keyword
https://read.qxmd.com/read/38533647/physical-activity-mental-activity-and-risk-of-incident-stroke-a-prospective-cohort-study
#1
JOURNAL ARTICLE
Zhi Cao, Jing Zhang, Zuolin Lu, Han Chen, Jiahao Min, Yabing Hou, Xiaohe Wang, Chenjie Xu
BACKGROUND: Cumulative evidence suggests a correlation between physical or mental activity and the risk of stroke. However, the combined impact of these activities on stroke onset remains unexplored. This study identified physical and mental activity patterns using principal component analysis and investigated their associations with risk of incident stroke in the general population. METHODS: Our study was sourced from the UK Biobank cohort between 2006 and 2010...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38532328/tools-to-measure-barriers-to-medication-management-capacity-in-older-adults-a-scoping-review
#2
JOURNAL ARTICLE
Bincy Baby, Annette McKinnon, Kirk Patterson, Hawa Patel, Rishabh Sharma, Caitlin Carter, Ryan Griffin, Catherine Burns, Feng Chang, Sara Jt Guilcher, Linda Lee, Sara Abu Fadaleh, Tejal Patel
BACKGROUND: Medication management capacity is a crucial component of medication adherence, particularly among older adults. Various factors, including physical abilities, cognitive functions, sensory capabilities, motivational, and environmental factors, influence older adults' ability to manage medications. It is, therefore, crucial to identify appropriate tools that allow clinicians to determine which factors may impact medication management capacity and, consequently, nonadherence to medications...
March 27, 2024: BMC Geriatrics
https://read.qxmd.com/read/38507619/newborn-screening-current-practice-and-our-journey-over-the-last-60-years
#3
JOURNAL ARTICLE
Jing Cao, Marzia Pasquali, Patricia M Jones
BACKGROUND: Inborn errors of metabolism comprise a set of more than 2000 known disorders which can result in significant morbidity and may be rapidly fatal. Diagnosing these disorders at birth and treating immediately, however, may often result in a normal to near-normal life for the affected infant. Thus, newborn screening (NBS) has saved or improved the lives of countless individuals since its inception in the 1960s. CONTENT: This review covers NBS, from its early beginnings up to the current day practice...
March 20, 2024: Journal of Applied Laboratory Medicine
https://read.qxmd.com/read/38501366/development-of-an-ultrafast-pcr-to-detect-clinically-relevant-acquired-vancomycin-resistance-genes-from-cultured-enterococci
#4
JOURNAL ARTICLE
Axel Philip, Saoussen Oueslati, Francesco Villa, Christophe Pannetier, Vincent Cattoir, Jacques Duranteau, Samy Figueiredo, Thierry Naas
BACKGROUND: VRE are increasingly described worldwide. Screening of hospitalized patients at risk for VRE carriage is mandatory to control their dissemination. Here, we have developed the Bfast [VRE Panel] PCR kit, a rapid and reliable quantitative PCR assay for detection of vanA, vanB, vanD and vanM genes, from solid and liquid cultures adaptable to classical and ultrafast real-time PCR platforms. METHODS: Validation was carried out on 133 well characterized bacterial strains, including 108 enterococci of which 64 were VRE...
March 19, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38492398/innovative-non-targeted-screening-approach-using-high-resolution-mass-spectrometry-for-the-screening-of-organic-chemicals-and-identification-of-specific-tracers-of-soil-and-dust-exposure-in-children
#5
JOURNAL ARTICLE
Olutobi Daniel Ogunbiyi, Luciana Teresa Dias Cappelini, Mymuna Monem, Emily Mejias, Florence George, Piero Gardinali, Daniel M Bagner, Natalia Quinete
Environmental contamination through direct contact, ingestion and inhalation are common routes of children's exposure to chemicals, in which through indoor and outdoor activities associated with common hand-to-mouth, touching objects, and behavioral tendencies, children can be susceptible and vulnerable to organic contaminants in the environment. The objectives of this study were the screening and identification of a wide range of organic contaminants in indoor dust, soil, food, drinking water, and urine matrices (N = 439), prioritizing chemicals to assess children's environmental exposure, and selection of unique tracers of soil and dust ingestion in young children by non-targeted analysis (NTA) using Q-Exactive Orbitrap followed data processing by the Compound Discoverer (v3...
March 12, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38477340/f-box-protein-fbxb-65-regulates-anterograde-transport-of-a-kinesin-3-motor-unc-104-through-a-ptm-near-its-cargo-binding-ph-domain
#6
JOURNAL ARTICLE
Vidur Sabharwal, Sri Padma Priya Boyanapalli, Amir Shee, Michael L Nonet, Amitabha Nandi, Debasish Chaudhuri, Sandhya P Koushika
Axonal transport in neurons is essential for cargo movement between the cell body and synapses. UNC-104/KIF1A, a Kinesin-3 motor in C. elegans that anterogradely transports precursors of synaptic vesicles (pre-SVs), is degraded at synapses. Touch neurons-specific knockdown of the E1 ubiquitin-activating enzyme, uba-1, leads to UNC-104 accumulation at neuronal ends and synapses. An RNAi screen identified fbxb-65, an F-box protein, that leads to UNC-104 accumulation at neuronal distal ends, alters UNC-104 net anterograde movement and levels of UNC-104 on cargo without changing synaptic UNC-104 levels...
March 13, 2024: Journal of Cell Science
https://read.qxmd.com/read/38471779/comparative-roles-of-caudate-and-putamen-in-the-serial-order-of-behavior-effects-of-striatal-glutamate-receptor-blockade-on-variable-versus-fixed-spatial-self-ordered-sequencing-in-marmosets
#7
JOURNAL ARTICLE
Stacey Anne Gould, Amy Hodgson, Hannah F Clarke, Trevor W Robbins, Angela C Roberts
Self-ordered sequencing is an important executive function involving planning and executing a series of steps to achieve goal-directed outcomes. Lateral frontal cortex is implicated in this behavior, but downstream striatal outputs remain relatively unexplored. We trained marmosets on a three-stimulus self-ordered spatial sequencing task using a touch-sensitive screen to explore the role of caudate nucleus and putamen in random and fixed response arrays. By transiently blocking glutamatergic inputs to these regions, using intra-striatal CNQX microinfusions, we demonstrate that caudate and putamen are both required for, but contribute differently to, flexible and fixed sequencing...
March 12, 2024: ENeuro
https://read.qxmd.com/read/38469215/digital-clock-drawing-test-reflects-visuospatial-ability-of-older-drivers
#8
JOURNAL ARTICLE
Satsuki Yamauchi, Naoko Kawano, Kan Shimazaki, Hiroko Shinkai, Masae Kojima, Kazumitsu Shinohara, Hirofumi Aoki
OBJECTIVES: To keep older drivers safe, it is necessary to assess their fitness to drive. We developed a touch screen-based digital Clock Drawing Test (dCDT) and examined the relationship between the dCDT scores and on-road driving performance of older drivers in a community-setting. METHODS: One hundred and forty-one community-dwelling older drivers (range; 64-88 years old) who participated in this study were included in the analysis. Participants completed the dCDT, the Mini-Mental State Examination-Japanese (MMSE-J), and an on-road driving assessment...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38449726/elliq-an-ai-driven-social-robot-to-alleviate-loneliness-progress-and-lessons-learned
#9
JOURNAL ARTICLE
E Broadbent, K Loveys, G Ilan, G Chen, M M Chilukuri, S G Boardman, P M Doraiswamy, D Skuler
BACKGROUND: Loneliness is a significant issue in older adults and can increase the risk of morbidity and mortality. OBJECTIVE: To present the development of ElliQ, a proactive, AI-driven social robot with multiple social and health coaching functions specifically designed to address loneliness and support older people. DEVELOPMENT/IMPLEMENTATION: ElliQ, a consumer robot with a friendly appearance, uses voice, sounds, light, and buttons through a touch screen to facilitate conversation, music, video calls, well-being assessments, stress reduction, cognitive games, and health reminders...
2024: JAR Life
https://read.qxmd.com/read/38442586/brain-responses-to-a-lab-evolved-artificial-language-with-space-time-metaphors
#10
JOURNAL ARTICLE
Tessa Verhoef, Tyler Marghetis, Esther Walker, Seana Coulson
What is the connection between the cultural evolution of a language and the rapid processing response to that language in the brains of individual learners? In an iterated communication study that was conducted previously, participants were asked to communicate temporal concepts such as "tomorrow," "day after," "year," and "past" using vertical movements recorded on a touch screen. Over time, participants developed simple artificial 'languages' that used space metaphorically to communicate in nuanced ways about time...
March 4, 2024: Cognition
https://read.qxmd.com/read/38429591/visual-perspective-and-body-ownership-modulate-vicarious-pain-and-touch-a-systematic-review
#11
REVIEW
Matteo P Lisi, Martina Fusaro, Salvatore Maria Aglioti
We conducted a systematic review investigating the influence of visual perspective and body ownership (BO) on vicarious brain resonance and vicarious sensations during the observation of pain and touch. Indeed, the way in which brain reactivity and the phenomenological experience can be modulated by blurring the bodily boundaries of self-other distinction is still unclear. We screened Scopus and WebOfScience, and identified 31 articles, published from 2000 to 2022. Results show that assuming an egocentric perspective enhances vicarious resonance and vicarious sensations...
March 1, 2024: Psychonomic Bulletin & Review
https://read.qxmd.com/read/38429566/chunking-as-a-function-of-sequence-length
#12
JOURNAL ARTICLE
Laure Tosatto, Joël Fagot, Dezso Nemeth, Arnaud Rey
Chunking mechanisms are central to several cognitive processes. During the acquisition of visuo-motor sequences, it is commonly reported that these sequences are segmented into chunks leading to more fluid, rapid, and accurate performances. The question of a chunk's storage capacity has been often investigated but little is known about the dynamics of chunk size evolution relative to sequence length. In two experiments, we studied the dynamics and the evolution of a sequence's chunking pattern as a function of sequence length in a non-human primate species (Guinea baboons, Papio papio)...
March 2, 2024: Animal Cognition
https://read.qxmd.com/read/38422162/reptilearn-an-automated-home-cage-system-for-behavioral-experiments-in-reptiles-without-human-intervention
#13
JOURNAL ARTICLE
Tal Eisenberg, Mark Shein-Idelson
Understanding behavior and its evolutionary underpinnings is crucial for unraveling the complexities of brain function. Traditional approaches strive to reduce behavioral complexity by designing short-term, highly constrained behavioral tasks with dichotomous choices in which animals respond to defined external perturbation. In contrast, natural behaviors evolve over multiple time scales during which actions are selected through bidirectional interactions with the environment and without human intervention...
February 29, 2024: PLoS Biology
https://read.qxmd.com/read/38394072/open-source-milligram-scale-four-channel-automated-protein-purification-system
#14
JOURNAL ARTICLE
Robert R Puccinelli, Samia S Sama, Caroline M Worthington, Andreas S Puschnik, John E Pak, Rafael Gómez-Sjöberg
Liquid chromatography purification of multiple recombinant proteins, in parallel, could catalyze research and discovery if the processes are fast and approach the robustness of traditional, "one-protein-at-a-time" purification. Here, we report an automated, four channel chromatography platform that we have designed and validated for parallelized protein purification at milligram scales. The device can purify up to four proteins (each with its own single column), has inputs for up to eight buffers or solvents that can be directed to any of the four columns via a network of software-driven valves, and includes an automated fraction collector with ten positions for 1...
2024: PloS One
https://read.qxmd.com/read/38356136/assessing-the-motivational-value-of-infant-video-clips-on-chimpanzees-through-discrimination-learning-task
#15
JOURNAL ARTICLE
Yuri Kawaguchi, Masaki Tomonaga
The motivational value of visual infant stimuli in humans is considered to encourage parental behavior. To explore the evolutionary roots of this preference for infants, we examined the reward value of conspecific infant videos compared to adult ones in nine chimpanzees. We employed a novel approach, a simultaneous discrimination task with differential sensory reinforcement. In Experiments 1 and 2, we tested if watching conspecific infant videos is more rewarding than watching adult ones. Participants were required to discriminate between two visual stimuli by a touch panel task...
February 2024: Developmental Psychobiology
https://read.qxmd.com/read/38341308/fish-oil-supplementation-and-risk-of-dementia-among-diabetic-patients-a-prospective-study-of-16-061-older-patients
#16
JOURNAL ARTICLE
Yin Li, Xiaohui Liu, Pan Zhuang, Lange Zhang, Yuqi Wu, Shanyun Wu, Yu Zhang, Jingjing Jiao
BACKGROUND: Although n-3 Polyunsaturated fatty acids (PUFAs) may benefit cognitive performance, the association of n-3 PUFA intake with dementia risk under dysglycemia has not been examined. We aimed to evaluate the relationship between fish oil supplement use or fish consumption and dementia risk among older patients with diabetes. METHOD: A total of 16,061 diabetic patients aged over 60 years were followed up in the UK Biobank. Fish oil supplements use (yes or no) was collected by the touch screen questionnaire...
February 9, 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38340961/retroarticular-drilling-for-osteochondritis-dissecans-of-the-talus-a-systematic-review
#17
REVIEW
Rémi Pelletier Roy, Ylan Tran, Géraldine Merle, Marie-Lyne Nault
BACKGROUND: Opinions differ on the optimal treatment for stable talar osteochondritis dissecans (OCD) with intact cartilage. Some recommend conservative management, while others prefer surgical care which includes debridement and micro-fractures, transarticular drilling through a direct or medial malleolus approach and retroarticular drilling. The rationale behind retroarticular drilling is to induce bone marrow healing without touching the intact cartilage. The goal of this systematic review is to summarize the clinical outcomes of retroarticular drilling as a standalone procedure for stable talar OCD with intact cartilage...
February 8, 2024: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/38331893/the-utility-of-behavioral-biometrics-in-user-authentication-and-demographic-characteristic-detection-a-scoping-review
#18
JOURNAL ARTICLE
O L Finnegan, J W White, B Armstrong, E L Adams, S Burkart, M W Beets, S Nelakuditi, E A Willis, L von Klinggraeff, H Parker, M Bastyr, X Zhu, Z Zhong, R G Weaver
BACKGROUND: Objective measures of screen time are necessary to better understand the complex relationship between screen time and health outcomes. However, current objective measures of screen time (e.g., passive sensing applications) are limited in identifying the user of the mobile device, a critical limitation in children's screen time research where devices are often shared across a family. Behavioral biometrics, a technology that uses embedded sensors on modern mobile devices to continuously authenticate users, could be used to address this limitation...
February 8, 2024: Systematic Reviews
https://read.qxmd.com/read/38329983/the-research-of-touch-screen-usability-in-civil-aircraft-cockpit
#19
JOURNAL ARTICLE
Xiaoli Wang, Wei Guo, Zhenwei Zhong, Rui Zeng, Jiong Zhang, Lijing Wang
With the advancement of touch screen technology, the application of touch screens in civil aircraft cockpits has become increasingly popular. However, further analysis and research are required to fully promote its applications. The paper researched the usability of touch screens in aircraft cockpit considering the operation performance and subjective NASA-TLX workload evaluation, conducted experimental research on three touch gestures: click, drag, and zoom. Additionally, a comparative analysis was conducted on the touch performance under different layouts, positions, touch sizes, dragging direction angles, and zoom multiples...
2024: PloS One
https://read.qxmd.com/read/38327470/contrast-enhanced-ultrasound-ceus-and-shear-wave-elastography-swe-features-for-characterizing-serous-microcystic-adenomas-smas-in-comparison-to-pancreatic-neuroendocrine-tumors-pnets
#20
JOURNAL ARTICLE
Xiao-Fan Tian, Ling-Yun Yu, Dao-Hui Yang, Dan Zuo, Jia-Ying Cao, Ying Wang, Zi-Yi Yang, Wen-Hui Lou, Wen-Ping Wang, Wei Gong, Yi Dong
OBJECTIVES: Serous microcystic adenoma (SMA), a primary benign pancreatic tumor which can be clinically followed-up instead of undergoing surgery, are sometimes mis-distinguished as pancreatic neuroendocrine tumor (pNET) in regular preoperative imaging examinations. This study aimed to analyze preoperative contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) features of SMAs in comparison to pNETs. MATERIAL AND METHODS: In this retrospective study, patients with imaging-diagnosed pancreatic lesions were screened between October 2020 to October 2022 (ethical approval No...
February 15, 2024: Heliyon
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