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Chao-Hua Fang, Cheng-Kung Cheng, Tie-Bing Qu, Jun-Hui Zhang, Bo Zhang, Qun Hua, Shi-Gui Yan
Rotational malalignment between the femoral and tibial components in total knee arthroplasty (TKA) can affect clinical outcomes, but there is no consensus on how to best determine tibia tray orientation. The posterolateral corner-locked (PLCL) technique may be a new method. This study aims to assess the applicability of this technique in a Chinese population. Forty normal Chinese volunteers were recruited and underwent computed tomography (CT) of the lower limbs. Knee model reconstructions and simulated standard tibial osteotomy were conducted digitally...
February 14, 2019: Journal of Knee Surgery
Yu Huang, Xianchuan Xie, Li Jun Zhou, Xiaowen Ji, Bin Gao, Gui Zhou Xu, Aimin Li
Herein we investigated the multi-phase distribution and estrogenic effects of endocrine disrupting chemicals (EDCs) in suspended particulate matter (SPM), colloids, and soluble phases from the Shaying River to assess the composition of estrogenic compounds and associated estrogenic risk. The yeast two hybrid (YES) method, cross-flow ultrafiltration (CFUF), and LC-MS/MS were employed. Risk quotient (RQ) values ranged from 0.72 to 3.88, revealing that the Shaying River posed high estrogenic risk to aquatic organisms...
February 11, 2019: Ecotoxicology and Environmental Safety
Jin Wu, Zixuan Wu, Xing Lu, Songjia Han, Bo-Ru Yang, Xuchun Gui, Kai Tao, Jianmin Miao, Chuan Liu
Ionic hydrogels, a class of intrinsically stretchable and conductive materials, are widely used in soft electronics. However, the easy freezing and drying of water-based hydrogels significantly limit their long-term stability. Here, a facile solvent-replacement strategy is developed to fabricate ethylene glycol (Eg)/glycerol (Gl)-water binary anti-freezing and anti-drying organohydrogels for ultrastretchable and sensitive strain sensing within a wide temperature range. Due to the ready formation of strong hydrogen bonds between Eg/Gl and water molecules, the organohydrogels gain exceptional freezing and drying tolerance with retained deformability, conductivity and self-healing ability even stay at extreme temperature for a long time...
February 14, 2019: ACS Applied Materials & Interfaces
Weidong Nie, Wei Wei, Liping Zuo, Chengliang Lv, Fan Zhang, Gui-Hong Lu, Feng Li, Guanghao Wu, Li-Li Huang, Xiaobo Xi, Hai-Yan Xie
Although adoptive T-cell therapy has been successful in hematological malignancy treatment, its application in solid tumors remains a great challenge. Here, using a pH sensitive benzoic-imine bond and inverse electron-demand Diels-Alder cycloaddition, we prepared magnetic nano-clusters (NCs) armed with responsive PD-1 antibody (aP), which could then bind onto effector T cells due to their PD-1 expression. After adoptive transfer, the magnetization and superparamagnetism of NCs enabled us to magnetically recruit effector T cells and aP simultaneously to tumor sites with MRI guiding...
February 14, 2019: ACS Nano
Junqin Li, Jing Yang, Shan Lu, Dong Jin, Xin-He Lai, Gui Zhang, Zhi Tian, Ji Pu, Xiaomin Wu, Ying Huang, Suping Wang, Jianguo Xu
Strains 449T and 622 are both aerobic, Gram-stain-positive, short, rod-shaped bacilli that were recently isolated from the faeces of Tibetan antelopes on the Qinghai-Tibet Plateau in China. Their 16S rRNA gene sequences were most similar to those of Mycetocola zhadangensis ZD1-4T (97.9-98.0 %) and Mycetocola miduiensis CGMCC 1.11101T (97.3-97.4 %). Phylogenetic analysis of the 16S rRNA gene sequences further suggested that strains 449T and 622 represent a new lineage within the genus Mycetocola. The G+C content of strain 449T is 64...
February 14, 2019: International Journal of Systematic and Evolutionary Microbiology
Xiao Yu Huang, Wen Yang Sun, Zun Qiang Yan, Hai Ren Shi, Qiao Li Yang, Peng Fei Wang, Sheng Gui Li, Li Xia Liu, Sheng Guo Zhao, Shuang Bao Gun
LncRNA play important roles in regulation of host immune and inflammation responses in defending bacterial infection. Clostridium perfringens (C. perfringens) type C is one of primary bacteria leading to piglet diarrhea and other intestinal inflammatory diseases. For the differences of host immune capacity, individuals usually show resistance and susceptibility to bacterial infection. However, whether and how lncRNAs involved in modulating host immune resistance have not been reported. We have investigated the expression patterns of ileum lncRNAs of 7-day-old piglets infected by C...
February 13, 2019: Scientific Reports
Jinghua Gui, Yunxian Huang, Martin Montanari, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi
At the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling. Here, using the Drosophila pupal wing, we address how decapentaplegic (Dpp)/bone morphogenetic protein (BMP) signaling and 3D wing morphogenesis are coordinated...
February 13, 2019: Proceedings of the National Academy of Sciences of the United States of America
Shengling Xie, Gui Chen, Hao Yan, Jieping Hou, Yongping He, Tongyun Zhao, Jing Xu
Herein, we report a concise total synthesis of atropurpuran, a unique and synthetically challenging pentacyclic diterpene that bears a tetracyclo[,9.04,12]-tridecane skeleton that is unprecedented among natural terpenes. This 13-step approach features a strategy that include early-stage rapid skeleton formation and the late-stage introduction of reactive functional groups, thus allowed a high overall synthetic efficiency with minimal use of PGs. The key transformations of our work include a rapid construction of the spiro[5...
February 13, 2019: Journal of the American Chemical Society
Chloe Gui, Jonathan C Lau, Suzanne E Kosteniuk, Donald H Lee, Joseph F Megyesi
BACKGROUND: An important aspect in the management of patients with diffuse low-grade gliomas (LGGs) involves monitoring the lesions via serial magnetic resonance imaging (MRI). However, radiological interpretations of LGG interval scans are often qualitative and thus difficult to use clinically. METHODS: To contextualize these assessments, we retrospectively compared radiological interpretations of LGG growth or stability to volume change measured by manual segmentation...
February 13, 2019: Acta Neurochirurgica
Zi Ye, Renchang Zhang, Meng Gao, Zhongshan Deng, Lin Gui
A low voltage 3D parallel electroosmotic flow (EOF) pump composed of two electrode layers and a fluid layer is proposed in this work. The fluid layer contains twenty parallel fluid channels and is set at the middle of the two electrode layers. The distance between fluid and electrode channels was controlled to be under 45 μm, to reduce the driving voltage. Room temperature liquid metal was directly injected into the electrode channels by syringe to form non-contact electrodes. Deionized (DI) water with fluorescent particles was used to test the pumping performance of this EOF pump...
February 11, 2019: Micromachines
Junqin Li, Shan Lu, Dong Jin, Jing Yang, Xin-He Lai, Gui Zhang, Zhi Tian, Wentao Zhu, Ji Pu, Xiaomin Wu, Ying Huang, Suping Wang, Jianguo Xu
Two novel aerobic, Gram-staining-positive and non-spore-forming bacterial strains, 194T and S1194, were isolated from faeces of Tibetan antelopes sampled at the Qinghai-Tibet Plateau of China. The strains were able to grow in medium up to 10 % NaCl, similar to the NaCl-resistant property of the genus Salinibacterium members. The 16S rRNA gene sequences of the strains showed the highest similarity to Salinibacterium xinjiangense(98.1-98.2 %), and phylogenetic analysis based on 16S rRNA gene sequences indicated that strains 194T and S1194 represent a new lineage...
February 12, 2019: International Journal of Systematic and Evolutionary Microbiology
Mu-Yang Li, Xin-Ming Zhu, Xiao-Tian Niu, Xiu-Mei Chen, Jia-Xin Tian, Yi-Di Kong, Dong-Ming Zhang, Lei Zhao, Gui-Qin Wang
The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. A basal diet was supplemented with AMRP at 0, 1, 1.5 or 2 g/kg feed for 56 days. After the 56 days feeding period, weight gain (WG), specific growth rate (SGR) and feed conversion ratio (FCR) were significantly increased or decreased (P < 0.05) by dietary AMRP, with the highest WG, SGR and the minimum FCR occurring in 1...
February 12, 2019: Molecular Biology Reports
Rya Ero, Veerendra Kumar, Weixin Su, Yong-Gui Gao
Members of the ATP-binding cassette F (ABC-F) proteins confer resistance to several classes of clinically important antibiotics through ribosome protection. Recent structures of two ABC-F proteins, Pseudomonas aeruginosa MsrE and Bacillus subtilis VmlR bound to ribosome have shed light onto the ribosome protection mechanism whereby drug resistance is mediated by the antibiotic resistance domain (ARD) connecting the two ATP binding domains. ARD of the E site bound MsrE and VmlR extends towards the drug binding region within the peptidyl transferase center (PTC) and leads to conformational changes in the P site tRNA acceptor stem, the PTC, and the drug binding site causing the release of corresponding drugs...
February 12, 2019: Protein Science: a Publication of the Protein Society
Sergey Morozov, R J Scott McCairns, Juha Merilä
Intermittent-flow respirometry is widely used to measure oxygen uptake rates and subsequently estimate aerobic metabolic rates of aquatic animals. However, the lack of a standard quality-control software to detect technical problems represents a potential impediment to comparisons across studies in the field of evolutionary and conservation physiology. Here, we introduce 'FishResp', a versatile R package and its graphical implementation for quality-control and filtering of raw respirometry data. Our goal is to provide a straightforward, cross-platform and free software to help improve the quality and comparability of metabolic rate estimates for reducing methodological fragmentation in the field of aquatic respirometry...
2019: Conservation Physiology
Ya-Fei Cheng, Gui-Feng Li, Ying-Yi Liu, Bing-Qian Zhu, Qian Zhang, Yuan Xue, Zheng-Zhe Zhang, Ren-Cun Jin
High-rate denitrification is a popular and efficient process for treatment of nitrate-rich wastewater. Knowing the effect of heavy metals on denitrification is essential for industrial development. In the present study, the long-term impacts of Zn(II) on denitrifying granular sludge were investigated. The suppression threshold of Zn(II) on denitrifying bacteria was 10 mg L-1 for long-term exposure. The nitrogen removal rate was decreased by long-term addition of 10 mg L-1 Zn(II). Castellaniella and Klebsiella were the two dominant genera under Zn(II) stress...
February 2, 2019: Bioresource Technology
Jianlei Jia, Qian Chen, Linsheng Gui, Jipeng Jin, Zan Yuan, Yongyuan Li, Qiaohong Ru, Shengzhen Hou
Objective: The present study was to investigate the association of polymorphisms in exon-9 of the BMPR-1B gene (C864T) with litter size in 240 Dorset, 232 Mongolian, and 124 Small Tail Han ewes. Methods: Blood samples were collected from 596 ewes and genomic DNA was extracted using the phenol: chloroform extraction method. The 304-bp amplified PCR product was analyzed for polymorphism by SSCP method. The genotypic frequency and allele frequency of BMPR-1B gene exon-9 were computed after sequence alignment...
February 9, 2019: Asian-Australasian Journal of Animal Sciences
Meng M Zhao, Yi-Ping Chen, Lin-Gui Xue, Tao T Fan, Brown Emaneghemi
The Yellow River flows through Lanzhou city and is the only drinking water source for 3.6 million residents. Yet, little is known regarding the safety and quality of the Yellow River for resident consumption. To address this knowledge-gap, water samples were collected from different sites within this section during the dry and wet seasons. Physico-chemical parameters and microbial community metrics were analyzed to assess the health risk associated with this Chinese mother river. Water quality of the river was better during the dry season (March-April) than in the wet season (September-October)...
December 10, 2018: Science of the Total Environment
Jiong Zhang, Li Tang, Gui Sen Li, Jia Wang
The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL-6 in the kidney; The morphology of kidney was examined by Periodic Acid-Schiff stain (PAS)...
November 2018: Renal Failure
Yongsheng Wang, Yinliang Qi, Xiang Wei, Shaolong Chen, Ning Jia, Qing Zhou, Sumei Zhang, Shuyu Gui, Yuan Wang
Hypoxia induces vigorous growth and a higher malignant phenotype in solid tumors. Hyperoxic treatment using hyperbaric oxygen (HBO) has previously been shown as a highly effective method to attenuate hypoxia. We aimed to investigate the effect of HBO on hypoxia-induced malignancy of lung cancer cells. Cobalt chloride (CoCl2 ) was used to induce chemical hypoxia in lung cancer cell line A549. Hypoxic inducible factor-1α (HIF-1α) expression, lactate dehydrogenase (LDH) activity, migration and invasion capacity, expression profiles of epithelial-mesenchymal transition (EMT) markers and apoptotic markers were assessed in CoCl2 -treated A549 cells, with or without HBO treatment...
February 10, 2019: Experimental Lung Research
Sheng-Jun Liao, Jing Luo, Dong Li, Yuan-Hong Zhou, Bin Yan, Jing-Jing Wei, Jian-Cheng Tu, Yi-Rong Li, Gui-Mei Zhang, Zuo-Hua Feng
TGF-β1 is a main inducer of epithelial to mesenchymal transition (EMT). However, many breast cancer cells are not sensitive to the EMT induction by TGF-β1 alone. So far, the mechanisms underlying the induction of TGF-β1-insensitive breast cancer cells remains unclear. Here we report that TNF-α can induce EMT and invasiveness of breast cancer cells which are insensitive to TGF-β1. Intriguingly, TGF-β1 could cooperate with TNF-α to promote the EMT and invasiveness of breast cancer cells. The prolonged co-stimulation with TGF-β1 and TNF-α could enhance the sustained activation of Smad2/3, p38 MAPK, ERK, JNK and NF-κB pathways by enhancing the activation of TAK1, which was mediated by the gradually up-regulated TβRs...
February 9, 2019: Journal of Cell Communication and Signaling
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