Mustapha Bouhrara, Keenan A Walker, Joseph S R Alisch, Zhaoyuan Gong, Caio H Mazucanti, Alexandria Lewis, Abhay R Moghekar, Lisa Turek, Victoria Collingham, Nader Shehadeh, Giovanna Fantoni, Mary Kaileh, Christopher M Bergeron, Jan Bergeron, Susan M Resnick, Josephine M Egan
The choroid plexus (CP) is a vital brain structure essential for cerebrospinal fluid (CSF) production. Moreover, alterations in the CP's structure and function are implicated in molecular conditions and neuropathologies including multiple sclerosis, Alzheimer's disease, and stroke. Our goal is to provide the first characterization of the association between variation in the CP microstructure and macrostructure/volume using advanced magnetic resonance imaging (MRI) methodology, and blood-based biomarkers of Alzheimer's disease (Aß42/40 ratio; pTau181), neuroinflammation and neuronal injury (GFAP; NfL)...
January 8, 2024: Aging and Disease