keyword
https://read.qxmd.com/read/38536869/study-protocol-identifying-transcriptional-regulatory-alterations-of-chronic-effects-of-blast-and-disturbed-sleep-in-united-states-veterans
#1
JOURNAL ARTICLE
Molly J Sullan, Kelly A Stearns-Yoder, Zhaoyu Wang, Andrew J Hoisington, Adam D Bramoweth, Walter Carr, Yongchao Ge, Hanga Galfalvy, Fatemah Haghighi, Lisa A Brenner
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries following blast, an exposure that may not result in a definitive physiologic marker (e.g., loss of consciousness). Recent research suggests that exposure to low level blasts and, more specifically repetitive blast exposure (RBE), which may be subconcussive in nature, may also impact long term physiologic and psychological outcomes, though findings have been mixed...
2024: PloS One
https://read.qxmd.com/read/38536645/recent-advances-in-understanding-the-biology-of-follicular-lymphoma
#2
REVIEW
Momoko Nishikori
Follicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt disease. BCL2 overexpression by t(14;18) confers a survival advantage to B cells during the germinal center reaction, and abnormalities in epigenetic modifier genes lead to desynchronization of gene expression changes in germinal center B cells. Studies in mouse models have shown that BCL2 overexpression and epigenetic deregulation in B cells cooperatively promote lymphomagenesis. The immune microenvironment also plays an essential role in the biology of FL, and many molecular prognostic indicators based on the immune microenvironment have been proposed...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38535997/adenine-methylation-enhances-the-conformational-flexibility-of-an-rna-hairpin-tetraloop
#3
JOURNAL ARTICLE
Lev Levintov, Harish Vashisth
The N6 -methyladenosine modification is one of the most abundant post-transcriptional modifications in ribonucleic acid (RNA) molecules. Using molecular dynamics simulations and alchemical free-energy calculations, we studied the structural and energetic implications of incorporating this modification in an adenine mononucleotide and an RNA hairpin structure. At the mononucleotide level, we found that the syn configuration is more favorable than the anti configuration by 2.05 ± 0.15 kcal/mol. The unfavorable effect of methylation was due to the steric overlap between the methyl group and a nitrogen atom in the purine ring...
March 27, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38535357/histone-acetylation-enhancing-host-melanization-in-response-to-parasitism-by-an-endoparasitoid-wasp
#4
JOURNAL ARTICLE
Kun Jiang, Yan Zhou, Wen Cui, Yan-Wei Han, Pei Chen, Gui-Ming Liao, You-Ming Hou, Bao-Zhen Tang
Endoparasitoids are insects that develop within other insects, employing unique strategies to enhance their offspring's survival. They inject polydnavirus and/or venom into their hosts along with eggs, effectively suppressing the host's immune system. Polydnavirus from Braconidae and Ichneumonidae wasps can integrate into the host's genome to express viral genes using the host's transcription systems. However, the ability of parasitoids without polydnavirus to manipulate host gene expression remains unclear...
February 27, 2024: Insects
https://read.qxmd.com/read/38535145/historical-text-line-segmentation-using-deep-learning-algorithms-mask-rcnn-against-u-net-networks
#5
JOURNAL ARTICLE
Florian Côme Fizaine, Patrick Bard, Michel Paindavoine, Cécile Robin, Edouard Bouyé, Raphaël Lefèvre, Annie Vinter
Text line segmentation is a necessary preliminary step before most text transcription algorithms are applied. The leading deep learning networks used in this context (ARU-Net, dhSegment, and Doc-UFCN) are based on the U-Net architecture. They are efficient, but fall under the same concept, requiring a post-processing step to perform instance (e.g., text line) segmentation. In the present work, we test the advantages of Mask-RCNN, which is designed to perform instance segmentation directly. This work is the first to directly compare Mask-RCNN- and U-Net-based networks on text segmentation of historical documents, showing the superiority of the former over the latter...
March 5, 2024: Journal of Imaging
https://read.qxmd.com/read/38535111/rna-binding-proteins-in-cardiomyopathies
#6
REVIEW
De-Li Shi
The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534961/adult-neoneurogenesis-and-oligodendrogenesis-in-multiple-sclerosis-a-systematic-review-of-human-and-animal-studies
#7
JOURNAL ARTICLE
Andreas Liampas, Vasilis-Spyridon Tseriotis, Artemios Artemiadis, Panagiotis Zis, Chrysanthi Argyropoulou, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Georgios Vavougyios
INTRODUCTION: The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In Multiple Sclerosis (MS) this regenerative capability in halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with SVZ dysfunction in MS. MATERIALS AND METHODS: Our systematic review was reported according to the PRISMA-ScR statement...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38534407/rna-interference-in-insects-from-a-natural-mechanism-of-gene-expression-regulation-to-a-biotechnological-crop-protection-promise
#8
REVIEW
Beltrán Ortolá, José-Antonio Daròs
Insect pests rank among the major limiting factors in agricultural production worldwide. In addition to direct effect on crops, some phytophagous insects are efficient vectors for plant disease transmission. Large amounts of conventional insecticides are required to secure food production worldwide, with a high impact on the economy and environment, particularly when beneficial insects are also affected by chemicals that frequently lack the desired specificity. RNA interference (RNAi) is a natural mechanism gene expression regulation and protection against exogenous and endogenous genetic elements present in most eukaryotes, including insects...
February 21, 2024: Biology
https://read.qxmd.com/read/38534138/the-functional-small-rna-interactome-reveals-targets-for-the-vancomycin-responsive-srna-rsaoi-in-vancomycin-tolerant-staphylococcus-aureus
#9
JOURNAL ARTICLE
Winton Wu, Chi Nam Ignatius Pang, Daniel G Mediati, Jai Justin Tree
UNLABELLED: Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge...
March 27, 2024: MSystems
https://read.qxmd.com/read/38533529/adar2-deficiency-ameliorates-non-alcoholic-fatty-liver-disease-and-muscle-atrophy-through-modulating-serum-amyloid-a1
#10
JOURNAL ARTICLE
Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38532605/discovery-of-ten-anti-hiv-hit-compounds-and-preliminary-pharmacological-mechanisms-studies
#11
JOURNAL ARTICLE
Yushan Lian, Zhimin Huang, Xinyi Liu, Zhicheng Deng, Dan Gao, Xiaohui Wang
BACKGROUND: The research and development of HIV drugs is very important, but at the same time it is a long cycle and expensive system project. High-throughput drug screening systems and molecular libraries of potential hit compounds remain the main ways for the discovery of hit compounds with anti-HIV activity. OBJECTIVE: The aim of this study was to screen out the hit compounds against HIV-1 in the natural product molecule library and the antiviral molecule library, and elucidate the molecular mechanism of their inhibition of HIV-1, so as to provide a new choice for AIDS drug research...
March 26, 2024: Current HIV Research
https://read.qxmd.com/read/38531882/rna-modifications-in-cellular-metabolism-implications-for-metabolism-targeted-therapy-and-immunotherapy
#12
REVIEW
Wei-Wei Liu, Si-Qing Zheng, Tian Li, Yun-Fei Fei, Chen Wang, Shuang Zhang, Fei Wang, Guan-Min Jiang, Hao Wang
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics. As a crucial component of epigenetics at post-transcription level, RNA modification significantly determines RNA fates, further affecting various biological processes and cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts...
March 27, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38531762/-alternative-transcription-start-sites-as-regulators-of-rna-processing
#13
REVIEW
Carlos Alfonso-Gonzalez, Valérie Hilgers
Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that enables genes to choose between multiple genomic loci for initiating transcription. This mechanism is tightly controlled during development and is often altered in disease states. In this review, we examine the growing evidence highlighting a role for transcription start sites (TSSs) in the regulation of mRNA isoform selection during and after transcription. We discuss how the choice of transcription initiation sites influences RNA processing and the importance of this crosstalk for cell identity and organism function...
March 25, 2024: Trends in Cell Biology
https://read.qxmd.com/read/38531685/comparative-diagnostic-utility-of-sars-cov-2-rapid-antigen-and-molecular-testing-in-a-community-setting
#14
JOURNAL ARTICLE
Ashley E Kim, Julia C Bennett, Kyle Luiten, Jessica A O'Hanlon, Caitlin R Wolf, Ariana Magedson, Peter D Han, Zack Acker, Lani Regelbrugge, Kathryn M McCaffrey, Jeremey Stone, David Reinhart, Benjamin J Capodanno, Stephen S Morse, Trevor Bedford, Janet A Englund, Michael Boeckh, Lea M Starita, Timothy M Uyeki, Marco Carone, Ana Weil, Helen Y Chu
BACKGROUND: SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) have become widely utilized but longitudinal characterization of their community-based performance remains incompletely understood. METHODS: This prospective longitudinal study at a large public university in Seattle, WA utilized remote enrollment, online surveys, and self-collected nasal swab specimens to evaluate Ag-RDT performance against real-time reverse transcription polymerase chain reaction (rRT-PCR) in the context of SARS-CoV-2 Omicron...
March 26, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38531482/dipeptidyl-peptidase-9-regulates-the-dynamics-of-tumorigenesis-and-metastasis-in-breast-cancer
#15
JOURNAL ARTICLE
Lisa Heß, Kazeera Aliar, Barbara T Grünwald, Ricarda Griffin, Alina Lozan, Mariel Knöller, Rama Khokha, Tilman Brummer, Thomas Reinheckel
The cytosolic dipeptidyl-aminopeptidase 9 (DPP9) cleaves protein N-termini post-proline or -alanine. Our analysis of DPP9 mRNA expression from the TCGA 'breast cancer' data set revealed that low/intermediate DPP9 levels are associated with poor overall survival of breast cancer patients. To unravel the impact of DPP9 on breast cancer development and progression, the transgenic MMTV-PyMT mouse model of metastasizing breast cancer was used. In addition, tissue- and time-controlled genetic deletion of DPP9 by the Cre-loxP recombination system was done...
March 24, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38530576/the-hsa_circ_0105558-mir-182-5p-atf6-cascade-affects-h-2-o-2-triggered-oxidative-damage-and-apoptosis-of-human-lens-epithelial-cells
#16
JOURNAL ARTICLE
Wei Mao, Zhe Zhang
Age-related cataract (ARC) is the prevalent cause of useful vision loss. Circular RNAs are related to ARC pathogenesis partly through their competing endogenous RNA (ceRNA) activity. Herein, we defined the action of hsa_circ_0105558 in hydrogen peroxide (H2 O2 )-driven apoptosis and oxidative damage in human lens epithelial SRA01/04 cells. Hsa_circ_0105558, microRNA (miR)-182-5p and activating transcription factor 6 (ATF6) were evaluated by a qRT-PCR or immunoblotting method. The hsa_circ_0105558/miR-182-5p and miR-182-5p/ATF6 relationships were predicted by bioinformatics analysis and confirmed by dual-luciferase reporter assay...
March 26, 2024: Biochemical Genetics
https://read.qxmd.com/read/38530034/hiv-1-capsid-stability-and-reverse-transcription-are-finely-balanced-to-minimize-sensing-of-reverse-transcription-products-via-the-cgas-sting-pathway
#17
JOURNAL ARTICLE
Jenna E Eschbach, Maritza Puray-Chavez, Shawn Mohammed, Qiankun Wang, Ming Xia, Lin-Chen Huang, Liang Shan, Sebla B Kutluay
UNLABELLED: A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms the conical core when it rearranges around the dimeric RNA genome and associated viral proteins. Although mutations in CA have been reported to alter innate immune sensing of HIV-1, a direct link between core stability and sensing of HIV-1 nucleic acids has not been established. Herein, we assessed how manipulating the stability of the CA lattice through chemical and genetic approaches affects innate immune recognition of HIV-1...
March 26, 2024: MBio
https://read.qxmd.com/read/38529808/human-%C3%AE-synuclein-overexpression-upregulates-skor1-in-a-rat-model-of-simulated-nigrostriatal-ageing
#18
JOURNAL ARTICLE
Noelia Morales-Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M Concannon, Susan R Goulding, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeffe
Parkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA) neurons from the substantia nigra (SN) and α-synuclein (αSyn) accumulation. Age is the biggest risk factor for PD and may create a vulnerable pre-parkinsonian state, but the drivers of this association are unclear. It is known that ageing increases αSyn expression in DA neurons and that this may alter molecular processes that are central to maintaining nigrostriatal integrity. To model this, adult female Sprague-Dawley rats received a unilateral intranigral injection of adeno-associated viral (AAV) vector carrying wild-type human αSyn (AAV-αSyn) or control vector (AAV-Null)...
March 26, 2024: Aging Cell
https://read.qxmd.com/read/38529738/non-concordant-epigenetic-and-transcriptional-responses-to-acute-thermal-stress-in-western-mosquitofish-gambusia-affinis
#19
JOURNAL ARTICLE
Xingyue Ren, Junjie Zhao, Juntao Hu
Climate change is intensifying the frequency and severity of extreme temperatures. Understanding the molecular mechanisms underlying the ability to cope with acute thermal stress is key for predicting species' responses to extreme temperature events. While many studies have focused on the individual roles of gene expression, post-transcriptional processes and epigenetic modifications in response to acute thermal stress, the relative contribution of these molecular mechanisms remains unclear. The wide range of thermal limits of western mosquitofish (Gambusia affinis) provides an opportunity to explore this interplay...
March 26, 2024: Molecular Ecology
https://read.qxmd.com/read/38528957/a-recognition-of-exosomes-as-regulators-of-epigenetic-mechanisms-in-central-nervous-system-diseases
#20
REVIEW
Shunxin Hu, Lei Feng, Zhonghong Yang, Xuechen Fan, Haozheng Gao, Tiancai Yang
Exosomes, vesicular structures originating from cells, participate in the conveyance of proteins and nucleic acids. Presently, the centrality of epigenetic modifications in neurological disorders is widely acknowledged. Exosomes exert influence over various epigenetic phenomena, thereby modulating post-transcriptional regulatory processes contingent upon their constituent makeup. Consequently, the heightened attention directed toward exosomes as instigators of epigenetic alterations has burgeoned in recent years...
2024: Frontiers in Molecular Neuroscience
keyword
keyword
161715
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.