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Metastasis head neck cancer

Liyuan Chen, Zhiguo Zhou, David Sher, Qiongwen Zhang, Jennifer Shah, Nhat-Long Pham, Steve B Jiang, Jing Wang
Lymph node metastasis (LNM) is a significant prognostic factor in patients with head and neck cancer, and the ability to predict it accurately is essential to optimizing treatment. Positron emission tomography (PET) and computed tomography (CT) imaging are routinely used to identify LNM. Although large or highly active lymph nodes (LNs) have a high probability of being positive, identifying small or less reactive LNs is challenging. The accuracy of LNM identification strongly depends on the physician's experience, so an automatic prediction model for LNM based on CT and PET images is warranted to assist LMN identification across care providers and facilities...
February 19, 2019: Physics in Medicine and Biology
Bas Vaarwerk, Marinka L F Hol, Reineke A Schoot, Willemijn B Breunis, Maartje M L de Win, Henrike Westerveld, Raquel Davila Fajardo, Peerooz Saeed, Michiel W van den Brekel, Bradley R Pieters, Simon D Strackee, Ludi E Smeele, Johannes H M Merks
BACKGROUND AND PURPOSE: Survival after relapse of head and neck rhabdomyosarcoma (HNRMS) after prior external beam radiotherapy (EBRT) is poor, since options for adequate local treatment are often lacking. In this study we describe our experience with salvage AMORE in patients with relapsed HNRMS after prior EBRT. MATERIALS AND METHODS: Patients with relapsed HNRMS after prior EBRT in which salvage AMORE treatment was considered feasible were analysed; this includes patients with parameningeal, head and neck non-parameningeal and orbital localization...
February 2019: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Shanmuga S Palaniswamy, Padma Subramanyam
Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Like other primary malignancies of the head and neck, DTC follows a consistent pattern of spread in the cervical LNs. The central compartment, level VI and VII, is the first sentinel node followed by spread to the lateral compartments levels II-V, followed by the contralateral side...
November 2018: Indian Journal of Endocrinology and Metabolism
Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak, Katarzyna Lamperska
INTRODUCTION: Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenchymal transition (EMT). However, it is unclear if let-7d and miR-205 together influence cancer cells. AIM: To determine if let-7d and miR-205 expression levels influence HNSCC patient outcome...
February 13, 2019: Journal of Biomedical Science
Mingyu Zhu, Xin Liu, Yuan Qu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Huijuan Yang, Liangping Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhongwu Lu, Zhiguo Luo, Xichun Hu
Background: Bone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis. In this study, we explored bone metastasis patterns in patients whose primary tumors had been well identified. Methods: We included 290 consecutive cancer patients with bone metastases but no visceral metastases, out of 2559 patients whose bone metastases were diagnosed by positron emission tomography/computed tomography, between Jan 2015 and Oct 2017 at the Fudan University Shanghai Cancer Center...
April 2019: Journal of Bone Oncology
Zhiguo Zhao, Dan Gao, Tie Ma, Liping Zhang
MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues ( P < 0...
February 8, 2019: Aging
Kazuaki Chikamatsu, Hiroe Tada, Hideyuki Takahashi, Yuki Kuwabara-Yokobori, Hiroki Ishii, Shota Ida, Masato Shino
OBJECTIVES: Circulating tumor cells (CTCs) are cells that have shed from tumor tissue into the bloodstream, and the detection and characterization of CTCs in head and neck squamous cell carcinoma (HNSCC) still remain a challenge. MATERIALS AND METHODS: CTCs were isolated from 30 patients with HNSCC with recurrent and/or distant metastasis, via the depletion of CD45-positive cells with magnetic beads and the expression of multiple epithelial markers (CK19, EpCAM, EGFR, and c-Met) was analyzed by RT-qPCR with a low concentration of RNA from the CTC population...
February 2019: Oral Oncology
Douglas R Farquhar, Maheer M Masood, Nicholas R Lenze, Philip McDaniel, Angela Mazul, Siddharth Sheth, Adam M Zanation, Trevor G Hackman, Mark Weissler, Jose P Zevallos, Andrew F Olshan
OBJECTIVE: There is considerable variation in the travel required for a patient with head and neck squamous cell carcinoma (HNSCC) to receive a diagnosis. The impact of this travel on the late diagnosis of cancer remains unexamined, even though presenting stage is the strongest predictor of mortality. Our aim is to determine whether travel time affects HNSCC stage at diagnosis independently of other risk factors, and whether this association is affected by socioeconomic status. MATERIALS AND METHODS: Cases were obtained from the CHANCE database, a population-based case-control study in North Carolina (n = 808)...
February 2019: Oral Oncology
Ammar Sukari, Misako Nagasaka, Roba Alhasan, Dhaval Patel, Antoinette Wozniak, Radhakrishnan Ramchandren, Ulka Vaishampayan, Amy Weise, Lawrence Flaherty, Hyejeong Jang, Seongho Kim, Shirish Gadgeel
BACKGROUND: Data on the characteristics of patients who are likely to experience adverse events, both immune-related and non-immune-related, from programmed cell death-1 (PD1) inhibitors are limited. PATIENTS AND METHODS: Data from patients who received ≥1 dose of single-agent PD1 inhibitor between August 3, 2011 and August 31, 2016 were obtained from our Institution's pharmacy database. AEs were graded using Common Terminology Criteria for Adverse Events version 4...
February 2019: Anticancer Research
Bayram Şahin, Can Doruk, Mehmet Çelik, Erkan Öztürk, Selçuk Güneş, Ökkeş Erkan Kıyak
Objective: We present 11 patients with distant metastases to the head and neck from an infraclavicularly located primary tumor and discuss the management strategies including the clinical presentation, treatment modalities, and prognosis. Methods: The retrospective data of the pathology reports and operation notes of 1239 patients who had undergone any kind of oncological surgical intervention between 2005 and 2017 were analyzed. All of the 11 patients included in the study were evaluated in our department's tumor board, and all patients with an operable lesion had undergone surgery...
December 2018: Turkish Archives of Otorhinolaryngology
Hin-Lun Liu, Joseph Chun-Kit Chung
INTRODUCTION: Vascularized lymph node transfer (VLNT) has become the established treatment for secondary lymphedema. The proposed mechanisms of VLNT include lymphangiogenesis and absorptive action of transplanted lymphatic tissue. Therefore, in theory, the lymph node content of lymph node flap is crucial to clinical response. The supraclavicular lymph node flap (SCLNF) has been described as one of the flap options for VLNT. However, its lymph node content has not been fully studied. The aim of this study is to find out the lymph node content of SCLNF with histological examination...
January 29, 2019: Lymphatic Research and Biology
Muhammad Faisal, Mohammad Adeel, Sheryar Riaz, Abdullah Anwar, Asma Rashid, Sadaf Usman, Arif Jamshed, Raza Hussain
Objectives: The submental flap provides an alternative technique in orofacial reconstruction, especially in situations where free flap services are not available. The objective of this study is to demonstrate the oncological safety and benefits of this flap in oral cavity reconstruction in a tertiary care cancer hospital. Materials and Methods: A total of 27 patients with oral cavity cancers, which underwent submental flap reconstruction from 2015 to 2017 at Shaukat Khanum Cancer Memorial Hospital, were included in the study...
July 2018: Annals of Maxillofacial Surgery
Shayanne A Lajud, Jaime A Aponte-Ortiz, Miguel Garraton, Laureano Giraldez
Medullary thyroid cancer (MTC) represents less than 1% of all thyroid cancers. Complete surgical resection remains the mainstay of treatment for locoregional disease. Unfortunately, patients with recurrence may present with metastasis to challenging anatomic locations. We describe the first case of a recurrent MTC metastatic to the parapharyngeal space (PPS) that was managed using a combined transoral robotic surgery (TORS) and transcervical (TC) approach. We review the presentation, natural history, diagnosis and management of recurrent MTC, and describe a novel combined TORS-TC surgical approach for the treatment of PPS metastasis...
January 28, 2019: Journal of Robotic Surgery
Yongming Qiao, Ying Wang, Peng Kang, Rui Li, Yiming Liu, Wei He
PURPOSE: The aim of the present study is to assess the accuracy of clinical preoperative lymph node and to define the degree of relation between the clinical preoperative assessment and histopathological examination in patients with head and neck cancer and cN+. METHODS: This retrospective study was performed on 125 patients (85 males and 40 females) at the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, between December 2012 and December 2014...
January 2019: Medicine (Baltimore)
Yan Li, Musaddiq J Awan, Tangel Chang, Pierre Lavertu, Chad Zender, Rod Rezaee, Nicole Fowler, Jay Wasman, Norbert E Avril, Nianyong Chen, Mitchell Machtay, Min Yao
PURPOSE: The purpose of this study was to retrospectively review the role of post-treatment (post-tx) FDG-PET/CT scans in patients receiving postoperative intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinomas (HNSCC). MATERIALS AND METHODS: Eighty-two patients with HNSCC treated with surgery and postoperative IMRT with or without chemotherapy from October 15, 2008 to December 31, 2014 that had post-tx PET/CT within 6 months of completing IMRT were included...
January 24, 2019: European Journal of Nuclear Medicine and Molecular Imaging
Naohiro Wakisaka, Kazuhira Endo, Tomohiro Kitazawa, Yuzo Shimode, Koroku Kato, Makiko Moriyama-Kita, Wataru Koda, Hiroko Ikeda, Kazuya Ishikawa, Takayoshi Ueno, Yosuke Nakanishi, Satoru Kondo, Hisashi Sugimoto, Kenichi Yoshimura, Hiroyuki Tsuji, Shuichi Kawashiri, Kiyoka Omoto, Tomokazu Yoshizaki
BACKGROUND: In sentinel lymph node (SLN) biopsy for head and neck cancers, the radioisotope method has been the gold standard. However, this method has several problems, such as unavoidable radiation exposure and requirements of expensive equipment. AIMS/OBJECTIVES: To overcome these problems, we evaluated the contrast-enhanced ultrasonography (CEUS)-guided SLN-detection method, and predicted the SLN metastatic status using novel ultrasound technology, superb microvascular imaging (SMI)...
January 24, 2019: Acta Oto-laryngologica
Patrícia Queirós, Diamantino Sousa, Artur Antunes, Mercedez Sanchez, Ricardo França, José Casquilho, Horácio Guerreiro
Gastrostomy site metastization is considered an uncommon complication of percutaneous endoscopic gastrostomy (PEG) placement in patients with head and neck tumours, but it is important to consider this possibility when evaluating gastrostomy-related symptoms. The authors present the case of a 40-year-old male with excessive alcohol consumption and active smoking, diagnosed with a stage IV oropharyngeal squamous cell carcinoma. The patient developed a paraneoplastic demyelinating motor polyneuropathy that, associated with tumour mass effect, caused dysphagia with need for nasogastric tube feeding...
December 2018: GE Portuguese Journal of Gastroenterology
Hua Wu, Da Hai Yu, Mian Hua Wu, Teng Huang
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer. Early detection and management of HNSCC may prevent progression of the disease. Long non-coding RNAs (lncRNAs) may serve as prognostic biomarkers for various cancer types. The current study downloaded an RNA-Seq dataset containing 43 tumor-normal pairs. An independent t-test identified that the expression level of lncRNA LOC541471 was significantly increased in tumor tissues compared with healthy tissues. Additionally, the current study demonstrated that high lncRNA LOC541471 expression was significantly associated with increasing lymph node metastasis classification and perineural invasion...
February 2019: Oncology Letters
Tian Liu, Jing Liu, Qiuyue Chen, Shengjian Jin, Sisi Mi, Wenhua Shao, Yasusei Kudo, Sien Zeng, Guangying Qi
Oral cancer is a common cancer of the head and neck. Oral squamous cell carcinoma (OSCC) represents almost 90% of the total cases of head and neck cancer. Ubiquitin-specific protease 22 (USP22) is a deubiquitinating hydrolase, and it is highly expressed in various types of cancer, which also typically have a poor prognosis. Aurora-B and Survivin, which belong to the chromosomal passenger complex, are also highly expressed in a number of types of cancer. In the present study, USP22 expression and its associations with Aurora-B and Survivin, and the clinicopathological features in OSCC were explored...
February 2019: Oncology Letters
Chunhui Wang, Lei Chen, Yuanyuan Huang, Kun Li, Anqi Jinye, Taotao Fan, Ren Zhao, Xianming Xia, Bing Shen, Juan Du, Yehai Liu
The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regulating EMT in human laryngeal squamous cell carcinoma. The present study examined whether exosomes/TRPP2 small interfering RNA (siRNA) complexes were able to reduce EMT by suppressing TRPP2 expression in FaDu cells, a cell line of human pharyngeal squamous cell carcinoma...
February 2019: Oncology Letters
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