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Testosterone and Increases

Yang Xu, Seung Hyun Park, Kyung Noh Yoon, Sun Jung Park, Myung Chan Gye
Citrate esters are considered functional alternatives to phthalate plasticizers, but their toxicity remains poorly understood. The toxicity of citrate esters, including triethyl 2-acetylcitrate (ATEC) and trihexyl O-acetylcitrate (ATHC), were examined together with that of bis (2-ethylhexyl) phthalate (DEHP) using the Organization for Economic Co-operation and Development Test Guideline 407 (OECD TG407). Following 28-day oral administration, no significant differences in body weight or the weight of the brain, pituitary, heart, epididymis, seminal vesicles, or coagulating gland were found between the vehicle control and DEHP, ATEC or ATHC groups...
March 8, 2019: Environmental Research
Nancy N Shahin, Nagla A El-Nabarawy, Ahmed S Gouda, Bruno Mégarbane
The exponentially increasing use of electromagnetic field (EMF)-emitting devices imposes substantial health burden on modern societies with particular concerns of male infertility. Limited studies have addressed the modulation of this risk by protective agents. We investigated the hazardous effects of rat exposure to EMF (900 MHz, 2 h/day for 8 weeks) on male fertility and evaluated the possible protective effect of the polyamine, spermine, against EMF-induced alterations. Exposure to EMF significantly decreased sperm count, viability and motility, and increased sperm deformities...
March 13, 2019: Toxicology and Applied Pharmacology
S Granato, G Barbaro, M R Di Giorgio, F M Rossi, C Marzano, F Impronta, M Spaziani, A Anzuini, A Lenzi, A F Radicioni
CONTEXT: Klinefelter syndrome (KS), in which subjects have additional copies of X chromosomes, is the most common male sex chromosome abnormality, with a prevalence of 1 in 660 and an incidence of about 1 in 500-700 newborns. Its sign and symptoms include infertility, generally low testosterone levels, and an increased prevalence of obesity and metabolic syndrome. Epicardial fat thickness (EFT) reflects visceral adiposity rather than general obesity. OBJECTIVE: The aim of this study was to analyze echocardiographic EFT in a cohort of patients with KS in comparison with non-obese and obese euploid controls, and to evaluate its correlation with biochemical parameters...
March 13, 2019: Metabolism: Clinical and Experimental
Anthonet Ndidiamaka Ezejiofor, Orish Ebere Orisakwe
INTRODUCTION: Lead is a multiple organ toxicant and an oxidative-stress inducer. The effect of Costus afer on metal- induced male reprotoxicity has not been previously carried out, hence this study. The present study investigates the protective effect of Costus afer aqueous leave extract on lead- induced reproductive damages in male albino Wistar rats. METHODS: Adult male albino Wistar rats were weighed and separated into five groups of five rats each. Groups 1 & 2 served as normal and toxic controls receiving deionized and leaded (CH3 COO)2 Pb...
March 15, 2019: JBRA Assisted Reproduction
Ayinuer Reheman, Ze-Yu Gao, Xirali Tursun, Xiao-Ping Pu, Tao Wu, Fei He, Xin Zhao, Haji Akber Aisa
We used Box-Behnken design-based (BBD) response surface methodology (RSM) in this research to optimize the extraction process of Traditional medicine Majun Mupakhi Ela (MME) and evaluate its effect on hydrocortisone-induced kidney yang deficiency. Three independent parameters were applied to evaluate the maximum phosphodiesterase type 5 (PDE5) inhibition activity of MME extracts in vitro. The optimal processing conditions (extraction time 2 h, solid-liquid ratio 1:16, extraction once) gave a maximum PDE5 inhibition rate of 84...
March 15, 2019: Scientific Reports
Solmaz Molaie, Abdolhossein Shahverdi, Mohsen Sharafi, Maryam Shahhoseini, Leila Rashki Ghaleno, Vahid Esmaeili, Elham Abed-Heydari, Mustafa Numan Bucak, AliReza Alizadeh
Our objectives were to assess sperm alteration and adipose tissue (AT) genes expression related to steroid metabolism subsequent to fatty acids consumption. Twenty-nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans and saturated fatty acids source for 60 days. Sperm parameters, levels of hormones and the mRNA abundance of the target genes in AT were assessed. The sperm concentration, total and progressive motilities were lower in FD group compared to that of control (p < 0...
March 15, 2019: Andrologia
Mario Rusnak, Melissa VanderMeulen, Brigid Byrd, Gregory Byrd, Raychel Rusnak, Jeffrey Martin, Tamara Hew-Butler
BACKGROUND: In 2014, 6 collegiate swimmers were hospitalized for symptomatic exertional rhabdomyolysis. OBJECTIVE: To serially monitor and assess relationships between skeletal muscle membrane disruption, upper body soreness (UBS) and lower body soreness (LBS), and stress during the first 6 weeks (timepoints) of preseason training in collegiate male and female swimmers. DESIGN: Prospective observational study. SETTING: College/university...
March 1, 2019: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Florence Belva, Maryse Bonduelle, Herman Tournaye
PURPOSE OF REVIEW: The impact of intracytoplasmic sperm injection (ICSI), on the reproductive health of the offspring is largely unknown. Here we provide a comprehensive overview of the endocrine and reproductive profile in boys and young male adults born after ICSI using ejaculated spermatozoa alleviating male factor infertility in their parents. RECENT FINDINGS: Levels of testosterone, anti-Müllerian hormone and inhibin B were found comparable in prepubertal and pubertal boys conceived by ICSI when compared with levels in boys conceived spontaneously...
March 11, 2019: Current Opinion in Obstetrics & Gynecology
Karen R Kilcoyne, Rod T Mitchell
BACKGROUND: Overall, the incidence of male reproductive disorders has increased in recent decades. Testicular development during fetal life is crucial for subsequent male reproductive function. Non-genomic factors such as environmental chemicals, pharmaceuticals and lifestyle have been proposed to impact on human fetal testicular development resulting in subsequent effects on male reproductive health. Whilst experimental studies using animal models have provided support for this hypothesis, more recently a number of experimental studies using human tissues and cells have begun to translate these findings to determine direct human relevance...
March 14, 2019: Human Reproduction Update
Samar Damiati
Background: Although vitamin D in not a traditional marker for cardiovascular and renal diseases, several studies have proposed a correlation between vitamin D deficiency and these diseases due to the effect of vitamin D on endothelial function. Asymmetric and symmetric dimethyl arginine (ADMA and SDMA, respectively) are endogenous markers of endothelial dysfunction, and are considered as future markers for the assessment of cardiovascular and renal diseases. The present study investigated the association of kidney function tests (urea and creatinine) and dimethylarginine toxins (ADMA and SDMA) in women with vitamin D insufficiency or deficiency...
April 2019: Journal of Medical Biochemistry
Mohammed Azeemuddin, Suryakanth D Anturlikar, Mallappa Onkaramurthy, Mirza R Baig, Basti K Ashok, Raghavendra P Rao, Mohamed Rafiq, Paramesh Rangesh
The objective of the present study was to evaluate "DXB-2030," a polyherbal combination of Trigonella foenum-graecum , Aloe vera , Sphaeranthus indicus , Nardostachys jatamansi , and Symplocos racemosa extracts in an experimental model of testosterone propionate (TP), induced polycystic ovary syndrome (PCOS) in female rats. Thirty animals were divided into 3 groups of 10 each; group 1 served as normal control; group 2 was administered with TP and served as positive control; along with TP, group 3 was treated with "DXB-2030" at a dose of 100 mg/kg p...
2019: Advances in Pharmacological Sciences
Wen Han Tong, Samira Abdulai-Saiku, Ajai Vyas
Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased exploration of area containing cat urine when castrated male mice are supplied with exogenous testosterone. We also report that exogenous testosterone leads to DNA hypomethylation of arginine vasopressin (AVP) promoter in posterodorsal medial amygdala (MePD) and medial bed nucleus of stria terminalis (BNST)...
2019: Frontiers in Behavioral Neuroscience
Jovana Joksimovic, Dragica Selakovic, Nemanja Jovicic, Slobodanka Mitrovic, Vladimir Mihailovic, Jelena Katanic, Dragan Milovanovic, Gvozden Rosic
The aim of our study was to evaluate the effects of chronic administration of nandrolone-decanoate (ND) or testosterone-enanthate (TE) in supraphysiological doses and a prolonged swimming protocol, alone and in combination with ND or TE, on anxiety-like behavior in rats. We investigated the immunohistochemical alterations of the hippocampal neuropeptide Y (NPY) and melanocortin 4 receptor (MC4R) neurons, as a possible underlying mechanism in a modulation of anxiety-like behavior in rats. Both applied anabolic androgenic steroids (AASs) induced anxiogenic effect accompanied with decreased serum and hippocampal NPY...
2019: Frontiers in Neuroscience
Neeraj Kumar, Annie van Dam, Hjalmar Permentier, Martijn van Faassen, Ido Kema, Manfred Gahr, Ton G G Groothuis
Several studies show effects of yolk androgens in avian eggs on the phenotype of the offspring. Yolk hormone concentrations decline strongly already in the first few days of incubation. Although early embryonic uptake of yolk androgens is suggested by the presence of radioactivity in the embryo when eggs are injected with radiolabelled androgens, these studies do not verify the chemical identity of radioactive compound(s), while it is known that these androgens can be metabolized substantially. By using stable isotope labelled testosterone and androstenedione in combination with mass spectrometry, enabling verification of the exact molecular identity of labelled compounds in the embryo, we found that after five days of incubation the androgens are not taken up by the embryo...
March 12, 2019: Journal of Experimental Biology
Aksam Yassin, Ahmad Haider, Karim S Haider, Monica Caliber, Gheorghe Doros, Farid Saad, W Timothy Garvey
OBJECTIVE: Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often have low testosterone. Since testosterone improves glycemic control in T2D, we investigated whether testosterone therapy (TTh) in men with hypogonadism and prediabetes prevents progression to T2D. RESEARCH DESIGN AND METHODS: Three hundred sixteen men with prediabetes (defined as HbA1c 5.7-6...
March 12, 2019: Diabetes Care
Hossein Pasha Zanussi, Farid Shariatmadari, Mohsen Sharafi, Hamed Ahmadi
Reproductive performance in aged broiler breeder roosters is not desirable. The purpose of this study was to assess the effects of dietary flaxseed oil and vitamin E on the semen parameters, hormonal profiles, fatty acid analysis of sperm, and fertility performance of aged roosters. Twenty four roosters were assigned into four treatments and received their diets as following: 1) basal diet as control group (CTRL), 2) basal diet supplemented with 200 mg/kg vitamin E (CTRL + VITE), 3) basal diet supplemented with 2% flaxseed oil (FLAX) and 4) basal diet supplemented with 2% flaxseed oil plus 200 mg/kg vitamin E (FLAX + VITE)...
February 25, 2019: Theriogenology
Randhall B Carteri, Afonso Kopzynski, Lizia Nardi Menegassi, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Luis Valmor Portela
We hypothesized that supraphysiological administration of the anabolic-androgenic steroids (AAS) like testosterone (TEST) and nandrolone decanoate (NAND) might differentially affect synaptic and extrasynaptic components of mitochondrial bioenergetics, thereby resulting in memory impairment. Oil (VEH), NAND or TEST (15 mg/Kg) were daily administered to male CF-1 albino mice for 19-days. We evaluated in the synaptosomes and extrasynaptic mitochondria, Ca2+ influx/efflux, membrane potential ΔѰm, oxidative respiratory states, dehydrogenases activity, H2O2 production, Tau phosphorylation, and spatial memory in the Morris water maze (MWM)...
March 8, 2019: Toxicology Letters
Fabiana Manservisi, Corina Lesseur, Simona Panzacchi, Daniele Mandrioli, Laura Falcioni, Luciano Bua, Marco Manservigi, Marcella Spinaci, Giovanna Galeati, Alberto Mantovani, Stefano Lorenzetti, Rossella Miglio, Anderson Martino Andrade, David Møbjerg Kristensen, Melissa J Perry, Shanna H Swan, Jia Chen, Fiorella Belpoggi
BACKGROUND: Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be "safe" (the US Acceptable Daily Intake - ADI - of 1...
March 12, 2019: Environmental Health: a Global Access Science Source
Pedro Montoya-Botero, Jorge Rodriguez-Purata, Nikolaos P Polyzos
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of androgen supplementation in ART with the most updated evidence, from animal studies to its clinical applications in poor ovarian responders (POR) and the future studies to be published. RECENT FINDINGS: Animal studies, has shown that testosterone supplementation, can be an option to increase the recruitable follicular pool in POR. However, the potential mechanism of action, dose, and duration of treatment is still under investigation...
February 21, 2019: Current Opinion in Obstetrics & Gynecology
Adrian L Lopresti, Peter D Drummond, Stephen J Smith
Ashwagandha ( Withania somnifera) is a herb commonly used in Ayurvedic medicine to promote youthful vigor, enhance muscle strength and endurance, and improve overall health. In this 16-week, randomized, double-blind, placebo-controlled, crossover study, its effects on fatigue, vigor, and steroid hormones in aging men were investigated. Overweight men aged 40-70 years, with mild fatigue, were given a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks...
March 2019: American Journal of Men's Health
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