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Conrad Leitsmann, Paul Thelen, Marianne Schmid, Johannes Meller, Carsten-Oliver Sahlmann, Birgit Meller, Lutz Trojan, Arne Strauss
PURPOSE: 68Ga-PSMA PET/CT imaging is a promising modality for the staging of recurrent prostate cancer (PCa). Current evidence suggests limited diagnostic value of the 68Ga-PSMA PET/CT in PSA-levels ≤0.3ng/mL. Experimental data have demonstrated na increase in PSMA-expression in PCa metastases by androgen deprivation in vitro. The aim of the current study was to investigate a possible enhancing effect of PSMA with low-dose androgen deprivation in patients with BCR and low PSA-levels...
March 20, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Lene Gaarsmand Christensen, Tina Di Caterino, Maj-Lis Talman
Phyllodes tumors (PTs) are uncommon fibroepithelial neoplasms that account for 0.3-1% of all primary breast tumors and for 2,5% of all fibroepithelial tumors of the breast in "Western" countries 1, 2. The median age at diagnosis is about 45 years. In Asian countries the median age at diagnosis is 25-30 years, and PTs account for a higher proportion of breast tumors 2. PTs are characterized by a combination of an expanding hypercellular stroma with enhanced intracanalicular growth pattern with leaf-like projections into irregular, elongated epithelial-lined clefts...
March 22, 2019: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
O P Singh, Veenita Yogi, Pallavi Redhu, H U Ghori, Ananya Pareek, Nancy Lal
Introduction: Prostate cancer is most frequently diagnosed cancer of men and bone is the most common site of metastasis. There is a lack of consensus for the selection criteria for bone scan in low-risk patients. Western guidelines do not recommend use of bone scan in asymptomatic patients and in low prostate-specific antigen (PSA) values. We try to correlate the PSA value with bone metastases through bone scan in the Indian population. Materials and Methods: A total of 68 histologically newly diagnosed prostate cancer subjected to bone scan were retrospectively analyzed...
March 2019: Journal of Cancer Research and Therapeutics
Sheeba M Joseph, John P Fulkerson
Medial patellofemoral ligament reconstruction risks patellar fracture with the osseous violation necessary for patellar attachment. Anatomic studies identify an entire medial patellofemoral complex of structures responsible for medial restraint to patellar lateral instability. One specific component of this complex is the medial quadriceps tendon femoral ligament (MQTFL). This note presents the technique, pearls and pitfalls, and critical surgical anatomy necessary for successful MQTFL reconstruction-a treatment strategy for patellar instability with no increased risk for patellar fracture...
January 2019: Arthroscopy Techniques
Luwei Tao, Jingxin Sun, Akriti Jain, Jie Ouyang, Daniel Tambunan
Fibrous dysplasia (FD) is a benign bone disorder, in which normal bone structure is replaced by fibrous connective tissue. Polyostotic FD is also related to McCune-Albright syndrome with possible endocrine disorder and Cafe-au-lait macules. Although FD commonly presents as craniofacial bone abnormality, atypical presentation can be misleading and pose a difficulty in clinical diagnosis. Here we report a case of polyostotic FD, who presented as an accidental finding of multiple spinal osseous lesions, leading to clinic workup for metastatic cancer...
January 14, 2019: Curēus
Louise Dunphy, Adrian Warfield, Rhodri Williams
Malignant infantile osteopetrosis (MIOP), an autosomal-recessive disorder, is extremely rare, presenting early in life with extreme sclerosis of the skeleton and reduced activity of osteoclasts. It was first described by Albers Schonberg in 1904. Disease manifestations include compensatory extramedullary haematopoiesis at sites such as the liver and spleen, hepatosplenomegaly, anaemia and thrombocytopaenia. Neurological manifestations can also occur due to narrowing of osseous foramina resulting in visual impairment, hearing loss, facial palsy and hydrocephalus...
March 20, 2019: BMJ Case Reports
H S Shin, B C Kim, H J Lim, S Y Jo, J Lee
Cemento-osseous dysplasia is a well-known condition in which healthy bone becomes sclerotic. Hypovascularity of the lesion (caused by cementum-like deposits) increases the risk of secondary infection and osteomyelitis, which can also be induced by the placement of implants.
March 18, 2019: British Journal of Oral & Maxillofacial Surgery
Steven P Daniels, J Jacob Kazam, Katherine V Yao, Helen S Xu, Daniel B Green
We present two cases of atraumatic costal cartilage fracture secondary to violent coughing. Although costal cartilage fractures due to trauma and bony rib fractures due to violent coughing have been described, to our knowledge there have been no prior reported cases of cough-induced costal cartilage fracture. It is important for radiologists to consider costal cartilage fractures, which are often more subtle than osseous injuries, in patients with chest pain, and understand that they may not always be preceded by direct trauma...
March 13, 2019: Clinical Imaging
Noëlle Cartayrade, Franck Lapègue, Zoé Cambon, Nicolas Sans, Marie Faruch
History A 28-year-old woman presented to the emergency department with painful swelling of the third finger on her right hand, which developed quickly. She had no relevant medical or surgical history. Her pain was worse at night, with stiffness decreasing during the morning. Clinical examination revealed generalized swelling of the third finger, cyanotic skin, and fingernail splitting on the second finger of the left hand ( Fig 1 ). Laboratory test results were normal, with no evidence of inflammatory disease...
April 2019: Radiology
Patrick S Buckley, Elizabeth R Morris, Colin M Robbins, Bryson R Kemler, Salvatore J Frangiamore, Michael G Ciccotti, Johnny Huard, Robert F LaPrade, Thomas R Hackett
BACKGROUND: The vascular supply of the ulnar collateral ligament (UCL) is unknown. Previous studies reported varying success in return-to-play rates after nonoperative management of partial UCL tears and suggested a varying healing capacity as possibly related to the location of the UCL injury. PURPOSE: To analyze the macroscopic vascular anatomy of the UCL of the elbow. STUDY DESIGN: Descriptive laboratory study. METHODS: Eighteen fresh-frozen male cadaveric elbows from 9 donors were sharply dissected 15 cm proximal to the medial epicondyle...
March 21, 2019: American Journal of Sports Medicine
Nesma Mohamed Awaad, Noha Mohamed Eladl, Nadia Ahmed Abbass
AIM: This randomized clinical study aimed to assess bone height loss when using mandibular implant overdentures retained by two and four endosseous implants using the telescopic attachments. METHODS: Twelve completely edentulous patients were randomly allocated so that six patients were treated by telescopic implant overdenture retained by two implants (group A) and six patients were treated with overdentures retained by four implants (group B). Digital radiographic evaluation of bone height using Digora was made starting at the functional loading day followed by time intervals of 12 months...
February 28, 2019: Open Access Macedonian Journal of Medical Sciences
Ewa Sierko, Dominika Hempel, Konrad Zuzda, Marek Z Wojtukiewicz
The majority of advanced cancer patients suffer from pain, which severely deteriorates their quality of life. Apart from analgesics, bisphosphonates, and invasive methods of analgesic treatment (e.g., intraspinal and epidural analgesics or neurolytic blockades), radiation therapy plays an important role in pain alleviation. It is delivered to a growing primary tumour, lymph nodes, or distant metastatic sites, producing pain of various intensity. Currently, different regiments of radiation therapy methods and techniques and various radiation dose fractionations are incorporated into the clinical practice...
March 19, 2019: Cancers
Yong Huang, Hongyi Shao, Yixin Zhou, Jianming Gu, Hao Tang, Dejin Yang
BACKGROUND: To our knowledge, no previous studies have compared periprosthetic bone remodeling around monoblock versus modular tapered fluted titanium stems with different stem length and thickness. METHODS: A retrospective comparative study was performed on 139 consecutive total hip arthroplasties (THAs) revised with a tapered fluted modular titanium stem and 114 consecutive THAs revised with a tapered fluted monoblock titanium stem. The latest follow-up radiographs were compared with immediate postoperative radiographs to assess bone restoration in residual osteolytic areas, femoral stress-shielding, spot-welds, and radiolucent lines...
March 20, 2019: Journal of Bone and Joint Surgery. American Volume
Ziad Sijari, Federica Romano, Gabriele Ciardo, Vanessa Martella, Marina Maggiora, Mario Bottone, Mario Aimetti
OBJECTIVES: The aim of this RCT study was to compare early wound healing and gingival crevicular fluid cytokine levels of patients treated with two different post-surgical cleansing protocols. METHODS: A total of 30 chronic periodontitis patients scheduled for osseous resective surgery with fiber retention technique was randomly assigned to follow one of two post-surgical protocols. Patients assigned to the test protocol (n = 15) were instructed to brush the surgical area with a sonic toothbrush starting the day after surgery in addition to 0...
March 20, 2019: International Journal of Dental Hygiene
Brenda L Nelson, Billy J Phillips
Benign fibro-osseous lesions (BFOLs) are a particularly challenging set of diagnoses for the pathologist. This diverse collection of diseases includes fibrous dysplasia, ossifying fibroma and cemento-osseous dysplasia. While all three conditions have similar microscopic presentations, their treatment and prognosis differ, demanding an accurate and definitive diagnosis. A practical and systematic approach considering the patient's history, demographics, intraoperative presentation, and gross appearance with an emphasis on radiology and histology will be discussed...
March 18, 2019: Head and Neck Pathology
D Adler, H Almansour, M Akbar
PURPOSE: Pediatric cervical spine injuries constitute approximately 1-2% of all pediatric trauma cases. Usually pediatric vertebral injuries appear as stable A type fractures, whereas B and C type injuries are relatively uncommon. In contrast to adults, the appropriate treatment strategy in children is still controversial and places spine surgeons in complex situations. This article reports the case of a 4-year-old girl with an unstable B type injury at the C6/7 level (AOSpine C6-7: B2 [F4 BL, C7:A1]) with bilateral locked fractures of the facet joints after falling down a flight of stairs...
March 18, 2019: Der Orthopäde
Ivo Dobrev, Jae Hoon Sim, Flurin Pfiffner, Alexander M Huber, Christof Röösli
OBJECTIVES: Investigation of bone conduction sound propagation by osseous and non-osseous pathways and their interactions based upon the stimulation site and coupling method of the actuator from a bone conduction hearing aid (BCHA). METHODS: Experiments were conducted on five Thiel embalmed whole head cadaver specimens. The electromagnetic actuator from a commercial bone conduction hearing aid (BCHA) (Baha® Cordelle II) was used to provide a stepped sine stimulus in the range of 0...
March 11, 2019: Hearing Research
Colten D Dougherty, Yun-Yi Hung, Miranda L Ritterman Weintraub, Sandeep Patel, Christy M King
There are multiple antirheumatic drug modalities available to patients with symptomatic rheumatoid arthritis (RA) that function to suppress the overactive immune system, but the inflammatory and immune suppression may contribute to postoperative complications. The purpose of this study was to determine if antirheumatic medications increased the risk of both soft tissue and osseous postoperative complications in patients with RA who underwent foot and ankle surgery. We reviewed patients with RA, aged 18years and older, who underwent either an elective or a nonelective foot or ankle surgery involving an osseous procedure between 2009 and 2014...
March 16, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Guillaume Gravel, Lambros Tselikas, Benjamin Moulin, Steven Yevich, Eric Baudin, Antoine Hakime, Salma Moalla, Fadila Mihoubi, Corinne Balleyguier, Thierry de Baere, Frederic Deschamps
OBJECTIVES: To evaluate post-ablation MRI for the detection of incompletely treated spinal osseous metastases (SOM) after cryoablation and to propose a post-ablation imaging classification. METHODS: After IRB consent, all patients treated with cryoablation of SOM between 2011 and 2017 having at least 1-year minimum follow-up and a spine MRI within 4 months after cryoablation were retrospectively included. A classification of MRI images into four types was set up...
March 15, 2019: European Radiology
Gerardo Guinto, Barbara Nettel, Eli Hernández, David Gallardo, Norma Aréchiga, Moisés Mercado
BACKGROUND: Empty sella (ES) is an anatomical finding that is usually asymptomatic. However, when patients showing this finding present with visual deficits, surgical treatment might be necessary. The main goal of surgery is to elevate the sellar content through a transsphenoidal approach. OBJECTIVE: The aim of the present study is to demonstrate a new technique for precise reconstruction of the sellar floor using a heterologous bone block to restore the anatomical elements of the sella turcica...
March 12, 2019: World Neurosurgery
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