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THERAPEUTIC Temperature Management

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https://read.qxmd.com/read/30773822/isolation-functional-characterization-and-biological-properties-of-mch-amp1-a-novel-antifungal-peptide-from-matricaria-chamomilla-l
#1
Sima Sadat Seyedjavadi, Soghra Khani, Hadi Zare-Zardini, Raheleh Halabian, Mehdi Goudarzi, Shohreh Khatami, Abbas Ali Imani Fooladi, Jafar Amani, Mehdi Razzaghi-Abyaneh
The antimicrobial activities of natural products have attracted much attention due to the increasing incidence of pathogens that have become resistant to drugs. Thus, it has been attempted to promisingly manage infectious diseases via a new group of therapeutic agents called antimicrobial peptides. In this study a novel antifungal peptide, MCh-AMP1, was purified by reverse phase-HPLC and sequenced by de novo sequencing and Edman degradation. The antifungal activity, safety, thermal and pH stability of MCh-AMP1 were determined...
February 18, 2019: Chemical Biology & Drug Design
https://read.qxmd.com/read/30762783/effectiveness-and-safety-of-fire-needle-moxibustion-on-insomnia-protocol-for-a-systematic-review-and-meta-analysis
#2
Cuiling Liu, Zhiqiang Chen, Ting Li, Zhihua Yang, Qingsong Zhang, Jianping Yin, Peng Zhou, Wei Fu, BaiShu Chen
BACKGROUND: Fire-needle moxibustion (FNM) is an ancient method of external therapy that combines acupuncture with moxibustion, and has the property of high temperature resistance. Insomnia is a major public health problem and strongly associated with a high prevalence, impact on daily life, comorbidity with other disorders, and societal costs. The clinical practice demonstrates that FNM has a therapeutic effect on insomnia. Here we will provide a protocol to evaluate the effectiveness and safety of FNM for insomnia...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30724671/clinical-q-a-translating-therapeutic-temperature-management-from-theory-to-practice
#3
Mary Kay Bader, Stephen A Figueroa, Claranne Mathiesen, Patricia Pat A Blissitt, Mary M Guanci, Leslie A Hamilton, Liz Fox, Teresa Wavra
No abstract text is available yet for this article.
February 6, 2019: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/30720647/monitoring-gas-exchange-during-hypothermia-for-hypoxic-ischemic-encephalopathy
#4
Bushra Afzal, Praveen Chandrasekharan, Daniel J Tancredi, James Russell, Robin H Steinhorn, Satyan Lakshminrusimha
OBJECTIVES: Therapeutic hypothermia is standard of care in management of moderate/severe hypoxic-ischemic encephalopathy. Persistent pulmonary hypertension of the newborn is associated with hypoxic-ischemic encephalopathy and is exacerbated by hypoxemia and hypercarbia. Gas exchange is assessed by arterial blood gas analysis (with/without correction for body temperature), pulse oximetry, and end-tidal CO2. DESIGN: A retrospective chart review. SETTINGS: Regional perinatal center in Western New York...
February 2019: Pediatric Critical Care Medicine
https://read.qxmd.com/read/30720542/the-neurointensive-nursery-concept-development-and-insights-gained
#5
Hannah C Glass, Donna M Ferriero, David H Rowitch, Thomas K Shimotake
PURPOSE OF REVIEW: With the advent of therapeutic hypothermia for treatment of hypoxic ischemic encephalopathy, and improvements in neuroimaging and bedside neuromonitoring, a new era of neonatal brain-focused care has emerged in recent years. We describe the development of the first neurointensive care nursery (NICN) as a model for comanagement of neonates with identified neurologic risk factors by a multidisciplinary team constituted of neurologists, neonatologists, specialized nurses, and others with the goal of optimizing management, preventing secondary injury and maximizing long-term outcomes...
January 31, 2019: Current Opinion in Pediatrics
https://read.qxmd.com/read/30697063/therapeutic-efficacy-and-safety-of-radiofrequency-ablation-for-the-treatment-of-trigeminal-neuralgia-a-systematic-review-and-meta-analysis
#6
Huiqun Wu, Ju Zhou, Jialu Chen, Yuwei Gu, Lili Shi, Haosheng Ni
Objective: The objective of this study was to summarize the effectiveness and safety of trigeminal neuralgia (TN) treatment via different radiofrequency approaches such as continuous radiofrequency (CRF), pulsed radiofrequency (PRF), and combined CRF and pulsed radiofrequency (CCPRF) treatments, thus providing high-quality clinical evidence for TN treatment. Methods: A series of databases were searched for relevant articles published between January 1998 and April 2018...
2019: Journal of Pain Research
https://read.qxmd.com/read/30692228/the-pain-of-sleep-loss-a-brain-characterization-in-humans
#7
Adam J Krause, Aric A Prather, Tor D Wager, Martin A Lindquist, Matthew P Walker
Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following sleep deprivation are unknown. Moreover, it remains unclear whether ecologically modest night-to-night changes in sleep, within an individual, confer consequential day-to-day changes in experienced pain. Here, we demonstrate that acute sleep-deprivation amplifies pain reactivity within human (male and female) primary somatosensory cortex yet blunts pain-reactivity in higher-order valuation and decision-making regions of the striatum and insula cortex...
January 28, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://read.qxmd.com/read/30668532/topical-treatment-of-primary-focal-hyperhidrosis-part-1
#8
Eyal Zur
Primary focal hyperhidrosis is idiopathic, localized, uncontrollable, excessive, and unpredictable sweating beyond what is necessary to regulate body temperature. Primary hyperhidrosis is thought to affect approximately 2% to 3% of the population, and its effect on a patient's quality of life is very significant. Primary focal hyperhidrosis can be managed using various therapeutic options, including drugs (topical and systemic), nonsurgical interventions (e.g., iontophoresis, botulinum toxin injections), and surgery...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30646357/temporal-trends-in-the-use-of-therapeutic-hypothermia-for-out-of-hospital-cardiac-arrest
#9
Steven M Bradley, Wenhui Liu, Bryan McNally, Kimberly Vellano, Timothy D Henry, Michael R Mooney, M Nicholas Burke, Emmanouil S Brilakis, Gary K Grunwald, Mehul Adhaduk, Michael Donnino, Saket Girotra
Importance: Despite evidence that therapeutic hypothermia improves patient outcomes for out-of-hospital cardiac arrest, use of this therapy remains low. Objective: To determine whether the use of therapeutic hypothermia and patient outcomes have changed after publication of the Targeted Temperature Management trial on December 5, 2013, which supported more lenient temperature management for out-of-hospital cardiac arrest. Design, Setting, and Participants: A retrospective cohort was conducted between January 1, 2013, and December 31, 2016, of 45 935 US patients in the Cardiac Arrest Registry to Enhance Survival who experienced out-of-hospital cardiac arrest and survived to hospital admission...
November 2, 2018: JAMA network open
https://read.qxmd.com/read/30614015/management-of-hypothalamic-disease-in-patients-with-craniopharyngioma
#10
Christopher J Thompson, Richard W Costello, Rachel K Crowley
Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively...
January 4, 2019: Clinical Endocrinology
https://read.qxmd.com/read/30611705/repetitive-anodal-transcranial-direct-current-stimulation-improves-neurological-outcome-and-survival-in-a-ventricular-fibrillation-cardiac-arrest-rat-model
#11
Chenxi Dai, Gang Chen, Bihua Chen, Juan Wang, Changlin Yin, Jianjie Wang, Yushun Gong, Liang Wei, Yuanyuan Huang, Yongqin Li
BACKGROUND: Transcranial direct current stimulation (tDCS) modulates neuronal activity and is a potential therapeutic tool for many neurological diseases. However, its beneficial effects on post cardiac arrest syndrome remains uncertain. OBJECTIVE/HYPOTHESIS: We investigated the effects of repetitive anodal tDCS on neurological outcome and survival in a ventricular fibrillation (VF) cardiac arrest rat model. METHODS: Cardiopulmonary resuscitation was initiated after 6 min of VF in 36 Sprague-Dawley rats...
December 27, 2018: Brain Stimulation
https://read.qxmd.com/read/30585771/characterization-of-the-effect-of-prolonged-therapeutic-hypothermia-on-serum-magnesium-and-potassium-following-neurological-injury
#12
Caroline Beaulieu, Lisa Kurczewski
Current American Heart Association/American Stroke Association guidelines for the management of spontaneous intracerebral hemorrhage suggest therapeutic hypothermia (TH) as a salvage therapy in patients with elevated intracranial pressure. Electrolyte disorders may develop at any stage of the cooling process. Such deregulation can place patients at an increased risk for arrhythmias and worsened neurologic outcomes. The impact of TH on serum electrolyte concentration has been described, but electrolyte changes and repletions are yet to be quantified...
December 26, 2018: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/30572071/pediatric-out-of-hospital-cardiac-arrest-time-to-goal-target-temperature-and-outcomes
#13
Frank W Moler, Faye S Silverstein, Vinay M Nadkarni, Kathleen L Meert, Samir H Shah, Beth Slomine, James Christensen, Richard Holubkov, Kent Page, J Michael Dean
AIM: Although recent out-of-hospital cardiac arrest (CA) trials found no benefits of hypothermia versus normothermia targeted temperature management, preclinical models suggest earlier timing of hypothermia improves neuroprotective efficacy. This study investigated whether shorter time to goal temperature was associated with better one-year outcomes in the Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial. METHODS: Patients were classified by tertiles of time to attain assigned goal temperature range (32-34 °C or 36-37...
December 17, 2018: Resuscitation
https://read.qxmd.com/read/30567590/mild-decrease-in-heart-rate-during-early-phase-of-targeted-temperature-management-following-tachycardia-on-admission-is-associated-with-unfavorable-neurological-outcomes-after-severe-traumatic-brain-injury-a-post-hoc-analysis-of-a-multicenter-randomized-controlled
#14
Akihiko Inoue, Toru Hifumi, Yasuhiro Kuroda, Naoki Nishimoto, Kenya Kawakita, Susumu Yamashita, Yasutaka Oda, Kenji Dohi, Hitoshi Kobata, Eiichi Suehiro, Tsuyoshi Maekawa
BACKGROUND: The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activation, hypovolemia, fever, body temperature). Therefore, admission HR and gross HR change should be examined in patients with TBI treated with a well-designed protocol, such as was done in the Brain Hypothermia (B-HYPO) Study...
December 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30547304/effectiveness-and-safety-of-the-pre-prescription-of-garenoxacin-in-comparison-to-moxifloxacin-for-low-risk-febrile-neutropenia-in-breast-cancer-patients-undergoing-adjuvant-and-neoadjuvant-chemotherapy
#15
Masaya Takahashi, Katsuyuki Takahashi, Kazuki Ogawa, Tsutomu Takashima, Yuka Asano, Shinichiro Kashiwagi, Satoru Noda, Naoyoshi Onoda, Masaichi Ohira, Katsuya Nagayama
PURPOSE: The purpose of this study was to compare the efficacy of the pre-prescription of garenoxacin mesylate hydrate (GRNX) with that of moxifloxacin hydrochloride (MFLX) in the management of breast cancer patients with low-risk febrile neutropenia. METHODS: Data from female patients who had been instructed to take previously prescribed oral GRNX or MFLX for 3 days during adjuvant and neoadjuvant chemotherapy if their body temperature exceeded 38 °C were analyzed...
December 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30523923/validation-of-non-invasive-brain-temperature-estimation-models-during-swine-therapeutic-hypothermia
#16
Dong Suk Sung, Soo Young Sim, Hyung Won Jin, Woon Yong Kwon, Kyung Su Kim, Taegyun Kim, Yoon Sun Jung, Jung-In Ko, So Mi Shin, Gil Joon Suh, Kwang Suk Park
This paper introduces a mathematical model that can estimate deep brain temperature during therapeutic hypothermia based on a double sensor method. Although the cerebral temperature is more important than the non-cerebral core temperature during therapeutic hypothermia, pulmonary artery, rectal, and esophageal measurements (i.e., the typical core temperature measurement locations) have all been used for target temperature management. This is because there is no safe means of measuring the exact brain temperature...
November 14, 2018: Physiological Measurement
https://read.qxmd.com/read/30475159/therapeutic-hypothermia-and-targeted-temperature-management-for-traumatic-arrest-and-surgical-patients
#17
Benjamin N Cragun, Frances Hite Philp, John O'Neill, Matthew R Noorbakhsh, Rachel P Tindall, Allan S Philp, Michael F Ditillo
Therapeutic hypothermia (TH) and targeted temperature management (TTM) have been shown to improve outcomes in survivors of cardiac arrest, but prior research has excluded trauma and postoperative patients. We sought to determine whether TH/TTM is safe in trauma and surgical patients. A retrospective cohort study was conducted at a single level I trauma center reviewing adults presenting as a traumatic arrest or cardiac arrest in the postoperative period with a Glasgow Coma Scale <8 after return of circulation who were treated with either TH or TTM...
November 22, 2018: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/30474762/usefulness-of-cell-free-and-concentrated-ascites-reinfusion-therapy-in-the-therapeutic-management-of-advanced-ovarian-cancer-patients-with-massive-ascites
#18
Yoshiko Kawata, Kazunori Nagasaka, Yoko Matsumoto, Katsutoshi Oda, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Takahide Arimoto, Yutaka Osuga, Tomoyuki Fujii
BACKGROUND: The management of refractory ascites in advanced ovarian cancer (AOC) is vital for patients with abdominal distention, respiratory distress, and anorexia due to massive ascites with cancer peritonitis. We analyzed the benefits of concentrated ascites reinfusion therapy (CART) in the management of AOC. METHODS: We reviewed records of AOC patients who underwent CART between January 2011 and March 2017. We retrospectively analyzed patients' backgrounds and physiological changes, including body weight, abdominal girth, urine volume, blood component values, blood pressure, heart rate, and body temperature before and after CART...
November 24, 2018: International Journal of Clinical Oncology
https://read.qxmd.com/read/30463964/functional-analysis-and-anti-virulent-properties-of-a-new-depolymerase-from-a-myovirus-that-infects-acinetobacter-baumannii-capsule-k45
#19
Hugo Oliveira, Ana Rita Costa, Alice Ferreira, Nico Konstantinides, Sílvio B Santos, Maarten Boon, Jean-Paul Noben, Rob Lavigne, Joana Azeredo
Acinetobacter baumannii is an important pathogen causative of healthcare-associated infections and is able to rapidly develop resistance to all known antibiotics including colistin. As an alternative therapeutic agent, we have isolated a novel myovirus (vB_AbM_B9) which specifically infects and makes lysis from without in strains of the K45 and K30 capsule type, respectively. Phage B9 has a genome of 93,641 bp and encodes 167 predicted proteins, of which 29 were identified by mass spectrometry. This phage holds a capsule depolymerase (B9gp69) able to digest extracted exopolysaccharides of both K30 and K45 strains and that remains active in a wide range of pH values (5 to 9), ionic strengths (0 to 500 mM), and temperatures (20 to 80°C)...
November 21, 2018: Journal of Virology
https://read.qxmd.com/read/30427772/clinical-q-a-translating-therapeutic-temperature-management-from-theory-to-practice
#20
Mary Kay Bader, Stephen A Figueroa, Teresa Wavra, Sarah L Livesay, William D Cahoon, Leslie A Hamilton
No abstract text is available yet for this article.
November 14, 2018: Therapeutic Hypothermia and Temperature Management
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