Alexis Hermida, Jean-Baptiste Gourraud, Isabelle Denjoy, Véronique Fressart, Florence Kyndt, Alice Maltret, Diala Khraiche, Didier Klug, Philippe Mabo, Frédéric Sacher, Philippe Maury, Pierre Winum, Pascal Defaye, Gael Clerici, Dominique Babuty, Yedid Elbez, Charles Morgat, Elodie Surget, Anne Messali, Patrick De Jode, Aurélien Clédel, Damien Minois, Pierre Maison-Blanche, Adrien Bloch, Antoine Leenhardt, Vincent Probst, Fabrice Extramiana
BACKGROUND: Efficacy of beta blocker treatment in type 3 long QT syndrome (LQT3) remains debated. OBJECTIVES: To test the hypothesis that beta-blocker use is associated with cardiac events in a French cohort of LQT3 patients. METHODS: All the patients with a likely pathogenic/pathogenic variant in the SCN5A gene (linked to LQT3) were included and followed up. Documented ventricular tachycardia/ventricular fibrillation, torsade de pointes, aborted cardiac arrest, sudden death, and appropriate shocks were considered as severe cardiac events (SCEs)...
November 11, 2023: Heart Rhythm: the Official Journal of the Heart Rhythm Society