Dzmitry Shcharbin, Anna Janaszewska, Barbara Klajnert-Maculewicz, Barbara Ziemba, Volha Dzmitruk, Inessa Halets, Svetlana Loznikova, Natallia Shcharbina, Katarzyna Milowska, Maksim Ionov, Antos Shakhbazau, Maria Bryszewska
This paper reviews the biodistribution, toxicity and pharmacokinetics of pure dendrimers and their complexes with nucleic acids (dendriplexes) in animals, including mice, rats, rabbits, and guinea pigs. Methods and results will both be discussed. The paradigm about dendrimers' toxicity based on in vitro studies should be revised; almost all dendrimers of low and middle generations are non-toxic in vivo, despite showing some cytotoxic effects in vitro. Only the high generations of unmodified cationic dendrimers in high doses have some toxicity in vivo...
May 10, 2014: Journal of Controlled Release