Fatime Geyikoglu, Kubra Koc, Suat Colak, Huseyin Serkan Erol, Salim Cerig, Berna Kavakcioglu Yardimci, Ozge Cakmak, Muhammed Bahaeddin Dortbudak, Gizem Eser, Ferhunde Aysin, Nihal Simsek Ozek, Serkan Yildirim
Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Sprague-Dawley rats were subjected to 50 min of ischemia followed by 3 h of reperfusion. Animals were randomly divided into a control group (the abdominal wall was just opened and closed), an I/R injury group, the propolis intervention group (200 mg/kg, intragastric administration, 1 h before ischemia), boric acid intervention group (14 mg/kg, intragastric administration 1 h before ischemia), and the propolis + boric acid intervention group (intragastric administration 1 h before ischemia)...
February 19, 2019: Biological Trace Element Research