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https://read.qxmd.com/read/30771743/the-influence-of-temperature-on-the-effects-induced-by-triclosan-and-diclofenac-in-mussels
#1
Rosa Freitas, Francesca Coppola, Silvana Costa, Carlo Pretti, Luigi Intorre, Valentina Meucci, Amadeu M V M Soares, Montserrat Solé
Little is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0μg/L of either the antimicrobial Triclosan (TCS) or the anti-inflammatory drug Diclofenac (DIC), at control (17°C) and 4°C raised (21°C) temperatures for 28days. Triclosan and DIC concentrations in the water and tissues were subsequently measured and related to biomarker responses including: energy metabolism (electron transport system (ETS) activity, glycogen and protein reserves), oxidative stress markers, glutathione balance between the reduced and the oxidised form (GSH/GSSG), and damage to proteins and lipids...
January 16, 2019: Science of the Total Environment
https://read.qxmd.com/read/30771588/multivariate-copula-temporal-modeling-of-intersection-crash-consequence-metrics-a-joint-estimation-of-injury-severity-crash-type-vehicle-damage-and-driver-error
#2
Kai Wang, Tanmoy Bhowmik, Shamsunnahar Yasmin, Shanshan Zhao, Naveen Eluru, Eric Jackson
This study employs a copula-based multivariate temporal ordered probit model to simultaneously estimate the four common intersection crash consequence metrics - driver error, crash type, vehicle damage and injury severity - by accounting for potential correlations due to common observed and unobserved factors, while also accommodating the temporal instability of model estimates over time. To this end, a comprehensive literature review of relevant studies was conducted; four different copula model specifications including Frank, Clayton, Joe and Gumbel were estimated to identify the dominant factors contributing to each crash consequence indicator; the temporal effects on model estimates were investigated; the elasticity effects of the independent variables with regard to all four crash consequence indicators were measured to express the magnitude of the effects of an independent variable on the probability change for each level of four indicators; and specific countermeasures were recommended for each of the contributing factors to improve the intersection safety...
February 13, 2019: Accident; Analysis and Prevention
https://read.qxmd.com/read/30771522/chk1-inhibition-enhances-cisplatin-cytotoxicity-and-overcomes-cisplatin-resistance-in-small-cell-lung-cancer-by-promoting-mitotic-cell-death
#3
Wei-Hsun Hsu, Xiaoliang Zhao, Jianquan Zhu, In-Kyu Kim, Guanhua Rao, Justine McCutcheon, Shuo-Tse Hsu, Beverly Teicher, Bhaskar Kallakury, Afshin Dowlati, Yu-Wen Zhang, Giuseppe Giaccone
INTRODUCTION: Platinum-based chemotherapy remains the standard treatment for patients with small cell lung cancer (SCLC), but the benefit of the treatment is often hampered by rapid development of drug resistance. Thus far, there is no targeted therapy available for SCLC. Over 90% of SCLC tumors harbor mutations in the tumor suppressor gene p53, an important DNA damage checkpoint regulator, and these tumor cells rely predominantly on the checkpoint kinases to control DNA damage response...
February 13, 2019: Journal of Thoracic Oncology
https://read.qxmd.com/read/30771456/vegf-c-attenuates-ischemia-reperfusion-injury-of-liver-graft-in-rats
#4
Ming-Xiang Cheng, Jin-Zheng Li, Yong Chen, Ding Cao, Jian-Ping Gong, Bing Tu
BACKGROUND: Vascular endothelial growth factor receptor-3 (VEGFR-3) / vascular endothelial growth factor -c (VEGF-C) signaling is reported to negatively regulate TLR4-triggered inflammation of macrophages. This study aims to clarify whether the VEGFR-3/VEGF-C signaling can suppress Kupffer cells (KCs) activation and attenuate hepatic ischemia-reperfusion injury (IRI) after liver transplantation. METHODS: A rat model of liver transplantation was performed. Donor livers were perfused with VEGF-C injection via portal vein during cold preservation, and controls were perfused with UW solution...
February 13, 2019: Transplant Immunology
https://read.qxmd.com/read/30771376/methamphetamine-regulates-%C3%AE-app-processing-in-human-neuroblastoma-cells
#5
Mayuri Shukla, Subhamita Maitra, Jean-François Hernandez, Piyarat Govitrapong, Bruno Vincent
Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Strikingly, brain changes, tissue damage and neuropsychological symptoms due to Meth exposure compels and necessitates to link the probability of risk of developing premature Alzheimer's disease, a progressive neurodegenerative disorder characterized by amyloid plaques composed of amyloid-β peptides and clinical dementia...
February 13, 2019: Neuroscience Letters
https://read.qxmd.com/read/30771272/strategies-for-controlling-egress-of-therapeutic-cells-from-hydrogel-microcapsules
#6
Ainara Benavente-Babace, Kristina Haase, Duncan J Stewart, Michel Godin
Endothelial progenitor cells (EPCs) and human mesenchymal stem cells (hMSCs) have shown great regenerative potential to repair damaged tissue; however, their injection in vivo results in low retention and poor cell survival. Early clinical research has focused on cell-encapsulation, to improve viability and integration of delivered cells. However, this strategy has been limited by the inability to reproduce large volumes of standardized microcapsules and the lack of information on cell-specific egress and timed release from hydrogel microcapsules...
February 16, 2019: Journal of Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/30771210/recent-advances-in-the-pathogenesis-of-microvascular-complications-in-diabetes
#7
REVIEW
Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortality. Diabetes has been implicated in ischemia in the microvasculature of the target tissues, which occurs due to the insufficient perfusion of tissues. The resulting occlusion and pain affect the quality of life...
February 15, 2019: Archives of Pharmacal Research
https://read.qxmd.com/read/30770948/influence-of-land-use-and-cover-on-toxicogenetic-potential-of-surface-water-from-central-west-brazilian-rivers
#8
Juliana Caroline Vivian Sposito, Luiza Flavia Veiga Francisco, Bruno do Amaral Crispim, Fabiana Gomes da Silva Dantas, Jéssica Pereira de Souza, Lucilene Finoto Viana, Julio César Jut Solórzano, Kelly Mari Pires de Oliveira, Alexeia Barufatti
The objective of this study was to evaluate toxicogenetic potential of surface water samples from rivers of center-west Brazil and analyze the influence of land use and cover and physicochemical parameters in genetic damage. Samples were collected during winter (June) and summer (November) at sampling sites from Dourados and Brilhante Rivers (Mato Grosso do Sul/Brazil). The toxicogenetic variables, including chromosomal alterations, micronuclei, and mitotic index, were analyzed in meristematic cells of Allium cepa; and micronuclei, nuclear abnormalities, and DNA strand breaks (arbitrary units, AUT ) were analyzed in erythrocytes of Astyanax lacustris...
February 15, 2019: Archives of Environmental Contamination and Toxicology
https://read.qxmd.com/read/30770735/alterations-in-tissue-microrna-after-heat-stress-in-the-conscious-rat-potential-biomarkers-of-organ-specific-injury
#9
Matthew G Permenter, Bonna C McDyre, Danielle L Ippolito, Jonathan D Stallings
BACKGROUND: Heat illness remains a significant cause of morbidity in susceptible populations. Recent research elucidating the cellular mechanism of heat stress leading to heat illness may provide information to develop better therapeutic interventions, risk assessment strategies, and early biomarkers of organ damage. microRNA (miRNA) are promising candidates for therapeutic targets and biomarkers for a variety of clinical conditions since there is the potential for high specificity for individual tissues and unique cellular functions...
February 15, 2019: BMC Genomics
https://read.qxmd.com/read/30770646/strategic-design-of-peptide-decorated-aligned-nanofibers-impregnated-with-triiodothyronine-for-neural-regeneration
#10
Aishwarya Satish, Purna Sai Korrapati
Nerve injuries are often debilitating as its regeneration occurs in a slow and laborious manner. Remediation of nerve injury is a colossal task as functional restoration in larger gaps seldom occurs due to the complex nerve regeneration mechanism. A nanofiber-based graft material has been fabricated to provide topographical and biochemical cues to encourage neural differentiation. Laminin plays a crucial role in supporting peripheral nerve regeneration and hence aligned polyvinyl cinnamate nanofibers surface-conjugated with laminin-derived cell-adhesion peptides have been fabricated to improve selective neural adhesion and regeneration...
February 15, 2019: Journal of Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/30770642/the-exaggerated-natriuresis-of-essential-hypertension-occurs-independently-of-changes-in-renal-medullary-blood-flow
#11
Kasper B Assersen, Poul F Høilund-Carlsen, Michael H Olsen, Sara V Greve, Jens C Gam-Hadberg, Poul-Erik Braad, Mads Damkjaer, Peter Bie
AIMS: In patients with essential hypertension abnormal renal sodium handling includes exaggerated natriuresis in response to extracellular volume expansion. We tested the hypothesis that exaggerated natriuresis is associated with increases in medullary and/or cortical renal blood flow. METHODS: Patients with mild essential hypertension, but no signs of end organ damage, and control subjects were studied after four days of dietary standardization (<60 mmol Na+ day-1 ) preceded in patients by a 14-days drug washout period...
February 15, 2019: Acta Physiologica
https://read.qxmd.com/read/30770563/ras-erk1-2-signaling-promotes-the-development-of-uveal-melanoma-by-downregulating-h3k14ac
#12
Yaping Li, Weixuan Sun, Dajun Sun, Dexin Yin
Ras-extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signaling has been proposed as the crucial regulators in the development of various cancers. Histone acetylation at H3 lysine 14 (H3K14ac) is closely associated with gene expression and DNA damage. However, whether H3K14ac participates in mediating Ras-ERK1/2-induced cell proliferation and migration in uveal melanoma cells remains unknown. The purpose of this study is to investigate the effect of H3K14ac on Ras-ERK1/2 affected uveal melanoma cell phenotypes...
February 15, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30770551/the-roles-of-signaling-pathways-in-liver-repair-and-regeneration
#13
REVIEW
Amir Valizadeh, Maryam Majidinia, Hossein Samadi-Kafil, Mehdi Yousefi, Bahman Yousefi
The liver has remarkable regeneration potency that restores liver mass and sustains body hemostasis. Liver regeneration through signaling pathways following resection or moderate damages are well studied. Various cell signaling, growth factors, cytokines, receptors, and cell types implicated in liver regeneration undergo controlled hypertrophy and proliferation. Some aspects of liver regeneration have been discovered and many investigations have been carried out to identify its mechanisms. However, for optimizing liver regeneration more should be understood about mechanisms that control the growth of hepatocytes and other liver cell types in adults...
February 15, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30770519/radiographic-progression-inhibition-with-intravenous-golimumab-in-psoriatic-arthritis-week-24-results-of-a-phase-iii-randomized-double-blind-placebo-controlled-trial
#14
Arthur Kavanaugh, M Elaine Husni, Diane D Harrison, Lilianne Kim, Kim Hung Lo, Lenore Noonan, Elizabeth C Hsia
OBJECTIVE: Evaluate effects of intravenous (IV) golimumab (GOL) on radiographic progression in psoriatic arthritis (PsA). METHODS: This phase III, randomized, double-blind, placebo-controlled trial (GO-VIBRANT) randomized patients with active PsA to receive IV placebo (n = 239) or IV GOL 2 mg/kg (n = 241) at weeks 0, 4, 12, and 20. Radiographic progression (controlled secondary endpoint) was evaluated as change from baseline at Week 24 in PsA-modified total Sharp/van der Heijde scores (SvdH)...
February 15, 2019: Journal of Rheumatology
https://read.qxmd.com/read/30770399/immune-challenge-induced-oxidative-damage-may-be-mitigated-by-biliverdin
#15
Jessica L Baylor, Michael W Butler
An effective immune response results in the elimination of pathogens, but this immunological benefit may be accompanied by increased levels of oxidative damage. However, organisms have evolved mechanisms to mitigate the extent of such oxidative damage, including the production and mobilization of antioxidants. One potential mechanism of mitigating immune-challenge-induced changes in oxidative physiology is increasing biliverdin production. Biliverdin is chemically an antioxidant, but within-tissue correlations between biliverdin concentration and oxidative damage have never been directly examined...
February 15, 2019: Journal of Experimental Biology
https://read.qxmd.com/read/30770349/atr-inhibition-potentiates-the-radiation-induced-inflammatory-tumour-microenvironment
#16
Magnus T Dillon, Katharina F Bergerhoff, Malin Pedersen, Emmanuel C Patin, Harriet Whittock, Eva Crespo-Rodriguez, Alex Pearson, James T Paget, Henry G Smith, Radhika R Patel, Shane Foo, Galabina Bozhanova, Chanthirika Ragulan, Elisa Fontana, Krisha Desai, Anna C Wilkins, Anguraj Sadanandam, Alan Melcher, Martin McLaughlin, Kevin J Harrington
PURPOSE: ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitise to chemotherapy and radiotherapy preclinically. No data have been published about the effect of these drugs on the tumor microenvironment. EXPERIMENTAL DESIGN: We used an immunocompetent mouse model of HPV-driven malignancies to investigate the ATR inhibitor AZD6738 in combination with fractionated radiation (RT). Gene expression analysis and flow cytometry were performed post-therapy...
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://read.qxmd.com/read/30769313/mercury-levels-and-genotoxic-effect-in-caimans-from-tropical-ecosystems-impacted-by-gold-mining
#17
José Marrugo-Negrete, José Durango-Hernández, Clelia Calao-Ramos, Iván Urango-Cárdenas, Sergi Díez
One of the most representative predator species in tropical ecosystems is caiman that can provide relevant information about the impact of mercury (Hg) associated with artisanal and small-scale gold mining. To evaluate the degree to which adverse effects are likely to occur in Caiman crocodilus, total Hg (THg) concentrations in different tissues and DNA damage in erythrocytes were determined. Samples of claws, scutes, and blood were taken from 65 specimens in sites impacted by upstream gold mining, and in a crocodile breeding center as control site, located in a floodplain in northern Colombia...
January 28, 2019: Science of the Total Environment
https://read.qxmd.com/read/30769206/multi-generational-exposure-to-pb-in-two-monophyletic-daphnia-species-individual-functional-and-population-related-endpoints
#18
G S Araujo, D M S Abessa, A M V M Soares, S Loureiro
To better evaluate chemical damage in chronically contaminated habitats, a nine-generational exposure to Lead (Pb) was done with two monophyletic Daphnia species, from temperate (Daphnia magna) and tropical (Daphnia similis) environments. The multi-generational test consisted generally of a continuous Pb exposed set of organisms, plus an extra control set running simultaneously. To assess daphnids recovery after Pb exposure, some organisms from the sixth generation were transferred to clean media for three extra generations (recovery period; F6 to F9), while others were keep Pb exposed...
February 12, 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30769138/association-between-polymorphisms-of-xeroderma-pigmentosum-complementation-group-c-gene-xpc-and-susceptibility-to-schizophrenia
#19
Nahid Taghipour, Iraj Saadat, Mostafa Saadat
Previous studies revealed that polymorphisms in several DNA repair genes are associated with the risk of schizophrenia. The relationship between three polymorphisms (Ala499Val, PAT, and Lys939Gln) of the XPC (MIM: 613208) and the risk of schizophrenia is investigated. A total of 361 schizophrenia cases and 360 healthy controls were included in the study. Statistical analysis revealed that the Ala/Val genotype (OR = 0.62, P = 0.004) and the carriers of the Val allele (OR = 0.64, P = 0.006) were negatively associated with the risk of schizophrenia...
February 12, 2019: Gene
https://read.qxmd.com/read/30769137/microgels-modular-tunable-constructs-for-tissue-regeneration
#20
REVIEW
Jake P Newsom, Karin A Payne, Melissa D Krebs
Biopolymer microgels are emerging as a versatile tool for aiding in the regeneration of damaged tissues due to their biocompatible nature, tunable microporous structure, ability to encapsulate bioactive factors, and tailorable properties such as stiffness and composition. These properties of microgels, along with their injectability, have allowed for their utilization in a multitude of different tissue engineering applications. Controlled release of growth factors, antibodies, and other bioactive factors from microgels have demonstrated their capabilities as transporters for essential bioactive molecules necessary for guiding tissue reconstruction...
February 12, 2019: Acta Biomaterialia
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