keyword
https://read.qxmd.com/read/38529341/extranodal-extension-in-laryngeal-squamous-cell-carcinoma
#1
JOURNAL ARTICLE
Aman M Patel, Sudeepti Vedula, Ariana L Shaari, Hannaan S Choudhry, Andrey Filimonov
OBJECTIVE: Although large retrospective database studies have associated extranodal extension (ENE) with worse survival in several head and neck cancers, the prognostic significance of ENE in laryngeal squamous cell carcinoma (LSCC) remains unclear. Our study examines ENE and overall survival (OS) in LSCC. METHODS: The 2006-2017 National Cancer Database was queried for patients with LSCC undergoing surgical resection and neck dissection, with or without adjuvant therapy...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38519500/single-cell-deciphering-of-progression-trajectories-of-the-tumor-ecosystem-in-head-and-neck-cancer
#2
JOURNAL ARTICLE
Z L Liu, X Y Meng, R J Bao, M Y Shen, J J Sun, W D Chen, F Liu, Y He
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide and has high heterogeneity and unsatisfactory outcomes. To better characterize the tumor progression trajectory, we perform single-cell RNA sequencing of normal tissue, precancerous tissue, early-stage, advanced-stage cancer tissue, lymph node, and recurrent tumors tissue samples. We identify the transcriptional development trajectory of malignant epithelial cells and a tumorigenic epithelial subcluster regulated by TFDP1. Furthermore, we find that the infiltration of POSTN+ fibroblasts and SPP1+ macrophages gradually increases with tumor progression; their interaction or interaction with malignant cells also gradually increase to shape the desmoplastic microenvironment and reprogram malignant cells to promote tumor progression...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38517817/prognostic-modeling-for-nasopharyngeal-carcinoma-nc-undergoing-concurrent-chemoradiotherapy-using-clinical-and-enhanced-mri-delta-radiomics-data-a-preliminary-study
#3
JOURNAL ARTICLE
Qiuyang Wang, Peng An, Lina Song, Junjie Liu, Jisheng Liu
BACKGROUND: Nasopharyngeal carcinoma (NC) is one of the prevalent malignancies of the head and neck region with poor prognosis. OBJECTIVE: The aim of this study is to establish a predictive model for assessing NC prognosis based on clinical and MR radiomics data, subsequently to develop a nomogram for practical application. METHODS: Retrospective analysis was conducted on clinical and imaging data collected between May 2010 and August 2018, involving 211 patients diagnosed with histologically confirmed NC who received concurrent chemoradiotherapy or radical surgery in Xiangyang No...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38514830/involvement-of-tgfbi-tagln-axis-in-cancer-stem-cell-property-of-head-and-neck-squamous-cell-carcinoma
#4
JOURNAL ARTICLE
Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo
Head and neck squamous cell carcinoma (HNSCC) is a significant healthcare burden globally. Previous research using single-cell transcriptome analysis identified TGFBI as a crucial marker for the partial-epithelial-mesenchymal transition (partial-EMT) program. However, the precise role of TGFBI in HNSCC progression remains unclear. Therefore, our study aimed to clarify the impact of TGFBI on the malignant behavior of HNSCC cells. Through RNA-sequencing data from the TCGA database, we validated that increased TGFBI expression correlates with a higher occurrence of lymph node metastasis and unfavorable prognosis in HNSCC cases...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38513711/head-and-neck-soft-tissue-sarcoma-patient-age-and-tumor-region-are-predictive-in-disease-free-survival-and-overall-survival
#5
JOURNAL ARTICLE
YiMing Chen, Sandhya Gokavarapu, Ahmed Abdelrehem, Tong Ji
BACKGROUND: Head and neck soft tissue sarcoma (HNSTS), rare and heterogeneous malignancies, are treated primarily treated with surgery. However, prognostic indicators that might guide HNSTS management are poorly defined. PURPOSE: Main purpose of this study is to find variables linked to HNSTS patients' prognosis. Assessment of the TNM system is the secondary purpose. STUDY DESIGN, SETTING, SAMPLE: This study is a retrospective cohort performed on HNSTS patients who received surgery at the Department of Oral and Maxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University from January 1, 2006, to December 31, 2014...
March 5, 2024: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38509710/synchronous-papillary-thyroid-cancer-and-asymptomatic-cervical-lymph-node-sarcoidosis-a-case-report
#6
JOURNAL ARTICLE
Wu You-Syuan, She Yun-Ying
Sarcoidosis is a systemic inflammatory disease characterized by the formation of immune granulomas in multiple organs. The cause of this disease is not yet clear. Papillary thyroid cancer (PTC) is the most common malignant endocrine tumor and is often associated with cervical lymph node metastasis. Assessment of risk factors associated with a poor prognosis is crucial in PTC. The coexistence of sarcoidosis and thyroid cancer is rarely reported in the literature. We describe a case of a 54-year-old female diagnosed with PTC and asymptomatic cervical and thoracic hilar lymphadenopathy due to concurrent sarcoidosis...
March 20, 2024: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38506408/advances-in-testing-for-human-papillomavirus-mediated-head-and-neck-cancer
#7
JOURNAL ARTICLE
Hisham Mehanna, Laia Alemany, Christian von Buchwald
PURPOSE OF REVIEW: New evidence has recently emerged regarding the utility and benefits of dual p16INKa (p16) and Human papillomavirus (HPV) status testing when determining the diagnosis and prognosis of patients with oropharyngeal cancer. RECENT FINDINGS: HPV RNA polymerase chain reaction (PCR) is the most accurate diagnostic test. The other assays (HPV DNA PCR, HPV DNA/RNA in-situ hybridization (ISH) and p16) applied to formalin fixed tumour tissue have varying but high sensitivities and specificities...
March 20, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38504984/tyrosine-phosphatase-ptpn11-shp2-in-solid-tumors-bull-s-eye-for-targeted-therapy
#8
REVIEW
Xun Chen, Steffen Johannes Keller, Philipp Hafner, Asma Y Alrawashdeh, Thomas Yul Avery, Johana Norona, Jinxue Zhou, Dietrich Alexander Ruess
Encoded by PTPN11 , the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proliferation. Activating mutations in the PTPN11 gene may trigger signaling pathways leading to the development of hematological malignancies, but are rarely found in solid tumors. Yet, aberrant SHP2 expression or activation has implications in the development, progression and metastasis of many solid tumor entities...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38503157/c-met-pathway-in-human-malignancies-and-its-targeting-by-natural-compounds-for-cancer-therapy
#9
REVIEW
Chakrabhavi Dhananjaya Mohan, Muthu K Shanmugam, Siddegowda Gopalapura Shivanne Gowda, Arunachalam Chinnathambi, Kanchugarakoppal S Rangappa, Gautam Sethi
BACKGROUND: c-MET is a receptor tyrosine kinase which is classically activated by HGF to activate its downstream signaling cascades such as MAPK, PI3K/Akt/mTOR, and STAT3. The c-MET modulates cell proliferation, epithelial-mesenchymal transition (EMT), immune response, morphogenesis, apoptosis, and angiogenesis. The c-MET has been shown to serve a prominent role in embryogenesis and early development. The c-MET pathway is deregulated in a broad range of malignancies, due to overexpression of ligands or receptors, genomic amplification, and MET mutations...
January 18, 2024: Phytomedicine
https://read.qxmd.com/read/38501325/comparison-of-the-prognostic-value-of-lymph-node-yield-lymph-node-ratio-and-number-of-lymph-node-metastases-in-patients-with-oral-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Ann-Kristin Struckmeier, Mayte Buchbender, Rainer Lutz, Abbas Agaimy, Marco Kesting
BACKGROUND: The aim of this study was to assess the prognostic significance of lymph node yield (LNY), lymph node ratio (LNR), and the number of lymph node metastases (LNMs) in patients affected by oral squamous cell carcinoma (OSCC). METHODS: The study included patients who underwent surgical treatment for primary OSCC. Receiver operating characteristic curves were generated to determine the optimal threshold values. Kaplan-Meier curves were employed, along with the log-rank test, for the analysis of survival...
March 19, 2024: Head & Neck
https://read.qxmd.com/read/38501053/immune-related-adverse-event-related-adrenal-insufficiency-mediates-immune-checkpoint-inhibitors-efficacy-in-cancer-treatment
#11
JOURNAL ARTICLE
Shasha Zhang, Jianhua Wu, Yue Zhao, Jingjing Zhang, Xiaoyun Zhang, Chensi Wu, Zhidong Zhang, Zhanjun Guo
PURPOSE: Immune checkpoint inhibitors (ICIs) have significantly improved the outcomes of patients with cancer; however, these agents may initiate immune-related adverse events (irAEs). Previous studies have demonstrated a robust correlation between disease prognosis and the occurrence of irAEs, specifically skin or endocrine irAEs. Herein, we aimed to evaluate the correlation between irAE-related adrenal insufficiency (AI) and ICI treatment efficacy. PATIENTS AND METHODS: Patients diagnosed with gastrointestinal, respiratory, head and neck, urological, skin and gynecologic cancers treated with anti-programmed cell death 1 (PD-1)/anti-programmed cell death ligand 1 (PD-L1) antibody as monotherapy or combined therapy (combined with chemotherapy or targeted therapy) were divided into irAE-A (patients with irAE-related AI), irAE-B (patients with other irAEs) and non-irAE groups...
2024: Cancer Management and Research
https://read.qxmd.com/read/38497548/the-impact-of-multidisciplinary-approaches-on-the-outcomes-of-olfactory-neuroblastoma-treated-with-postoperative-radiotherapy
#12
JOURNAL ARTICLE
Yuki Tsutsumi, Kazuhiro Omura, Yoshikazu Kijima, Masao Kobayashi, Nei Fukasawa, Teppei Takeda, Teru Ebihara, Satoshi Aoki, Nobuyoshi Otori, Hiromi Kojima, Manabu Aoki
BACKGROUND: We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross-departmental collaboration to enhance the effectiveness of cancer treatment. METHODS: We retrospectively evaluated 22 patients with ONB who underwent postoperative radiotherapy after tumor resection. En bloc resection was performed; pathology specimens were prepared in coronal sections; and irradiation fields were determined after discussion with radiation oncologists, head and neck surgeons, and pathologists...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38497534/rate-of-occult-metastasis-in-lip-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Sagar Kansara, Evrim Oral, Indrani Sarkar, Vlad Sandulache, Rula Mualla, Rohan R Walvekar, William Ryan, Patrick Ha
OBJECTIVES: The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer. MATERIALS AND METHODS: Systematic review and meta-analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms "sentinel node biopsy" and "squamous cell carcinoma...
March 18, 2024: Head & Neck
https://read.qxmd.com/read/38495489/impact-of-linc00312-gene-polymorphism-coupled-with-habitual-risks-on-buccal-mucosa-cancer
#14
JOURNAL ARTICLE
Hui-Ting Hsu, Yen-Ting Lu, Yi-Tzu Chen, Ming-Tai Hsing, Chun-Wen Su, Shih-Chi Su, Chiao-Wen Lin, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of LINC00312 single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two LINC00312 SNPs, namely rs12497104 and rs164966, were investigated among 469 male patients with cancer of buccal mucosa and 1194 gender- and age-matched controls...
2024: Journal of Cancer
https://read.qxmd.com/read/38493725/critical-role-of-exosome-exosomal-non-coding-rnas-and-non-coding-rnas-in-head-and-neck-cancer-angiogenesis
#15
REVIEW
Saade Abdalkareem Jasim, Sulieman Ibraheem Shelash Al-Hawary, Irwanjot Kaur, Irfan Ahmad, Ahmed Hjazi, Iliya Petkov, Saad Hayif Jasim Ali, Ahmed Huseen Redhee, Mahmood Hasen Shuhata Alubiady, Ahmed Muzahem Al-Ani
Head and neck cancer (HNC) refers to the epithelial malignancies of the upper aerodigestive tract. HNCs have a constant yet slow-growing rate with an unsatisfactory overall survival rate globally. The development of new blood vessels from existing blood conduits is regarded as angiogenesis, which is implicated in the growth, progression, and metastasis of cancer. Aberrant angiogenesis is a known contributor to human cancer progression. Representing a promising therapeutic target, the blockade of angiogenesis aids in the reduction of the tumor cells oxygen and nutrient supplies...
March 7, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38493544/myb-alternative-promoter-activity-is-increased-in-adenoid-cystic-carcinoma-metastases-and-is-associated-with-a-specific-gene-expression-signature
#16
JOURNAL ARTICLE
Junchi Huang, André Fehr, Fredrik Jäwert, Jonas A Nilsson, Luc G T Morris, Göran Stenman, Mattias K Andersson
OBJECTIVE: Adenoid cystic carcinoma (ACC) is a head and neck cancer with a poor long-term prognosis that shows frequent local recurrences and distant metastases. The tumors are characterized by MYB oncogene activation and are notoriously unresponsive to systemic therapies. The biological underpinnings behind therapy resistance of disseminated ACC are largely unknown. Here, we have studied the molecular and clinical significance of MYB alternative promoter (TSS2) usage in ACC metastases...
March 16, 2024: Oral Oncology
https://read.qxmd.com/read/38491920/clinical-implication-of-neck-dissection-for-metastatic-lymph-nodes-originating-from-non-head-and-neck-regions
#17
JOURNAL ARTICLE
Min Ji Kim, So Hee Kang, MinSu Kwon, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam, Yoon Se Lee
BACKGROUND: Cervical lymph node metastasis (CLNM) from remote primary sites is rare in head and neck cancer. The efficacy of neck dissection is still being investigated for therapeutic benefits of local management in oligometastasis from non-head and neck cancer. OBJECTIVES: To evaluate the clinical efficacy of neck dissection (ND) in CLNM from distant primary cancers and identify factors contributing to improved survival. MATERIALS AND METHODS: This retrospective case-control study enrolled patients who underwent ND for CLNM from distant primary cancer at Asan Medical Centre between January 2010 and December 2020...
March 16, 2024: Acta Oto-laryngologica
https://read.qxmd.com/read/38487725/neck-management-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#18
JOURNAL ARTICLE
Ning Xu, Qiang Sun
OBJECTIVE: Optimal neck management remains unclear in head and neck cutaneous squamous cell carcinoma (HNcSCC) with parotid metastasis. Our goal was to compare the impact of different cervical treatments on HNcSCC with parotid metastasis. METHODS: Patients were retrospectively included. The primary outcome variables were regional control (RC) and disease-specific survival (DSS). The impacts of observation, elective neck irradiation (ENI), and elective neck dissection (END) were analyzed using the Cox model and presented as hazard ratios (HRs) and 95% confidence intervals (CIs)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38486204/adult-head-and-neck-rhabdomyosarcoma-radiotherapy-based-treatment-outcomes-and-predictors-of-survival
#19
JOURNAL ARTICLE
Dan Zhao, Fang Zhou, Weixin Liu, Zhou Huang, Xiaolong Xu, Baomin Zheng, Changqing Liu, Chujie Bai, Jiayong Liu, Yan Sun, Weihu Wang, Shaowen Xiao
BACKGROUND: Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations. This study aimed to assess the outcomes and identify survival predictors in adult HNRMS. METHODS: We retrospectively evaluated 42 adult patients (> 16 years) with HNRMS who received radiotherapy (RT)-based treatment at our institute between 2008 and 2022...
March 14, 2024: BMC Cancer
https://read.qxmd.com/read/38485986/hypoxia-induced-mir-5100-promotes-exosome-mediated-activation-of-cancer-associated-fibroblasts-and-metastasis-of-head-and-neck-squamous-cell-carcinoma
#20
JOURNAL ARTICLE
Yuansheng Duan, Mengqian Zhou, Beibei Ye, Kai Yue, Feng Qiao, Yuxuan Wang, Qingchuan Lai, Yue Wu, Jiayan Cao, Yansheng Wu, Xudong Wang, Chao Jing
The invasion-metastasis cascade in head and neck squamous cell carcinoma (HNSCC) is predominantly caused by the interaction between tumor cells and tumor microenvironment, including hypoxia as well as stromal cells. However, the mechanism of hypoxia-activated tumor-stroma crosstalk in HNSCC metastasis remains to be deciphered. Here, we demonstrated that HIF1α was upregulated in HNSCC specimens compared with adjacent normal tissues, whose overexpression was associated with lymph node metastasis and predicted unfavorable prognosis...
March 14, 2024: Cell Death & Disease
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