpha-ceranae-in-honey-bees-apis-mellifera-over-one-year-and-the-primary-assessment-of-probiotic-treatment-in-taichung-taiwan
#34
JOURNAL ARTICLE
Yi-Hsuan Li, Yu-Hsin Chen, Fang-Min Chang, Ming-Cheng Wu, Yu-Shin Nai
Microsporidiosis, which is caused by the pathogen Vairimorpha ceranae , is a prevalent disease in the honey bee ( Apis mellifera ) and might lead to significant adult honey bee mortality. In this study, we conducted an annual survey of the mature spore load of V. ceranae in the guts of nurse bees and forager bees in the apiary of National Chung Hsing University (NCHU) in Taiwan. The results indicated that, on average, honey bees hosted approximately 2.13 × 106 mature spore counts (MSCs)/bee in their guts throughout the entire year...
March 19, 2024: Insects
https://read.qxmd.com/read/38535389/presence-of-multiple-genetic-mutations-related-to-insecticide-resistance-in-chinese-field-samples-of-two-phthorimaea-pest-species
#35
JOURNAL ARTICLE
Jiang Zhu, Ruipeng Chen, Juan Liu, Weichao Lin, Jiaxin Liang, Ralf Nauen, Suhua Li, Yulin Gao
Potatoes hold the distinction of being the largest non-cereal food crop globally. The application of insecticides has been the most common technology for pest control. The repeated use of synthetic insecticides of the same chemical class and frequent applications have resulted in the emergence of insecticide resistance. Two closely related pests that feed on potato crops are the potato tuber moth, Phthorimaea operculella , and the tomato leafminer, Phthorimaea absoluta (syn. Tuta absoluta ). Previous studies indicated the existence of insecticide resistance to various classes of insecticides including organophosphates, carbamates, and pyrethroids in field populations of P...
March 14, 2024: Insects
https://read.qxmd.com/read/38535385/effects-of-various-nectar-and-pollen-plants-on-the-survival-reproduction-and-predation-of-neoseiulus-bicaudus
#36
JOURNAL ARTICLE
Yue Han, Wurigemu Lipeizhong, Xinqi Liang, Zhiping Cai, Weiru Liu, Jifei Dou, Yanhui Lu, Jianping Zhang, Shaoshan Wang, Jie Su
Neoseiulus bicaudus is a predatory mite species that could potentially be used for the biological control of spider mites and thrips. Floral resources can provide excellent habitats and abundant nutrients for natural enemies. The objective of this experiment was to evaluate the effects of eight floral resources on the longevity, fecundity, and predation ability of N. bicaudus . Among the considered plants, Cnidium monnieri led to the highest longevity (24 days) and fecundity (13.8 eggs) of N. bicaudus , while Tagetes erecta resulted in the lowest longevity (7 days) and fecundity (0...
March 13, 2024: Insects
https://read.qxmd.com/read/38535375/night-warming-has-mixed-effects-on-the-development-of-the-fall-armyworm-spodoptera-frugiperda-lepidoptera-noctuidae-in-southern-china
#37
JOURNAL ARTICLE
Yangcheng Xu, Haipeng Chi, Mingyue Shi, Zhaozhi Lu, Myron P Zalucki
The Fall Armyworm, Spodoptera frugiperda (Lepidoptera, Noctuidae), is a serious migratory pest. After invading China in 2019, the species was established as a year-round breeding population in most of the southern provinces. The area of winter maize in this region has been increasing due to the huge demand of fresh maize consumption, which is potentially at risk from this invasive pest, although the growth and development of S. frugiperda in the region's changing climate is unclear, particularly with rising temperatures at night...
March 7, 2024: Insects
https://read.qxmd.com/read/38535372/development-and-metabolomic-profiles-of-bactrocera-dorsalis-diptera-tephritidae-larvae-exposed-to-phytosanitary-irradiation-dose-in-hypoxic-environment-using-di-spme-gc-ms
#38
JOURNAL ARTICLE
Changyao Shan, Baishu Li, Li Li, Qun Liu, Hang Zou, Tao Liu
X-ray irradiation and modified atmospheres (MAs) provide eco-friendly, chemical-free methods for pest management. Although a low-oxygen atmospheric treatment improves the performance of some irradiated insects, its influence on the irradiation of quarantine insects and its impacts on pest control efficacy have yet to be investigated. Based on bioassay results, this study employed direct immersion solid-phase microextraction (DI-SPME) combined with gas chromatography-mass spectrometry (GC-MS) to determine metabolic profiles of late third-instar B...
March 6, 2024: Insects
https://read.qxmd.com/read/38535369/intergenerational-effects-of-sublethal-lambda-cyhalothrin-exposure-on-aphis-gossypii-glover-hemiptera-aphididae-reproduction-and-development
#39
JOURNAL ARTICLE
Yuepeng Qiu, Zhaorong Chen
Aphis gossypii Glover, a widespread insect, presents a substantial danger to global agriculture. Lambda-cyhalothrin is a pyrethroid insecticide that has been widely studied for its effects on arthropods. Studies have reported that sublethal doses of insecticides can produce various consequences on arthropod reproduction. Hence, the objective of this research was to examine the potential effects of a sublethal dose of lambda-cyhalothrin (LC30 , 1.15 mg/L) on A. gossypii , for which we created life tables and conducted qPCR analysis...
March 4, 2024: Insects
https://read.qxmd.com/read/38535347/biodiversity-and-spatiotemporal-variations-of-mecoptera-in-thailand-influences-of-elevation-and-climatic-factors
#40
JOURNAL ARTICLE
Theerapan Dokjan, Wesley J Bicha, Piyawan Suttiprapan, Bajaree Chuttong, Chun-I Chiu, Kittipat Aupalee, Atiporn Saeung, Chayanit Sulin, Wichai Srisuka
Ecological analyses of the small and lesser-known insect order Mecoptera in Thailand are presented. Specimens were collected monthly over a period of 12 consecutive months, using both Malaise and pan traps, from 29 sampling sites located in 18 national parks throughout Thailand. A total of 21 species in four genera were identified from 797 specimens, including Panorpa (1 species), Neopanorpa (18 species), Bittacus (1 species), and Terrobittacus (1 species), with the latter genus representing a new genus record to Thailand...
February 23, 2024: Insects
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