Junjun Yao, Shaoxing Dai, Ran Zhu, Ju Tan, Qiancheng Zhao, Yu Yin, Jiansen Sun, Xuewei Du, Longjiao Ge, Jianhua Xu, Chunli Hou, Nan Li, Jun Li, Weizhi Ji, Chuhong Zhu, Runrui Zhang, Tianqing Li
While accumulated publications support the existence of neurogenesis in the adult human hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas of the human hippocampus across neonatal, adult, aging, and injury, we dissected the molecular heterogeneity and transcriptional dynamics of human hippocampal NSCs under different contexts. We further identified new specific neurogenic lineage markers that overcome the lack of specificity found in some well-known markers...
April 12, 2024: ELife