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“Ketamine” AND “trauma”

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https://read.qxmd.com/read/30734264/functional-reorganization-in-the-primary-somatosensory-cortex-of-rat-following-hind-paw-amputation-a-study-of-functional-imaging-with-1-5-tesla-mri
#1
Murat Ekşi, Emel Özcan-Ekşi, Ayça Arslanhan, Hakan Şirinoğlu, Sertaç Erbil, Abuzer Güngör, Oktay Algin, Deniz Konya
AIM: Trauma and diabetes with concomitant vascular pathologies are leading causes of limb amputations. Functionality following amputation procedures is very important for social re-integration of the patients. In this study, we aimed to learn how rat primary somatosensory cortex (pSSC) responses to the loss of inputs from hind-paw, using fMRI of an inferior magnetic power (1.5 Tesla) with special designed high-powered rat coil. MATERIAL AND METHODS: Ten adult male Sprague-Dawley rats were enrolled in this study...
January 24, 2019: Turkish Neurosurgery
https://read.qxmd.com/read/30723838/effects-of-subanesthetic-intravenous-ketamine-infusion-on-neuroplasticity-related-proteins-in-the-prefrontal-cortex-amygdala-and-hippocampus-of-sprague-dawley-rats
#2
Michael Zhang, Kennett D Radford, Mercedes Driscoll, Salsabila Purnomo, Jean Kim, Kwang H Choi
Ketamine, a multimodal dissociative anesthetic, is a powerful analgesic administered following trauma due to its hemodynamic and respiratory stability. However, ketamine can cause hallucination and dissociation which may adversely impact traumatic memory after an injury. The effects of ketamine on proteins implicated in neural plasticity are unclear due to different doses, routes, and timing of drug administration in previous studies. Here, we investigated the effects of a single intravenous (IV) ketamine infusion on protein levels in three brain regions of rats...
June 2019: IBRO Reports
https://read.qxmd.com/read/30598714/rapid-sequence-induction-rsi-in-trauma-patients-insights-from-healthcare-providers
#3
Bianca M Wahlen, Ayman El-Menyar, Mohammad Asim, Hassan Al-Thani
BACKGROUND: We aimed to describe the current practice of emergency physicians and anaesthesiologists in the selection of drugs for rapid-sequence induction (RSI) among trauma patients. METHODS: A prospective survey audit was conducted based on a self-administered questionnaire among two intubating specialties. The preferred type and dose of hypnotics, opioids, and muscle relaxants used for RSI in trauma patients were sought in the questionnaire. Data were compared for the use of induction agent, opioid use and muscle relaxant among stable and unstable trauma patients by the intubating specialties...
2019: World Journal of Emergency Medicine
https://read.qxmd.com/read/30592476/effect-of-intranasal-ketamine-vs-fentanyl-on-pain-reduction-for-extremity-injuries-in-children-the-prime-randomized-clinical-trial
#4
Theresa M Frey, Todd A Florin, Michelle Caruso, Nanhua Zhang, Yin Zhang, Matthew R Mittiga
Importance: Timely analgesia is critical for children with injuries presenting to the emergency department, yet pain control efforts are often inadequate. Intranasal administration of pain medications provides rapid analgesia with minimal discomfort. Opioids are historically used for significant pain from traumatic injuries but have concerning adverse effects. Intranasal ketamine may provide an effective alternative. Objective: To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries...
December 28, 2018: JAMA Pediatrics
https://read.qxmd.com/read/30587052/an-analysis-of-injuries-and-prehospital-interventions-sustained-by-females-in-the-iraq-and-afghanistan-combat-zones
#5
Steven G Schauer, Jason F Naylor, Adrianna Long, Alejandra Mora, Tuan D Le, Joseph K Maddry, Michael D April
BACKGROUND: Women served in both combat and non-combat units in the recent conflicts in Iraq and Afghanistan. Moreover, the recent conflicts lacked traditional separation of civilians from combatants carrying additional risk for injury to local civilians. There is a relative paucity of data specific to this topic. We compare injury patterns and interventions performed in the prehospital, combat setting among females versus males. METHODS: This is a secondary analysis of previously published data from the Department of Defense Trauma Registry...
December 27, 2018: Prehospital Emergency Care
https://read.qxmd.com/read/30534093/decreased-blood-levels-of-oxytocin-in-ketamine-dependent-patients-during-early-abstinence
#6
Ming-Chyi Huang, Lian-Yu Chen, Hu-Ming Chang, Xiao-Yu Liang, Chih-Ken Chen, Wan-Ju Cheng, Ke Xu
Background: Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a common drug of abuse worldwide. Existing evidence suggest a disruption of oxytocin system involves in the development of addiction. In this study, we aimed to investigate the role of oxytocin in ketamine addiction by measuring the blood oxytocin levels in ketamine-dependent (KD) patients. Methods: Sixty-five KD patients and 65 controls were enrolled. Fasting plasma levels of oxytocin were determined at baseline and 1 and 2 weeks after ketamine withdrawal...
2018: Frontiers in Psychiatry
https://read.qxmd.com/read/30528051/prehospital-ketamine-administration-to-pediatric-trauma-patients-with-head-injuries-in-combat-theaters
#7
Guyon J Hill, Michael D April, Joseph K Maddry, Steven G Schauer
BACKGROUND: Head injuries frequently occur in combat. Tactical Combat Casualty Care (TCCC) guidelines recommend pre-hospital use of ketamine for analgesia. Yet the use of this medication in patients with head injuries remains controversial, particularly among pediatric patients. We compare survival to hospital discharge rates among pediatric head injury subjects who received prehospital ketamine versus those who did not. METHODS: We queried the Department of Defense Trauma Registry (DODTR) for all pediatric (<18 years of age) subjects from January 2007 to January 2016...
October 22, 2018: American Journal of Emergency Medicine
https://read.qxmd.com/read/30504810/enhanced-fear-memories-and-brain-glucose-metabolism-18-f-fdg-pet-following-sub-anesthetic-intravenous-ketamine-infusion-in-sprague-dawley-rats
#8
Kennett D Radford, Thomas Y Park, Shalini Jaiswal, Hongna Pan, Andrew Knutsen, Michael Zhang, Mercedes Driscoll, Lisa A Osborne-Smith, Bernard J Dardzinski, Kwang H Choi
Ketamine is a multimodal dissociative anesthetic, which provides powerful analgesia for victims with traumatic injury. However, the impact of ketamine administration in the peri-trauma period on the development of post-traumatic stress disorder (PTSD) remains controversial. Moreover, there is a major gap between preclinical and clinical studies because they utilize different doses and routes of ketamine administration. Here, we investigated the effects of sub-anesthetic doses of intravenous (IV) ketamine infusion on fear memory and brain glucose metabolism (BGluM) in rats...
November 30, 2018: Translational Psychiatry
https://read.qxmd.com/read/30376537/ketamine-infusion-for-pain-control-in-adult-patients-with-multiple-rib-fractures-results-of-a-randomized-control-trial
#9
Thomas W Carver, Nathan W Kugler, Janelle Juul, William J Peppard, Karin Madsen Drescher, Lewis B Somberg, Aniko Szabo, Ziyan Yin, Jasmeet S Paul
INTRODUCTION: Rib fractures occur in up to 40% of trauma patients and are associated with increased mortality. Opiate-based pain regimens remain the cornerstone of rib fracture management; however, concerns around opioids have fostered interest in alternative analgesics. Ketamine is currently being used in lieu of opioids, but little evidence exists supporting its use within the trauma population. METHODS: A prospective, randomized, double-blind placebo-controlled trial of adult patients with ≥3 rib fractures admitted to a Level 1 trauma center was conducted...
October 29, 2018: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/30307341/effect-of-cholinergic-crisis-on-the-potency-of-different-emergency-anaesthesia-protocols-in-soman-poisoned-rats
#10
Katharina Marquart, Julia Herbert, Niko Amend, Horst Thiermann, Franz Worek, Timo Wille
BACKGROUND: In a military or terrorist scenario, combination of organophosphorus compounds (OP) poisoning with physical trauma requiring surgical treatment and thus general anaesthesia are possible. Previous in vitro studies showed an altered potency of relevant anaesthetics during cholinergic crisis. Hence, it is not clear, which anaesthetics are suitable to achieve the necessary stage of surgical anaesthesia in OP poisoning. METHODS: In the present study, different anaesthetic regimens (ketamine-midazolam, propofol-fentanyl, thiopental-fentanyl), relevant in military emergency medicine, were examined in soman-poisoned rats...
October 11, 2018: Clinical Toxicology
https://read.qxmd.com/read/30214945/postoperative-pain-management-in-patients-undergoing-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis-a-narrative-review
#11
REVIEW
Hiroyuki Seki, Satoshi Ideno, Taiga Ishihara, Kota Watanabe, Morio Matsumoto, Hiroshi Morisaki
Posterior spinal fusion for adolescent idiopathic scoliosis is one of the most invasive surgical procedures performed in children and adolescents. Because of the extensive surgical incision and massive tissue trauma, posterior spinal fusion causes severe postoperative pain. Intravenous patient-controlled analgesia with opioids has been the mainstay of postoperative pain management in these patients. However, the use of systemic opioids is sometimes limited by opioid-related side effects, resulting in poor analgesia...
2018: Scoliosis and Spinal Disorders
https://read.qxmd.com/read/30188513/early-life-stress-leads-to-sex-differences-in-development-of-depressive-like-outcomes-in-a-mouse-model
#12
Haley L Goodwill, Gabriela Manzano-Nieves, Meghan Gallo, Hye-In Lee, Esther Oyerinde, Thomas Serre, Kevin G Bath
Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability. From P4 to P11, a limited bedding model that leads to fragmented maternal care, was used to induce ELS...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/30181792/effect-of-sedative-agent-selection-on-morbidity-mortality-and-length-of-stay-in-patients-with-increase-in-intracranial-pressure
#13
Brian G Cornelius, Elizabeth Webb, Angela Cornelius, Kenneth W G Smith, Srdan Ristic, Jay Jain, Urska Cvek, Marjan Trutschl
BACKGROUND: To identify the effects of sedative agent selection on morbidity, mortality, and length of stay in patients with suspected increase in intracranial pressure. Recent trends and developments have resulted in changes to medications that were previously utilized as pharmacological adjuncts in the sedation and intubation of patients with suspected increases in intracranial pressure. Medications that were previously considered contraindicated are now being used with increasing regularity without demonstrated safety and effectiveness...
2018: World Journal of Emergency Medicine
https://read.qxmd.com/read/30118637/trends-in-prehospital-analgesia-administration-by-us-forces-from-2007-through-2016
#14
Steven G Schauer, Jason F Naylor, Joseph K Maddry, Carmen Hinojosa-Laborde, Michael D April
BACKGROUND: Tactical Combat Casualty Care (TCCC) guidelines regarding prehospital analgesia agents have evolved. The guidelines stopped recommending intramuscular (IM) morphine in 1996, recommending only intravenous (IV) routes. In 2006, the guidelines recommended oral transmucosal fentanyl citrate (OTFC), and in 2012 it added ketamine via all routes. It remains unclear to what extent prehospital analgesia administered on the battlefield adheres to these guidelines. We seek to describe trends in analgesia administration patterns on the battlefield during 2007-2016...
August 17, 2018: Prehospital Emergency Care
https://read.qxmd.com/read/30050444/what-acute-stress-protocols-can-tell-us-about-ptsd-and-stress-related-neuropsychiatric-disorders
#15
REVIEW
Laura Musazzi, Paolo Tornese, Nathalie Sala, Maurizio Popoli
Posttraumatic stress disorder (PTSD), the fifth most prevalent mental disorder in the United States, is a chronic, debilitating mental illness with as yet limited options for treatment. Hallmark symptoms of PTSD include intrusive memory of trauma, avoidance of reminders of the event, hyperarousal and hypervigilance, emotional numbing, and anhedonia. PTSD is often triggered by exposure to a single traumatic experience, such as a traffic accident, a natural catastrophe, or an episode of violence. This suggests that stressful events have a primary role in the pathogenesis of the disorder, although genetic background and previous life events are likely involved...
2018: Frontiers in Pharmacology
https://read.qxmd.com/read/30031556/the-characteristics-and-prevalence-of-agitation-in-an-urban-county-emergency-department
#16
James R Miner, Lauren R Klein, Jon B Cole, Brian E Driver, Johanna C Moore, Jeffrey D Ho
STUDY OBJECTIVE: We seek to determine the characteristics and prevalence of agitation among patients in an urban county emergency department (ED). METHODS: This was a prospective observational study of ED patients at an urban Level I trauma center. All ED patients were screened during daily randomized 8-hour enrollment periods. Adult agitated patients, defined as having an altered mental status score greater than 1, were included. Trained research volunteers collected demographics and baseline data, including the presenting altered mental status score, use and type of restraints, and whether any initial sedative was given...
October 2018: Annals of Emergency Medicine
https://read.qxmd.com/read/30026698/psychedelic-assisted-psychotherapy-a-paradigm-shift-in-psychiatric-research-and-development
#17
Eduardo Ekman Schenberg
Mental disorders are rising while development of novel psychiatric medications is declining. This stall in innovation has also been linked with intense debates on the current diagnostics and explanations for mental disorders, together constituting a paradigmatic crisis. A radical innovation is psychedelic-assisted psychotherapy (PAP): professionally supervised use of ketamine, MDMA, psilocybin, LSD and ibogaine as part of elaborated psychotherapy programs. Clinical results so far have shown safety and efficacy, even for "treatment resistant" conditions, and thus deserve increasing attention from medical, psychological and psychiatric professionals...
2018: Frontiers in Pharmacology
https://read.qxmd.com/read/30018022/effect-of-acute-restraint-stress-in-a-polytrauma-rat-model
#18
Françoise Arnaud, Georgina Pappas, Ye Chen, Eric Maudlin-Jeronimo, Richard McCarron
INTRODUCTION: A stressful environment may contribute to poor outcomes after TBI. The current study evaluates the impact of acute stress in a polytrauma rat model. METHODS: Rats were stressed by a 45-minute immobilization period before instrumentation under ketamine (t1). Polytrauma was produced by blast overpressure and controlled hemorrhage (t2). Rats were euthanized immediately after a 3 h simulated Medevac-transport time (t3) or after 72 h post-trauma (t4)...
September 25, 2018: Neuroscience Letters
https://read.qxmd.com/read/30013730/chronic-postsurgical-pain-current-evidence-for-prevention-and-management
#19
REVIEW
Parineeta Thapa, Pramote Euasobhon
Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain...
July 2018: Korean Journal of Pain
https://read.qxmd.com/read/29965991/prehospital-ultrasound-guided-nerve-blocks-improve-reduction-feasibility-of-dislocated-extremity-injuries-compared-to-systemic-analgesia-a-randomized-controlled-trial
#20
Benedikt Büttner, Ashham Mansur, Matthias Kalmbach, José Hinz, Thomas Volk, Karoly Szalai, Markus Roessler, Ingo Bergmann
BACKGROUND: Out-of-hospital analgosedation in trauma patients is challenging for emergency physicians due to associated complications. We compared peripheral nerve block (PNB) with analgosedation (AS) as an analgetic approach for patients with isolated extremity injury, assuming that prehospital required medical interventions (e.g. reduction, splinting of dislocation injury) using PNB are less painful and more feasible compared to AS. METHODS: Thirty patients (aged 18 or older) were randomized to receive either ultrasound-guided PNB (10 mL prilocaine 1%, 10 mL ropivacaine 0...
2018: PloS One
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