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Nicole L Prokopishyn, Brent R Logan, Deidre M Kiefer, Jennifer A Sees, Pintip Chitphakdithai, Ibrahim A Ahmed, Paolo N Anderlini, Amer M Beitinjaneh, Christopher Bredeson, Jan Cerny, Saurabh Chhabra, Andrew Daly, Miguel Angel Diaz, Nosha Farhadfar, Haydar A Frangoul, Siddhartha Ganguly, Dennis A Gastineau, Usama Gergis, Gregory A Hale, Peiman Hematti, Rammurti T Kamble, Kimberly A Kasow, Hillard M Lazarus, Jane L Liesveld, Hemant S Murthy, Maxim Norkin, Richard F Olsson, Mona Papari, Bipin N Savani, Jeffrey Szer, Edmund K Waller, Baldeep Wirk, Jean A Yared, Michael A Pulsipher, Nirali N Shah, Galen E Switzer, Paul V O'Donnell, Dennis L Confer, Bronwen E Shaw
Bone Marrow (BM) is an essential hematopoietic stem cell (HSC) source for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplant strategies) and the majority of pediatric transplants. However, since the advent of Granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC), there has been a significant decrease in utilization of BM in transplant patients, predominantly thought to be due to the increased logistical challenges around BM harvesting compared to PBSC, and generally no significant survival advantage of BM or PBSC...
February 1, 2019: Biology of Blood and Marrow Transplantation
Yu Cai, Liping Wan, Juan Yang, Jun Zhu, Jieling Jiang, Su Li, Xianmin Song, Chun Wang
To evaluate the strategy of using high-dose etoposide mobilization followed by autologous peripheral blood stem cell transplantation (APBSCT) in patients with diffuse large B cell lymphoma (DLBCL) refractory to rituximab-based chemotherapy. Forty patients with refractory DLBCL were treated with high-dose etoposide for stem cell mobilization. All patients were in progressive disease (PD) prior to mobilization and underwent high-dose chemotherapy followed by APBSCT. Successful PBSC mobilization was achieved in all patients...
February 4, 2019: Annals of Hematology
Shang-Hsien Yang, Hsiang-Lin Wan, Ming-Hui Gu, Tso-Fu Wang
Polycythemia vera (PV) is relatively uncommon in early adulthood, and evidence about the prevalence of the Janus kinase 2 (JAK2) V617F mutation in the general population is limited. Here, we report a previously healthy volunteer peripheral blood stem cell (PBSC) donor who developed symptomatic PV with the JAK2 V617F mutation 2 years after PBSC mobilization and harvest. The characteristic mutation was identified retrospectively in the blood sample of the donor at the confirmation typing stage, which was before granulocyte colony-stimulating factor injection...
January 2019: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Rasika Dhawan Setia, Satyam Arora, Anil Handoo, Dharma Choudhary, Sanjeev Kumar Sharma, Vipin Khandelwal, Meenu Kapoor, Shalu Bajaj, Tina Dadu, Gaurav Dhamija, Virendra Bachchas
BACKGROUND AND OBJECTIVE: Controlled-rate freezing is a complicated, expensive, and time-consuming procedure. Therefore, there is a growing interest in uncontrolled-rate freezing (UCF) with -80°C mechanical freezers for cryopreservation of hematopoietic stem cells. This is a retrospective analysis of efficiency of UCF and outcome of autologous peripheral hematopoietic stem cell (PBSC) transplants at our center from December 2011 to June 2016. MATERIALS AND METHODS: Cryoprotectant solutions used included 5% dimethyl sulfoxide and 5% albumin with 2% hydroxyethyl starch and stored at -80°C mechanical freezer till transplant...
July 2018: Asian Journal of Transfusion Science
Lance A Williams, James Sikora, Carole Richardson, Mohammed Rigi, Nick Boshell, Lakeyra Palmer, Sondra Dunn, Terry Slover, Daniel Peavey, Bryan Guillory, Marisa B Marques
PURPOSE: During a national shortage of calcium gluconate, we switched to calcium chloride for routine supplementation for peripheral blood stem cell (PBSC) collections. Subsequently, we analyzed the postprocedure ionized calcium level, as we aimed for an equivalent result compared to before the shortage. METHODS: Pharmacy representatives helped us to find an "equivalent" substitute for calcium gluconate at 46.5 mEq in 500 mL normal saline, infused at 100 mL/hour...
January 23, 2019: Journal of Clinical Apheresis
Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada, Koichi Akashi
BACKGROUND: The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the appropriate conditioning regimen remain unclear. This study aimed to compare the efficacy and safety of CD34-selected auto-HSCT with unmanipulated auto-HSCT to treat severe SSc. METHODS: This study was a post hoc analysis of a phase I/II clinical trial conducted in Japan...
January 22, 2019: Arthritis Research & Therapy
P Varlet, S Rogeau, J Trauet, J Demaret, M Labalette
PURPOSE OF THE STUDY: While acute graft-versus-host-disease (GVHD) is a T cell-mediated disease caused by alloreactive donor T cells, we and others have highlighted that patients who received higher proportion of donor CD4+ naïve and central memory T cells expressing the chemokine receptor 7 (CCR7) more often developed acute GVHD than those who did not. Consequently, we then investigated in vitro the impact of selective CD4+ CCR7+ T cell depletion on immune reactions and showed that such a depletion reduced alloreactivity without altering acquired anti-infectious reactions...
January 19, 2019: Current Research in Translational Medicine
Changcun Guo, Guanya Guo, Xia Zhou, Yu Chen, Zheyi Han, Caifeng Yang, Shimin Zhao, Hongling Su, Zhexiong Lian, Patrick S C Leung, M Eric Gershwin, Xinmin Zhou, Ying Han
BACKGROUND AND AIMS: Peripheral blood stem cells (PBSCs) mobilized with colony stimulating factor can promote liver regeneration and increase liver function in patients with liver diseases. However, the long-term effects of stem cell treatments on survival and risk of hepatocellular carcinoma (HCC) in patients with liver cirrhosis have not been determined. We investigated the long-term effects of autologous stem cell transplantation and risk of HCC in patients with liver cirrhosis. METHODS: We performed a retrospective analysis of 2 cohorts of patients with decompensated cirrhosis who received transplantations of autologous PBSCs (n=282) or standard medical treatment (SMT, n=286) in China from January 1, 2006 through December 31, 2016...
October 26, 2018: Clinical Gastroenterology and Hepatology
Michael A Pulsipher, Brent R Logan, Deidre M Kiefer, Pintip Chitphakdithai, Marcie L Riches, J Douglas Rizzo, Paolo Anderlini, Susan F Leitman, James W Varni, Hati Kobusingye, RaeAnne M Besser, John P Miller, Rebecca J Drexler, Aly Abdel-Mageed, Ibrahim A Ahmed, Edward D Ball, Brian J Bolwell, Nancy J Bunin, Alexandra Cheerva, David C Delgado, Christopher C Dvorak, Alfred P Gillio, Theresa E Hahn, Gregory A Hale, Ann E Haight, Brandon M Hayes-Lattin, Kimberly A Kasow, Michael Linenberger, Margarida Magalhaes-Silverman, Shahram Mori, Vinod K Prasad, Troy C Quigg, Indira Sahdev, Jeffrey R Schriber, Shalini Shenoy, William T Tse, Gregory A Yanik, Willis H Navarro, Mary M Horowitz, Dennis L Confer, Bronwen E Shaw, Galen E Switzer
Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation...
December 31, 2018: Biology of Blood and Marrow Transplantation
Afsaneh Amouzegar, Bimalangshu R Dey, Thomas R Spitzer
Although peripheral blood stem cells (PBSC) have worldwide become the predominant source of progenitor cells for hematopoietic stem cell transplantation (HSCT), debate about their role compared with bone marrow (BM) has recently intensified, in large part based on the results of a multicenter Clinical Trials Network study which showed lower incidence of chronic graft-versus-host disease (cGVHD) and improved quality of life in recipients of myeloablative HLA-matched unrelated BM compared with PBSC transplants...
November 12, 2018: Transfusion Medicine Reviews
Jeffrey Quek, Jing Jing Lee, Francesca Lorraine Lim, Colin Diong, Yeow Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Mickey Koh, Yvonne Loh, Yeh Ching Linn
BACKGROUND: Hemolysis at the time of graft infusion is one of the immediate complications in major ABO-incompatible allogeneic hematopoietic stem cell transplants (HSCTs). We conducted a retrospective analysis to evaluate the efficacy of donor-type fresh frozen plasma (FFP) in reducing isohemagglutinin titer and preventing hemolysis, as well as its effect on delayed red cell engraftment. MATERIALS AND METHODS: This is a single-center study on a series of 380 allogeneic HSCT between 2005 and 2015; of which 99 were either major (n = 74) or bidirectional (n = 25) ABO mismatched...
November 22, 2018: Transfusion
Michael A Pulsipher, Brent R Logan, Pintip Chitphakdithai, Deidre M Kiefer, Marcie L Riches, J Douglas Rizzo, Paolo Anderlini, Susan F Leitman, James W Varni, Hati Kobusingye, RaeAnne M Besser, John P Miller, Rebecca J Drexler, Aly Abdel-Mageed, Ibrahim A Ahmed, Luke P Akard, Andrew S Artz, Edward D Ball, Ruthee-Lu Bayer, Carolyn Bigelow, Brian J Bolwell, E Randolph Broun, Nancy J Bunin, David C Delgado, Katharine Duckworth, Christopher C Dvorak, Theresa E Hahn, Ann E Haight, Parameswaran N Hari, Brandon M Hayes-Lattin, David A Jacobsohn, Ann A Jakubowski, Kimberly A Kasow, Hillard M Lazarus, Jane L Liesveld, Michael Linenberger, Mark R Litzow, Walter Longo, Margarida Magalhaes-Silverman, John M McCarty, Joseph P McGuirk, Shahram Mori, Vinod K Prasad, Scott D Rowley, Witold B Rybka, Indira Sahdev, Jeffrey R Schriber, George B Selby, Paul J Shaughnessy, Shalini Shenoy, Thomas Spitzer, William T Tse, Joseph P Uberti, Madhuri Vusirikala, Edmund K Waller, Daniel J Weisdorf, Gregory A Yanik, Willis H Navarro, Mary M Horowitz, Galen E Switzer, Bronwen E Shaw, Dennis L Confer
The development of reduced intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RD) of PBSC. The effects of age on donation efficacy, toxicity, and long-term recovery in RD are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms and recovery in 1211 related PBSC donors aged 18-79 enrolled in the Related Donor Safety Study (RDSafe). RD >60 had a lower median CD34+ level pre-apheresis compared to younger RD (age >60, 59 × 106 /L; age 41-60, 81 × 106 /L; age 18-40, 121 × 106 /L; p<0...
November 10, 2018: Biology of Blood and Marrow Transplantation
Salah Ali, Sami AlThubaiti, Samuele Renzi, Joerg Krueger, K Y Chiang, Ahmed Naqvi, Tal Schechter, Angela Punnett, Muhammad Ali
EBV-related PTLD developing after HSCT is a potentially life-threatening disease. HLH is uncommon after allogeneic HSCT. Data on outcome of patients with PTLD and concomitant HLH after allogeneic HSCT are limited. In this retrospective study, we collected demographic, clinical, laboratory, and outcome data for 408 patients who underwent allogeneic HSCT from 2006 to 2015. Graft source included CB (n = 135; 33.1%), PBSCs (n = 34; 8.3%), and BM (n = 239; 58.6%). Eight out of 408 patients (2%) developed EBV-PTLD with a median age at HSCT of 5...
November 11, 2018: Pediatric Transplantation
Serife Solmaz, Selda Kahraman, Omur Gokmen Sevindik, Celal Acar, Munire Turkyilmaz, Inci Alacacioglu, Ozden Piskin, Mehmet Ali Ozcan, Hayri Guner Ozsan, Bulent Undar, Fatih Demirkan
Peripheral blood is the prefered source for hematopoietic stem cells for hematopoietic stem cell transplantation. The efficiency of peripheral blood stem cell (PBSC) collection can vary among devices. In this study we aimed to compare feasibility and effectivity of apheresis procedures of the different systems. Two apheresis systems [Com.Tec (Fresenius Healthcare) and Spectra Optia (Caridian BCT)] were used in our center for the collection of PBSCs for autologous and allogeneic transplantation. We retrospectively analysed 190 apheresis procedures performed in healthy donors and patients between June 2012 and November 2014 in Department of Hematology, Dokuz Eylul University...
October 2018: Indian Journal of Hematology & Blood Transfusion
Zonghuai Zhang, Beibei He, Liangjian Chen, Huanwen Wang, Rui Wang, Ling Zhao, Yansheng Gong
The development of efficient, robust and low-cost catalyst for water electrolysis is critically important for renewable energy conversion. Herein, we fulfil a significant improvement on electrocatalytic activity for both oxygen-evolution reaction (OER) and hydrogen-evolution reaction (HER) by constructing a novel hierarchical PrBa0.5Sr0.5Co2O5+δ (PBSC)@FeOOH hybrid catalyst. The optimized PBSC@FeOOH-20 catalyst consisted of layered perovskite PBSC nanorods and 20 nm thick amorphous FeOOH nanoflakes exhibits an excellent electrocatalytic activity for OER and HER in 0...
October 15, 2018: ACS Applied Materials & Interfaces
Ricardo Melendez-Munoz, Rachel Marchalik, Theresa Jerussi, Dimana Dimitrova, Veronique Nussenblatt, Andrea Beri, Khalid Rai, Jennifer S Wilder, A John Barrett, Minoo Battiwalla, Richard W Childs, Courtney D Fitzhugh, Daniel H Fowler, Terry J Fry, Ronald E Gress, Matthew M Hsieh, Sawa Ito, Elizabeth M Kang, Steven Z Pavletic, Nirali N Shah, John F Tisdale, Juan Gea-Banacloche, Christopher G Kanakry, Jennifer A Kanakry
Human cytomegalovirus (CMV) infection and disease remains a significant cause of morbidity and mortality for hematopoietic cell transplantation (HCT) recipients. Disruption of or weak reconstitution of virus-specific cellular immune function, such as with certain HCT approaches, poses significant risk for CMV-related complications. The incidence of and risk factors for CMV infection and the nature of CMV disease were evaluated retrospectively among 356 consecutive HCT recipients transplanted at the National Institutes of Health using all graft sources, including bone marrow, peripheral blood stem cell (PBSC), and umbilical cord blood (UCB), and a range of in vivo and ex vivo approaches for graft-versus-host disease (GVHD) prophylaxis...
October 18, 2018: Biology of Blood and Marrow Transplantation
Annette Künkele, Christopher Brown, Adam Beebe, Stephanie Mgebroff, Adam J Johnson, Agne Taraseviciute, Lisa S Rolczynski, Cindy A Chang, Olivia C Finney, Julie R Park, Michael C Jensen
Cytotoxic chemotherapy and radiation can render lymphocyte repertoires qualitatively and quantitatively defective. Thus, heavily treated patients are often poor candidates for the manufacture of autologous chimeric antigen receptor (CAR)-T cell products. In the United States and Europe, children with high-risk neuroblastoma undergo apheresis early in the course of treatment to collect peripheral blood stem cells (PBSCs) for cryopreservation in preparation for high-dose chemotherapy followed by autologous stem cell rescue...
October 10, 2018: Biology of Blood and Marrow Transplantation
Koichi Miyamura
In other countries, unrelated donor peripheral blood stem cell transplantation (PBSCT) is more prevalent than bone marrow transplantation; however, in Japan, it was introduced in 2010 after confirming the safety of donors. PBSCT does not require blood donation, general anesthesia, or frequent bone marrow aspiration of the donor. After PBSCT, numerous hematopoietic cells can prompt blood recovery and engraftment, which has enabled reduced intensity transplantation in elderly patients and patients with concurrent diseases, such as infection...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Anna Margret Halldorsdottir, Sveinlaug Atladottir, Margret A Thorsteinsdottir, Niels A Arnason, Gudmundur Runarsson, Torbjorn Jonsson, Olafur E Sigurjonsson, Sigrun Reykdal
BACKGROUND: Prior to infusion, cryopreserved autologous peripheral blood stem cell (auto-PBSC) grafts can either be thawed at the bedside or thawed and washed at the laboratory. At our center, manual washing of grafts prior to infusion was discontinued in April 2012 and bedside thawing was implemented. METHODS: This study compares the outcomes of two patient groups who received auto-PBSC either after post-thaw washing (n = 84) or bedside thawing (n = 83). RESULTS: No life-threatening infusion-related side effects were reported in either group...
2018: Acta Haematologica
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