Guangyu Zhou, Qian Zhan, Lingle Huang, Xi Dou, Jin Cui, Lin Xiang, Yuhong Qi, Sicen Wu, Lin Liu, Qing Xiao, Jianbin Chen, Xiaoqiong Tang, Hongbin Zhang, Xin Wang, Xiaohua Luo, Guosheng Ren, Zesong Yang, Lanxiang Liu, Xinyu Yan, Qin Luo, Caixia Pei, Yulian Dai, Yu Zhu, Hao Zhou, Guilin Ren, Li Wang
BACKGROUND: The immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is crucial for preventing infections and relapse and enhancing graft-versus-tumor effects. B cells play an important role in humoral immunity and immune regulation, but their reconstitution after allo-HSCT has not been well studied. METHODS: In this study, we analyzed the dynamics of B cells in 252 patients who underwent allo-HSCT for 2 years and assessed the impact of factors on B-cell reconstitution and their correlations with survival outcomes, as well as the development stages of B cells in the bone marrow and the subsets in the peripheral blood...
March 4, 2024: Journal of Internal Medicine