keyword
https://read.qxmd.com/read/37879792/tripterygium-hypoglaucum-extract-ameliorates-adjuvant-induced-arthritis-in-mice-through-the-gut-microbiota
#1
JOURNAL ARTICLE
Jianghui Hu, Jimin Ni, Junping Zheng, Yanlei Guo, Yong Yang, Cheng Ye, Xiongjie Sun, Hui Xia, Yanju Liu, Hongtao Liu
Traditionally, Tripterygium hypoglaucum (Levl.) Hutch (THH) are widely used in Chinese folk to treat rheumatoid arthritis (RA). This study aimed to investigate whether the anti-RA effect of THH is related with the gut microbiota. The main components of prepared THH extract were identified by HPLC-MS. C57BL/6 mice with adjuvant-induced arthritis (AIA) were treated with THH extract by gavage for one month. THH extract significantly alleviated swollen ankle, joint cavity exudation, and articular cartilage destruction in AIA mice...
October 2023: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/34642235/determination-of-potential-risk-characteristics-for-cauda-equina-compression-in-emergency-department-patients-presenting-with-atraumatic-back-pain-a-4-year-retrospective-cohort-analysis-within-a-tertiary-referral-neurosciences-centre
#2
JOURNAL ARTICLE
Michelle Angus, Carlos M Curtis-Lopez, Roberto Carrasco, Vicki Currie, Irfan Siddique, Daniel E Horner
OBJECTIVE: Atraumatic back pain is an increasingly common presentation to the ED. A minority of these cases will have significant structural pathology, resulting in acute cauda equina compression (CEC). Although clinicians often look for 'red flags' to identify potential CEC, the prognostic accuracy of these presenting symptoms and clinical examination findings is unclear. We sought to evaluate the accuracy of individual clinical features in a large cohort of ED patients with atraumatic backpain and reference standard imaging, for the diagnosis of CEC...
October 12, 2021: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/31682283/variants-of-accessory-pathways
#3
REVIEW
Kurt S Hoffmayer, Frederick T Han, David Singh, Melvin M Scheinman
Variant accessory pathways include atriofascicular, nodofascicular, nodoventricular, atrio-Hisian, and fasciculoventricular pathways. Atriofascicular pathways are the most common with others occurring rarely. The anatomical descriptions, electrocardiographic findings, electrophysiologic findings, and clincial manifestations are discussed.
January 2020: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/31341032/gnrh-antagonists-have-direct-inhibitory-effects-on-castration-resistant-prostate-cancer-via-intracrine-androgen-and-ar-v7-expression
#4
JOURNAL ARTICLE
Vito Cucchiara, Joy C Yang, Chengfei Liu, Hans H Adomat, Emma S Tomlinson Guns, Martin E Gleave, Allen C Gao, Christopher P Evans
Hormone therapy is currently the mainstay in the management of locally advanced and metastatic prostate cancer. Degarelix (Firmagon), a gonadotropin-releasing hormone (GnRH) receptor antagonist differs from luteinizing hormone-releasing hormone (LHRH) agonists by avoiding "testosterone flare" and lower follicle-stimulating hormone (FSH) levels. The direct effect of degarelix and leuprolide on human prostate cancer cells was evaluated. In LNCaP, C4-2BMDVR, and CWR22Rv1 cells, degarelix significantly reduced cell viability compared with the controls ( P ≤ 0...
October 2019: Molecular Cancer Therapeutics
https://read.qxmd.com/read/26262062/improving-hospital-wide-early-resource-allocation-through-machine-learning
#5
JOURNAL ARTICLE
Daniel Gartner, Rema Padman
The objective of this paper is to evaluate the extent to which early determination of diagnosis-related groups (DRGs) can be used for better allocation of scarce hospital resources. When elective patients seek admission, the true DRG, currently determined only at discharge, is unknown. We approach the problem of early DRG determination in three stages: (1) test how much a Naïve Bayes classifier can improve classification accuracy as compared to a hospital's current approach; (2) develop a statistical program that makes admission and scheduling decisions based on the patients' clincial pathways and scarce hospital resources; and (3) feed the DRG as classified by the Naïve Bayes classifier and the hospitals' baseline approach into the model (which we evaluate in simulation)...
2015: Studies in Health Technology and Informatics
https://read.qxmd.com/read/25518728/comparative-genomic-analysis-of-clinical-and-environmental-strains-provides-insight-into-the-pathogenicity-and-evolution-of-vibrio-parahaemolyticus
#6
COMPARATIVE STUDY
Lei Li, Hin-chung Wong, Wenyan Nong, Man Kit Cheung, Patrick Tik Wan Law, Kai Man Kam, Hoi Shan Kwan
BACKGROUND: Vibrio parahaemolyticus is a Gram-negative halophilic bacterium. Infections with the bacterium could become systemic and can be life-threatening to immunocompromised individuals. Genome sequences of a few clinical isolates of V. parahaemolyticus are currently available, but the genome dynamics across the species and virulence potential of environmental strains on a genome-scale have not been described before. RESULTS: Here we present genome sequences of four V...
December 18, 2014: BMC Genomics
https://read.qxmd.com/read/23245638/past-present-and-future-of-68ge-68ga-generators
#7
JOURNAL ARTICLE
F Rösch
(68)Ga represents one of the very early radionuclides applied to positron emission tomography (PET) imaging at a time when even the wording PET itself was not established. Today it faces a renaissance in terms of new (68)Ge/(68)Ga radionuclide generators, sophisticated (68)Ga radiopharmaceuticals, and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/CT). Thanks to the pioneering achievement of radiochemists in Obninsk, Russia, a new type of (68)Ge/(68)Ga generators became commercially available in the first years of the 21st century...
June 2013: Applied Radiation and Isotopes
https://read.qxmd.com/read/13955/clincial-pharmacokinetics-in-neonates
#8
REVIEW
P L Morselli
Recent concern over toxic effects of drugs in newborns, infants and children have stressed the need for better knowledge of drug kinetics during development. The present review focuses on the available data on clinical pharmacokientics in the neonate. Despite the lack of systematic approaches on drug disposition during the first month of life, the body of data currently available indicates profound differences in drug disposition between neonates and older infants, children and adults. In terms of physiological and anatomical factors the neonate has to be considered as a 'unique drug recipient'...
1976: Clinical Pharmacokinetics
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