Elizabeth Vera, Alexa Christ, Ewa Grajkowska, Nicole Briceno, Anna Choi, Sonja K Crandon, Kathleen Wall, Matthew Lindsley, Heather E Leeper, Jason Levine, Jennifer Reyes, Alvina A Acquaye, Amanda L King, Varna Jammula, Kayla Roche, James L Rogers, Michael Timmer, Lisa Boris, Nicole Lollo, Marissa Panzer, Lily Polskin, Tina Pillai, Eric Burton, Marta Penas-Prado, Brett Theeler, Mark R Gilbert, Terri S Armstrong, Tito R Mendoza
Background: Recognising the importance of clinical outcomes assessments (COAs), the Response Assessment in Neuro-Oncology-Patient Reported Outcome (RANO-PRO) Working Group recommended inclusion of core symptoms and functions in clinical care or research for malignant glioma patients. This study evaluated the association of the recommended symptoms (pain, perceived cognition, seizures, aphasia, symptomatic adverse events) and functions (weakness, walking, work, usual activities) with disease progression in these patients...
January 2023: EClinicalMedicine