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Salima Gasmi, Nicholas H Ogden, Marion Ripoche, Patrick A Leighton, Robbin L Lindsay, Mark P Nelder, Erin Rees, Catherine Bouchard, Linda Vrbova, Richard Rusk, Curtis Russell, Yann Pelcat, Samir Mechai, Serge-Olivier Kotchi, Jules K Koffi
Lyme disease, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi sensu stricto, which is transmitted by Ixodes scapularis in eastern Canada and Ixodes pacificus in western Canada. Recently, the northward range expansion of I. scapularis ticks, in south-eastern Canada, has resulted in a dramatic increase in the incidence of human Lyme disease. Detecting emerging areas of Lyme disease risk allows public health to target disease prevention efforts...
2019: PloS One
Qi Wang, Matthew A Rodrigues, Mikhail Repin, Sergey Pampou, Lindsay A Beaton-Green, Jay Perrier, Guy Garty, David J Brenner, Helen C Turner, Ruth C Wilkins
The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and standardized method for radiation biodosimetry. The assay is typically performed using microscopy, which is labor intensive, time consuming and impractical after a large-scale radiological/nuclear event. Imaging flow cytometry (IFC), which combines the statistical power of traditional flow cytometry with the sensitivity and specificity of microscopy, has been recently used to perform the CBMN assay. Since this technology is capable of automated sample acquisition and multi-file analysis, we have integrated IFC into our Rapid Automated Biodosimetry Technology (RABiT-II)...
February 19, 2019: Radiation Research
Ashley M Jackson, Lindsay A Mullican, Jingjing Yin, Zion Tsz Ho Tse, Hai Liang, King-Wa Fu, Jennifer O Ahweyevu, Jimmy J Jenkins Iii, Nitin Saroha, Isaac Chun-Hai Fung
BACKGROUND: The CDC hosts monthly panel presentations titled 'Public Health Grand Rounds' and publishes monthly reports known as Vital Signs. Hashtags #CDCGrandRounds and #VitalSigns were used to promote them on Twitter. Objectives: This study quantified the effect of hashtag count, mention count, and URL count and attaching visual cues to #CDCGrandRounds or #VitalSigns tweets on their retweet frequency. METHODS: Through Twitter Search Application Programming Interface, original tweets containing the hashtag #CDCGrandRounds (n = 6,966; April 21, 2011-October 25, 2016) and the hashtag #VitalSigns (n = 15,015; March 19, 2013-October 31, 2016) were retrieved respectively...
November 5, 2018: Annals of Global Health
Jennifer A Silvers, Lindsay M Squeglia, Kristine Rømer Thomsen, Karen A Hudson, Sarah W Feldstein Ewing
Although adolescents are developmentally distinct from adults, they often receive addiction treatment based on adult models. This is problematic because adolescents face significantly different conditions in addiction treatment, including distinct basic biological and neurodevelopmental stages, unique sociodevelopmental concerns, distinctive addiction trajectories, and in turn, disparate treatment goals and outcomes. In sum, it can be difficult for even savvy clinicians to know how to approach addiction treatment with this important age group...
February 19, 2019: Alcoholism, Clinical and Experimental Research
Lindsay Hoogenboom, David Margolis, Lynnette Anderson, Rachel Phelan
We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Unfortunately, he developed ESRD secondary to prolonged CNI exposure, for which he underwent cadaveric RT. These processes then resulted in 7 years largely free from complications, during which a multi-disciplinary team monitored the patient for complications...
February 18, 2019: Pediatric Transplantation
Kenneth Mangion, David Carrick, Guillaume Clerfond, Christopher Rush, Christie McComb, Keith G Oldroyd, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Margaret McEntegart, Stuart Hood, Stuart Watkins, Andrew Davie, Daniel A Auger, Xiaodong Zhong, Frederick H Epstein, Caroline E Haig, Colin Berry
OBJECTIVE: We hypothesized that Displacement Encoding with Stimulated Echoes (DENSE) and feature-tracking derived circumferential strain would provide incremental prognostic value over the extent of infarction for recovery of segmental myocardial function. METHODS: Two hundred and sixty-one patients (mean age 59 years, 73% male) underwent MRI 2 days post-ST elevation myocardial infarction (STEMI) and 241 (92%) underwent repeat imaging 6 months later. The MRI protocol included cine, 2D-cine DENSE, T2 mapping and late enhancement...
March 2019: European Journal of Radiology
Lindsay Tetreault, Hiroaki Nakashima, So Kato, Michael Kryshtalskyj, Nagoshi Nagoshi, Aria Nouri, Anoushka Singh, Michael G Fehlings
Design: Systematic review. Objective: To conduct a systematic review to (1) summarize various classification systems used to describe cervical ossification of the posterior longitudinal ligament (OPLL) and (2) evaluate the diagnostic accuracy of various imaging modalities and the reliability of these classification systems. Methods: A search was performed to identify studies that used a classification system to categorize patients with OPLL...
February 2019: Global Spine Journal
Colleen M Carlston, Steven B Bleyl, Ashley Andrews, Lindsay Meyers, Sara Brown, Pinar Bayrak-Toydemir, James F Bale, Lorenzo D Botto
The NONO gene encodes a nuclear protein involved in RNA metabolism. Hemizygous loss-of-function NONO variants have been associated with syndromic intellectual disability and with left ventricular noncompaction (LVNC). A two-year-old boy presented to the University of Utah's Penelope Undiagnosed Disease Program with developmental delay, nonfamilial features, relative macrocephaly, and dilated cardiomyopathy with LVNC and Ebstein anomaly. Brain MRI showed a thick corpus callosum, mild Chiari I malformation, and a flattened pituitary...
February 17, 2019: American Journal of Medical Genetics. Part A
Shamina M Rangwala, Katharine D'Aquino, Yue-Mei Zhang, Lindsay Bader, Wilson Edwards, Songmao Zheng, Annette Eckardt, Ann Lacombe, Rebecca Pick, Veronica Moreno, Lijuan Kang, Wenying Jian, Eric Arnoult, Martin Case, Celia Jenkinson, Ellen Chi, Ronald V Swanson, Paul Kievit, Kevin Grove, Mark Macielag, Mark D Erion, Ranabir SinhaRoy, James N Leonard
The gut hormone PYY3-36 reduces food intake in humans and exhibits at least additive efficacy in combination with GLP-1. However, the utility of PYY analogs as anti-obesity agents has been severely limited by emesis and rapid proteolysis, a profile similarly observed with native PYY3-36 in obese rhesus macaques. Here, we found that antibody conjugation of a cyclized PYY3-36 analog achieved high NPY2R selectivity, unprecedented in vivo stability, and gradual infusion-like exposure. These properties permitted profound reduction of food intake when administered to macaques for 23 days without a single emetic event in any animal...
February 11, 2019: Cell Metabolism
Lindsay C Burrage, John J Reynolds, Nissan Vida Baratang, Jennifer B Phillips, Jeremy Wegner, Ashley McFarquhar, Martin R Higgs, Audrey E Christiansen, Denise G Lanza, John R Seavitt, Mahim Jain, Xiaohui Li, David A Parry, Vandana Raman, David Chitayat, Ivan K Chinn, Alison A Bertuch, Lefkothea Karaviti, Alan E Schlesinger, Dawn Earl, Michael Bamshad, Ravi Savarirayan, Harsha Doddapaneni, Donna Muzny, Shalini N Jhangiani, Christine M Eng, Richard A Gibbs, Weimin Bi, Lisa Emrick, Jill A Rosenfeld, John Postlethwait, Monte Westerfield, Mary E Dickinson, Arthur L Beaudet, Emmanuelle Ranza, Celine Huber, Valérie Cormier-Daire, Wei Shen, Rong Mao, Jason D Heaney, Jordan S Orange, Débora Bertola, Guilherme L Yamamoto, Wagner A R Baratela, Merlin G Butler, Asim Ali, Mehdi Adeli, Daniel H Cohn, Deborah Krakow, Andrew P Jackson, Melissa Lees, Amaka C Offiah, Colleen M Carlston, John C Carey, Grant S Stewart, Carlos A Bacino, Philippe M Campeau, Brendan Lee
SPONASTRIME dysplasia is an autosomal-recessive spondyloepimetaphyseal dysplasia characterized by spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disproportionate short stature. Scoliosis, coxa vara, childhood cataracts, short dental roots, and hypogammaglobulinemia have also been reported in this disorder. Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic variants in a specific gene have not been discovered in individuals with SPONASTRIME dysplasia...
February 11, 2019: American Journal of Human Genetics
Julie Kelman, Lindsay R Pool, Penny Gordon-Larsen, J Jeffrey Carr, James G Terry, Jamal S Rana, Kiarri N Kershaw
Background While prior studies have linked the neighborhood environment and development of subclinical atherosclerosis, it is unknown whether living in neighborhoods with greater availability of "unhealthy" food outlets (fast-food chain restaurants and convenience stores) is associated with risk of developing coronary artery calcification ( CAC ). Methods and Results We included 2706 CARDIA study (Coronary Artery Risk Development in Young Adults) participants who underwent CAC measurement during follow-up years 15 (2000-2001), 20 (2005-2006), and 25 (2010-2011)...
February 19, 2019: Journal of the American Heart Association
Noah R Wolkowicz, Lindsay S Ham, Byron L Zamboanga
No abstract text is available yet for this article.
February 6, 2019: Addictive Behaviors
R Botha, R Lindsay, R T Newman, P P Maleka, G Chimba
The prospect of unconventional shale gas development in the semi-arid Karoo Basin (South Africa) has created the prerequisite to temporally characterise the natural radioactivity in associated groundwater which is solely depended on for drinking and agriculture purposes. Radon (222 Rn) was the primary natural radionuclide of interest in this study; however, supplementary radium (226 Ra and 228 Ra) in-water measurements were also conducted. A total of 53 aquifers spanning three provinces were studied during three separate measurement campaigns from 2014 to 2016...
February 7, 2019: Applied Radiation and Isotopes
Clint Cameron, Lindsay B Hutley, Daniel A Friess
Mangrove forests are extremely productive, with rates of growth rivaling some terrestrial tropical rainforests. However, our understanding of the full suite of processes underpinning carbon exchange with the atmosphere and near shore-waters, the allocation of carbon in mangroves, and fluxes of non-CO2 greenhouse gases (GHGs) are limited to a handful of studies. This constrains the scientific basis from which to advocate for greater support for and investment in mangrove restoration and conservation. Improving understanding is urgently needed given the on-going landuse pressures mangrove forests face, particularly throughout much of Southeast Asia...
February 8, 2019: Science of the Total Environment
Alexandra R Tabachnick, K Lee Raby, Alison Goldstein, Lindsay Zajac, Mary Dozier
The present study used a longitudinal randomized clinical trial to test whether an early intervention has causal effects on children's autonomic nervous system regulation. When children were infants, parents involved with Child Protective Services received Attachment and Biobehavioral Catch-up (ABC; N = 43), an intervention that promotes sensitive parenting, or a control intervention (N = 53). When children were 9 years old, children whose parents had received ABC exhibited higher respiratory sinus arrhythmia and lower heart rate at rest and during a parent-child interaction than children in the control group...
February 14, 2019: Biological Psychology
Caroline Kuo, Catherine Mathews, Ashleigh LoVette, Abigail Harrison, Lindsay Orchowski, Jennifer A Pellowski, Millicent Atujuna, Dan J Stein, Larry K Brown
INTRODUCTION: In South Africa, one in three men have reported perpetrating rape. Adolescence presents a unique developmental period for primary prevention of violence. However, few studies characterize the epidemiology of sexual violence among adolescents in South Africa. METHOD: We evaluated rates of sexual violence behaviors using a baseline survey of N = 200 South African adolescents, age 13-15, recruited for participation in an intervention trial. The intervention focused on preventing onset of depression and sexual risk behavior among adolescents...
February 13, 2019: Journal of Adolescence
Ben Li, Konrad Salata, Charles de Mestral, Mohamad A Hussain, Badr A Aljabri, Thomas F Lindsay, Subodh Verma, Mohammed Al-Omran
BACKGROUND: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group. METHODS: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. RESULTS: Forty-eight participants (30%) completed the survey...
February 13, 2019: Annals of Vascular Surgery
Lindsay Duy, Arwa Badeeb, Walter Duy, Eman Alqahtani, Walter Champion, Dae Hee Kim, Dann Martin, Vartan Vartanians, Phillip Coffin, Juan E Small
BACKGROUND AND PURPOSE: Isodense and hypodense acute subdural hematomas have been reported in the literature in anemic patients. The purpose of this study is to see if there is a statistically significant difference between the Hounsfield unit measurements of acute subdural hematomas in anemic and nonanemic patients. METHODS: A total of 109 patients were analyzed. We measured the most hyperdense component of the subdural hematoma and compared these measurements for both anemic and nonanemic patients...
February 16, 2019: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Phuong T Lam, Stephanie L Padula, Thanh V Hoang, Justin E Poth, Lin Liu, Chun Liang, Adam S LeFever, Lindsay M Wallace, Ruth Ashery-Padan, Penny K Riggs, Jordan E Shields, Ohad Shaham, Sheldon Rowan, Nadean L Brown, Tom Glaser, Michael L Robinson
BACKGROUND: Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lead to the expression of Cre recombinase in the lens and a comparative analysis of currently available transgenic lines with a particular emphasis on the Le-Cre and P0-3.9GFPCre lines that can mediate DNA deletion in the lens placode...
February 15, 2019: Human Genomics
Alison Han, Lindsay M Czajkowski, Amanda Donaldson, Holly Ann Baus, Susan M Reed, Rani S Athota, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Jeffery K Taubenberger, Matthew J Memoli
BACKGROUND: The development of vaccines and therapeutics have relied on healthy volunteer influenza challenge studies. A validated human infection model with wild-type A(H1N1)pdm09 was reported previously. OBJECTIVE: To characterize a wild-type Influenza A/Bethesda/MM1/H3N2 challenge virus in healthy volunteers. METHODS: Participants received a single dose of a cell-based, reverse-genetics, GMP-produced wild-type influenza A/H3N2/2011 virus intranasally and were isolated at the NIH Clinical Center for > 9 days...
February 16, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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