Jianghui Hu, Jimin Ni, Junping Zheng, Yanlei Guo, Yong Yang, Cheng Ye, Xiongjie Sun, Hui Xia, Yanju Liu, Hongtao Liu
Traditionally, Tripterygium hypoglaucum (Levl.) Hutch (THH) are widely used in Chinese folk to treat rheumatoid arthritis (RA). This study aimed to investigate whether the anti-RA effect of THH is related with the gut microbiota. The main components of prepared THH extract were identified by HPLC-MS. C57BL/6 mice with adjuvant-induced arthritis (AIA) were treated with THH extract by gavage for one month. THH extract significantly alleviated swollen ankle, joint cavity exudation, and articular cartilage destruction in AIA mice...
October 2023: Chinese Journal of Natural Medicines