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Metastatic endometrial cancer

M Bedyńska, G Szewczyk, T Klepacka, K Sachadel, T Maciejewski, D Szukiewicz, A Fijałkowska
PURPOSE: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery. METHODS: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018...
February 14, 2019: Archives of Gynecology and Obstetrics
O Abu-Shawer, M Abu-Shawer, N Hirmas, A Alhouri, A Massad, B Alsibai, H Sultan, H Hammo, M Souleiman, Y Shebli, M Al-Hussaini
BACKGROUND: Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the carcinogenesis process including metastasis. The high neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) were found to be associated with poor survival rates in the majority of solid tumors. However, only a few studies were conducted to further investigate this association in patients with advanced gynecological cancers...
February 12, 2019: BMC Cancer
Tian Wang, Yuanjing Hu, Ya He, Peisong Sun, Zhengchen Guo
OBJECTIVES: To determine the feasibility and performance of sentinel lymph-node (SLN) mapping among women with high-risk endometrial cancer (EC). MATERIALS AND METHODS: Ninety-eight patients at high-risk EC were enrolled in this retrospective surgical trial from August 2016 to August 2018. All patients underwent intraoperative SLN biopsy, with ICG injection for laparoscopic staging; this was followed by pelvic and paraaortic lymphadenectomy (LAD). Outcomes included SLN detection rate, false-negative SLN algorithm rate, and the negative predictive value (NPV) of the SLN algorithm...
February 12, 2019: Archives of Gynecology and Obstetrics
Clémentine Bouchez, Emmanuelle Kempf, Christophe Tournigand
Checkpoints inhibitors are known to induce striking tumor responses in advanced MSI colorectal cancers, which used to be related to a poor clinical outcome. The incidence of the MSI phenotype is highly heterogeneous across non-colorectal cancers. The highest incidence rates are found in endometrioid forms of uterine cancers and in gastric tumors (20 to 40 % and 10 to 33 %, respectively). The association between a "MSI" tumor phenotype and other clinical or biological tumor characteristics is still under debate...
February 5, 2019: Bulletin du Cancer
Lobna Ouldamer, Sofiane Bendifallah, Gilles Body, Cyril Touboul, Olivier Graesslin, Emilie Raimond, Pierre Collinet, Charles Coutant, Alexandre Bricou, Vincent Lavoué, Jean Lévêque, Emile Daraï, Marcos Ballester
Patterns of distant metastatic failure of endometrial cancer (EC) by specific anatomic site are not well described in the literature. In this manuscript, we evaluated the metastatic patterns of EC cancer and analysed the potential distribution of metastatic disease in this malignancy. METHODS: A total of 1444 women with EC were identified. Of which we extracted women with locoregional and distant recurrence or with distant recurrence alone. Women were scored based on first site of metastasis: multiple versus one site: bone, brain, lung, liver or sus diaphragmatic lymph nodes...
January 19, 2019: European Journal of Surgical Oncology
Chan-Hee Lee, Hyun Jung Kim, Chi-Heum Cho, IlSeon Hwang
A 73-year-old woman was referred to the pulmonology department for abnormal findings on chest computed tomography. She had undergone a laparoscopic staging operation including a hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic node and para-aortic node dissection, and concurrent chemo-radiation therapy for endometrial serous carcinoma stage IIIc cancer 15 months earlier. A follow-up chest computed tomography after the chemotherapy showed that the right lower lobe bronchus was obstructed, and it was necessary to differentiate a primary lung malignancy from a metastasis and secretion...
2019: SAGE Open Medical Case Reports
Zhi-Hang Zhou, Qing-Liang Wang, Lin-Hong Mao, Xiao-Qin Li, Peng Liu, Jin-Wen Song, Xue Liu, Feng Xu, Jing Lei, Song He
The acidic extracellular microenvironment, namely acidosis, is a biochemical hallmark of solid tumors. However, the tumorigenicity, metastatic potential, gene expression profile and chromatin accessibility of acidosis-adapted colorectal cancer cells remain unknown. The colorectal cancer cell SW620 was cultured in acidic medium (pH 6.5) for more than 3 months to be acidosis-adapted (SW620-AA). In comparison to parental cells, SW620-AA cells exhibit enhanced tumorigenicity and liver metastatic potential in vivo...
February 4, 2019: Cell Cycle
Emma C Rossi
Sentinel lymph node (SLN) biopsy has been investigated as an alternative to conventional pelvic and para-aorticlymphadenectomy for the surgical staging of endometrial cancer. Clinical trials have established the accuracy of sentinel nodes in the detecting metastatic disease. Novel advancements in tracers from the historically favored blue dyes and radio labeled colloids to near infrared imaging of fluorescent dyes has improved the ability to detect sentinel nodes and increased options for surgeons. The uterine cervix has been shown to be a feasible and accurate injection site for tracer, though the potential for under-evaluation of the para-aortic nodes remains a controversy, particularly for high-risk cancers...
February 1, 2019: International Journal of Gynecological Cancer
Sewoon Kim, Sunjoo Jeong
Mutations in the β-catenin gene ( CTNNB1 ) have been implicated in the pathogenesis of some cancers. The recent development of cancer genome databases has facilitated comprehensive and focused analyses on the mutation status of cancer-related genes. We have used these databases to analyze the CTNNB1 mutations assembled from different tumor types. High incidences of CTNNB1 mutations were detected in endometrial, liver, and colorectal cancers. This finding agrees with the oncogenic role of aberrantly activated β-catenin in epithelial cells...
January 31, 2019: Molecules and Cells
Görkem Vayısoğlu Şahin, Gülistan Karadeniz, Gülru Polat, Fatma Demirci Üçsular, Zekiye Aydoğdu, Enver Yalnız
Pulmonary metastases are usually seen as parenchymal nodules, lymphatic-interstitial spread and pleural effusion, however cavitary and cystic metastatic lesions are rare. While breast cancer, gastrointestinal tumors, kidney tumors, malignant melanoma, sarcomas, lymphoma and leukemia mostly metastasize to the lung, endometrial adenocarcinoma rarely metastasizes. A 73-year-old woman with multiple cystic-cavitary lung lesions was referred to our clinic because of chronic cough. She had endometrial adenocarcinoma metastasis to the lung...
December 2018: Tüberküloz Ve Toraks
Diana Monsivais, Jia Peng, Yibin Kang, Martin M Matzuk
The endometrial lining of the uterine cavity is a highly dynamic tissue that is under the continuous control of the ovarian steroid hormones, estrogen and progesterone. Endometrial adenocarcinoma arises from the uncontrolled growth of the endometrial glands, which is typically associated with unopposed estrogen action and frequently occurs in older postmenopausal women. The incidence of endometrial cancer among younger women has been rising due to increasing rates of obesity, a major risk factor for the disease...
January 17, 2019: Proceedings of the National Academy of Sciences of the United States of America
F Moro, M Leombroni, T Pasciuto, I N Trivellizzi, F Mascilini, F Ciccarone, G F Zannoni, F Fanfani, G Scambia, A C Testa
OBJECTIVE: To compare the ultrasound characteristics of patients with synchronous primary cancers of the endometrium and ovary versus those of patients with endometrial cancer with ovarian metastases. METHODS: This is a single retrospective observational study. We identified patients with a histological diagnosis of endometrial cancer and an ovarian malignant mass, who had undergone preoperative ultrasound examination, in order to compare the ultrasound features of ovarian malignant masses between patients with synchronous primary cancers of the endometrium and ovary (synchronous group) and patients with endometrial cancer with ovarian metastases (metastatic group)...
January 8, 2019: Ultrasound in Obstetrics & Gynecology
Tamás Deli, Mónika Orosz, Attila Jakab
Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT)...
January 8, 2019: Pathology Oncology Research: POR
Yi Su, Jing Wang, Zhao Ma, Wenjing Gong, Lianzhi Yu
Endometrial cancer (EC), a prevalent gynecologic tumor, is a great threat to women. We aimed to explore miR-142's effects on EC and the relevant mechanisms. Cell proliferation was evaluated with MTT, cell counting, and colony formation assay. MRNA abundances of miR-142 and cyclin D1 (CCND1) were examined with quantitative real-time PCR. CCND1 protein level in cells was analyzed with Western blot. miR-142's downstream target was identified with targetscan and luciferase reporter assay. Nude mice were injected subcutaneously with Ishikawa (ISK) cells transfected with or without miR-142 mimics...
December 26, 2018: DNA and Cell Biology
Javier Mariscal, Patricia Fernández-Puente, Valentina Calamia, Alicia Abalo, Maria Santacana, Xavier Matias-Guiu, Rafael Lopez-Lopez, Antonio Gil-Moreno, Lorena Alonso-Alconada, Miguel Abal
Endometrial cancer (EC) is the most frequent gynecological cancer. Tumor dissemination affecting around 20% of EC patients is characterized at the primary carcinoma by epithelial-to-mesenchymal transition (EMT) associated with myometrial infiltration. At distant sites, the interaction of circulating tumor cells (CTCs) with the microenvironment results crucial for metastatic colonization, with a participation of the extracellular vesicles (EVs). We comprehensively approached these primary and secondary sites to study the impact of tumor EVs on the metastatic efficiency of CTCs in EC...
December 26, 2018: Journal of Proteome Research
Fabio Barra, Giulio Evangelisti, Lorenzo Ferro Desideri, Stefano Di Domenico, Domenico Ferraioli, Valerio Gaetano Vellone, Franco De Cian, Simone Ferrero
Endometrial cancer (EC) is the most common neoplasm of the female genital tract in developed countries. Despite the progress in early detection and treatment, a significant number of cases of advanced ECs are still diagnosed. These patients have few treatment options and a poor prognosis. Our understanding of EC pathogenesis and progression has been enhanced by recent genomic studies. Among the relevant biological pathways, phosphatidylinositol 3-kinase/AKT (PIK3/AKT)-mammalian target of rapamycin (mTOR) signaling is frequently upregulated in this cancer...
December 21, 2018: Expert Opinion on Investigational Drugs
Jan Kosťun, Martin Pešta, Jiří Sláma, Robert Slunéčko, Pavel Vlasák, Jiří Bouda, Zdeněk Novotný, Ondřej Topolčan, Radek Kučera, Vlastimil Kulda, Kateřina Houfková, Denis Berezovskiy, Alena Bartáková, Jiří Presl
BACKGROUND AND OBJECTIVES: Utilisation of the one-step nucleic acid amplification (OSNA) molecular biology method for the detection of the metastatic involvement of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients. A comparison with histopathological ultrastaging and a description of the clinical consequences. METHODS: Surgically treated EC patients underwent detection of SLNs. Nodes greater than 5 mm were cut into sections 2-mm thick parallel to the short axis of the node...
December 3, 2018: Journal of Surgical Oncology
Yutaka Yoneoka, Hiroshi Yoshida, Mitsuya Ishikawa, Hanako Shimizu, Takashi Uehara, Takashi Murakami, Tomoyasu Kato
OBJECTIVE: Gynecologists occasionally encounter synchronous endometrial and ovarian endometrioid carcinoma (SEO-EC) patients who show favorable prognosis than locally advanced or metastatic disease patients. This study aimed to elucidate prognostic factors of SEO-EC and identify patients who have a sufficiently low risk of recurrence without receiving adjuvant chemotherapy. METHODS: We retrospectively reviewed 46 patients with pathologically confirmed SEO-EC who underwent surgery at the National Cancer Center Hospital between 1997 and 2016...
September 17, 2018: Journal of Gynecologic Oncology
R Montero Macias, V Balaya, H Bonsang-Kitzis, M Deloménie, M Gosset, M Mimouni, V Simon, C Lecurieux-Lafayette, E Larouzee, C Ngô, As Bats, F Lécuru
We here describe a case report of a positive precaval sentinel lymph node with negative pelvic sentinel lymph node in a patient with endometrial cancer. A 45-years-old woman was diagnosed with a grade 2 endometrioid carcinoma of the endometrium. She was treated with a hysterectomy and bilateral salpingo-oophorectomy, associated with dissection of sentinel lymph nodes (SLNs). We detected bilateral external and common bilateral iliac nodes and one precaval node. At pathological examination the pelvic nodes were non-metastatic, but the precaval node was positive...
November 23, 2018: Journal of gynecology obstetrics and human reproduction
Jing Zuo, Ling Ying Wu, Min Cheng, Ping Bai, Cheng Zhi Lei, Ning Li, Gong Yi Zhang, Dan Zhao, Bin Li
STUDY OBJECTIVE: To evaluate the detection rate and accuracy of sentinel lymph node (SLN) mapping using cervical and fundal injections of carbon nanoparticles (CNPs) in laparoscopic surgery of endometrioid endometrial cancer (EC) and to identify uterine lymphatic drainage pathways validated by mapping. DESIGN: A prospective consecutive study (Canadian Task Force classification II-2). SETTING: An academic research center. PATIENTS: Consecutive patients with a pathologic diagnosis of early-stage EC scheduled for primary laparoscopic-assisted staging surgery (laparoscopic hysterectomy, bilateral salpingo-oophorectomy, or comprehensive lymphadenectomy)...
November 14, 2018: Journal of Minimally Invasive Gynecology
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