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Choroid And Quantitative

Gisung Son, Suhwan Lee, Yoon Jeon Kim, Joo Yong Lee, June-Gone Kim, Young Hee Yoon
We aimed to correlate the visual function and structural characteristics of the retina and choroid in advanced retinitis pigmentosa (RP) patients. A cross-sectional, retrospective review was conducted of medical records of 149 RP patients who reported visual field constriction on a central 30-2 Humphrey visual field chart. Using spectral domain-optical coherence tomography, central foveal thickness (CFT), ellipsoid zone (EZ) length, macular volume (MV), and submacular choroidal thickness (SMChT) were measured...
March 20, 2019: Ophthalmologica. Journal International D'ophtalmologie
Tudor C Tepelus, Sheena Song, Enrico Borrelli, Muneeswar G Nittala, Elmira Baghdasaryan, SriniVas R Sadda, Vikas Chopra
PRéCIS:: By using OCT-A, we observed a reduction of the superficial macular, peripapillary, and optic nerve, as well as the choriocapillaris in eyes with low tension glaucoma, compared with normal controls. PURPOSE: To investigate macular and optic disc vascular parameters in patients with low tension glaucoma (LTG) using optical coherence tomography angiography (OCTA). METHODS: In this cross-sectional study, images were prospectively acquired from both eyes of 26 patients with clinically-diagnosed LTG and 22 age-matched volunteers with normal healthy eyes using the Zeiss swept-source (SS) OCTA (Plex Elite 9000, Carl Zeiss Meditec)...
March 18, 2019: Journal of Glaucoma
Ayşegül Çömez, Abdullah Beyoğlu, Yalçın Karaküçük
PURPOSE: To evaluate the retinal vascular plexus and choriocapillaris structures in patients with non-ocular Behçet's disease (BD) using optical coherence tomography angiography (OCTA). METHODS: The study included 42 eyes of non-ocular BD patients (study group) and 40 eyes of 20 healthy subjects (control group). Flow area (mm2 ), mean vascular density (VD) (%) and foveal avascular zone (FAZ) (mm2 ) were measured using OCTA (Optovue Inc., Fremont, CA, USA). Subfoveal choroidal thickness (CT) (μm) and central macular thickness (CMT) (μm) measurements were also performed...
March 15, 2019: International Ophthalmology
Liang Li, Siham Almansoob, Pu Zhang, Yan-Dan Zhou, Yao Tan, Ling Gao
PURPOSE: To perform a quantitative analysis of retinal and choroid capillary ischaemia in diabetic patients by using optical coherence tomography angiography (OCTA). METHODS: A total of 97 type 2 diabetic patients and 48 controls were included in this cross-sectional study. Diabetic patients without diabetic retinopathy (DR) were categorized as no DR (NDR) group; DR was classified into mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR)...
February 27, 2019: Acta Ophthalmologica
Federico Corvi, Mariano Cozzi, Erika Barbolini, Dario Nizza, Maria Belotti, Giovanni Staurenghi, Andrea Giani
PURPOSE: To compare indocyanine green angiography and four different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of choroidal neovascularization (CNV). METHODS: This study was an observational case series of Type 1 and Type 2 CNV presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan, imaged with indocyanine green angiography and four different OCTA devices: prototype PlexElite (Carl Zeiss Meditec), prototype Spectralis OCTA (Spectralis; Heidelberg Engineering, Heidelberg, Germany), Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), and AngioPlex (Cirrus 5000 HD-OCT; Carl Zeiss Meditec, Inc, Dublin, CA)...
February 18, 2019: Retina
Bingyao Tan, Jacqueline Chua, Veluchamy Amutha Barathi, Mani Baskaran, Anita Chan, Emily Lin, Marcus Ang, Gerd Klose, Leopold Schmetterer
The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed different algorithms to quantify flow voids in non-human primates that can be easily implemented into clinical research...
January 1, 2019: Biomedical Optics Express
Mircea Mujat, Yang Lu, Gopi Maguluri, Youbo Zhao, Nicusor Iftimia, R Daniel Ferguson
The platform described here combines the non-invasive measurement of the retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide-field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same platform enables comprehensive assessment of blood flow in the retina and choroid in animals and human subjects for diagnostic purposes. Ultra-widefield vasculature visualization is demonstrated here for the first time without injecting additional contrast agents and based only on the motion of particles within the vasculature...
January 1, 2019: Biomedical Optics Express
Justin V Migacz, Iwona Gorczynska, Mehdi Azimipour, Ravi Jonnal, Robert J Zawadzki, John S Werner
Angiographic imaging of the human eye with optical coherence tomography (OCT) is becoming an increasingly important tool in the scientific investigation and clinical management of several blinding diseases, including age-related macular degeneration and diabetic retinopathy. We have observed that OCT angiography (OCTA) of the human choriocapillaris and choroid with a 1.64 MHz A-scan rate swept-source laser yields higher contrast images as compared to a slower rate system operating at 100 kHz. This result is unexpected because signal sensitivity is reduced when acquisition rates are increased, and the incident illumination power is kept constant...
January 1, 2019: Biomedical Optics Express
Klaas-Ole Blohm, Katharina M Hittmair, Alexander Tichy, Barbara Nell
OBJECTIVE: To assess quantitative perfusion of intra- and extraocular regions of interest (ROIs) in conscious, healthy dogs utilizing contrast-enhanced ultrasonography (CEUS); to compare varying enhancement with the first and second bolus injection and in the right and left eye; and to determine the most appropriate examination time. PROCEDURES: Gray scale ultrasonography and contrast harmonic imaging using sulfur hexafluoride were performed randomly assigned in both eyes in 10 university-owned beagles...
February 17, 2019: Veterinary Ophthalmology
Yoshitaka Okuda, Masanori Fukumoto, Taeko Horie, Hidehiro Oku, Shinji Takai, Toyofumi Nakanishi, Kaori Matsuzaki, Hiroyuki Tsujimoto, Tsunehiko Ikeda
Purpose: Microparticle technology enables local administration of medication. The purpose of this study was to examine the inhibitory effect of locally administered candesartan (CAN)-encapsulated microparticles on experimental choroidal neovascularization (CNV). Methods: Laser photocoagulation was used to induce CNV in Brown Norway rats. The rats were pretreated with subconjunctival injections of CAN (5.0 mg/eye) or phosphate buffer saline for 3 days before photocoagulation...
2019: Clinical Ophthalmology
Marco Rispoli, Maria Cristina Savastano, Bruno Lumbroso
BACKGROUND AND OBJECTIVE: The authors have observed and quantified choriocapillaris vascular density changes ("dark halo") around choroidal neovascularization (CNV) before and after anti-vascular endothelium growth factor (VEGF) injections by optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Forty-three flow density areas of 11 eyes with CNV were evaluated before and after treatment in this observational case series. Four cases were CNV type 1 and seven were CNV type 2...
December 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Yuki Ogawa, Ichiro Maruko, Hideki Koizumi, Tomohiro Iida
PURPOSE: To determine the density of the choroidal vasculature by high-quality structure en face optical coherence tomography (OCT) scanned at the same time as OCT angiography in eyes with central serous chorioretinopathy (CSC). METHODS: Thirty-five eyes of 30 patients with CSC (20 men and 10 women; average age, 48.4 years) were studied. Volume scans (12 × 12 mm-square) were obtained at the same time as OCT angiographic scans (Plex Elite 9000; Swept-Source OCT, Zeiss)...
December 13, 2018: Retina
A Stepanov, J Studnička, M Středová, N Jirásková
Progress in optical coherent tomography (OCT) has recently provided new insights into variety of chorioretinal disorders. The use of EDI (Enhanced Depth Imaging) during OCT examinations and as well as OCT angiography provides a more accurate analysis of the choroid both quantitatively and qualitatively. "Pachychoroid" (greek pachy- [παχύ] - thick) is defined as an abnormal and sustained increase in choroidal thickness 300 μm, which is mainly due to dilated choroidal vessels in the Hallers layer and other structural changes in physiological choroidal architecture...
2018: Ceská a Slovenská Oftalmologie
Yoshihiro Otani, Kazuhiko Kurozumi, Joji Ishida, Masafumi Hiramatsu, Masahiro Kameda, Tomotsugu Ichikawa, Isao Date
Background: Surgeries for deep-seated lesions are challenging because making a corridor and observing the interface between lesions and normal brain tissue are difficult. The ViewSite Brain Access System, which is a clear plastic tubular retractor system, is used for resection of deep-seated lesions. However, the tapered shape of this system may result in limitation of the surgical field and cause brain injury to observe the interface between lesions and normal tissue. In this study, we evaluated the usefulness of the combination of ViewSite and brain spatulas...
2018: Surgical Neurology International
Sumit Randhir Singh, Kiran Kumar Vupparaboina, Abhilash Goud, Kunal K Dansingani, Jay Chhablani
The choroid is the vascular coat of the eye,and its role has been studied in multiple chorioretinal disorders. The recent advancements in choroidal imaging techniques including enhanced depth imaging optical coherence tomography (EDI-OCT), swept source (SS-OCT), enface OCT and OCT angiography have facilitated an in-depth analysis of choroid. The gradual shift from manual to automated segmentation and binarization methods have led to precise and reproducible measurements of choroidal parameters. These qualitative and quantitative parameters, called choroidal imaging biomarkers, have evolved over the past decade from a simple linear subfoveal choroidal thickness to more complex 3 dimensional (3-D) choroidal reconstruction thus widening the spectrum encompassing multiple parameters...
November 26, 2018: Survey of Ophthalmology
Ala'a El Ameen, Carl P Herbort
Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA). Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis. Results: The choroid was predominantly involved in 19 (82.6%) patients or 87% (40/46) of the eyes, and the retina in 2 (8...
October 2018: Journal of Ophthalmic & Vision Research
Malvika Arya, Ramy Rashad, Osama Sorour, Eric M Moult, James G Fujimoto, Nadia K Waheed
Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality for depth-resolved visualization of retinal vasculature. Angiographic data couples with structural data to generate a cube scan, from which en-face images of vasculature can be obtained at various axial positions. OCTA has expanded understanding of retinal vascular disorders and has primarily been used for qualitative analysis. Areas Covered: Recent studies have explored the quantitative properties of OCTA, which would allow for objective assessment and follow-up of retinal pathologies...
November 21, 2018: Expert Review of Medical Devices
Timothy D Weber, Jerome Mertz
The human retina is typically imaged in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface reflex are often encountered, which complicate quantitative interpretation of the reflection images. We present an alternative illumination method, which avoids these artifacts. The method uses deeply penetrating near-infrared (NIR) light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye...
August 1, 2018: Biomedical Optics Express
Xiaochun Zhao, Leandro Borba Moreira, Claudio Cavallo, Evgenii Belykh, Sirin Gandhi, Mohamed A Labib, Ali Tayebi Meybodi, Celene B Mulholland, Brandon D Liebelt, Michaela Lee, Peter Nakaji, Mark C Preul
OBJECTIVE: The contralateral interhemispheric transprecuneus approach (CITP) and the supracerebellar transtentorial transcollateral sulcus approach (STTC) are two novel approaches to access the atrium of the lateral ventricle. The authors quantitatively compared the two approaches. METHODS: Both approaches were performed in 6 sides of fixed and color-injected cadaver heads. We predefined 6 targets in the atrium for measurement and standardization of the approaches...
October 8, 2018: World Neurosurgery
Florence Coscas, Diogo Cabral, Telmo Pereira, Carlos Geraldes, Hemaxi Narotamo, Alexandra Miere, Marco Lupidi, Alexandre Sellam, Ana Papoila, Gabriel Coscas, Eric Souied
PURPOSE: To characterize quantitative optical coherence tomography angiography (OCT-A) parameters in active neovascular age-related macular degeneration (nAMD) patients under treatment and remission nAMD patients. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: One hundred and four patients of whom 72 were in Group 1 (active nAMD) and 32 in Group 2 (remission nAMD) based on SD-OCT (Spectral Domain OCT) qualitative morphology. METHODS: This study was conducted at the Centre Ophtalmologique de l'Odeon between June 2016 and December 2017...
2018: PloS One
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