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Lymph Node Dissection

Francesco A Mistretta, Elio Mazzone, Sophie Knipper, Carlotta Palumbo, Zhe Tian, Sebastiano Nazzani, Fred Saad, Emanuele Montanari, Derya Tilki, Alberto Briganti, Shahrokh F Shariat, Ottavio de Cobelli, Pierre I Karakiewicz
BACKGROUND: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age. MATERIALS AND METHODS: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified...
February 13, 2019: Cancer Epidemiology
Harris U Chengazi, Alok A Bhatt
The complex anatomy of the carotid space within a small confined area is unique to the head and neck and allows for a vast array of pathology. This paper will review the anatomy of the carotid space from the skull base to the thorax, defining its borders at multiple levels, as well as its contents. The paper will also describe the myriad of mass lesions and vascular pathologies that may occur within the carotid space. The discussion will include anatomic considerations in differential diagnoses, imaging features, and lesion characteristics across multiple imaging modalities including CT, MRI, ultrasound, and conventional angiography...
February 15, 2019: Insights Into Imaging
M Simon, S Vignes
INTRODUCTION: In France, breast cancer is the most frequent cancer in women. Lymphedema, the main complication, is poorly known. The objective of this study was to assess the state of knowledge of upper limb lymphedema (risk factors, complications, treatment) after treatment of breast cancer among general practitioners from the Haute-Normandie and Île-de-France regions. MATERIALS AND METHODS: A cross-sectional study with 23 closed questions was sent by email to 490 practicing doctors...
February 2019: Journal de Médecine Vasculaire
Yen-Ling Lai, Heng-Cheng Hsu, Kuan-Ting Kuo, Yu-Li Chen, Chi-An Chen, Wen-Fang Cheng
The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. The primary clinical presentation was enlarging abdominal masses at previous surgical scars. Four patients underwent initial/primary surgeries with/without adjuvant chemotherapy...
February 14, 2019: International Journal of Environmental Research and Public Health
Tian Sun, Richard L Ferrero, Stephen E Girardin, Jennifer L Gommerman, Dana J Philpott
The NOD-like receptor (NLR) family plays an important role in innate immunity. CIITA and NLRC5 are unusual members of the NLR family that instead of recognizing pathogen-associated or damage-associated molecular patterns, form enhanceosomes with adaptor molecules and modulate major histocompatibility complex (MHC) class II and MHC class I expression, respectively. While NLRC5 has been shown to play a role during intracellular pathogen infection and tumor cell immune evasion, its role in regulating antigen-specific CD8+ T cell responses at the intestinal mucosa has not been investigated...
February 15, 2019: Immunology and Cell Biology
Chih-Jung Wang, Ying-Jui Chao, Edgar D Sy, Yan-Shen Shan
BACKGROUND: Minimally invasive gastric cancer surgery requires an extended liver retraction in order to provide optimal operative view, working space for lymph node dissection, and esophageojejunal reconstruction. Ideally, it should avoid reposition of the retractor, additional skin incision or puncture, and liver parenchyma injury. Herein, we introduced an intracorporeal W-shaped liver retraction technique (W-LRT) for minimally invasive gastric cancer surgery without an additional incision or abodminal puncture...
February 12, 2019: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
José F Gallegos-Hernández, José A Abrego-Vázquez, Aldo Olvera-Casas, Gerardo G Minauro-Muñoz, Alma L Ortiz-Maldonado
Introduction: Patients with bulky metastases of squamous cell carcinoma of the head and neck represent a challenge for the therapeutic decision; balance between oncological control and complications should be achieved. The therapeutic sequence has no impact on survival but sequelae. Objective: We analyze the oncological results in patients with bulky metastases on the neck treated with induction chemotherapy and with up-front neck dissection. Method: Retrospective analysis of patients undergoing treatment for cervical lymph node metastasis of squamous cell carcinoma; The therapeutic sequence was decided based on volume, resectability, site, and size of the primary and general condition of the patient...
2019: Cirugia y Cirujanos
Giovanni E Cacciamani, Antonio B Porcaro, Marco Sebben, Alessandro Tafuri, Riccardo Rizzetto, Nicolò De Luyk, Elisa Ciochetta, Tania Processali, Marco Pirozzi, Nelia Amigoni, Paolo Corsi, Matteo Brunelli, Vincenzo De Marco, Walter Artibani
BACKGROUND: To assess the anatomical prevalence and secondary involvement of Cloquet's nodes in patients undergoing robotic radical prostatectomy (RRP) and extended pelvic lymph node dissection (ePLND) for prostate cancer (PCa). METHODS: RRP and ePLND were performed by two expert surgeons (WA and VDM). Data were prospectively collected and retrospectively analysed. Dissected pelvic lymph nodes were sampled according to an anatomical template as follows: external iliac, obturator, Marcille's, and Cloquet's...
February 14, 2019: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Koustav Mazumder, Arun Elangovan, Bhavana Rai, Vanita Suri, Vanita Jain, Jaswinder Kalra, Sushmita Ghoshal
Context: Vulvar cancer is one of the uncommon gynecological malignancies. Multimodality treatment with surgery, radiotherapy, and chemotherapy are required for treatment of the disease. Aims: The aim of the study was to evaluate clinical outcome in patients of carcinoma vulva, treated at our institution. Subjects and Methods: This was a retrospective-cohort study done in 50 patients with squamous cell carcinoma of the vulva, treated at our institution from January 2008 to December 2014...
January 2019: South Asian Journal of Cancer
Roma Pradhan, Amit Agarwal, Punita Lal, Niraj Kumari, Manoj Jain, Gyan Chand, Anjali Mishra, Gaurav Agarwal, Ashok K Verma, Saroj K Mishra
Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area. Material and Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Results: The mean age of patient was 58 years...
November 2018: Indian Journal of Endocrinology and Metabolism
Toshiki Noma, Tsuyoshi Takahashi, Yasuhiro Miyazaki, Yukinori Kurokawa, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Makoto Yamasaki, Masaki Mori, Yuichiro Doki
A 46-year-old male patient with anorexia consulted our hospital. A scirrhous gastric cancer was found, and he was introduced to us. Laparoscopic examination was performed, and advanced peritoneal disseminated nodules were confirmed(CY1, P1). S-1 plus docetaxel therapy was introduced as first-line chemotherapy. Although the best effect judgment was PR, the primary lesion re-increased in size. We changed to the secondary weekly paclitaxel therapy. After 7 courses of the therapy, a second laparoscopic examination was performed, which confirmed the microscopic residual cancer cells(P1)in the reduced peritoneal nodules...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Megumi Watanabe, Takayoshi Miyake, Yu Mikane, Ryohei Syoji, Yoshinori Kajiwara, Katsuyuki Aoyama, Tomohiro Nogami, Hitoshi Nishikawa, Susumu Shinoura, Kaori Shigemitsu, Yasuyuki Nonaka, Dofu Hayashi
The patient was a 59-year-old man with type 2 advanced gastric cancer in the antrum. Abdominal computed tomography revealed the primary tumor with regional lymph node metastasis. Distal gastrectomy and D2 lymph node dissection were performed. Histopathological findings indicated gastric small cell carcinoma. Lymph node metastasis was observed microscopically in the #6 lymph nodes. Peritoneal lavage cytology was positive. The pathologic stage of the disease was pT2(MP), med, INF b, ly2, v2, pPM0, pDM0, pN2(6/33: #5, #6), M1, P0, CY1, H0, stage Ⅳ, R1(cy+)...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Tadashi Tsukamoto, Shingo Togano, Eijiro Edagawa, Ryoji Kaizaki, Takaaki Hori, Satoshi Takatsuka
A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Computed tomography revealed bulky regional lymph node metastases, solitary liver metastasis, and left adrenal metastasis. After three courses of combined chemotherapy with S-1 and CDDP, the gastric lesion and lymph node metastases shrunk, but the liver metastasis and left adrenal metastasis enlarged...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Koki Tamai, Chikara Ebisui, Noriyuki Yamamura, Takayuki Minoji, Hiroyuki Takabatake, Tomohiro Kitahara, Noriyuki Watanabe, Shu Okamura, Nariaki Fukuchi, Hideoki Yokouchi, Masakatsu Kinuta, Kazuhito Ohishi
A 78-year-oldwoman was referredfor exertional dyspnea. Severe anemia(Hb 4.2 g/dL)was detected, and upper endoscopy revealeda giant ulcer at the posterior wall of the gastric body. Computedtomography showeda mass protruding from the gastric wall, suggestive of a submucosal tumor. Although biopsy did not confirm a diagnosis, we performed distal gastrectomy to control the bleeding. The pathological findings and systemic examination confirmed a diagnosis of extramedullary plasmacytoma of the stomach. Plasmacytoma is a tumor of the bone marrow derived from plasma cells that mature from B cells...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Chikara Ebisui, Noriyuki Yamamura, Takayuki Minoji, Hiroyuki Takabatake, Koki Tamai, Tomohiro Kitahara, Noriyuki Watanabe, Shu Okamura, Nariaki Fukuchi, Hideoki Yokouchi, Masakatsu Kinuta, Kazuhito Ohishi
An 82-year-oldwoman was admittedto our hospital because of appetite loss andwas diagnosedwith a Type 3 tumor in the lower gastric body. Pathological examination suggested moderately differentiated adenocarcinoma with negative staining for HER2 by immunohistochemistry. An abdominal CT revealedthickening of the gastric wall andparaaortic lymph node metastases. The clinical findings suggested Stage Ⅳ disease(T4aN3M1). Chemotherapy was administered with a combination of S-1 plus oxaliplatin(SOX). After 2 courses of the SOX regimen, an abdominal CT showed a reduction of the paraaor- tic lymph node metastases, and the CEA level hadd ecreasedto 6...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Naotake Funamizu, Moe Kobayashi, Katsushi Dairaku, Yuki Hiramoto, Kenta Tomori, Tomonori Iida, Kazunao Kurihara, Yukio Nakabayashi
A 70-year-old man with epigastralgia who initially visited a local hospital was referred to us for further examination. Gastrointestinal endoscopy exhibited a type 3 tumor of the stomach from the body to the antrum(adenocarcinoma, por1). Contrast-enhanced CT revealed thickness in the wall of the gastric body with bulky lymph nodes and ascites. Staging laparoscopy showed that the patient was diagnosed with sStage Ⅳ gastric cancer with positive peritoneal cytology. Therefore, SOX therapy was administered. Subsequently, total gastrectomy with D2 lymph node dissection was performed, since the primary tumor and lymph nodes were significantly reduced...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kojiro Ono, Takuo Takehana, Kazuhiro Yamamoto, Shunsuke Kawai, Michitaka Nagase
A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Contrast computed tomography(CT)showed upper gastric wall thickening, and #1, #3, #7, #8a, and #11p enlarged lymph nodes but no distant metastasis. We diagnosed gastric cancer, UM, Less, Type 3, gastric neuroendocrine carcinoma, cT4aN3M0P0CY0, Stage ⅢC...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Katsuya Gunjigake, Koichi Okamoto, Ryosuke Gabata, Takahisa Yamaguchi, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
Docetaxel, cisplatin, and 5-FU(DCF)chemotherapy for esophageal cancer has been reported to be highly effective, but often causes serious adverse events, including severe bone marrow suppression. We report the successful treatment of a 67- year-old man with highly advanced esophageal cancer with invasion of the left bronchus and broad lymph node metastases. He received induction chemotherapy with DCF therapy, and prophylactic administration of pegfilgrastim. He safely completed 5 courses of DCF therapy without serious adverse events, such as neutropenia and febrile neutropenia...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hayato Konno, Yasuhisa Ohde
This review article describes limited resection for lung cancer based on previous reports and a retrospective examination of the operative results at our hospital.The importance of limited resection as a surgical treatment is becoming much greater than before. In minimally invasive surgery for lung cancer, ① limited resection for pulmonary functional preservation, ② limited resection of lymph node dissection, and ③ minimally invasive thoracic approach may be considered. Radical segmentectomy was limited to the cases registered in the clinical trials [the Japan Clinical Oncology Group (JCOG) study 0802/1211]to verify the validity of limited surgery...
January 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Danique M S Berger, Martinus M van Veen, Max F Madu, Alexander C J van Akkooi, Wouter V Vogel, Alfons J M Balm, Willem M C Klop
BACKGROUND: Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien. METHODS: In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed. RESULTS: Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Eight of the 10 parotid-positive patients developed a recurrence vs 17 of the 30 parotid-negative patients (P = 0...
February 14, 2019: Head & Neck
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