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Chinese Herbal Medicine And Eczema OR Atopic Dermatitis

Kam Lun Hon, Alexander K C Leung, Theresa N H Leung, Vivian W Y Lee
BACKGROUND: Atopic Dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM). OBJECTIVE: This article reviews the pathophysiology of AD, clinical trials and recent patents involving various modalities of CAM in the treatment of AD. METHODS: A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis"...
2017: Recent Patents on Inflammation & Allergy Drug Discovery
Megan J Schlichte, Abbey Vandersall, Rajani Katta
In the context of increasing popularity of "natural" alternatives to conventional medicine, several dietary supplements have gained the attention of researchers and consumers alike in the treatment of atopic dermatitis (AD). Readily available without a prescription and frequently perceived to have fewer side effects than traditional medications, these "natural" remedies may be featured in discussions with patients, and clinicians should therefore be familiar with their efficacy and safety...
July 2016: Dermatology Practical & Conceptual
Sherman X Gu, Anthony L Zhang, Meaghan E Coyle, Dacan Chen, Charlie C Xue
Atopic eczema (AE), or atopic dermatitis, is a common inflammatory skin disease. As conventional medicines for moderate and severe AE patients have been reported to be associated with unwanted side effects, many patients with AE have sought other therapies. Chinese herbal medicine (CHM) is one of the most commonly used complementary therapies with a long history of being applied for the treatment of AE. Clinical evidence for CHM for AE in systematic reviews and randomised controlled trials (RCTs) published from 2013 to 2016 was reviewed...
May 2017: Journal of Dermatological Treatment
Sherman X Gu, Anthony L Zhang, Meaghan E Coyle, Xiumei Mo, George B Lenon, Noel E Cranswick, DaCan Chen, Charlie C Xue
BACKGROUND: Atopic eczema or atopic dermatitis is a chronic inflammatory skin disease. Current conventional medical treatment for moderate and severe atopic eczema is not satisfactory. There is promising evidence derived from randomised clinical trials to support the clinical use of Chinese herbal medicine in the management of atopic eczema. However, the available evidence is compromised by the high risk of bias associated with most of the included trials. Therefore, well-designed and adequately powered randomised clinical trials are needed...
July 7, 2015: Trials
Theresa N H Leung, K L Hon
Eczema or atopic dermatitis is a common childhood atopic disease associated with chronicity and impaired quality of life. As there is no cure for the disease, treatment relies on topical and systemic anti-allergic or immunomodulating therapies. Topical corticosteroid, macrolide immunosuppressants, and oral immunomodulating drugs for recalcitrant disease have been the mainstay of therapy. Management of atopic dermatitis must consider the individual symptomatic variability of the disease. Basic therapy is focused on patient/family education, hydrating topical treatment, and avoidance of specific and non-specific provocative factors...
June 2015: Hong Kong Medical Journal
V Madhok, M Futamura, K S Thomas, S Barbarot
This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life...
June 2015: Clinical and Experimental Dermatology
Song-lin Zhou, Guang-hong Tan, Feng-yin Huang, Hua Wang, Ying-ying Lin, Shuang-lin Chen
OBJECTIVE: To explore the effects of SANPAOCAO (SPC), a compound traditional Chinese folk medicine, on chronic dermatitis/eczema in mice induced by 2, 4-dinitrochlorobenzene (DNCB). METHODS: Thirty-three Balb/c mice were randomly divided into a negative control group, a positive control group, a prednisolone treatment group, an SPC ethanol extract treatment group, a Cardiospermum halicacabum ethanol extract treatment group, a Physalis minima ethanol extract treatment group, and a Jussiaea repens ethanol extract treatment group...
June 2014: Asian Pacific Journal of Allergy and Immunology
Sherman Gu, Angela Weihong Yang, Chun Guang Li, Chuanjian Lu, Charlie Changli Xue
BACKGROUND: Atopic eczema (AE) affects 10-20% of children in industrialised countries. OBJECTIVE: This review systematically evaluated the effects and safety of topical use of Chinese herbal medicine (CHM) for AE. METHODS: Randomised controlled trials on topical use of CHM were identified through searching electronic databases. Their risk of bias was assessed. Meta-analysis was conducted by employing the RevMan 5.2 software. RESULTS: Ten studies involving 1,058 participants were included...
2014: Dermatology: International Journal for Clinical and Investigative Dermatology
Motoko Yasutomi, Shintaro Okazaki, Akiko Kawakita, Hisako Hayashi, Hiroki Murai, Mitsufumi Mayumi, Taizo Wada, Yusei Ohshima
We report here a 4-month-old girl with atopic dermatitis accompanied by weight loss, electrolyte disturbance, hypoproteinemia and hypogammaglobulinemia. She has suffered from eczema since one-month of age. Although she was treated with Chinese herbal medicines, including Syosaikotokakikyosekko, Tokishigyakukagoshuyushokyoto and Jumihaidokuto and ibuprofen ointment since three-month of age, she was referred to our hospital due to deteriorated eczema, severe diarrhea and failure to thrive. Laboratory examination revealed hyponatremia, hyperpotassemia, hypoproteinemia, hypogammaglobulinemia and elevated levels of serum IL-18, TARC and fecal EDN...
July 2013: Arerugī, [Allergy]
Weiya Zhang, Tina Leonard, Fiona J Bath-Hextall, Colette Chambers, Chuanfang Lee, Rosemary Humphreys, Hywel C Williams
No abstract text is available yet for this article.
2013: Cochrane Database of Systematic Reviews
Sherman Gu, Angela W H Yang, Charlie C L Xue, Chun G Li, Carmen Pang, Weiya Zhang, Hywel C Williams
BACKGROUND: Chinese herbal medicine (CHM) has been increasingly used for atopic eczema. A previous version of this Cochrane review published in 2004 found some evidence of a possible benefit for oral ingestion of CHM for eczema, but the results were inconclusive and the evidence needs to be updated. We have expanded the scope of this review to include an assessment of the topical and oral effects of CHM for eczema. OBJECTIVES: To assess the effects of oral ingestion and topical applications of CHM for the management of eczema in children and adults...
2013: Cochrane Database of Systematic Reviews
D Torley, M Futamura, H C Williams, K S Thomas
This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption of unpasteurized milk, and early exposure to dogs, but antibiotic use in early life may increase the risk for AE. With regard to prevention of AE, there is currently no strong evidence of benefit for exclusive breastfeeding, hydrolysed protein formulas, soy formulas, maternal antigen avoidance, omega-3 or omega-6 fatty-acid supplementation, or use of prebiotics or probiotics...
July 2013: Clinical and Experimental Dermatology
C DiNicola, A Kekevian, C Chang
Atopic dermatitis (AD) is becoming increasingly prevalent in the pediatric population, with rates reportedly as high as 18-25 %. Westernized medicine has traditionally used a combination of emollients, antihistamines, corticosteroids, and immunomodulating agents to combat this often frustrating disease. Of late, integrative medicine has become the subject of more research as concerns grow regarding prolonged use of corticosteroids and their side effects in pediatric patients. Probiotics have been extensively studied to define their role in the treatment and prevention of AD in children...
June 2013: Clinical Reviews in Allergy & Immunology
Susan V Bershad
This issue provides a clinical overview of atopic dermatitis (exzema) focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic. Non-subscribers who wish to access this issue of In the Clinic can elect "Pay for View." Subscribers can receive 1.5 category 1 CME credits by completing the CME quiz that accompanies this issue of In the Clinic...
November 1, 2011: Annals of Internal Medicine
Kam Lun Hon, Ben Chung-Lap Chan, Ping Chung Leung
Eczema is a chronic relapsing atopic dermatitis (AD) associated with pruritus, sleep disturbance and poor quality of life of the patient. Treatment of eczema includes use of emollient, topical and systemic antimicrobial agents, corticosteroid or immunomodulating agents. Many patients also seek alternative treatments such as dietary avoidance, supplementation or both. This article reviews the basic pathophysiology of eczema and clinical trials involving Chinese medicine in the treatment of eczema. Research reports on Chinese herbal medicine for eczema were retrieved from PubMed and the Cochrane Database for Systematic Reviews for this review...
April 28, 2011: Chinese Medicine
Kam Lun Hon, Winnie Lo, William K F Cheng, Ting-Fan Leung, Chung-Mo Chow, Clara B S Lau, Tai Fai Fok, Pak-Cheung Ng, Ping-Chung Leung
OBJECTIVES: Traditional Chinese medicine (TCM) is popular as an alternative medicine in children with atopic dermatitis (AD). A concoction of five herbs in a capsular preparation has been confirmed to be efficacious in improving the quality of life and sparing topical corticosteroid usage. We evaluated the clinical efficacy and tolerability of the same concoction in syrup form. METHODS: This was a prospective self-controlled trial set in the pediatric dermatology clinic of a teaching hospital...
April 2012: Journal of Dermatological Treatment
David Farhi, Alain Taïeb, Gérard Tilles, Daniel Wallach
The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded...
January 2010: Clinics in Dermatology
Fares Salameh, David Perla, Michal Solomon, Dorit Gamus, Aviv Barzilai, Shoshana Greenberger, Henri Trau
BACKGROUND: Patients with atopic dermatitis increasingly use complementary medicine. OBJECTIVE: The objective of this study was to assess the effectiveness of the combination of Chinese herbal medicine and acupuncture for the treatment of atopic dermatitis. METHODS: Twenty (20) patients between the ages of 13 and 48 who had mild-to-severe atopic dermatitis were given a combined treatment of acupuncture and Chinese herbal medicine and were followed prospectively...
October 2008: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ben Chung Lap Chan, Kam Lun Ellis Hon, Ping Chung Leung, Sze Wing Sam, Kwok Pui Fung, Mavis Yuk Ha Lee, Hang Yung Alaster Lau
BACKGROUND: PentaHerbs formula (PHF) containing Cortex Moutan, root bark of Paeonia suffruticosa Andr. (Ranunculaceae), Cortex Phellodendri, bark of Phellodendron chinensis Schneid. (Rutaceae), Flos Lonicerae, flower of Lonicera japonica Thunb. (Capri-foliaceae), Herba Menthae, aerial part of Mentha haplocalyx Briq. (Labiatae) and Rhizoma Atractylodis, rhizome of Atractylodes lancea (Thunb.) DC. (Compositae) at the ratio of 2:2:2:1:2 was useful in the management of eczema. AIM OF THE STUDY: Since the mechanism of action of PHF is not known, we aimed to investigate the actions of PHF on mast cell activation...
October 30, 2008: Journal of Ethnopharmacology
Kam-Lun Ellis Hon, Kwok-Chiu Ma, Yin Wong, Ting Fan Leung, Tai-Fai Fok
Use of traditional Chinese medicine (TCM) for various paediatric diseases has been popular. Often, parents or caregivers believe that herbs possess therapeutic effects without any harmful consequence. This fallacy is especially prevalent in the caregivers of children with chronic diseases such as atopic dermatitis (AD). We interviewed 227 consecutive children with AD to assess the attitudes of the caregivers to TCM use, based on a 14-item questionnaire. Of these respondents, 67 (30%) admitted that the child had been given TCM in the past 12 months, one-third of these were currently taking TCM and one-quarter had used TCM for 6 months or more...
August 2005: Journal of Dermatological Treatment
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